hydroxyurea has been researched along with Metastase in 66 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Irinotecan has shown activity in advanced colorectal cancer resistant to leucovorin and fluorouracil." | 9.10 | Bimonthly leucovorin, infusion 5-fluorouracil, hydroxyurea, and irinotecan (FOLFIRI-2) for pretreated metastatic colorectal cancer. ( André, T; Artru, P; Carola, E; de Gramont, A; Gilles-Amar, V; Krulik, M; Louvet, C; Mabro, M, 2003) |
| "The aim of the study was to investigate the possibility of dual modulation of UFT with leucovorin and hydroxyurea in a phase II trial of metastatic colorectal cancer." | 9.09 | Dual modulation of UFT with leucovorin and hydroxyurea in metastatic colorectal cancer. ( Aabo, K; Hansen, F; Jakobsen, A; Pfeiffer, P; Sandberg, E, 2001) |
| "A clinical trial of parenteral, weekly, high-dose HU in combination with weekly, high-dose infusional fluorouracil (5FU) was initiated in patients with advanced pancreatic and gastric cancer." | 6.71 | Phase II clinical trial of parenteral hydroxyurea in combination with fluorouracil, interferon and filgrastim in the treatment of advanced pancreatic, gastric and neuroendocrine tumors. ( Haynes, H; Kaleya, R; Kaubisch, A; Rozenblit, A; Wadler, S, 2004) |
| "In this study 26 women with metastatic breast cancer responding to lower dose combination chemotherapy were treated with 18 g/m2 of hydroxyurea added to the widely used combination of cyclophosphamide (CY) 6 g/m2 and thiotepa 600 mg/m2." | 5.29 | High-dose cyclophosphamide, thiotepa and hydroxyurea with autologous hematopoietic stem cell rescue: an effective consolidation chemotherapy regimen for early metastatic breast cancer. ( Edwards, B; Kessinger, A; Reed, EC; Vaughan, WP, 1994) |
| "Irinotecan has shown activity in advanced colorectal cancer resistant to leucovorin and fluorouracil." | 5.10 | Bimonthly leucovorin, infusion 5-fluorouracil, hydroxyurea, and irinotecan (FOLFIRI-2) for pretreated metastatic colorectal cancer. ( André, T; Artru, P; Carola, E; de Gramont, A; Gilles-Amar, V; Krulik, M; Louvet, C; Mabro, M, 2003) |
| "The aim of the study was to investigate the possibility of dual modulation of UFT with leucovorin and hydroxyurea in a phase II trial of metastatic colorectal cancer." | 5.09 | Dual modulation of UFT with leucovorin and hydroxyurea in metastatic colorectal cancer. ( Aabo, K; Hansen, F; Jakobsen, A; Pfeiffer, P; Sandberg, E, 2001) |
| "In B16 melanoma cells, experimental metastasis induced by hydroxyurea appears to depend on a process that requires glutathione." | 3.68 | Role of antioxidant enzymes in the induction of increased experimental metastasis by hydroxyurea. ( Arguello, F; Cohen, HJ; Eskenazi, AE; Frantz, CN; Pinkas, J; Whitin, JC, 1993) |
| "Unscheduled DNA synthesis (UDS) indicated by melphalan was studied in freshly collected tumor cells from human melanoma metastases." | 3.66 | Different activities of unscheduled DNA synthesis in human melanoma and bone marrow cells. ( Hansson, J; Lewensohn, R; Ringborg, U, 1982) |
