hydroxyurea has been researched along with Hemoglobinuria, Paroxysmal in 3 studies
Hemoglobinuria, Paroxysmal: A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Accordingly, we conclude that clinical trials in SCD designed to increase the bioavailability of NO or association studies in which SCD clinical manifestations are related to plasma hemoglobin via its surrogates should be viewed with caution." | 2.46 | Pulmonary hypertension and nitric oxide depletion in sickle cell disease. ( Bunn, HF; Dover, GJ; Hebbel, RP; Nathan, DG; Platt, OS; Rosse, WF; Ware, RE, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cavanaugh, R | 1 |
| Bunn, HF | 1 |
| Nathan, DG | 1 |
| Dover, GJ | 1 |
| Hebbel, RP | 1 |
| Platt, OS | 1 |
| Rosse, WF | 1 |
| Ware, RE | 1 |
| Nakahata, J | 1 |
| Takahashi, M | 1 |
| Fuse, I | 1 |
| Nakamori, Y | 1 |
| Nomoto, N | 1 |
| Saitoh, H | 1 |
| Tatewaki, W | 1 |
| Imanari, A | 1 |
| Takeshige, T | 1 |
| Koike, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Substudy of the CADRE Study: Determination of Clinical Markers in Patients With Extreme Sickle Cell Disease Phenotype[NCT03352986] | 300 participants (Anticipated) | Observational | 2017-05-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyurea and Hemoglobinuria, Paroxysmal
| Article | Year |
|---|---|
Pulmonary hypertension and nitric oxide depletion in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Animals; Child; Clinical Trials as Topic; Disease Models, Animal; Echoca | 2010 |
2 other studies available for hydroxyurea and Hemoglobinuria, Paroxysmal
| Article | Year |
|---|---|
Lucio Luzzatto: tackling blood disorders on multiple continents.
Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Bone Marrow; Bone Marrow Examination; Glucosephos | 2021 |
Paroxysmal nocturnal hemoglobinuria with myelofibrosis: progression to acute myeloblastic leukemia.
Topics: Antigens, CD; Blood Proteins; CD55 Antigens; CD59 Antigens; Erythrocytes; Flow Cytometry; Granulocyt | 1993 |