hydroxyurea has been researched along with Hypogonadism in 5 studies
Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed at evaluating the effect of long-term use of hydroxyurea (HU) on gonad function in patients with beta-thalassemia intermedia (beta-TI) in Iran." | 7.78 | Comparative study of hypogonadism in beta-thalassemia intermedia patients with and without hydroxyurea. ( Haghpanah, S; Javad, P; Karamizadeh, Z; Karimi, M; Zekavat, OR, 2012) |
| "Hydroxyurea (HU), a drug for treating cancers of the blood and the management of sickle cell anemia, induces hypogonadism in males." | 4.31 | Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment. ( Alawode, O; Archibong, AE; Bourne, P; Bruner-Tran, K; Goodwin, S; Hildreth, J; Hills, ER; Lyons, L; Nayyar, T; Osteen, K; Sakwe, A; Virgous, C, 2023) |
| "Among Sickle cell disease patients without hydroxyurea therapy, 18% of patients developed oligospermia and 4% developed azoospermia." | 3.85 | Study of Seminal Fluid Parameters and Fertility of Male Sickle Cell Disease Patients and Potential Impact of Hydroxyurea Treatment. ( Kullu, BK; Meher, S; Patel, NK; Patel, S; Purohit, P; Rout, P; Sahoo, LK, 2017) |
| "We aimed at evaluating the effect of long-term use of hydroxyurea (HU) on gonad function in patients with beta-thalassemia intermedia (beta-TI) in Iran." | 3.78 | Comparative study of hypogonadism in beta-thalassemia intermedia patients with and without hydroxyurea. ( Haghpanah, S; Javad, P; Karamizadeh, Z; Karimi, M; Zekavat, OR, 2012) |
| "Two experiments were conducted to determine: 1) whether the adult male transgenic sickle cell mouse (Tg58 x Tg98; TSCM), exhibits the patterns of reproductive endpoints (hypogonadism) characteristic of men with sickle cell disease (SCD) and 2) whether hydroxyurea (HU) exacerbates this condition." | 3.75 | Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints. ( Aguinaga, MP; Archibong, AE; Bourne, P; Brooks, CM; Bruce, D; Hills, ER; Jones, KM; Niaz, MS; Rice, VM; Roberson, SI, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Virgous, C | 1 |
| Lyons, L | 1 |
| Sakwe, A | 1 |
| Nayyar, T | 1 |
| Goodwin, S | 1 |
| Hildreth, J | 1 |
| Osteen, K | 1 |
| Bruner-Tran, K | 1 |
| Alawode, O | 1 |
| Bourne, P | 2 |
| Hills, ER | 2 |
| Archibong, AE | 2 |
| Sahoo, LK | 1 |
| Kullu, BK | 1 |
| Patel, S | 1 |
| Patel, NK | 1 |
| Rout, P | 1 |
| Purohit, P | 1 |
| Meher, S | 1 |
| DeBaun, MR | 1 |
| Jones, KM | 1 |
| Niaz, MS | 1 |
| Brooks, CM | 1 |
| Roberson, SI | 1 |
| Aguinaga, MP | 1 |
| Rice, VM | 1 |
| Bruce, D | 1 |
| Karimi, M | 1 |
| Zekavat, OR | 1 |
| Haghpanah, S | 1 |
| Javad, P | 1 |
| Karamizadeh, Z | 1 |
1 review available for hydroxyurea and Hypogonadism
| Article | Year |
|---|---|
Hydroxyurea therapy contributes to infertility in adult men with sickle cell disease: a review.
Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Humans; Hydroxyurea; Hypogonadism; Infertility, M | 2014 |
4 other studies available for hydroxyurea and Hypogonadism
| Article | Year |
|---|---|
Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment.
Topics: Animals; Female; Fertility; Hydroxyurea; Hypogonadism; Male; Mice; Semen; Sperm Motility; Spermatoge | 2023 |
Study of Seminal Fluid Parameters and Fertility of Male Sickle Cell Disease Patients and Potential Impact of Hydroxyurea Treatment.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; Azoospermia; Fertility; Humans; Hydroxy | 2017 |
Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints.
Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Disease Models, Animal; Hydroxyurea; Hypogonadism | 2009 |
Comparative study of hypogonadism in beta-thalassemia intermedia patients with and without hydroxyurea.
Topics: Adolescent; Adult; Antineoplastic Agents; beta-Thalassemia; Case-Control Studies; Child; Estradiol; | 2012 |