| "BCNU, hydroxyurea, and imidazole carboxamide (DTIC) were administered to 89 patients with disseminated malignant melanoma." | 3.65 | Combination chemotherapy for disseminated malignant melanoma. ( Coltman, CA; Costanzi, JJ; Delaney, FC; Hoogstraten, B; Quagliana, JM; Vaitkevicius, VK, 1975) |
| "Eligibility criteria were recurrence or a second primary tumor in a previously irradiated area, no major sequelae resulting from the first radiotherapy, good general condition, no distant metastasis, and salvage surgery with macroscopic complete resection." | 2.73 | Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma. ( Bardet, E; Benhamou, E; Bensadoun, RJ; Bourhis, J; Castaing, M; de Raucourt, D; Dolivet, G; Ferron, C; Géry, B; Grégoire, V; Hamoir, M; Janot, F; Julieron, M, 2008) |
| "A clinical trial of parenteral, weekly, high-dose HU in combination with weekly, high-dose infusional fluorouracil (5FU) was initiated in patients with advanced pancreatic and gastric cancer." | 2.71 | Phase II clinical trial of parenteral hydroxyurea in combination with fluorouracil, interferon and filgrastim in the treatment of advanced pancreatic, gastric and neuroendocrine tumors. ( Haynes, H; Kaleya, R; Kaubisch, A; Rozenblit, A; Wadler, S, 2004) |
| "This paper presents an overview of studies of therapy of head and neck squamous cell carcinoma in which chemotherapy was combined with other modalities." | 2.35 | Current concepts of chemotherapy combined with other modalities for head and neck cancer. ( DeWys, WD, 1975) |
| "In cultured ovarian cancer cells, 5-LOX metabolites were increased under hypoxic conditons." | 1.42 | Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration. ( Fan, B; Gao, W; Li, B; Li, M; Liu, H; Qu, X; Shao, Q; Wang, Q; Wen, Z; Xie, Q; Yang, Y; Yu, J; Zhao, F, 2015) |
| "The expression of 5-LOX in the metastasis sample was notably greater than that in the tumors in situ." | 1.39 | Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin. ( Cao, R; Liu, T; Meng, Z; Wang, X; Wang, Y; Yang, Z, 2013) |
| "Granulocytic sarcoma is very rare in essential thrombocythemia, and this patient may be the first reported case of essential thrombocythemia that developed multiple lesions and a pathologic fracture without transformation to overt leukemia." | 1.33 | Multiple granulocytic sarcomas in essential thrombocythemia. ( Fujita, H; Kurata, M; Maeda, A; Matsushita, A; Mori, M; Nagai, K; Nagai, Y; Takahashi, T; Tanaka, K; Tanaka, Y; Togami, K, 2006) |
| "Hydroxyurea has some dermatological side-effects." | 1.32 | Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy. ( Altaner, S; Demir, M; Pamuk, GE; Tek, M; Turgut, B; Vural, O, 2003) |
| "Locoregionally advanced, stage IV head and neck cancer has traditionally carried a poor prognosis." | 1.32 | Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience. ( Brockstein, B; Fung, BB; Haraf, DJ; Kies, MS; Mittal, BB; Pelzer, H; Portugal, L; Rademaker, AW; Rosen, F; Stenson, KM; Vokes, EE; Weichselbaum, RW; Wenig, B; Witt, ME, 2004) |
