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hydroxyurea and Leukocytosis

hydroxyurea has been researched along with Leukocytosis in 41 studies

Leukocytosis: A transient increase in the number of leukocytes in a body fluid.

Research Excerpts

ExcerptRelevanceReference
"Hyperleukocytosis occurs in 15-20% of all newly diagnosed acute myeloid leukemia patients and requires emergent treatment with leukapheresis or hydroxyurea when accompanied by signs or symptoms of leukostasis."7.91Dose-related mucositis with hydroxyurea for cytoreduction in acute myeloid leukemia. ( Auten, JJ; Clark, SM; Trepte, ML; van Deventer, HW, 2019)
"The effect of hydroxyurea on blood viscosity was studied in 10 patients with Philadelphia chromosome positive chronic myelogenous leukemia (CML) and hyperleukocytosis (white blood cell counts over 200 x 10(9)/l)."7.68Effect of hydroxyurea on blood viscosity in chronic myelogenous leukemia with hyperleukocytosis. ( Bhat, SV; Rao, S; Sharma, K, 1991)
"The effect of hydroxyurea in 35 patients with chronic granulocytic leukemia (CGL), who either had entered an accelerated phase of the disease or had experienced excessive myelosuppression following alkylating agents, was studied."7.65Hydroxyurea in the management of the hematologic complications of chronic granulocytic leukemia. ( Cannellos, GP; Schwartz, JH, 1975)
" After two patients had a rapid increase in WBC counts and clinical signs reminiscent of the 'ATRA syndrome' seen in acute promyelocytic leukemia, with fatal outcome in one of them, it was decided to add hydroxyurea (HY) to ATRA to patients with high WBC at inclusion or during ATRA treatment, and no more cases of ATRA syndrome were seen."5.08All-trans retinoic acid in adult chronic myelomonocytic leukemia: results of a pilot study. ( Cambier, N; Chomienne, C; Fenaux, P; Guerci, A; Menot, ML; Wattel, E, 1996)
"A 48-year-old woman was admitted with chronic myelogenous leukemia in November, 1996 and was treated with hydroxyurea (HU), because of marked leukocytosis; WBC 404,000/microliter."4.80[Chronic myelogenous leukemia with long-term hypoplasia induced by alpha-interferon and hydroxyurea]. ( Fujimaki, K; Fujisawa, S; Hattori, M; Kodama, F; Maruta, A; Mohri, H; Motomura, S; Okubo, T; Sakai, R; Takahashi, N; Tomita, N, 1998)
"Hyperleukocytosis occurs in 15-20% of all newly diagnosed acute myeloid leukemia patients and requires emergent treatment with leukapheresis or hydroxyurea when accompanied by signs or symptoms of leukostasis."3.91Dose-related mucositis with hydroxyurea for cytoreduction in acute myeloid leukemia. ( Auten, JJ; Clark, SM; Trepte, ML; van Deventer, HW, 2019)
"Imatinib mesylate has been reported to produce positive results in atypical chronic myeloproliferative disorders (CMD) with chromosomal translocations that disrupt the platelet-derived growth factor receptor beta gene (PDGFRB)."3.72Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor beta-gene. ( Bastie, JN; Castaigne, S; Cross, NC; Garcia, I; Mahon, FX; Terré, C, 2004)
"The effect of hydroxyurea on blood viscosity was studied in 10 patients with Philadelphia chromosome positive chronic myelogenous leukemia (CML) and hyperleukocytosis (white blood cell counts over 200 x 10(9)/l)."3.68Effect of hydroxyurea on blood viscosity in chronic myelogenous leukemia with hyperleukocytosis. ( Bhat, SV; Rao, S; Sharma, K, 1991)
"The effect of hydroxyurea in 35 patients with chronic granulocytic leukemia (CGL), who either had entered an accelerated phase of the disease or had experienced excessive myelosuppression following alkylating agents, was studied."3.65Hydroxyurea in the management of the hematologic complications of chronic granulocytic leukemia. ( Cannellos, GP; Schwartz, JH, 1975)
"Leukostasis is a life-threatening complication of high concentrations of circulating leukemic cells, most often myeloblasts."2.82Hyperleukocytosis and leukostasis in acute and chronic leukemias. ( Macaron, W; Sargsyan, Z; Short, NJ, 2022)
"In idiopathic myelofibrosis (IMF) PDGF is considered to be one of the growth factors responsible for the development of bone marrow fibrosis."2.71Imatinib mesylate in idiopathic and postpolycythemic myelofibrosis. ( Birgens, H; Bjerrum, OW; Clausen, NT; Hansen, PB; Hasselbalch, HC; Jensen, BA; Ralfkiaer, E; Therkildsen, MH, 2003)
"Hyperleukocytosis is defined as a white blood cell count greater than 100."2.58The management of hyperleukocytosis in 2017: Do we still need leukapheresis? ( Korkmaz, S, 2018)
"Hyperleukocytosis can induce leukostasis, which can lead to vascular obstructions (usually in the lungs and central nervous system), tumor lysis syndrome, and disseminated intravascular coagulation."2.52How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. ( Pham, HP; Schwartz, J, 2015)
"Hyperleukocytosis, arbitrarily defined in acute leukemia as a white blood cell count greater than 100,000/mL, often is associated with increased morbidity and mortality in patients with leukemic processes."2.48Hyperleukocytosis, leukostasis and leukapheresis: practice management. ( Becker, J; Ganzel, C; Lazarus, HM; Mintz, PD; Rowe, JM, 2012)
"These data suggest a role of GM-CSF in leukocytosis of SCD."1.34Leukocyte numbers correlate with plasma levels of granulocyte-macrophage colony-stimulating factor in sickle cell disease. ( Conran, N; Costa, FF; Ikuta, T; Saad, ST, 2007)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19906 (14.63)18.7374
1990's7 (17.07)18.2507
2000's10 (24.39)29.6817
2010's14 (34.15)24.3611
2020's4 (9.76)2.80

