hydroxyurea has been researched along with Liver Diseases in 8 studies
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Black pigment gallstones caused by elevated bilirubin excretion are common." | 4.86 | Gastrointestinal and hepatic complications of sickle cell disease. ( Ebert, EC; Hagspiel, KD; Nagar, M, 2010) |
| " Our results, while no longer the product of a randomized study because of the ethical concerns of withholding an efficacious treatment, suggest that long-term use of hydroxyurea is safe and might decrease mortality." | 2.75 | The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. ( Armstrong, FD; Ataga, K; Ballas, SK; Castro, O; DeCastro, L; Kutlar, A; McCarthy, WF; Smith, W; Steinberg, MH; Swerdlow, P; Waclawiw, MA, 2010) |
| "Treatment with WEB 2086, alone or in combination with Zileuton, did not inhibit LPS-mediated hepatic neutrophil infiltration or liver injury, as assessed by histologic evaluation and increases in plasma alanine aminotransferase activity." | 1.30 | Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration. ( Bailie, MB; Fink, GD; Pearson, JM; Roth, RA, 1997) |
| "Because of the frequent reports of hepatic toxicity associated with long-term administration of methotrexate, a rat model was developed utilizing daily methotrexate administration." | 1.26 | Choline antagonism of methotrexate liver toxicity in the rat. ( Freeman-Narrod, M, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebert, EC | 1 |
| Nagar, M | 1 |
| Hagspiel, KD | 1 |
| Steinberg, MH | 1 |
| McCarthy, WF | 1 |
| Castro, O | 1 |
| Ballas, SK | 1 |
| Armstrong, FD | 1 |
| Smith, W | 1 |
| Ataga, K | 1 |
| Swerdlow, P | 1 |
| Kutlar, A | 1 |
| DeCastro, L | 1 |
| Waclawiw, MA | 1 |
| Tripathi, A | 1 |
| Jerrell, JM | 1 |
| Stallworth, JR | 1 |
| Bailie, MB | 2 |
| Dahm, LJ | 1 |
| Peters-Golden, M | 1 |
| Harris, RR | 1 |
| Carter, GW | 1 |
| Roth, RA | 2 |
| Pearson, JM | 1 |
| Fink, GD | 1 |
| Freeman-Narrod, M | 1 |
| Hillyer, MH | 1 |
| Mair, TS | 1 |
| Delage, C | 1 |
| Lagacé, R | 1 |
1 review available for hydroxyurea and Liver Diseases
| Article | Year |
|---|---|
Gastrointestinal and hepatic complications of sickle cell disease.
Topics: Anemia; Anemia, Sickle Cell; Antisickling Agents; Bilirubin; Blood Transfusion; Gallstones; Humans; | 2010 |
1 trial available for hydroxyurea and Liver Diseases
| Article | Year |
|---|---|
The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up.
Topics: Adolescent; Adult; Anemia, Sickle Cell; DNA Damage; Drug Utilization; Early Termination of Clinical | 2010 |
6 other studies available for hydroxyurea and Liver Diseases
| Article | Year |
|---|---|
Clinical complications in severe pediatric sickle cell disease and the impact of hydroxyurea.
Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Cardiovascular Diseases; Child; Child, Prescho | 2011 |
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; | 1995 |
Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration.
Topics: Administration, Oral; Alanine Transaminase; Animals; Azepines; Blood Platelets; Chemical and Drug In | 1997 |
Choline antagonism of methotrexate liver toxicity in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Hydroxyurea; Liver; Liver Diseases; Male; | 1977 |
Multisystemic eosinophilic epitheliotropic disease in a horse: attempted treatment with hydroxyurea and dexamethasone.
Topics: Animals; Dexamethasone; Eosinophilia; Epithelium; Female; Gastrointestinal Diseases; Horse Diseases; | 1992 |
[Hepatic peliosis: possible etiologic role of medication].
Topics: Aged; Allopurinol; Chemical and Drug Induced Liver Injury; Humans; Hydroxyurea; Iatrogenic Disease; | 1973 |