| "11." | 1.31 | Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters. ( Bisevac, M; Guski, H; Khodadayan, C; Kilian, M; Müller, JM; Schimke, I; von Seebach, M; Wenger, FA, 2002) |
| "The experimental anti-metastasis agent Razoxane reduced growth, but had no detectable effects on motility." | 1.29 | Simultaneous assessment of migration and proliferation of murine fibrosarcoma cells, as affected by hydroxyurea, vinblastine, cytochalasin B, Razoxane and interferon. ( Benestad, HB; Grimstad, IA; Haug, IJ; Siebke, EM, 1993) |
| "In this study 26 women with metastatic breast cancer responding to lower dose combination chemotherapy were treated with 18 g/m2 of hydroxyurea added to the widely used combination of cyclophosphamide (CY) 6 g/m2 and thiotepa 600 mg/m2." | 1.29 | High-dose cyclophosphamide, thiotepa and hydroxyurea with autologous hematopoietic stem cell rescue: an effective consolidation chemotherapy regimen for early metastatic breast cancer. ( Edwards, B; Kessinger, A; Reed, EC; Vaughan, WP, 1994) |
| "Surgery combined with chemotherapy was applied in 34 out of 178 patients (19." | 1.29 | Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD). ( Kietlińska, Z; Sablińska, B; Zieliński, J, 1993) |
| "Cell free extracts from metastases of human melanoma contain a highly active ribonucleoside diphosphate reductase (RR) which uses guanosine diphosphate (GDP) as substrate and deoxythymidine triphosphate (dTTP) as effector." | 1.28 | Ribonucleotide diphosphate reductase from human metastatic melanoma. ( Elgren, TE; Hogenkamp, HP; MacFarlan, S; Nelson, LS; Schallreuter, KU; Yan-Sze, I, 1992) |
| "Lung metastases obtained after the injection of uncloned cells retained their metastatic phenotype for three generations, indicating that the phenotypic change was a heritable characteristic." | 1.27 | Selection of metastatic variants with identifiable karyotypic changes from a nonmetastatic murine tumor after treatment with 2'-deoxy-5-azacytidine or hydroxyurea: implications for the mechanisms of tumor progression. ( Frost, P; Hunt, B; Kerbel, RS; Man, S; Pathak, S, 1987) |
| "mm." | 1.26 | Hydroxyurea in stage D carcinoma of prostate. ( Lerner, HJ; Malloy, TR, 1977) |
| "mm." | 1.25 | Hydroxyurea in stage D carcinoma of the prostate: a pilot study. ( Cromie, W; Lerner, H; Longo, S; Malloy, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (68.18) | 18.7374 |
| 1990's | 8 (12.12) | 18.2507 |
| 2000's | 9 (13.64) | 29.6817 |
| 2010's | 3 (4.55) | 24.3611 |
| 2020's | 1 (1.52) | 2.80 |
| Authors | Studies |
|---|---|
| Kiweler, N | 1 |
| Wünsch, D | 1 |
| Wirth, M | 1 |
| Mahendrarajah, N | 1 |
| Schneider, G | 1 |
| Stauber, RH | 1 |
| Brenner, W | 1 |
| Butter, F | 1 |
| Krämer, OH | 1 |
| Meng, Z | 1 |
| Cao, R | 1 |
| Yang, Z | 1 |
| Liu, T | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| Wen, Z | 1 |
