hydroxyurea has been researched along with Experimental Neoplasms in 89 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of choriocarcinoma cells (JAr line) for 24 hr with methotrexate, fluorodeoxyuridine, 1-beta-D-arabinofuranosylcytosine, or hydroxyurea, in doses that inhibit DNA synthesis, results in a 2." | 3.66 | Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis. ( Azizkhan, JC; Goode, D; Speeg, KV; Stromberg, K, 1979) |
| "Mutant cell lines resistant to hydroxyurea (HU), an inhibitor of the enzyme ribonucleotide reductase, were selected from a line of Syrian hamster melanoma cells." | 3.66 | Resistance to bromodeoxyuridine mutagenesis and toxicity in mammalian cells selected for resistance to hydroxyurea. ( Davidson, RL; Kaufman, ER, 1979) |
| "A number of chemotherapeutic agents, including L-asparaginase, actinomycin D, chloroethylcyclohexy-nitrosourea, 5-flourouracil, cyclophosphamide, hydroxyurea, cis-platinum, adriamycin and methotrexate, alone and in combination and at variable dose levels, were applied against the Dunning R3327 rat prostatic adenocarcinoma-subline G." | 3.66 | Further experience with chemotherapy in the Dunning prostatic adenocarcinoma. ( Block, NL; Camuzzi, F; Claflin, A; Politano, VA; Stover, B; Troner, M, 1978) |
| "Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to male Fischer rats led to hepatocellular carcinoma in 100 percent with metastasis to the lung in 40 percent, of the animals living for the full experimental period of 20 weeks." | 3.65 | Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. ( Madison, RM; Viguera, C; Ward, JM; Weisburger, EK; Weisburger, JH, 1975) |
| " Optimum anticancer activity required twice daily dosing due to the duration of inhibition of DNA synthesis which lasted about 10 hr in L1210 cells treated with Triapine in vivo." | 1.31 | Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. ( Cheng, Y; Finch, RA; Grill, SP; Liu, M; Loomis, R; Rose, WC; Sartorelli, AC; Vasquez, KM, 2000) |
| "Caracemide was found to be about twelve times more effective than hydroxyurea." | 1.27 | In vitro cytotoxicity of caracemide alone and in combination with hydroxyurea or iron-chelating agents in human chronic myeloid leukemia cells and murine tumors. ( Advani, SH; Chitnis, MP; Satyamoorthy, K, 1988) |
| "N1-S1/FdUrd Novikoff hepatoma cells, which lack thymidine kinase activity, are resistant to 5-fluorouracil (FUra) as well as 5-fluorodeoxyuridine (FdUrd), suggesting that the pathway, FUra leads to FdUrd leads to FdUMP, is utilized for the conversion of FUra to FdUMP." | 1.26 | Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells. ( Crumley, J; Wilkinson, DS, 1977) |
| "Populations of Novikoff rat hepatoma cells (subline N1S1-67) were monitored for the rates of transport of various substrates and for their incorporation into acid-insoluble material as a function of the age of cultures of randomly growing cells in suspension as well as during traverse of the cells through the cell cycle." | 1.25 | Cell cycle and growth stage-dependent changes in the transport of nucleosides, hypoxanthine, choline, and deoxyglucose in cultured Novikoff rat hepatoma cells. ( Erbe, J; Plagemenn, PG; Richey, DP; Zylka, JM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 83 (93.26) | 18.7374 |
