hydroxyurea and Kidney Diseases studies

Research Excerpts

Excerpt	Relevance	Reference
"The prevalence of albuminuria was lower among patients on hydroxyurea (34."	7.80	Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease. ( Ataga, KI; Derebail, VK; Desai, PC; Laurin, LP; Nachman, PH, 2014)
" Pregnancy is a high-risk situation for the mother and child The efficacy and safety of hydroxyurea and long-term blood transfusions in adults with sickle cell disease are currently under investigation."	4.84	[New issues in adult sickle sell disease]. ( Girot, R; Lionnet, F; Stankovic, K, 2008)
"SCD patients, in steady state and asymptomatic for pulmonary hypertension, were studied stressing on hydroxyurea therapy, serum ferritin, urinary albumin creatinine ratio (UACR), high-sensitivity C-reactive protein (hs-CRP) and sFas/sFasL levels."	3.83	Soluble Fas/FasL ratio as a marker of vasculopathy in children and adolescents with sickle cell disease. ( Adly, AA; Andrawes, NG; Eladawy, R; Ismail, EA; Mahmoud, MM, 2016)
"The prevalence of albuminuria was lower among patients on hydroxyurea (34."	3.80	Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease. ( Ataga, KI; Derebail, VK; Desai, PC; Laurin, LP; Nachman, PH, 2014)
" Our results, while no longer the product of a randomized study because of the ethical concerns of withholding an efficacious treatment, suggest that long-term use of hydroxyurea is safe and might decrease mortality."	2.75	The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. ( Armstrong, FD; Ataga, K; Ballas, SK; Castro, O; DeCastro, L; Kutlar, A; McCarthy, WF; Smith, W; Steinberg, MH; Swerdlow, P; Waclawiw, MA, 2010)
"Zileuton was well tolerated by all participants including those with severe renal impairment and those receiving hemodialysis."	2.68	Pharmacokinetics of zileuton and its metabolites in patients with renal impairment. ( Awni, WM; Chu, SY; Drajesk, J; Halstenson, CE; Hansen, R; Keane, WF; Machinist, JM; Patterson, K; Wong, S, 1997)
"Renal dysfunction is common in children with SCD and can be detected early using simple urine parameters and can be prevented with an early and appropriate dosage of HU with good compliance."	1.91	Early detection of glomerular dysfunction and renal tubulopathy in children with sickle cell disease in India. ( Ghildiyal, R; Karapurkar, S; Keshwani, R; Shah, N; Sharma, S, 2023)
"Hydroxyurea treatment augmented plasma nitrite and attenuated plasma arginase in HbSS mice."	1.62	Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice. ( Dunaway, LS; Kasztan, M; Molina, PA; Pollock, DM; Pollock, JS; Sedaka, R; Taylor, CM, 2021)
"Sickle cell disease is the most common inherited disease in the U."	1.35	The clinical care of adult patients with sickle cell disease. ( Howard, J; Olujohungbe, A, 2008)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (16.00)	18.7374
1990's	3 (12.00)	18.2507
2000's	5 (20.00)	29.6817
2010's	9 (36.00)	24.3611
2020's	4 (16.00)	2.80