| Liu, H | 1 |
| Li, M | 1 |
| Li, B | 1 |
| Gao, W | 1 |
| Shao, Q | 1 |
| Fan, B | 1 |
| Zhao, F | 1 |
| Wang, Q | 1 |
| Xie, Q | 1 |
| Yang, Y | 1 |
| Yu, J | 1 |
| Qu, X | 1 |
| Janot, F | 1 |
| de Raucourt, D | 1 |
| Benhamou, E | 1 |
| Ferron, C | 1 |
| Dolivet, G | 1 |
| Bensadoun, RJ | 1 |
| Hamoir, M | 1 |
| Géry, B | 1 |
| Julieron, M | 1 |
| Castaing, M | 1 |
| Bardet, E | 1 |
| Grégoire, V | 1 |
| Bourhis, J | 1 |
| Lambertz, N | 1 |
| Koehler, J | 1 |
| Schulte, DM | 1 |
| Kuehl, H | 1 |
| Wohlschlaeger, J | 1 |
| Hense, J | 1 |
| Schuler, M | 1 |
| Mueller, OM | 1 |
| Wenger, FA | 1 |
| Kilian, M | 1 |
| Bisevac, M | 1 |
| Khodadayan, C | 1 |
| von Seebach, M | 1 |
| Schimke, I | 1 |
| Guski, H | 1 |
| Müller, JM | 1 |
| Mabro, M | 1 |
| Louvet, C | 1 |
| André, T | 1 |
| Carola, E | 1 |
| Gilles-Amar, V | 1 |
| Artru, P | 1 |
| Krulik, M | 1 |
| de Gramont, A | 1 |
| Pamuk, GE | 1 |
| Turgut, B | 1 |
| Vural, O | 1 |
| Demir, M | 1 |
| Tek, M | 1 |
| Altaner, S | 1 |
| BICKERS, JN | 1 |
| Kaubisch, A | 1 |
| Kaleya, R | 1 |
| Haynes, H | 1 |
| Rozenblit, A | 1 |
| Wadler, S | 1 |
| Brockstein, B | 1 |
| Haraf, DJ | 1 |
| Rademaker, AW | 1 |
| Kies, MS | 1 |
| Stenson, KM | 1 |
| Rosen, F | 1 |
| Mittal, BB | 1 |
| Pelzer, H | 1 |
| Fung, BB | 1 |
| Witt, ME | 1 |
| Wenig, B | 1 |
| Portugal, L | 1 |
| Weichselbaum, RW | 1 |
| Vokes, EE | 1 |
| Cramer, P | 1 |
| Thomale, UW | 1 |
| Okuducu, AF | 1 |
| Lemke, AJ | 1 |
| Stockhammer, F | 1 |
| Woiciechowsky, C | 1 |
| Tanaka, Y | 1 |
| Nagai, Y | 1 |
| Mori, M | 1 |
| Fujita, H | 1 |
| Togami, K | 1 |
| Kurata, M | 1 |
| Matsushita, A | 1 |
| Maeda, A | 1 |
| Nagai, K | 1 |
| Tanaka, K | 1 |
| Takahashi, T | 1 |
| Stehlin, JS | 1 |
| Hills, WJ | 1 |
| Rufino, C | 1 |
| Cassileth, PA | 1 |
| Hyman, GA | 1 |
| Bagshawe, KD | 1 |
| Weed, JC | 1 |
| Barnard, DE | 1 |
| Currie, JL | 1 |
| Clayton, LA | 1 |
| Hammond, CB | 1 |
| Kao, AK | 1 |
| Muggia, FM | 1 |
| Dubin, N | 1 |
| Lerner, WA | 1 |
| Stark, R | 1 |
| Wernz, JC | 1 |
| Speyer, JL | 1 |
| Blum, RH | 1 |
| Liberati, AM | 1 |
| Di Costanzo, F | 1 |
| Buzzi, F | 1 |
| Fatati, G | 1 |
| Biscottini, B | 1 |
| Ballatori, E | 1 |
| Falchi, R | 1 |
| Grignani, F | 1 |
| Lewensohn, R | 1 |
| Ringborg, U | 1 |
| Hansson, J | 1 |
| Haug, IJ | 1 |
| Siebke, EM | 1 |
| Grimstad, IA | 1 |
| Benestad, HB | 1 |
| Vaughan, WP | 1 |
| Reed, EC | 1 |
| Edwards, B | 1 |
| Kessinger, A | 1 |
| Sablińska, B | 1 |
| Kietlińska, Z | 1 |
| Zieliński, J | 1 |
| Eskenazi, AE | 2 |
| Pinkas, J | 2 |
| Whitin, JC | 1 |
| Arguello, F | 1 |
| Cohen, HJ | 1 |
| Frantz, CN | 2 |
| Gerritsen, RJ | 1 |
| Teske, E | 1 |
| Kraus, JS | 1 |
| Rutteman, GR | 1 |
| Powers, J | 1 |
| Oesterreich, S | 1 |
| Fuqua, SA | 1 |
| Smith, TA | 1 |
| Jakobsen, A | 1 |
| Pfeiffer, P | 1 |
| Hansen, F | 1 |
| Sandberg, E | 1 |
| Aabo, K | 1 |
| DeWys, WD | 1 |
| Donelli, MG | 1 |
| Colombo, T | 1 |
