hydroxyurea has been researched along with Experimental Hepatoma in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxyurea treatment induced G1 arrest and a senescence-like changes in rat hepatoma McA-RH7777 cells may be the likely results of signal disruption of MAP kinases (ERK, JNK, and p38 MAP kinase) and p21(Waf1) over-expression." | 1.32 | Involvement of mitogen-activated protein kinases and p21Waf1 in hydroxyurea-induced G1 arrest and senescence of McA-RH7777 rat hepatoma cell line. ( Hong, B-; Hong, SH; Jeong, JS; Jun, HS; Kim, DC; Park, JI; Rha, SH; Rho, MS, 2004) |
| "Mouse L-cells, BHK cells, Novikoff hepatoma cells, hepatocytes in primary culture, and an epithelial-like rat liver-derived cell line (Clone 9) were tested, and none of the cells could be stimulated." | 1.27 | Isolation of an autocrine growth factor from hepatoma HTC-SR cells. ( Coetzee, ML; Francavilla, A; Ove, P; Scalamogna, P; Starzl, TE, 1987) |
| "Benzohydroxamic acids inhibit mammalian ribonucleotide reductase and exhibit antineoplastic activity in L1210 leukemic mice." | 1.26 | Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: inhibition of ribonucleotide reductase and antitumor activity. ( Elford, HL; van't Riet, B; Wampler, GL, 1979) |
| "In variants of the Novikoff hepatoma cell line, the ability to use D-ribose as a carbon source appeared to be due to changes in the expression of ribokinase." | 1.26 | Multiple genetic changes determine ribose utilization by Novikoff hepatoma cell variants. ( Jargiello, P, 1980) |
| " Treatment for 1 hr with VF 122 of exponentially growing culture resulted in a biphasic exponential dose-response curve (Do = 0." | 1.26 | Cytotoxic and cell kinetic effects of 3,4,5-trihydroxybenzohydroxamic acid (VF 122) in hepatoma 3924A cells. ( Ban, J; Olah, E; Weber, G, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (76.19) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van't Riet, B | 1 |
| Wampler, GL | 1 |
| Elford, HL | 1 |
| Hong, SH | 1 |
| Hong, B- | 1 |
| Kim, DC | 1 |
| Rho, MS | 1 |
| Park, JI | 1 |
| Rha, SH | 1 |
| Jun, HS | 1 |
| Jeong, JS | 1 |
| Barra, R | 2 |
| Randolph, V | 2 |
| Sumas, M | 1 |
| Lanighan, K | 1 |
| Lea, MA | 3 |
| Jargiello, P | 1 |
| Andrae, U | 2 |
| Sumas, ME | 1 |
| Miller-Faurès, A | 1 |
| Michel, N | 1 |
| Aguilera, A | 1 |
| Blave, A | 1 |
| Miller, AO | 1 |
| Ban, J | 1 |
| Olah, E | 1 |
| Weber, G | 1 |
| Collin, GR | 1 |
| Parsons, J | 1 |
| Iwasaki, T | 1 |
| Shinkai, K | 1 |
| Mukai, M | 1 |
| Yoshioka, K | 1 |
| Fujii, Y | 1 |
| Nakahara, K | 1 |
| Matsuda, H | 1 |
| Akedo, H | 1 |
| Bayly, AC | 1 |
| Roberts, RA | 1 |
| Dive, C | 1 |
| Lerman, MI | 1 |
| Abakumova, OIu | 1 |
| Kutsenko, NG | 1 |
| Podobed, OV | 1 |
| Lincoln, DW | 1 |
| Hoffee, P | 1 |
| Rabes, HM | 2 |
| Kerler, R | 1 |
| Wilhelm, R | 1 |
| Rode, G | 1 |
| Riess, H | 1 |
| Zeindl-Eberhart, E | 1 |
| Contreres, JO | 1 |
| Debant, A | 1 |
| Ponzio, G | 1 |
| Rossi, B | 1 |
| Chevanne, M | 1 |
| Caldini, R | 1 |
| Ove, P | 1 |
| Coetzee, ML | 1 |
| Scalamogna, P | 1 |
| Francavilla, A | 1 |
| Starzl, TE | 1 |
| Rossberger, S | 1 |
| Wiebel, FJ | 1 |
| Louters, L | 1 |
| Chalkley, R | 1 |
| Bezlepkin, VG | 1 |
| Malinovskiĭ, IuIu | 1 |
| Velcovský, V | 1 |
| Gaziev, AI | 1 |
21 other studies available for hydroxyurea and Experimental Hepatoma
| Article | Year |
|---|---|
Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: inhibition of ribonucleotide reductase and antitumor activity.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Hydroxamic Acids; Hydroxyu | 1979 |
Involvement of mitogen-activated protein kinases and p21Waf1 in hydroxyurea-induced G1 arrest and senescence of McA-RH7777 rat hepatoma cell line.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cellular | 2004 |
Effects of nicotinamide, isonicotinamide, and bleomycin on DNA synthesis and repair in rat hepatocytes and hepatoma cells.