Authors	Studies
Karapurkar, S	1
Ghildiyal, R	1
Shah, N	1
Keshwani, R	1
Sharma, S	1
Taylor, CM	1
Kasztan, M	2
Sedaka, R	1
Molina, PA	1
Dunaway, LS	1
Pollock, JS	2
Pollock, DM	2
Cunha, M	1
Simão, C	1
Ferrão, A	1
Palaré, MJ	1
Kwiatkowski, J	1
Kuliszkiewicz-Janus, M	1
Rymer, W	1
Jaźwiec, B	1
Małecki, R	1
Hariri, E	1
Mansour, A	1
El Alam, A	1
Daaboul, Y	1
Korjian, S	1
Aoun Bahous, S	1
Taylor, C	1
Tao, B	1
Olaniran, KO	1
Eneanya, ND	1
Nigwekar, SU	1
Vela-Parada, XF	1
Achebe, MM	1
Sharma, A	1
Thadhani, RI	1
Laurin, LP	1
Nachman, PH	1
Desai, PC	1
Ataga, KI	1
Derebail, VK	1
Adly, AA	1
Ismail, EA	1
Andrawes, NG	1
Mahmoud, MM	1
Eladawy, R	1
Olujohungbe, A	1
Howard, J	1
Girot, R	1
Stankovic, K	1
Lionnet, F	1
Steinberg, MH	1
McCarthy, WF	1
Castro, O	1
Ballas, SK	1
Armstrong, FD	1
Smith, W	1
Ataga, K	1
Swerdlow, P	1
Kutlar, A	1
DeCastro, L	1
Waclawiw, MA	1
Tripathi, A	1
Jerrell, JM	1
Stallworth, JR	1
Rees, DC	1
Williams, TN	1
Gladwin, MT	1
Bartolucci, P	1
Galactéros, F	1
Louvet, C	1
Carrat, F	1
Mal, F	1
Mabro, M	1
Beerblock, K	1
Vaillant, JC	1
Cady, J	1
André, T	1
Gamelin, E	1
de Gramont, A	1
SAMUELS, ML	1
HOWE, CD	1
Patel, NS	1
Cuzzocrea, S	1
Chatterjee, PK	1
Di Paola, R	1
Sautebin, L	1
Britti, D	1
Thiemermann, C	1
Bernardini, K	1
Lanthaler, AJ	1
Buratti, T	1
Mitterer, M	1
Morschhauser, F	1
Wattel, E	1
Pagniez, D	1
Lovi, V	1
Rose, C	1
Bauters, F	1
Fenaux, P	1
Awni, WM	1
Wong, S	1
Chu, SY	1
Patterson, K	1
Hansen, R	1
Machinist, JM	1
Drajesk, J	1
Keane, WF	1
Halstenson, CE	1
Page, RL	1
Stiff, ME	1
McEntee, MC	1
Walter, LG	1
Engstrom, PF	1
MacIntyre, JM	1
Schutt, AJ	1
Douglass, HO	1
Janicki, RH	1
Janicki, R	1
Lingis, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Aerobic Physical Fitness and Health-related Quality of Life in Children With Sickle Cell Disease.[NCT05995743]		72 participants (Actual)	Observational	2021-11-01	Completed
Evaluation of the Hemostatic Potential in Sickle Cell Disease Patients[NCT02565082]		64 participants (Actual)	Interventional	2015-09-30	Completed
Evaluation of Impact of Disease on Quality of Life, Education and Socio-professional Integration of Adults and Parents of Children Living With Sickle- Cell Disease in France[NCT04413539]		1,088 participants (Actual)	Observational	2020-06-02	Completed
Treatment With Hydoxycarbamide and L-Carnitine in Adult Patients With Severe Forms of Sickle Cell Anemia: An Overview[NCT05081349]	Phase 4	91 participants (Actual)	Interventional	2017-01-10	Completed
Evaluation of Sickle Cell Liver Disease[NCT01950429]		42 participants (Actual)	Observational	2013-10-16	Completed
Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE): a Randomized Controlled Trial[NCT05253781]	Phase 3	476 participants (Anticipated)	Interventional	2020-07-01	Recruiting
National Transfusion Treatment Survey in Patients With Sickle Cell Disease (SCD)[NCT03397017]		200 participants (Actual)	Observational	2016-07-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment. International urology and nephrology, 2018, Volume: 50, Issue:6 Topics: Analgesics; Anemia, Sickle Cell; Biomarkers; Glomerular Filtration Rate; Hematuria; Humans; Hydroxyu	2018
Sickle Cell Nephropathy in the Pediatric Population. Blood purification, 2019, Volume: 47, Issue:1-3 Topics: Adolescent; Adult; Albuminuria; Anemia, Sickle Cell; Angiotensin-Converting Enzyme Inhibitors; Bioma	2019
[New issues in adult sickle sell disease]. Bulletin de l'Academie nationale de medecine, 2008, Volume: 192, Issue:7 Topics: Adult; Anemia, Sickle Cell; Blood Transfusion; Cardiomyopathies; Combined Modality Therapy; Female;	2008
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Sickle-cell disease. Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757 Topics: Acute Chest Syndrome; Africa; Anemia, Sickle Cell; Antisickling Agents; Blood Transfusion; Disease S	2010
Clinical management of adult sickle-cell disease. Current opinion in hematology, 2012, Volume: 19, Issue:3 Topics: Anemia, Sickle Cell; Antisickling Agents; Humans; Hydroxyurea; Hypertension, Pulmonary; Kidney Disea	2012

Article	Year
The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. American journal of hematology, 2010, Volume: 85, Issue:6 Topics: Adolescent; Adult; Anemia, Sickle Cell; DNA Damage; Drug Utilization; Early Termination of Clinical	2010
Pharmacokinetics of zileuton and its metabolites in patients with renal impairment. Journal of clinical pharmacology, 1997, Volume: 37, Issue:5 Topics: Adult; Aged; Female; Humans; Hydroxyurea; Kidney Diseases; Kidney Failure, Chronic; Kidney Function	1997
Chemotherapy of large bowel carcinoma--fluorouracil (FU) + hydroxyurea (HU) vs. methyl-CCNU, oncovin, fluorouracil, and streptozotocin (MOF-Strep). An Eastern Cooperative Oncology Group study. American journal of clinical oncology, 1985, Volume: 8, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Fluorour	1985

hydroxyurea and Kidney Diseases

Research Excerpts

Research

Studies (25)