Authors

AuthorsStudies
Macaron, W1
Sargsyan, Z1
Short, NJ1
Cerrano, M1
Seegers, V1
Raffoux, E2
Rabian, F1
Sébert, M1
Itzykson, R1
Lemiale, V2
Adès, L1
Boissel, N2
Dombret, H2
Azoulay, E2
Lengliné, E2
Bewersdorf, JP1
Giri, S1
Tallman, MS1
Zeidan, AM1
Stahl, M1
Diao, S1
Nichols, ED1
DiNardo, C1
Konopleva, M1
Ning, J1
Qiao, W1
Maiti, A1
DiPippo, AJ1
Bertolini, F1
Cassisa, A1
Miggiano, MC1
Gasparin, P1
Trepte, ML1
Auten, JJ1
Clark, SM1
van Deventer, HW1
Korkmaz, S1
Bertoli, S1
Tavitian, S1
Picard, M1
Huguet, F1
Vergez, F1
Delabesse, E1
Sarry, A1
Bérard, E1
Récher, C1
Park, SH1
Chi, HS1
Cho, YU1
Jang, S1
Park, CJ1
Kim, DY1
Lee, JH1
Lee, KH1
Scott, KM1
Gardner, FP1
Eidelman, BH1
Rivera, CE1
Menke, DM1
Barrett, KM1
Kuo, KH1
Callum, JL1
Panzarella, T1
Jacks, LM1
Brandwein, J1
Crump, M1
Curtis, JE1
Gupta, V1
Lipton, JH1
Minden, MD1
Sher, GD1
Schimmer, AD1
Schuh, AC1
Yee, KW1
Keating, A1
Messner, HA1
Pham, HP1
Schwartz, J1
Mamez, AC1
Chevret, S1
Canet, E1
Schlemmer, B1
Badawy, SM1
Caramazza, D1
Caracciolo, C1
Barone, R1
Malato, A1
Saccullo, G1
Cigna, V1
Berretta, S1
Schinocca, L1
Quintini, G1
Abbadessa, V1
Di Raimondo, F1
Siragusa, S1
Bajwa, AA1
Usman, F1
Wolfson, D1
Laos, LF1
Cury, JD1
Martínez-Trillos, A1
Gaya, A1
Maffioli, M1
Arellano-Rodrigo, E2
Calvo, X1
Díaz-Beyá, M1
Cervantes, F2
Yannaki, E1
Papayannopoulou, T1
Jonlin, E1
Zervou, F1
Karponi, G1
Xagorari, A1
Becker, P1
Psatha, N1
Batsis, I1
Kaloyannidis, P1
Tahynopoulou, V1
Constantinou, V1
Bouinta, A1
Kotta, K1
Athanassiadou, A1
Anagnostopoulos, A1
Fassas, A1
Stamatoyannopoulos, G1
Ganzel, C1
Becker, J1
Mintz, PD1
Lazarus, HM1
Rowe, JM1
Binder, WD1
Brown, DF1
Nadel, ES1
Au, WY1
Ma, SK1
Wan, TS1
Wang, EP1
Lau, TC1
Kwong, YL1
Hasselbalch, HC1
Bjerrum, OW1
Jensen, BA1
Clausen, NT1
Hansen, PB1
Birgens, H1