| 1990's | 2 (2.25) | 18.2507 |
| 2000's | 3 (3.37) | 29.6817 |
| 2010's | 1 (1.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kimura, K | 1 |
| Sakamoto, Y | 1 |
| Fujisawa, N | 1 |
| Uesugi, S | 1 |
| Aburai, N | 1 |
| Kawada, M | 1 |
| Ohba, S | 1 |
| Yamori, T | 1 |
| Tsuchiya, E | 1 |
| Koshino, H | 1 |
| MOHLER, WC | 1 |
| YOUNG, CW | 1 |
| HODAS, S | 1 |
| Li, N | 1 |
| Sood, S | 1 |
| Wang, S | 1 |
| Fang, M | 1 |
| Wang, P | 1 |
| Sun, Z | 1 |
| Yang, CS | 1 |
| Chen, X | 1 |
| Yarbro, JW | 3 |
| Pollack, A | 1 |
| Prudhomme, DL | 1 |
| Greenstein, DB | 1 |
| Irvin, GL | 1 |
| Claflin, AJ | 1 |
| Block, NL | 2 |
| Müller, HW | 1 |
| Seifert, W | 1 |
| Caras, IW | 1 |
| Jones, T | 1 |
| Eriksson, S | 1 |
| Martin, DW | 1 |
| Moore, EC | 2 |
| Loo, TL | 1 |
| Brock, WA | 1 |
| Trostle-Weige, PK | 1 |
| Williams, M | 1 |
| Meistrich, ML | 1 |
| Iversen, OH | 2 |
| Sackett, LL | 1 |
| Haus, E | 1 |
| Lakatua, D | 1 |
| Swoyer, J | 1 |
| Demeestere, M | 1 |
| Rockwell, S | 1 |
| Valleron, AJ | 2 |
| Frindel, E | 2 |
| Tubiana, M | 2 |
| Zietz, S | 1 |
| Lessin, S | 1 |
| Grattarola, M | 1 |
| Desaive, C | 1 |
| Nicolini, C | 1 |
| Rioux, N | 1 |
| Castonguay, A | 1 |
| Finch, RA | 1 |
| Liu, M | 1 |
| Grill, SP | 1 |
| Rose, WC | 1 |
| Loomis, R | 1 |
| Vasquez, KM | 1 |
| Cheng, Y | 1 |
| Sartorelli, AC | 1 |
| Vacek, A | 1 |
| Tacev, T | 1 |
| Hofer, M | 1 |
| Segerling, M | 2 |
| Ohanian, SH | 2 |
| Borsos, T | 2 |
| Igarashi, T | 1 |
| Okada, M | 1 |
| Kishimoto, T | 1 |
| Yamamura, Y | 1 |
| Barranco, SC | 1 |
| Haenelt, BR | 1 |
| Gee, EL | 1 |
| Azizkhan, JC | 1 |
| Speeg, KV | 1 |
| Stromberg, K | 1 |
| Goode, D | 1 |
| Plagemenn, PG | 1 |
| Richey, DP | 2 |
| Zylka, JM | 2 |
| Erbe, J | 3 |
| Weisburger, JH | 1 |
| Madison, RM | 1 |
| Ward, JM | 1 |
| Viguera, C | 1 |
| Weisburger, EK | 1 |
| Balhorn, R | 2 |
| Jackson, V | 1 |
| Granner, D | 2 |
| Chalkey, R | 1 |
| Wilkinson, DS | 1 |
| Crumley, J | 1 |
| Blocker, R | 1 |
| Roth, JS | 1 |
| Cameron, IL | 1 |
| Rogers, W | 1 |
| Plagemann, PG | 3 |
| Marz, R | 1 |
| Wohlhueter, RM | 1 |
| Gambari, R | 1 |
| Terada, M | 1 |
| Bank, A | 1 |
| Rifkind, RA | 1 |
| Marks, PA | 1 |
| Lowe, JK | 1 |
| Henderson, JF | 1 |
| Volm, M | 4 |
| Krieg, L | 2 |
| Mattern, J | 3 |
| Wayss, K | 4 |
| Honn, KV | 1 |
| Dunn, JR | 1 |
| Morgan, LR | 1 |
| Bienkowski, M | 1 |
| Marnett, LJ | 1 |
| Davidson, RL | 1 |
| Kaufman, ER | 1 |
| Kummermehr, J | 1 |
| Trott, KR | 1 |
| Zänker, KS | 1 |
| Stavrou, D | 1 |
| Osterkamp, U | 1 |
| Wriedt-Lübbe, I | 1 |
| Blümel, G | 1 |
| Bateman, AE | 1 |
| Steel, GG | 1 |
| Donelli, MG | 1 |
| Colombo, T | 1 |
| Broggini, M | 1 |
| Garattini, S | 1 |