| Broggini, M | 1 |
| Garattini, S | 1 |
| Krein, BM | 1 |
| Conroy, JF | 1 |
| Brodsky, I | 1 |
| Katakkar, SB | 1 |
| Franks, CR | 1 |
| Lerner, HJ | 2 |
| Malloy, TR | 1 |
| Aranha, GV | 1 |
| Grage, TB | 1 |
| Costanzi, JJ | 1 |
| Vaitkevicius, VK | 1 |
| Quagliana, JM | 1 |
| Hoogstraten, B | 1 |
| Coltman, CA | 1 |
| Delaney, FC | 1 |
| Lerner, H | 1 |
| Malloy, T | 1 |
| Cromie, W | 1 |
| Longo, S | 1 |
| Lokich, JJ | 1 |
| Pitman, SW | 1 |
| Skarin, AT | 1 |
| Wollner, N | 2 |
| Burchenal, JH | 2 |
| Lieberman, PH | 2 |
| Exelby, PR | 1 |
| D'Angio, GJ | 1 |
| Murphy, ML | 2 |
| Luce, JK | 2 |
| Exelby, P | 1 |
| D'Angio, G | 1 |
| Schallreuter, KU | 1 |
| Elgren, TE | 1 |
| Nelson, LS | 1 |
| MacFarlan, S | 1 |
| Yan-Sze, I | 1 |
| Hogenkamp, HP | 1 |
| Frost, P | 1 |
| Kerbel, RS | 1 |
| Hunt, B | 1 |
| Man, S | 1 |
| Pathak, S | 1 |
| Wong, LC | 1 |
| Choo, YC | 1 |
| Ma, HK | 1 |
| Bezwoda, WR | 1 |
| Nissenbaum, M | 1 |
| Derman, DP | 1 |
| Sullivan, RD | 1 |
| Wagenknecht, L | 2 |
| Kondi, ES | 1 |
| Gallitano, AL | 1 |
| Evjy, JT | 1 |
| Barnard, DR | 1 |
| Marchetta, FC | 1 |
| Stephens, FO | 1 |
| Johnson, FD | 1 |
| Jacobs, EM | 1 |
| Smithers, DW | 1 |
| Jones, PA | 1 |
| Taderera, JV | 1 |
| Hawtrey, AO | 1 |
| Magrath, IT | 1 |
| Mugerwa, J | 1 |
| Bailey, I | 1 |
| Olweny, C | 1 |
| Kiryabwire, Y | 1 |
| Pouillart, P | 1 |
| Schwarzenberg, L | 1 |
| Mathé, G | 1 |
| Schneider, M | 1 |
| Jasmin, C | 1 |
| Hayat, M | 1 |
| Weiner, R | 1 |
| de Vassal, F | 1 |
| Amiel, JL | 1 |
| Beyer, HP | 1 |
| Fajbisowicz, S | 1 |
| Laugier, P | 1 |
| Orusco, M | 1 |
| Jaccard, MA | 1 |
| Garin, AM | 1 |
| Lichinitser, MR | 1 |
| Moroz, LV | 1 |
| Smith, JP | 1 |
| Rutledge, F | 1 |
| Burns, BC | 1 |
| Soffar, S | 1 |
| Hussey, DH | 1 |
| Samuels, ML | 1 |
| Larsen, RR | 1 |
| Hill, GJ | 1 |
| Gottlieb, JA | 1 |
| Frei, E | 1 |
| Sutow, WW | 1 |
| Vietti, TJ | 2 |
| Fernbach, DJ | 1 |
| Lane, DM | 1 |
| Donaldson, MH | 1 |
| Lonsdale, D | 2 |
| Lucas, GJ | 1 |
| Lehrnbecher, W | 1 |
| Beckloff, GL | 1 |
| Godwin, MC | 1 |
| Willbanks, OL | 1 |
| Fogelmann, MJ | 1 |
| Berry, DH | 1 |
| Holcomb, TM | 1 |
| Nora, AH | 1 |
| Sullivan, MP | 1 |
| Thurman, WG | 1 |
| Kaufman, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.[NCT04392479] | Phase 3 | 202 participants (Anticipated) | Interventional | 2020-09-02 | Active, not recruiting | ||
| A Phase II Randomised Controlled Study Assessing the Role of Dose Escalation Using [18F] FMISO PET CT in Head and Neck Cancer: The DE-HyART (Dose Escalation Using Hypoxia-adjusted Radiotherapy) Protocol[NCT06087614] | Phase 2 | 124 participants (Anticipated) | Interventional | 2023-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for hydroxyurea and Metastase
| Article | Year |
|---|---|
Treatment of high-risk choriocarcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin; Cycl | 1984 |
Current concepts of chemotherapy combined with other modalities for head and neck cancer.