Therkildsen, MH1
Ralfkiaer, E1
Bastie, JN1
Garcia, I1
Terré, C1
Cross, NC1
Mahon, FX1
Castaigne, S1
Rudolph, G1
Haritoglou, C1
Schmid, I1
Hochhaus, F1
Kampik, A1
Conran, N1
Saad, ST1
Costa, FF1
Ikuta, T1
Bhave, AA1
Rao, RG1
Patil, GT1
Berger, R1
Hillion, J1
Janvier, D1
Chen, Z1
Bussel, A1
Hwang, WL1
Gau, JP1
Chen, MC1
Young, JH1
Cambier, N1
Wattel, E1
Menot, ML1
Guerci, A1
Chomienne, C1
Fenaux, P1
Motomura, S1
Sakai, R1
Tomita, N1
Fujimaki, K1
Hattori, M1
Fujisawa, S1
Mohri, H1
Takahashi, N1
Maruta, A1
Kodama, F1
Okubo, T1
Hernández-Boluda, JC1
Carreras, E1
Marín, P1
Rovira, M1
Solé, F1
Lloveras, E1
Espinet, B1
Ocejo, A1
Montserrat, E1
Hur, M1
Song, EY1
Kang, SH1
Shin, DH1
Kim, JY1
Park, SS1
Cho, HI1
Berg, J1
Vincent, PC1
Gunz, FW1
Schwartz, JH1
Cannellos, GP1
Balducci, L1
Hardy, CL1
Sharma, K1
Rao, S1
Bhat, SV1
Snyder, AB1
Barone, JG1
DiGiacomo, JC1
Barone, JE1
Schwarzenberg, L1
Mathé, G1
Pouillart, P1
Weiner, R1
Locour, J1
Genin, J1
Schneider, M1
De Vassal, F1
Hayat, M1
Amiel, JL1
Schlumberger, JR1
Jasmin, C1
Rosenfeld, C1
Konior, GS1
Yarbro, JW1
Stein, KM1
Shelley, WB1
Weinberg, RA1
Lerner, LJ1
Bianchi, A1
Yiacas, E1
Borman, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Vinblastine Versus Oral Hydroxiurea in Newly Diagnosed AML With Hyperleukocytosis: a Phase 2 Clinical Study[NCT05062278]Phase 246 participants (Anticipated)Interventional2021-07-26Recruiting
A Multicentric, Exploratory, Non-randomised, Non-controlled, Prospective, Open-label Phase II Study Evaluating Safety and Efficacy of IBU, G-CSF and Plerixafor as Stem Cell Mobilization Regimen in Patients Affected by X-CGD[NCT03055247]Phase 23 participants (Anticipated)Interventional2015-11-06Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for hydroxyurea and Leukocytosis