| Camuzzi, F | 1 |
| Stover, B | 1 |
| Claflin, A | 1 |
| Troner, M | 1 |
| Politano, VA | 1 |
| Philips, FS | 1 |
| Sternberg, SS | 1 |
| Theiss, JC | 1 |
| Stoner, GD | 1 |
| Shimkin, MB | 1 |
| Twentyman, PR | 1 |
| Chou, JT | 1 |
| Beck, WT | 1 |
| Khwaja, T | 1 |
| Mayer, K | 1 |
| Lien, E | 1 |
| Maruyama, Y | 2 |
| Raju, MR | 1 |
| Bains, E | 1 |
| Jett, J | 1 |
| Stevens, J | 1 |
| Stevens, YW | 1 |
| Grüneisen, A | 2 |
| Rajewsky, MF | 2 |
| Remmer, I | 1 |
| Uschkoreit, J | 1 |
| Vassort, F | 1 |
| Von Hoff, DD | 1 |
| McGill, JR | 1 |
| Forseth, BJ | 1 |
| Davidson, KK | 1 |
| Bradley, TP | 1 |
| Van Devanter, DR | 1 |
| Wahl, GM | 1 |
| Satyamoorthy, K | 1 |
| Chitnis, MP | 1 |
| Advani, SH | 1 |
| Seidel, HJ | 1 |
| Goffinet, DR | 1 |
| Bagshaw, MA | 1 |
| Sugiura, K | 2 |
| Kuroki, T | 1 |
| Frankfurt, OS | 1 |
| Elford, HL | 1 |
| Lea, MA | 1 |
| Sasovetz, D | 1 |
| Musella, A | 1 |
| Morris, HP | 1 |
| Schultz, A | 1 |
| Sasaki, M | 1 |
| Natelson, S | 1 |
| Tanphaichitr, N | 1 |
| Chalkley, R | 1 |
| Laerum, OD | 1 |
| Griswold, DP | 1 |
| Dykes, DJ | 1 |
| Kelley, CA | 1 |
| Roberts, BJ | 1 |
| Dominick, CA | 1 |
| Zubrod, CG | 1 |
| Hahn, MA | 1 |
| Adamson, RH | 1 |
| Cikes, M | 2 |
| Klein, G | 2 |
| Friberg, S | 1 |
| Bhuyan, BK | 1 |
| Fraser, TJ | 1 |
| Gray, LG | 1 |
| Kuentzel, SL | 1 |
| Neil, GL | 1 |
| Hennings, H | 2 |
| Michael, D | 1 |
| Patterson, E | 1 |
| Lee, TC | 1 |
| Sullivan, S | 1 |
| Schuhmacher, J | 1 |
| Kampmann, H | 1 |
| Zimmerer, J | 1 |
| Bono, VH | 1 |
| Muranyi-Kovacs, I | 1 |
| Rudali, G | 1 |
| Connors, TA | 1 |
| Vogler, WR | 1 |
| Horwitz, S | 1 |
| Groth, DP | 1 |
| Mauro, F | 2 |
| Madoc-Jones, H | 2 |
| Chan, PC | 1 |
| Goldman, A | 1 |
| Wynder, EL | 1 |
| Harmon, RE | 1 |
| Dabrowiak, JC | 1 |
| Brown, DJ | 1 |
| Gupta, SK | 1 |
| Herbert, M | 1 |
| Chitharanjan, D | 1 |
| Perpich, J | 1 |
| Kennedy, BJ | 1 |
| Kucera, LS | 1 |
| Granoff, A | 1 |
| Giri, CP | 1 |
| Bhide, SV | 1 |
| Ranadive, KJ | 1 |
3 reviews available for hydroxyurea and Experimental Neoplasms
| Article | Year |
|---|---|
Clinical use of radiation sensitizing agents.
Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura | 1974 |
[Chemical carcinogenesis in vitro. 2].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Culture Techniques; Dactinomycin; DNA; Genes; | 1970 |
Present status of cancer chemotherapy.
Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Antimetabolites; Carmustine; DNA, Neoplasm; Evalu | 1974 |
86 other studies available for hydroxyurea and Experimental Neoplasms
| Article | Year |
|---|---|
Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Asteraceae; Cell Proliferation; Dose-Response | 2012 |
CYTOTOXICITY OF HYDROXYUREA (NSC-32065) REVERSIBLE BY PYRIMIDINE DEOXYRIBOSIDES IN A MAMMALIAN CELL LINE GROWN IN VITRO.
Topics: Antimetabolites; Cell Line; Cricetinae; Hydroxyurea; In Vitro Techniques; Neoplasms; Neoplasms, Expe | 1964 |
HYDROXYUREA: INHIBITORY EFFECT ON DNA METABOLISM.
