hydroxyurea has been researched along with Neural Tube Defects in 7 studies
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Various doses of hydroxyurea, a teratogen to the rodent central nervous system, were administered to curly-tail mice on either day 8 or day 9 of pregnancy in an attempt to increase the number of NTD in the embryos." | 7.66 | Effect of hydroxyurea on neural tube defects in the curly-tail mouse. ( Perkins, KJ; Seller, MJ, 1983) |
| "Chemotherapeutic agents such as methotrexate (MTX), raltitrexed (RTX), 5-fluorouracil (5-FU), hydroxyurea (HU), and retinoic acid (RA), and valproic acid (VPA), an antiepileptic drug, all can cause malformations in the developing central nervous system (CNS), such as neural tube defects (NTDs)." | 4.12 | Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis. ( Guan, Z; Li, S; Liang, Y; Niu, B; Wang, J; Wang, X; Yang, A; Yu, J; Zhu, Z, 2022) |
| " Various doses of hydroxyurea, a teratogen to the rodent central nervous system, were administered to curly-tail mice on either day 8 or day 9 of pregnancy in an attempt to increase the number of NTD in the embryos." | 3.66 | Effect of hydroxyurea on neural tube defects in the curly-tail mouse. ( Perkins, KJ; Seller, MJ, 1983) |
| " It has been found that maternal administration of hydroxyurea, mitomycin C, or 5-fluorouracil on day 9 of pregnancy, that is, when the fetal neural tube is in the final stages of closure, leads to a significant reduction in the proportion of NTD (to 15 to 20%) in the offspring, while total litter size is unaffected." | 3.66 | The cause of neural tube defects: some experiments and a hypothesis. ( Seller, MJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, Z | 2 |
| Liang, Y | 1 |
| Wang, X | 2 |
| Zhu, Z | 2 |
| Yang, A | 1 |
| Li, S | 1 |
| Yu, J | 1 |
| Niu, B | 2 |
| Wang, J | 2 |
| Dong, Y | 1 |
| Xu, L | 1 |
| Zhang, T | 1 |
| Seller, MJ | 2 |
| Perkins, KJ | 1 |
| Rain, JD | 1 |
| Wu, CF | 1 |
| Nakamura, H | 1 |
| Chan, AP | 1 |
| Zhou, YH | 1 |
| Cao, T | 1 |
| Kuang, J | 1 |
| Gong, SG | 1 |
| He, G | 1 |
| Etkin, LD | 1 |
| Herken, R | 1 |
7 other studies available for hydroxyurea and Neural Tube Defects
| Article | Year |
|---|---|
Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis.
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Class I Phosphatidylinositol 3-Kinases; ErbB Recept | 2022 |
dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development.
Topics: Abnormalities, Drug-Induced; Animals; Apoptosis; Brain; Caspase 3; Cell Proliferation; Deoxyribonucl | 2015 |
Effect of hydroxyurea on neural tube defects in the curly-tail mouse.
Topics: Animals; Female; Fetal Resorption; Hydroxyurea; Male; Mice; Mice, Neurologic Mutants; Neural Tube De | 1983 |
The cause of neural tube defects: some experiments and a hypothesis.
Topics: Animals; Disease Models, Animal; DNA; Female; Fluorouracil; Gestational Age; Hydroxyurea; Mice; Mice | 1983 |
[Hydroxyurea--is it a harmless drug in Vaquez disease?]].
Topics: Aged; Alopecia; Combined Modality Therapy; Cystitis; Erectile Dysfunction; Female; Fever; Follow-Up | 2001 |
Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biomarkers; Carrier Proteins; Cell Differentiation; Cel | 2001 |
Ultrastructural changes in the neural tube of 10-day-old mouse embryos exposed to colchicine and hydroxyurea.
Topics: Abnormalities, Drug-Induced; Animals; Colchicine; Drug Administration Schedule; Drug Interactions; H | 1985 |