ArticleYear
Hyperleukocytosis and leukostasis in acute and chronic leukemias.
    Leukemia & lymphoma, 2022, Volume: 63, Issue:8

    Topics: Chronic Disease; Humans; Hydroxyurea; Leukapheresis; Leukemia, Myeloid, Acute; Leukocytosis; Leukost

2022
Leukapheresis for the management of hyperleukocytosis in acute myeloid leukemia-A systematic review and meta-analysis.
    Transfusion, 2020, Volume: 60, Issue:10

    Topics: Disease-Free Survival; Humans; Hydroxyurea; Leukapheresis; Leukemia, Myeloid, Acute; Leukocytosis; R

2020
The management of hyperleukocytosis in 2017: Do we still need leukapheresis?
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2018, Volume: 57, Issue:1

    Topics: Acute Disease; Female; Humans; Hydroxyurea; Induction Chemotherapy; Leukapheresis; Leukemia; Leukocy

2018
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis.
    Transfusion, 2015, Volume: 55, Issue:10

    Topics: Antisickling Agents; Disseminated Intravascular Coagulation; Humans; Hydroxyurea; Leukapheresis; Leu

2015
Hyperleukocytosis, leukostasis and leukapheresis: practice management.
    Blood reviews, 2012, Volume: 26, Issue:3

    Topics: Acute Disease; Humans; Hydroxyurea; Induction Chemotherapy; Leukapheresis; Leukemia; Leukocyte Count

2012
[Chronic myelogenous leukemia with long-term hypoplasia induced by alpha-interferon and hydroxyurea].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1998, Volume: 39, Issue:4

    Topics: Antineoplastic Agents; Bone Marrow; Female; Humans; Hydroxyurea; Interferon-alpha; Leukemia, Myeloge

1998
Lymphoid preponderance and the absence of basophilia and splenomegaly are frequent in m-bcr-positive chronic myelogenous leukemia.
    Annals of hematology, 2002, Volume: 81, Issue:4

    Topics: Aged; Basophils; Female; Fusion Proteins, bcr-abl; Humans; Hydroxyurea; Leukemia, Myelogenous, Chron

2002

Trials

3 trials available for hydroxyurea and Leukocytosis

ArticleYear
Hematopoietic stem cell mobilization for gene therapy of adult patients with severe β-thalassemia: results of clinical trials using G-CSF or plerixafor in splenectomized and nonsplenectomized subjects.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2012, Volume: 20, Issue:1

    Topics: Adult; Antigens, CD34; Benzylamines; beta-Thalassemia; Cyclams; Female; Genetic Therapy; Granulocyte

2012
Imatinib mesylate in idiopathic and postpolycythemic myelofibrosis.
    American journal of hematology, 2003, Volume: 74, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Female;

2003
All-trans retinoic acid in adult chronic myelomonocytic leukemia: results of a pilot study.
    Leukemia, 1996, Volume: 10, Issue:7

    Topics: Aged; Antineoplastic Agents; Bone Marrow; Colony-Forming Units Assay; Female; Hematopoietic Stem Cel

1996

Other Studies

31 other studies available for hydroxyurea and Leukocytosis

ArticleYear
Predictors and outcomes associated with hydroxyurea sensitivity in acute myeloid leukemia patients with high hyperleukocytosis.
    Leukemia & lymphoma, 2020, Volume: 61, Issue:3

    Topics: Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Leukocytosis

2020
Incidence of tumor lysis syndrome in patients with acute myeloid leukemia undergoing low-intensity induction with venetoclax.
    American journal of hematology, 2021, 03-01, Volume: 96, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds,