Topics: Antineoplastic Agents; Cytosine Nucleotides; DNA; DNA, Neoplasm; Guanine Nucleotides; HeLa Cells; Hu | 1964 |
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogen | 2005 |
Relationship of histone synthesis to DNA synthesis in mouse ascites tumor 6C3HED.
Topics: Amino Acids; Animals; Carbon Isotopes; DNA, Neoplasm; Histones; Hydroxyurea; Mice; Neoplasms, Experi | 1967 |
Flow cytometric analysis of RNA content in different cell populations using pyronin Y and methyl green.
Topics: Animals; Cells, Cultured; Dactinomycin; Demecolcine; DNA; Flow Cytometry; Humans; Hydroxyurea; Inter | 1982 |
2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNPase) activity in cultured nerve cell lines from central nervous system: comparison of proliferating and resting growth states and cell cycle-dependent activity changes.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Brain Neoplasms; Cell Cycle; Cell Line; Cells, | 1982 |
Direct photoaffinity labeling of the catalytic site of mouse ribonucleotide reductase by CDP.
Topics: Affinity Labels; Animals; Cytidine Diphosphate; Cytosine Nucleotides; Deoxyribonucleotides; Hydroxyu | 1983 |
Inhibition of ribonucleotide reductase by caracemide.
Topics: Animals; Antineoplastic Agents; Hydroxyurea; In Vitro Techniques; Neoplasms, Experimental; Rats; Rib | 1984 |
Histone and DNA synthesis in differentiating and rapidly proliferating cells in vivo and in vitro.
Topics: Animals; Animals, Newborn; Brain Neoplasms; Cell Cycle; Cell Differentiation; Cell Line; DNA Replica | 1983 |
Enhancement of methylnitrosourea skin carcinogenesis by inhibiting cell proliferation with hydroxyurea or skin extracts.
Topics: Animals; Cell Division; DNA; Female; Hydroxyurea; Male; Methylnitrosourea; Mice; Mice, Inbred Strain | 1982 |
Hydroxyurea enhances methylnitrosourea skin tumorigenesis when given shortly before, but not after, the carcinogen.
Topics: Animals; DNA; Hydroxyurea; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; N | 1982 |
Circadian host and tumor rhythms in Balb/C mice, rhythm induction in Harding-passey Melanoma.
Topics: Animals; Bone Marrow; Circadian Rhythm; Darkness; DNA Replication; Female; Hydroxyurea; Light; Melan | 1981 |
Cell proliferation in EMT6 tumours treated with single doses of X-rays or hydroxyurea. II. Computer simulations.
Topics: Animals; Cell Division; Clone Cells; Computers; Hydroxyurea; Interphase; Mice; Mitotic Index; Neopla | 1980 |
FPi analysis. II. Use of the method to monitor the in vivo kinetics of cell populations perturbed by hydroxyurea.
Topics: Animals; Bone Marrow; Cell Division; Hydroxyurea; Lung Neoplasms; Mathematics; Melanoma; Mice; Mice, | 1980 |
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Aspirin; Body Weight; Carcinogens; Drug Screenin | 1998 |
Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; | 2000 |
Modulation of radioprotective effects of respiratory hypoxia by changing the duration of hypoxia before irradiation and by combining hypoxia and administration of hemopoiesis-stimulating agents.
Topics: Adaptation, Physiological; Animals; Antineoplastic Agents; Cobalt Radioisotopes; Dextran Sulfate; Fe | 2001 |
Enhancing effect by metabolic inhibitors on the killing of tumor cells by antibody and complement.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antineoplastic Agents; Azacitidine; Carci | 1975 |
In vitro induction of polyclonal killer T cells with 2-mercaptoethanol and the essential role of macrophages in this process.
Topics: Animals; Antigens, Neoplasm; Burkitt Lymphoma; Cell Division; Cells, Cultured; Clone Cells; Cytarabi | 1977 |
Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyta | 1978 |
Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis.
Topics: Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Cycloheximide; Cytarabine; DNA, Neoplasm; Dose-R | 1979 |
Cell cycle and growth stage-dependent changes in the transport of nucleosides, hypoxanthine, choline, and deoxyglucose in cultured Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Choline; D | 1975 |
Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.
Topics: Animals; Antilymphocyte Serum; Carcinoma, Hepatocellular; Diethylnitrosamine; Hydroxyurea; Immunosup | 1975 |
Phosphorylation of the lysine-rich histones throughout the cell cycle.