Authors

Clinical Trials (7)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Early detection of glomerular dysfunction and renal tubulopathy in children with sickle cell disease in India. Journal of tropical pediatrics, 2023, 02-06, Volume: 69, Issue:2 Topics: Albuminuria; Anemia, Sickle Cell; Child; Humans; Hydroxyurea; India; Kidney; Kidney Diseases; Water	2023
Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice. American journal of physiology. Regulatory, integrative and comparative physiology, 2021, 05-01, Volume: 320, Issue:5 Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Arginase; Disease Models, Animal; Hemoglobin A; H	2021
Nephrotic syndrome on sickle cell disease: the impact of Hydroxyurea. BMJ case reports, 2021, Mar-05, Volume: 14, Issue:3 Topics: Adolescent; Albuminuria; Anemia, Sickle Cell; Child; Female; Humans; Hydroxyurea; Kidney Diseases; N	2021
Treatment of Essential Thrombocythemia with Anagrelide Is Associated with an Increased Risk of Worsened Kidney Function. Pharmacology, 2021, Volume: 106, Issue:5-6 Topics: Aged; Calreticulin; Creatinine; Disease Progression; Female; Humans; Hydroxyurea; Janus Kinase 2; Ki	2021
Combined hydroxyurea and ET Acta physiologica (Oxford, England), 2019, Volume: 225, Issue:2 Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Disease Models, Animal; Drug Therapy, Combination	2019
Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014, Volume: 29, Issue:6 Topics: Acute Chest Syndrome; Adolescent; Adult; Aged; Albuminuria; Anemia, Sickle Cell; Angiotensin-Convert	2014
Soluble Fas/FasL ratio as a marker of vasculopathy in children and adolescents with sickle cell disease. Cytokine, 2016, Volume: 79 Topics: Adolescent; Albuminuria; Anemia, Sickle Cell; Antisickling Agents; Apoptosis; Biomarkers; C-Reactive	2016
The clinical care of adult patients with sickle cell disease. British journal of hospital medicine (London, England : 2005), 2008, Volume: 69, Issue:11 Topics: Adult; Anemia, Sickle Cell; Antisickling Agents; Female; Genetic Testing; Heart Diseases; Humans; Hy	2008
Clinical complications in severe pediatric sickle cell disease and the impact of hydroxyurea. Pediatric blood & cancer, 2011, Volume: 56, Issue:1 Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Cardiovascular Diseases; Child; Child, Prescho	2011
Prognostic factor analysis in advanced gastric cancer patients treated with hydroxyurea, leucovorin, 5-fluorouracil, and cisplatin (HLFP regimen). Cancer investigation, 2003, Volume: 21, Issue:1 Topics: Adenocarcinoma; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, T	2003
RENAL ABNORMALITIES INDUCED BY HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Blood; Hematologic Diseases; Hematuria; Hydroxyurea; Kidney Diseases; Kidney	1964
Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. Molecular pharmacology, 2004, Volume: 66, Issue:2 Topics: Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Inflammation; Intercellul	2004
Monolateral renal infarction and erythromelalgia in a case of chronic myelogenous leukemia. American journal of hematology, 2006, Volume: 81, Issue:3 Topics: Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides	2006
Glomerular injury in chronic myelomonocytic leukemia. Leukemia & lymphoma, 1995, Volume: 18, Issue:5-6 Topics: Aged; Amyloidosis; Etoposide; Female; Humans; Hydroxyurea; Kidney Diseases; Kidney Glomerulus; Leuke	1995
Transient glomerulonephropathy associated with primary erythrocytosis in a dog. Journal of the American Veterinary Medical Association, 1990, Feb-15, Volume: 196, Issue:4 Topics: Animals; Bloodletting; Combined Modality Therapy; Dog Diseases; Dogs; Doxorubicin; Female; Hydroxyur	1990
Renal adaptation during chronic NH4Cl acidosis in the rat: no role for hyperplasia. The American journal of physiology, 1970, Volume: 219, Issue:3 Topics: Acidosis; Adaptation, Physiological; Ammonium Chloride; Animals; Cell Division; DNA; Functional Late	1970
Unabated renal hypertrophy in uninephrectomized rats treated with hydroxyurea. The American journal of physiology, 1970, Volume: 219, Issue:5 Topics: Animals; Colorimetry; DNA; Hydroxyurea; Hyperplasia; Hypertrophy; Kidney; Kidney Diseases; Male; Nep	1970