hydroxyurea has been researched along with Malaria, Falciparum in 8 studies
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention." | 7.11 | Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial. ( Clapp, S; Freedman, B; Green, CL; Kirui, JK; Korwa, S; Njuguna, FM; O'Meara, WP; Taylor, SM; Wu, A, 2022) |
| "Children with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention." | 3.11 | Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial. ( Clapp, S; Freedman, B; Green, CL; Kirui, JK; Korwa, S; Njuguna, FM; O'Meara, WP; Taylor, SM; Wu, A, 2022) |
| "Because malaria is thought to be a significant cause of morbidity and mortality in patients with SCD, malaria chemoprophylaxis is often recommended for these patients." | 2.49 | Systematic review of current and emerging strategies for reducing morbidity from malaria in sickle cell disease. ( Aneni, EC; Gill, CJ; Hamer, DH, 2013) |
| "The lower legs of homozygous sickle cell anemia patients are areas of marginal vascularity where minor abrasions become foci of inflammation." | 2.40 | [Falciform anemia and Plasmodium falciparum malaria: a threat to flap survival?]. ( Humbert, J; Loutan, L; Mariéthoz, S; Montandon, D; Pittet, B, 1999) |
| " These data endorse broad, safe, and long-term use of HU for SCA in malaria-endemic countries and provide a novel biological model for the treatment of a genetic disorder with simultaneous, adjunct therapy of a life-threatening infection needed in a global health setting." | 1.91 | Simultaneous adjunctive treatment of malaria and its coevolved genetic disorder sickle cell anemia. ( Haldar, K; Mohandas, N; Safeukui, I; Ware, RE, 2023) |
| "Using human in vitro models of cerebral malaria, we evaluated the interaction of HU with parasites and demonstrated that HU pretreatment increased the number of infected red blood cells adhering to the endothelium, but did not increase endothelial apoptosis." | 1.33 | Effects of hydroxyurea on malaria, parasite growth and adhesion in experimental models. ( Brun, M; Ciceron, L; Franetich, JF; Krishnamoorthy, R; Mazier, D; Pino, P; Taoufiq, Z; Tefit, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, ME | 1 |
| Parrott, EE | 1 |
| Singh, R | 1 |
| Nelson, SW | 1 |
| Taylor, SM | 1 |
| Korwa, S | 1 |
| Wu, A | 1 |
| Green, CL | 1 |
| Freedman, B | 1 |
| Clapp, S | 1 |
| Kirui, JK | 1 |
| O'Meara, WP | 1 |
| Njuguna, FM | 1 |
| Safeukui, I | 1 |
| Ware, RE | 1 |
| Mohandas, N | 1 |
| Haldar, K | 1 |
| Mwaiswelo, RO | 1 |
| Mawala, W | 1 |
| Iversen, PO | 1 |
| de Montalembert, M | 1 |
| Luzzatto, L | 1 |
| Makani, J | 1 |
| Wautier, JL | 1 |
| Wautier, MP | 1 |
| Aneni, EC | 1 |
| Hamer, DH | 1 |
| Gill, CJ | 1 |
| Pino, P | 1 |
| Taoufiq, Z | 1 |
| Brun, M | 1 |
| Tefit, M | 1 |
| Franetich, JF | 1 |
| Ciceron, L | 1 |
| Krishnamoorthy, R | 1 |
| Mazier, D | 1 |
| Mariéthoz, S | 1 |
| Pittet, B | 1 |
| Loutan, L | 1 |
| Humbert, J | 1 |
| Montandon, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)[NCT03178643] | Phase 4 | 246 participants (Actual) | Interventional | 2018-01-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydroxyurea and Malaria, Falciparum
| Article | Year |
|---|---|
Molecular basis of erythrocyte adhesion to endothelial cells in diseases.
Topics: Anemia, Sickle Cell; Animals; Cell Adhesion; Cell Adhesion Molecules; Diabetes Mellitus; Erythrocyte | 2013 |
Systematic review of current and emerging strategies for reducing morbidity from malaria in sickle cell disease.
Topics: Africa South of the Sahara; Anemia, Sickle Cell; Antimalarials; Antisickling Agents; Comorbidity; Dr | 2013 |
[Falciform anemia and Plasmodium falciparum malaria: a threat to flap survival?].
Topics: Anemia, Sickle Cell; Antisickling Agents; Child; Humans; Hydroxyurea; Leg Ulcer; Malaria, Falciparum | 1999 |
1 trial available for hydroxyurea and Malaria, Falciparum
| Article | Year |
|---|---|
Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial.
Topics: Amodiaquine; Anemia, Sickle Cell; Antimalarials; Artemisinins; Chemoprevention; Child; Child, Presch | 2022 |
4 other studies available for hydroxyurea and Malaria, Falciparum
| Article | Year |
|---|---|
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
Topics: Antimalarials; Apicoplasts; Chloroplasts; DNA; DNA-Directed DNA Polymerase; Drug Discovery; Exonucle | 2014 |
Simultaneous adjunctive treatment of malaria and its coevolved genetic disorder sickle cell anemia.
Topics: Anemia, Sickle Cell; Blood Transfusion; Erythrocytes; Humans; Hydroxyurea; Malaria; Malaria, Falcipa | 2023 |
Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum.
Topics: Adolescent; Anemia, Sickle Cell; Antimalarials; Antisickling Agents; Humans; Hydroxyurea; Malaria, F | 2020 |
Effects of hydroxyurea on malaria, parasite growth and adhesion in experimental models.
Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Apoptosis; Cell Adhesion; Endothelial Cells; Endo | 2006 |