Topics: Autoradiography; Carcinoma, Hepatocellular; Cells, Cultured; Demecolcine; DNA, Neoplasm; Electrophor | 1975 |
Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Deoxyuridine; DNA Replication; Drug Re | 1977 |
The reduction of uridine 5'-diphosphate and uridine 5'-triphosphate in some transplantable rat hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Deoxyribonucleosides; Deoxyribonucleotides; Hydrolysis; Hydroxyu | 1977 |
Total intravenous hyperalimentation and hydroxyurea chemotherapy in hepatoma-bearing rats.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Drinking; Eating; Hydroxyurea; Intestine, Small; Li | 1977 |
Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis.
Topics: Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cells, Cultured; Cytarabine; Deoxy | 1978 |
Synthesis of globin mRNA in relation to the cell cycle during induced murine erythroleukemia differentiation.
Topics: Acetamides; Animals; Cell Cycle; Cell Differentiation; Cells, Cultured; Diamines; Dimethyl Sulfoxide | 1978 |
Enhancement by caffeine of the growth inhibitory effects of antimetabolites in lymphoma L5178Y cells.
Topics: Antimetabolites; Caffeine; Cell Division; Cells, Cultured; Deoxyadenosines; Drug Synergism; Hydroxyu | 1977 |
Effect of synchronization on chemotherapy of solid transplanted tumours.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Cycle; Cyclophosphamide; Cytological Tec | 1977 |
[Chemotherapy in solid transplantation tumors following synchronization (author's transl)].
Topics: Animals; Carcinoma 256, Walker; Cell Cycle; Cyclophosphamide; Cytarabine; Hydroxyurea; Male; Neoplas | 1979 |
Inhibition of DNA synthesis in Harding-Passey melanoma cells by prostaglandins A1 and A2: comparison with chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; DNA Replication; DNA, Neoplasm; Doxo | 1979 |
Resistance to bromodeoxyuridine mutagenesis and toxicity in mammalian cells selected for resistance to hydroxyurea.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cricetinae; DNA; Drug Resistance; Hydroxyurea; Melanoma; Meso | 1979 |
[Modification of the radiosensitivity of a transplantable fibrosarcoma by synchronization with hydroxyurea].
Topics: Animals; Cell Cycle; Fibrosarcoma; Hydroxyurea; Mice; Neoplasms, Experimental | 1978 |
Fibrinolysis induced by rat glioma cells. A mitosis-triggered process?
Topics: Animals; Astrocytoma; Cell Line; Dactinomycin; Fibrin Fibrinogen Degradation Products; Fibrinolysis; | 1978 |
The proliferative state of clonogenic cells in the Lewis lung tumour after treatment with cytotoxic agents.
Topics: Animals; Cell Cycle; Cell Division; Cell Survival; Clone Cells; Culture Techniques; Cyclophosphamide | 1978 |
Differential distribution of antitumor agents in primary and secondary tumors.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma 256, Walker; Cyclophosphamide; Daunorubici | 1977 |
Further experience with chemotherapy in the Dunning prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Dactinomycin; Doxoru | 1978 |
Tests for tumor induction by antitumor agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Benz(a)Anthracenes; Carcinogens; D | 1975 |
Murine pulmonary adenoma bioassay of potentially effective agents against slow-growing solid tumors.
Topics: Adenoma; Animals; Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Cytarabine; | 1977 |
Sensitivity to cytotoxic agents of the EMT6 tumour in vivo: tumour volume versus in vitro plating. 1. Cyclophosphamide.
Topics: Animals; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Hydroxyurea; Lun | 1977 |
Synthesis and anticancer activity of novel cyclic N-hydroxyureas.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cyclization; Female; Humans; Hydroxyurea; | 1977 |
Study of in vivo tumor state and response to therapy by analysis of DNA distribution.
Topics: Animals; Carmustine; Cell Survival; Cobalt Radioisotopes; DNA, Neoplasm; Female; Hydroxyurea; Kineti | 1976 |
Mathematic models of cell synchrony and drug scheduling.
Topics: Cell Division; Cell Survival; Clone Cells; Computers; Drug Administration Schedule; Hydroxyurea; Kin | 1976 |
Sequential irreversible, actinomycin D-sensitive, and cycloheximide-sensitive steps prior to cortisol inhibition of uridine utilization by P1798 tumor lymphocytes.
