hydroxyurea and Edema
hydroxyurea has been researched along with Edema in 12 studies
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a murine model of arachidonic acid-induced ear inflammation, the LTA(4)H inhibitor, JNJ-26993135 (1-[4-(benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid), dose-dependently inhibited ex vivo LTB(4) production in blood, in parallel with dose-dependent inhibition of neutrophil influx (ED(50), 1-3 mg/kg) and ear edema." | 3.74 | Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. ( Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Jiang, X; Karlsson, L; Lundeen, KA; Rao, NL; Riley, JP; Williams, KN; Xue, X, 2007) |
| "To determine the role of polymorphonuclear leukocytes (PMNs) in the airway edema that accompanies airway inflammation, we studied the effects of a 1-h exposure to 2 ppm toluene diisocyanate (TDI) on tracheal extravasation of Evans blue dye and on the concentration of PMNs in the tracheal wall." | 3.67 | Granulocyte-mediated airway edema in guinea pigs. ( Gordon, T; Horn, J; Scypinski, L; Sheppard, D; Thompson, JE, 1986) |
| "A 63-year-old patient with primary myelofibrosis underwent kidney biopsy to investigate nephrotic-range proteinuria and reduced kidney function." | 1.46 | Membranous Nephropathy and Intrarenal Extramedullary Hematopoiesis in a Patient With Myelofibrosis. ( Aniort, J; Heng, AE; Kemeny, JL; Philipponnet, C; Ronco, P, 2017) |
| " Plasma level of intact SC-57461 (3 h after oral gavage dosing with 3 mg/kg) was 0." | 1.31 | Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies. ( Askonas, LJ; Ghoreishi-Haack, N; Kachur, JF; Liang, CD; Russell, MA; Smith, WG; Villani-Price, D; Won-Kim, S, 2002) |
| "Zileuton was highly effective in preventing 6-sulfidopeptide LT formation in the rat peritoneal cavity triggered by an antigen-antibody reaction with an ED50 of 3 mg/kg." | 1.28 | 5-lipoxygenase inhibitory activity of zileuton. ( Albert, DH; Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Dyer, R; Summers, JB; Young, PR, 1991) |
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| dos Santos, JL | 1 |
| Lanaro, C | 1 |
| Lima, LM | 1 |
| Gambero, S | 1 |
| Franco-Penteado, CF | 1 |
| Alexandre-Moreira, MS | 1 |
| Wade, M | 1 |
| Yerigenahally, S | 1 |
| Kutlar, A | 1 |
| Meiler, SE | 1 |
| Costa, FF | 1 |
| Chung, M | 1 |
| Philipponnet, C | 1 |
| Ronco, P | 1 |
| Aniort, J | 1 |
| Kemeny, JL | 1 |
| Heng, AE | 1 |
| Kim, JA | 1 |
| Kim, N | 1 |
| Choi, HS | 1 |
| Choung, HK | 1 |
| Khwarg, SI | 1 |
| Chernoff, N | 1 |
| Rogers, JM | 1 |
| Boschi, D | 1 |
| Giorgis, M | 1 |
| Cena, C | 1 |
| Talniya, NC | 1 |
| Di Stilo, A | 1 |
| Morini, G | 1 |
| Coruzzi, G | 1 |
| Guaita, E | 1 |
| Fruttero, R | 1 |
| Gasco, A | 1 |
| da Silva, NG | 1 |
| Sampaio, SC | 1 |
| Gonçalves, LR | 1 |
| Rechner, I | 1 |
| Brito-Babapulle, F | 1 |
| Fielden, J | 1 |
| Rao, NL | 1 |
| Dunford, PJ | 1 |
| Xue, X | 1 |
| Jiang, X | 1 |
| Lundeen, KA | 1 |
| Coles, F | 1 |
| Riley, JP | 1 |
| Williams, KN | 1 |
| Grice, CA | 1 |
| Edwards, JP | 1 |
| Karlsson, L | 1 |
| Fourie, AM | 1 |
| Mori, M | 1 |
| Kobayashi, H | 1 |
| Naganuma, M | 1 |
| Sugiyama, C | 1 |
| Katsumura, Y | 1 |
| Furihata, C | 1 |
| Kachur, JF | 1 |
| Askonas, LJ | 1 |
| Villani-Price, D | 1 |
| Ghoreishi-Haack, N | 1 |
| Won-Kim, S | 1 |
| Liang, CD | 1 |
| Russell, MA | 1 |
| Smith, WG | 1 |
| Carter, GW | 1 |
| Young, PR | 1 |
| Albert, DH | 1 |
| Bouska, J | 1 |
| Dyer, R | 1 |
| Bell, RL | 1 |
| Summers, JB | 1 |
| Brooks, DW | 1 |
| Sheppard, D | 1 |
| Scypinski, L | 1 |
| Horn, J | 1 |
| Gordon, T | 1 |
| Thompson, JE | 1 |
Reviews
1 review available for hydroxyurea and Edema
| Article | Year |
|---|---|
Hypoxia and the Edema Syndrome: elucidation of a mechanism of teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Blister; Chick Embryo; Cocaine; Edema; Epinephrine; Hematoma; | 2010 |
Other Studies
11 other studies available for hydroxyurea and Edema
| Article | Year |
|---|---|
Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms.
Topics: Acetic Acid; Analgesics; Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents; Antisickling Agents | 2011 |
Membranous Nephropathy and Intrarenal Extramedullary Hematopoiesis in a Patient With Myelofibrosis.
Topics: Acute Kidney Injury; Antineoplastic Agents; Edema; Glomerulonephritis, Membranous; Hematopoiesis, Ex | 2017 |
Eyelid Swelling and Subconjunctival Infiltration as Ophthalmic Manifestations in a Child with Idiopathic Hypereosinophilic Syndrome.
Topics: Child; Conjunctival Diseases; Drug Therapy, Combination; Edema; Enzyme Inhibitors; Eosinophils; Eyel | 2018 |
Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Drug Design; Edema; Hydroxyurea; Leu | 2010 |
Inhibitory effect of Crotalus durissus terrificus venom on chronic edema induced by injection of bacillus Calmette-Guérin into the footpad of mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BCG Vaccine; Chronic Disease; Crotalid Venoms; Cro | 2013 |
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Capillary Leak Syndrome; Combined Modality Th | 2003 |
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ascitic Fluid; Benzothiazoles; D | 2007 |
Induction of unscheduled DNA synthesis in hairless mouse epidermis by ultraviolet light.
Topics: Animals; DNA; DNA Damage; Dose-Response Relationship, Radiation; Edema; Epidermis; Erythema; Female; | 2000 |
Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.
Topics: Administration, Oral; Administration, Topical; Animals; Arthus Reaction; beta-Alanine; Dermatitis; E | 2002 |
5-lipoxygenase inhibitory activity of zileuton.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; | 1991 |
Granulocyte-mediated airway edema in guinea pigs.
Topics: Animals; Edema; Evans Blue; Granulocytes; Guinea Pigs; Hydroxyurea; Male; Toluene 2,4-Diisocyanate; | 1986 |