Topics: Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Fluorouracil; Head; Head and Neck Neoplasms; | 1975 |
5 trials available for hydroxyurea and Metastase
| Article | Year |
|---|---|
Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Disease Progression; Fem | 2008 |
Bimonthly leucovorin, infusion 5-fluorouracil, hydroxyurea, and irinotecan (FOLFIRI-2) for pretreated metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dru | 2003 |
Phase II clinical trial of parenteral hydroxyurea in combination with fluorouracil, interferon and filgrastim in the treatment of advanced pancreatic, gastric and neuroendocrine tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; F | 2004 |
Dual modulation of UFT with leucovorin and hydroxyurea in metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Surv | 2001 |
Treatment of metastatic and recurrent cervix cancer with chemotherapy: a randomised trial comparing hydroxyurea with cisdiamminedichloro-platinum plus methotrexate.
Topics: Actuarial Analysis; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trial | 1986 |
59 other studies available for hydroxyurea and Metastase
| Article | Year |
|---|---|
Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes.
Topics: Animals; Benzamides; Cell Plasticity; Cisplatin; DNA Repair; DNA Repair Enzymes; DNA-Binding Protein | 2020 |
Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cadherins; Cell Migration Assays; Enzyme-Linked Immunosorbent | 2013 |
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Cell Line, Tumor; Chemotaxis, Leukocyte; Disease Mo | 2015 |
Multivisceral systemic metastases from an intracranial anaplastic meningioma: a case report and review of literature.
Topics: Aged; Antineoplastic Agents; Biopsy; Brain Neoplasms; Carcinoma; Fatal Outcome; Female; Humans; Hydr | 2011 |
Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cricetinae; Hydroxyurea; Lipid Peroxida | 2002 |
Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy.
Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Leukemia, Myelogenous, C | 2003 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CARCINOMA OF THE LUNG.
Topics: Adult; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Drug Therapy; Humans; Hydroxyurea | 1964 |
Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Com | 2004 |
An atypical spinal meningioma with CSF metastasis: fatal progression despite aggressive treatment. Case report.
Topics: Adult; Antineoplastic Agents; Cervical Vertebrae; Decompression, Surgical; Disease Progression; Fata | 2005 |
Multiple granulocytic sarcomas in essential thrombocythemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Chromosome Deletion; Chromosomes, | 2006 |
Disseminated melanoma. Biologic behavior and treatment.
Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Hydrazine | 1967 |
Treatment of malignant melanoma with hydroxyurea.
Topics: Adult; Aged; Female; Humans; Hydroxyurea; Leukopenia; Male; Melanoma; Middle Aged; Neoplasm Metastas | 1967 |
Chemotherapy with the modified Bagshawe protocol for poor prognosis metastatic trophoblastic disease.
Topics: Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Administration Schedule; Dr | 1982 |
Evaluation of a sequential 5-FU and hydroxyurea combination in advanced bowel cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; | 1984 |
5-Fluorouracil, vincristine and hydroxyurea combination chemotherapy in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Hyd | 1983 |
Different activities of unscheduled DNA synthesis in human melanoma and bone marrow cells.
Topics: Bone Marrow; Cell Line; DNA Repair; DNA Replication; DNA, Neoplasm; Female; Humans; Hydroxyurea; Mal | 1982 |
Simultaneous assessment of migration and proliferation of murine fibrosarcoma cells, as affected by hydroxyurea, vinblastine, cytochalasin B, Razoxane and interferon.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Movement; Chemotaxis; Cytochalasin B; Dose-Respo | 1993 |
High-dose cyclophosphamide, thiotepa and hydroxyurea with autologous hematopoietic stem cell rescue: an effective consolidation chemotherapy regimen for early metastatic breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; | 1994 |
Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD).
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chorioca | 1993 |
Role of antioxidant enzymes in the induction of increased experimental metastasis by hydroxyurea.