Topics: Animals; Cycloheximide; Dactinomycin; Depression, Chemical; Female; Hydrocortisone; Hydroxyurea; Lym | 1975 |
[Failure to partial synchronization with hydroxyurea to improve results of chemotherapy of solid neurosarcoma in the rat (author's transl)].
Topics: Animals; Cell Division; Cyclophosphamide; DNA, Neoplasm; Doxorubicin; Hydroxyurea; Male; Mitosis; Ne | 1975 |
Inhibition of 3H-thymidine incorporation by hydroxyurea: atpical response of mycoplasma-infected cells in culture.
Topics: Animals; Cell Line; DNA Replication; DNA, Neoplasm; HeLa Cells; Humans; Hydroxyurea; Mammary Neoplas | 1975 |
Critical survey of experimental data on in vivo synchronization by hydroxyurea.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Survival; Clone Cells; DNA, Neoplasm; H | 1975 |
Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Chromosome Disorders; Extrachromosomal Inheritance; G | 1992 |
In vitro cytotoxicity of caracemide alone and in combination with hydroxyurea or iron-chelating agents in human chronic myeloid leukemia cells and murine tumors.
Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Chelating Ag | 1988 |
[Estimation of tumor sensitivity in vitro. II. Studies with the solid Ehrlich carcinoma of the mouse and the GW 77, a heterotransplanted human carcinoma].
Topics: Animals; Antibiotics, Antineoplastic; Autoradiography; Carcinoma; Carcinoma, Ehrlich Tumor; Colonic | 1970 |
Chemotherapy of induced skin tumors in mice.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Benz(a)Anthracenes; Busulfan; Ca | 1968 |
Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.
Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Count; Floxuridine; Fluorouracil; Hydroxyurea; | 1973 |
Effect of hydroxyurea on ribonucleotide reductase.
Topics: Animals; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Chick Embryo; Cytosine Nucleotide | 1968 |
Effects of hydroxyurea and 6-mercaptopurine on growth and some aspects of carbohydrate metabolism in regenerating and neoplastic liver.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; DNA; DNA, Neoplasm; Glucokinase; Glucose; Hepatecto | 1970 |
Thymidine transport by Novikoff rat hepatoma cells synchronized by double hydroxyurea treatment.
Topics: Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chroma | 1974 |
Comparison of the ribonucleotide with the canavanine reductase system.
Topics: Amino Acid Oxidoreductases; Animals; Canavanine; Carcinoma, Hepatocellular; Cell Division; Cells, Cu | 1974 |
Intracellular conversions of deoxyribonucleosides by Novikoff rat hepatoma cells and effects of hydroxyurea.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cycloheximide; Cytidine; Deamination | 1974 |
Further studies of histone phosphorylation in the presence of inhibitors of DNA synthesis.
Topics: Carcinoma, Hepatocellular; Cells, Cultured; Cycloheximide; DNA, Neoplasm; Enzyme Activation; Histone | 1974 |
Effect of metabolic inhibitors on killing of tumor cells by antibody and complement.
Topics: Animals; Antigen-Antibody Reactions; Antimetabolites; Carcinoma, Hepatocellular; Cell Line; Compleme | 1974 |
Proliferative properties of malignant cell populations cultured in intraperitoneal diffusion chambers.
Topics: Animals; Cell Count; Cell Division; Cell Line; Cells, Cultured; Humans; Hydroxyurea; Leukemia, Myelo | 1973 |
Approaches to combination chemotherapy in rat, mouse, and hamster tumors.
Topics: Adenocarcinoma; Amides; Androstanols; Animals; Antineoplastic Agents; Cricetinae; Cyclohexanes; Cycl | 1974 |
Pharmacology of 3,5-diamino-1,24-triazole (guanazole). 1. Antitumor activity of guanazole.
Topics: Amines; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cyclophosphamide; Cytarabine; Depress | 1972 |
Effects of inhibitors of protein and nucleic acid synthesis on the expression of H-2 and Moloney leukemia virus-determined cell-surface antigens on cultured murine lymphoma cells.
Topics: Animals; Antigens; Antigens, Neoplasm; Antigens, Viral; Antineoplastic Agents; Cell Membrane; Cells, | 1972 |
Quantitative studies of antigen expression in cultured murine lymphoma cells. II. Cell-surface antigens in synchronized cultures.