2021
Skin nodules in onset of acute myeloid leukemia, a myelomonocytic variant case.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2017, Volume: 152, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cytarabine; Daunorubicin; Delayed Diagnosis;

2017
Dose-related mucositis with hydroxyurea for cytoreduction in acute myeloid leukemia.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:4

    Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Leuk

2019
Hydroxyurea prior to intensive chemotherapy in AML with moderate leukocytosis.
    Leukemia research, 2018, Volume: 75

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Female; Hemat

2018
Two cases of myeloproliferative neoplasm with a concurrent JAK2 (V617F) mutation and BCR/ABL translocation without chronic myelogenous leukemia phenotype acquisition during hydroxyurea treatment.
    Annals of laboratory medicine, 2013, Volume: 33, Issue:3

    Topics: Adult; Alleles; Fusion Proteins, bcr-abl; Heterozygote; Humans; Hydroxyurea; Janus Kinase 2; Leukemi

2013
Clinical reasoning: a 69-year-old man with leukocytosis and hemorrhagic brain lesions.
    Neurology, 2014, Jul-01, Volume: 83, Issue:1

    Topics: Aged; Enzyme Inhibitors; Humans; Hydroxyurea; Intracranial Hemorrhages; Leukocytosis; Male

2014
A retrospective observational study of leucoreductive strategies to manage patients with acute myeloid leukaemia presenting with hyperleucocytosis.
    British journal of haematology, 2015, Volume: 168, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Combined Modality Therapy; Female

2015
Pre-treatment with oral hydroxyurea prior to intensive chemotherapy improves early survival of patients with high hyperleukocytosis in acute myeloid leukemia.
    Leukemia & lymphoma, 2016, Volume: 57, Issue:10

    Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Comorbidity; Female; Ho

2016
The Use of Hydroxyurea and Leukapheresis in Childhood Acute Leukemia With Hyperleukocytosis.
    Journal of pediatric hematology/oncology, 2016, Volume: 38, Issue:5

    Topics: Acute Disease; Child; Humans; Hydroxyurea; Leukapheresis; Leukemia, Myeloid, Acute; Leukocytosis

2016
Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms.
    Annals of hematology, 2009, Volume: 88, Issue:10

    Topics: Aged; Female; Humans; Hydroxyurea; Janus Kinase 2; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Neg

2009
A 62-year-old woman with dyspnea, leukocytosis, and diffuse ground-glass opacities.
    Chest, 2010, Volume: 137, Issue:6

    Topics: Combined Modality Therapy; Diagnosis, Differential; Dyspnea; Female; Hematopoiesis, Extramedullary;

2010
Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: results in 40 patients.
    Annals of hematology, 2010, Volume: 89, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anemia; Antisickling Agents; Bone and Bones; Female; Humans; Hydroxy

2010
Blurred vision, epistaxis, and fever in a young man.
    The Journal of emergency medicine, 2002, Volume: 23, Issue:3

    Topics: Acute Disease; Adult; Allopurinol; Antimetabolites; Antineoplastic Agents; Epistaxis; Fever; Fluid T

2002
Concurrent mediastinal B cell lymphoma and chronic myeloid leukemia with an unusually favorable response to chemotherapy.
    Leukemia & lymphoma, 2003, Volume: 44, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Clone Cells; Combined Modal

2003
Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor beta-gene.
    Haematologica, 2004, Volume: 89, Issue:10

    Topics: Benzamides; Biomarkers; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 5; Disease Progression

2004
Visual loss as a first sign of adult-type chronic myeloid leukemia in a child.
    American journal of ophthalmology, 2005, Volume: 140, Issue:4

    Topics: Blindness; Blood Cell Count; Child; Fluorescein Angiography; Hematopoietic Stem Cell Transplantation

2005
Leukocyte numbers correlate with plasma levels of granulocyte-macrophage colony-stimulating factor in sickle cell disease.
    Annals of hematology, 2007, Volume: 86, Issue:4