Topics: Animals; Buthionine Sulfoximine; Catalase; Female; Gene Expression; Glutathione; Glutathione Peroxid | 1993 |
Multi-agent chemotherapy for mast cell tumours in the dog.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dog Diseases; Dogs; Doxor | 1998 |
Induction of heat shock protein 27 by hydroxyurea and its relationship to experimental metastasis.
Topics: Animals; Female; Gene Expression Regulation, Neoplastic; Heat Stress Disorders; Heat-Shock Proteins; | 1998 |
Hydroxyurea treatment enhances metastatic cell adhesiveness: a possible chemotherapy-induced increase in metastatic potential?
Topics: Antineoplastic Agents; Cell Adhesion; Colonic Neoplasms; Humans; Hydroxyurea; Neoplasm Metastasis; T | 1999 |
Differential distribution of antitumor agents in primary and secondary tumors.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma 256, Walker; Cyclophosphamide; Daunorubici | 1977 |
Sequential 5-fluorouracil and hydroxyurea therapy for metastatic colorectal adenocarcinoma.
Topics: Adenocarcinoma; Colonic Neoplasms; Fluorouracil; Humans; Hydroxyurea; Neoplasm Metastasis; Rectal Ne | 1978 |
Chemo-hormonal therapy for metastatic renal cell carcinoma with adriamycin, hydroxyurea, vinblastine, and medroxyprogesterone acetate.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Doxorubicin; Drug Evaluation; Drug Therapy, Combination | 1978 |
Hydroxyurea in stage D carcinoma of prostate.
Topics: Aged; Chlorotrianisene; Drug Therapy, Combination; Humans; Hydroxyurea; Male; Middle Aged; Neoplasm | 1977 |
Single drug and combination chemotherapy in the treatment. Disseminated malignant melanoma.
Topics: Antineoplastic Agents; Carmustine; Dacarbazine; Drug Therapy, Combination; Humans; Hydroxyurea; Lomu | 1977 |
Combination chemotherapy for disseminated malignant melanoma.
Topics: Adolescent; Adult; Aged; Amides; Antineoplastic Agents; Brain Neoplasms; Carmustine; Drug Therapy, C | 1975 |
Hydroxyurea in stage D carcinoma of the prostate: a pilot study.
Topics: Adenocarcinoma; Aged; Anemia; Bone Neoplasms; Chlorotrianisene; Estrogens; Humans; Hydroxyurea; Leuk | 1975 |
Combined 5-fluorouracil and hydroxyurea therapy for gastrointestinal cancer.
Topics: Administration, Oral; Ataxia; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Gastrointe | 1975 |
Non-Hodgkin's lymphoma in children.
Topics: Adolescent; Asparaginase; Bone Marrow; Brain Neoplasms; Carmustine; Child; Child, Preschool; Cycloph | 1975 |
Chemotherapy of melanoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; D | 1975 |
Non-Hodgkin's lymphoma in children. A comparative study of two modalities of therapy.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Carmustine; Child; Child, Preschool; Cyclophosphami | 1976 |
Ribonucleotide diphosphate reductase from human metastatic melanoma.
Topics: Antineoplastic Agents; Cell-Free System; Electron Spin Resonance Spectroscopy; Humans; Hydroxyurea; | 1992 |
Selection of metastatic variants with identifiable karyotypic changes from a nonmetastatic murine tumor after treatment with 2'-deoxy-5-azacytidine or hydroxyurea: implications for the mechanisms of tumor progression.
Topics: Animals; Azacitidine; Cell Division; Clone Cells; Decitabine; DNA; Female; Hydroxyurea; Karyotyping; | 1987 |
Modified Bagshawe's regimen in high-risk gestational trophoblastic disease.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; | 1986 |
Chemotherapy in head and neck cancer.
Topics: Administration, Oral; Antineoplastic Agents; Arteries; Carcinoma, Squamous Cell; Head; Head and Neck | 1971 |
[Chemotherapy of malignant melanoma].
Topics: Alkylating Agents; Amides; Antineoplastic Agents; Bleomycin; Carmustine; Cyclohexanes; Drug Therapy, | 1973 |
Prolonged survival in a patient with hepatic malignant melanoma treated by intra-arterial bleomycin and oral hydroxyurea.