Topics: Absorption; Animals; Antibody Specificity; Antigen-Antibody Reactions; Antigens, Neoplasm; Antigens, | 1972 |
Cell-kill kinetics of several S-phase-specific drugs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Cell Line; Cell Survival; Cricetinae; C | 1973 |
Enhancement of skin tumorigenesis by a single application of croton oil before or soon after initiation by urethan.
Topics: Animals; Cell Division; Croton Oil; DNA; DNA Replication; Female; Hydroxyurea; Mice; Neoplasms, Expe | 1973 |
Age cohort variation of tumor cells.
Topics: Animals; Cell Division; Disease Models, Animal; DNA, Neoplasm; Fluorouracil; Hydroxyurea; Lymphoma; | 1973 |
Incorporation of 131 iododeoxyuridine into the DNA of tumour-bearing rats after partial synchronization as a tool in scintigraphic tumour localization.
Topics: Animals; Cell Division; DNA; DNA, Neoplasm; Hydroxyurea; Iodine Radioisotopes; Male; Neoplasm Transp | 1974 |
Biochemical rationales for the selection of combinations of chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Cycloheximide; DNA, Neoplasm; Drug The | 1974 |
The effects of ferrous ion and dithioerythritol on inhibition by hydroxyruea of ribonucleotide reductase.
Topics: Animals; Chemical Phenomena; Chemistry; Cytosine Nucleotides; Escherichia coli; Guanine Nucleotides; | 1969 |
Comparative study of carcinogenic activity of hydroxyurea and urethane in XVII-G mice.
Topics: Animals; Carcinogens; Hydroxyurea; Injections, Intraperitoneal; Injections, Subcutaneous; Lung Neopl | 1972 |
An outline of cancer chemotherapy.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Asparaginase; Breast Neoplasms; | 1971 |
Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and two related compounds on a spectrum of tumors.
Topics: Adenocarcinoma; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Fibrosarcoma; Glioma; Hydroxy | 1967 |
Studies on the effects of hydroxyurea and other anticancer drugs upon pyrimidine metabolism.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Cyclophosphamide; Cytarab | 1969 |
Age response to x-radiation of murine lymphoma cells synchronized in vivo.
Topics: Aging; Animals; Biological Assay; Cell Division; Cell Line; Clone Cells; HeLa Cells; Hydroxyurea; Ly | 1969 |
Hydroxyurea: suppression of two-stage carcinogensis in mouse skin.
Topics: Animals; Croton Oil; Hydroxyurea; Mice; Neoplasms, Experimental; Papilloma; Skin Neoplasms | 1970 |
Metal complexes of 1-substituted 3-hydroxyureas.
Topics: Antineoplastic Agents; Binding Sites; Hydroxyurea; Metals; Neoplasms, Experimental | 1970 |
Age responses to x rays, Vinca alkaloids, and hydroxyurea of murine lymphoma cells synchronized in vivo.
Topics: Animals; Bone Marrow; Cricetinae; Femoral Neoplasms; Hydroxyurea; Lymphoma; Mice; Neoplasms, Experim | 1970 |
Hydroxyurea: possible relationship of cytotoxicity to inhibition of skin carcinogenesis.
Topics: Animals; Carcinogens; Croton Oil; DNA; DNA, Neoplasm; Female; Hydroxyurea; Injections, Intraperitone | 1971 |
Effect of urethane, hydroxyurethane and hydroxyurea on synthesis of nucleic acid.
Topics: Animals; DNA, Neoplasm; Hydroxyurea; Mice; Neoplasms, Experimental; Phosphorus Isotopes; RNA, Neopla | 1968 |
Viruses and renal carcinoma of Rana pipiens. VI. Interrelationships of macromolecular synthesis and infectious virus production in frog virus 3-infected BHK 21/13 cells.
Topics: Adenine; Animals; Anura; Carbon Isotopes; Culture Techniques; Cycloheximide; Cytarabine; Dactinomyci | 1968 |
Further studies on the mechanism of action of hydroxyurea.
Topics: Animals; DNA; DNA Replication; DNA, Neoplasm; Hydroxyurea; In Vitro Techniques; Mice; Neoplasms, Exp | 1968 |
In vivo effect of urethan and hydroxyurea on the incorporation of labeled phosphate into nucleic acids.
Topics: Animals; Animals, Newborn; Depression, Chemical; DNA; DNA, Neoplasm; Hydroxyurea; Liver; Lung; Neopl | 1969 |