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Case-Control Studies; Child; Eosinophils; Female; Granulocyt

2007
Rare presentation of leucocytosis.
    The Journal of the Association of Physicians of India, 2006, Volume: 54

    Topics: Adult; Allopurinol; Humans; Hydroxyurea; Leukemia, Neutrophilic, Chronic; Leukocytosis; Male; Progno

2006
t(8;21) prior to acute leukemia.
    Cancer genetics and cytogenetics, 1993, Oct-15, Volume: 70, Issue:2

    Topics: Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Female; Humans; Hydroxyurea; Leukemia, Myel

1993
Treatment of acute promyelocytic leukemia with all-trans retinoic acid: successful control of hyperleukocytosis and leukostasis syndrome with leukaphereses and hydroxyurea.
    American journal of hematology, 1993, Volume: 43, Issue:4

    Topics: Administration, Oral; Adult; Female; Humans; Hydroxyurea; Leukapheresis; Leukemia, Promyelocytic, Ac

1993
Collection of Philadelphia-negative stem cells using recombinant human granulocyte colony-stimulating factor in chronic myeloid leukemia patients treated with alpha-interferon.
    Haematologica, 2002, Volume: 87, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Blood Component

2002
Extreme leucocytosis and prognosis of newly diagnosed patients with acute non-lymphocytic leukaemia.
    The Medical journal of Australia, 1979, Jun-02, Volume: 1, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Drug Therapy, Combination; Female; Hu

1979
Hydroxyurea in the management of the hematologic complications of chronic granulocytic leukemia.
    Blood, 1975, Volume: 46, Issue:1

    Topics: Busulfan; Humans; Hydroxyurea; Leukemia, Myeloid; Leukocyte Count; Leukocytosis; Mitobronitol; Splen

1975
High proliferation of early hemopoietic progenitors in tumor-bearing mice.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 1992, Volume: 60, Issue:2

    Topics: Anemia; Animals; Bone Marrow; Carcinoma; Cell Division; Hematopoiesis; Hematopoietic Cell Growth Fac

1992
Effect of hydroxyurea on blood viscosity in chronic myelogenous leukemia with hyperleukocytosis.
    Physiological chemistry and physics and medical NMR, 1991, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Blood Viscosity; Female; Humans; Hydroxyurea; Leukemia, Myelogenous, Chronic, BCR

1991
Postoperative pulmonary leukostasis.
    Critical care medicine, 1990, Volume: 18, Issue:1

    Topics: Aged; Allopurinol; Cytarabine; Drug Therapy, Combination; Humans; Hydroxyurea; Leukemia, Myelogenous

1990
Hydroxyurea, leucopheresis, and splenectomy in chronic myeloid leukaemia at the problastic phase.
    British medical journal, 1973, Mar-24, Volume: 1, Issue:5855

    Topics: Adolescent; Adult; Aged; Blood Transfusion; Busulfan; Demecolcine; Female; Humans; Hydroxyurea; Leuk

1973
Hydroxyurea in the treatment of chronic myeloid leukemia.
    Southern medical journal, 1971, Volume: 64, Issue:2

    Topics: DNA; Humans; Hydroxyurea; Leukemia; Leukocytosis; Middle Aged; Splenomegaly

1971
Hydroxyurea in the treatment of pustular psoriasis.
    The British journal of dermatology, 1971, Volume: 85, Issue:1

    Topics: Administration, Oral; Adolescent; Female; Fever; Humans; Hydroxyurea; Leukocyte Count; Leukocytosis;

1971
Effects of hydroxyurea and related compounds on the blood and marrow of experimental animals.
    Cancer research, 1966, Volume: 26, Issue:11

    Topics: Adrenal Glands; Animals; Antineoplastic Agents; Blood Cell Count; Blood Cells; Body Weight; Hydroxyu

1966