Topics: Animals; Bleomycin; Cell Division; DNA Repair; DNA Replication; Hydroxyurea; Liver; Liver Neoplasms, | 1982 |
Multiple genetic changes determine ribose utilization by Novikoff hepatoma cell variants.
Topics: Animals; Biological Transport; Cell Line; Drug Resistance; Genetic Variation; Hydroxyurea; Kinetics; | 1980 |
Evidence for the involvement of cytochrome P-450-dependent monooxygenase(s) in the formation of genotoxic metabolites from N-hydroxyurea.
Topics: Animals; Cell Differentiation; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Repair; | 1984 |
DNA in cytosol fractions obtained by differential centrifugation of homogenates of rapidly growing liver tumors.
Topics: Animals; Cell Nucleus; Cell Separation; Centrifugation; Cytosol; DNA; DNA, Neoplasm; Female; Hydroxy | 1984 |
Laser flow cytofluorometric analysis of HTC cells synchronized with hydroxyurea, nocodazole and aphidicolin.
Topics: Animals; Aphidicolin; Benzimidazoles; Calcium; Carbamates; Cell Cycle; Demecolcine; Diterpenes; Flow | 1981 |
Cytotoxic and cell kinetic effects of 3,4,5-trihydroxybenzohydroxamic acid (VF 122) in hepatoma 3924A cells.
Topics: Animals; Cell Cycle; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Hydroxamic Ac | 1982 |
Differences in cytosol factors in liver and hepatomas revealed by real or apparent effects on the incorporation of [3H] thymidine.
Topics: Animals; Cell Division; Cell Extracts; Cell Fractionation; Cycloheximide; Cytosol; Ethanol; Hydroxyu | 1981 |
Cell-cycle-dependent invasion in vitro by rat ascites hepatoma cells.
Topics: Animals; Aphidicolin; Ascites; Cell Cycle; Cell Movement; Growth Inhibitors; Hydroxyurea; Liver Neop | 1995 |
Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin.
Topics: Animals; Apoptosis; Cells, Cultured; DNA Damage; Etoposide; Hydroxyurea; In Vitro Techniques; Liver; | 1994 |
[Accelerated microsomal DNA synthesis under the influence of xenobiotics and chemical carcinogens].
Topics: Animals; Benzopyrenes; Caffeine; Cell Nucleus; Cycloheximide; DNA; DNA, Mitochondrial; DNA, Neoplasm | 1979 |
Deoxyribose 5-phosphate aldolase: an enzyme that peaks in the G2 phase of rat hepatoma cells.
Topics: Aldehyde-Lyases; Animals; Cell Cycle; Deoxyribose; DNA, Neoplasm; Hydroxyurea; In Vitro Techniques; | 1979 |
Alkylation of DNA and RNA by [14C]dimethylnitrosamine in hydroxyurea-synchronized regenerating rat liver.
Topics: Alkylation; Animals; Cell Cycle; Diethylnitrosamine; DNA; Guanine; Hydroxyurea; Liver; Liver Neoplas | 1979 |
Variant protein patterns in hepatomas and transformed liver cell lines as determined by high resolution two-dimensional gel electrophoresis (2DE).
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Electropho | 1992 |
Cell-cycle regulation of insulin-stimulated tyrosine aminotransferase activity in rat hepatoma cells.
Topics: Amino Acids; Animals; Binding Sites; Biological Transport; Cell Cycle; Dexamethasone; Enzyme Inducti | 1990 |
Relationship between pyridine nucleotide levels and ribonucleotide reductase activity in Yoshida ascites hepatoma AH130.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Hydroxyurea; In Vitro Techniques; Liver Neoplasms, Ex | 1986 |
Isolation of an autocrine growth factor from hepatoma HTC-SR cells.
Topics: Animals; Chromatography, Affinity; DNA Replication; Dose-Response Relationship, Drug; Electrophoresi | 1987 |
Comparison of the continuous rat hepatoma cell line 2sFou with primary rat hepatocyte cultures for the induction of DNA repair synthesis by nitrosamines, benzo[a]pyrene and hydroxyurea.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enz | 1987 |
Exchange of histones H1, H2A, and H2B in vivo.
Topics: Animals; Cell Line; DNA Replication; Electrophoresis, Polyacrylamide Gel; Histones; Hydroxyurea; Liv | 1985 |
[Preferential initiation of unscheduled DNA synthesis on areas associated with the nuclear matrix].
Topics: Animals; Cell Nucleus; DNA Repair; DNA, Neoplasm; Drug Resistance; Gamma Rays; Hydroxyurea; Liver; L | 1985 |