Topics: Administration, Oral; Angiography; Biopsy; Bleomycin; Catheterization; Choroid Neoplasms; Drug Thera | 1974 |
Proceedings: Carcinoma of the oral cavity--general principles of therapy.
Topics: Azirines; Bleomycin; Carcinoma, Squamous Cell; Cryosurgery; Dactinomycin; Doxorubicin; Head and Neck | 1974 |
Combined chemotherapy, radiotherapy, and surgery in the treatment of advanced but localized solid malignant tumours.
Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cystadenocarcinoma; Drug Th | 1974 |
Chemotherapy of metastatic malignant melanoma. Experience with 73 patients.
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Eye Neop | 1971 |
Chemotherapy for metastatic teratomas of the testis.
Topics: Adult; Antineoplastic Agents; Dactinomycin; Dysgerminoma; Follow-Up Studies; Humans; Hydroxyurea; Lu | 1972 |
Transformation of hamster cells in vitro by 1- -D arabinofuranosylcytosine, 5-fluorodeoxyuridine and hydroxyurea.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Cytarabine; Cytosine Nucle | 1972 |
Intracerebral Burkitt's lymphoma: pathology, clinical features and treatment.
Topics: Adolescent; Allopurinol; Brain Neoplasms; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamid | 1974 |
[Clinical trial of chemotherapeutic combinations based on the notion of attempted cellular synchronization. Preliminary administration of an antimitotic followed by the use of cycle-dependent or phase dependent product(s)].
Topics: Amino Sugars; Anthraquinones; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Daunorubicin; D | 1972 |
[Polychemotherapy of metastatic melanoma. Preliminary report].
Topics: Adult; Female; Humans; Hydroxyurea; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Nitrosourea Co | 1972 |
[Imidazole carboxamide in the treatment of disseminated melanoblastoma].
Topics: Amides; Carmustine; Humans; Hydroxyurea; Imidazoles; Lymphatic Metastasis; Melanoma; Neoplasm Metast | 1973 |
Systemic chemotherapy for carcinoma of the cervix.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Fema | 1967 |
Combined hydroxyurea and radiotherapy: a new dosage schedule.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Head; Head and Neck Neoplasms; | 1972 |
Improved systemic chemotherapy for malignant melanoma.
Topics: Adult; Aged; Amides; Antineoplastic Agents; Azo Compounds; Biopsy; Female; Humans; Hydroxyurea; Imid | 1971 |
Dose-schedule studies with hydroxyurea (NSC-32065) in malignant melanoma.
Topics: Administration, Oral; Adult; Amides; Female; Humans; Hydroxyurea; Imidazoles; Injections, Intravenou | 1971 |
Evaluation of chemotherapy in children with metastatic Ewing's sarcoma and osteogenic sarcoma.
Topics: Adolescent; Amines; Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; | 1971 |
Hydroxyurea in nasopharyngeal cancer.
Topics: Carcinoma, Squamous Cell; Eye Neoplasms; Humans; Hydroxyurea; Male; Middle Aged; Nasopharyngeal Neop | 1969 |
Phase II study of hydroxyurea administered intermittently in malignant melanoma.
Topics: Adult; Aged; Chronic Disease; Female; Humans; Hydroxyurea; Leukocyte Count; Leukopenia; Male; Melano | 1970 |
Gastrointestinal melanosarcoma.
Topics: Adult; Aged; Biopsy; Colostomy; Female; Follow-Up Studies; Humans; Hydroxyurea; Intestinal Neoplasms | 1970 |
Chemotherapeutic trials in patients with metastatic retinoblastoma.
Topics: Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Hydroxyurea; Infan | 1968 |
Treatment of carcinoma of the bladder with combined radiotherapy, chemotherapy, and surgery.
Topics: Animals; Cricetinae; Female; Fluorouracil; Humans; Hydroxyurea; Male; Mitomycins; Neoplasm Metastasi | 1969 |