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hydroxyurea and Edema

hydroxyurea has been researched along with Edema in 12 studies

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
" In a murine model of arachidonic acid-induced ear inflammation, the LTA(4)H inhibitor, JNJ-26993135 (1-[4-(benzothiazol-2-yloxy)-benzyl]-piperidine-4-carboxylic acid), dose-dependently inhibited ex vivo LTB(4) production in blood, in parallel with dose-dependent inhibition of neutrophil influx (ED(50), 1-3 mg/kg) and ear edema."3.74Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. ( Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Jiang, X; Karlsson, L; Lundeen, KA; Rao, NL; Riley, JP; Williams, KN; Xue, X, 2007)
"To determine the role of polymorphonuclear leukocytes (PMNs) in the airway edema that accompanies airway inflammation, we studied the effects of a 1-h exposure to 2 ppm toluene diisocyanate (TDI) on tracheal extravasation of Evans blue dye and on the concentration of PMNs in the tracheal wall."3.67Granulocyte-mediated airway edema in guinea pigs. ( Gordon, T; Horn, J; Scypinski, L; Sheppard, D; Thompson, JE, 1986)
"A 63-year-old patient with primary myelofibrosis underwent kidney biopsy to investigate nephrotic-range proteinuria and reduced kidney function."1.46Membranous Nephropathy and Intrarenal Extramedullary Hematopoiesis in a Patient With Myelofibrosis. ( Aniort, J; Heng, AE; Kemeny, JL; Philipponnet, C; Ronco, P, 2017)
" Plasma level of intact SC-57461 (3 h after oral gavage dosing with 3 mg/kg) was 0."1.31Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies. ( Askonas, LJ; Ghoreishi-Haack, N; Kachur, JF; Liang, CD; Russell, MA; Smith, WG; Villani-Price, D; Won-Kim, S, 2002)
"Zileuton was highly effective in preventing 6-sulfidopeptide LT formation in the rat peritoneal cavity triggered by an antigen-antibody reaction with an ED50 of 3 mg/kg."1.285-lipoxygenase inhibitory activity of zileuton. ( Albert, DH; Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Dyer, R; Summers, JB; Young, PR, 1991)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's1 (8.33)18.2507
2000's4 (33.33)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
dos Santos, JL1
Lanaro, C1
Lima, LM1
Gambero, S1
Franco-Penteado, CF1
Alexandre-Moreira, MS1
Wade, M1
Yerigenahally, S1
Kutlar, A1
Meiler, SE1
Costa, FF1
Chung, M1
Philipponnet, C1
Ronco, P1
Aniort, J1
Kemeny, JL1
Heng, AE1
Kim, JA1
Kim, N1
Choi, HS1
Choung, HK1
Khwarg, SI1
Chernoff, N1
Rogers, JM1
Boschi, D1
Giorgis, M1
Cena, C1
Talniya, NC1
Di Stilo, A1
Morini, G1
Coruzzi, G1
Guaita, E1
Fruttero, R1
Gasco, A1
da Silva, NG1
Sampaio, SC1
Gonçalves, LR1
Rechner, I1
Brito-Babapulle, F1
Fielden, J1
Rao, NL1
Dunford, PJ1
Xue, X1
Jiang, X1
Lundeen, KA1
Coles, F1
Riley, JP1
Williams, KN1
Grice, CA1
Edwards, JP1
Karlsson, L1
Fourie, AM1
Mori, M1
Kobayashi, H1
Naganuma, M1
Sugiyama, C1
Katsumura, Y1
Furihata, C1
Kachur, JF1
Askonas, LJ1
Villani-Price, D1
Ghoreishi-Haack, N1
Won-Kim, S1
Liang, CD1
Russell, MA1
Smith, WG1
Carter, GW1
Young, PR1
Albert, DH1
Bouska, J1
Dyer, R1
Bell, RL1
Summers, JB1
Brooks, DW1
Sheppard, D1
Scypinski, L1
Horn, J1
Gordon, T1
Thompson, JE1

Reviews

1 review available for hydroxyurea and Edema

ArticleYear
Hypoxia and the Edema Syndrome: elucidation of a mechanism of teratogenesis.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2010, Volume: 89, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Blister; Chick Embryo; Cocaine; Edema; Epinephrine; Hematoma;

2010

Other Studies

11 other studies available for hydroxyurea and Edema

ArticleYear
Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms.
    Journal of medicinal chemistry, 2011, Aug-25, Volume: 54, Issue:16

    Topics: Acetic Acid; Analgesics; Anemia, Sickle Cell; Animals; Anti-Inflammatory Agents; Antisickling Agents

2011
Membranous Nephropathy and Intrarenal Extramedullary Hematopoiesis in a Patient With Myelofibrosis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017, Volume: 70, Issue:6

    Topics: Acute Kidney Injury; Antineoplastic Agents; Edema; Glomerulonephritis, Membranous; Hematopoiesis, Ex

2017
Eyelid Swelling and Subconjunctival Infiltration as Ophthalmic Manifestations in a Child with Idiopathic Hypereosinophilic Syndrome.
    Korean journal of ophthalmology : KJO, 2018, Volume: 32, Issue:6

    Topics: Child; Conjunctival Diseases; Drug Therapy, Combination; Edema; Enzyme Inhibitors; Eosinophils; Eyel

2018
Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.
    ChemMedChem, 2010, Sep-03, Volume: 5, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Drug Design; Edema; Hydroxyurea; Leu

2010
Inhibitory effect of Crotalus durissus terrificus venom on chronic edema induced by injection of bacillus Calmette-Guérin into the footpad of mice.
    Toxicon : official journal of the International Society on Toxinology, 2013, Mar-01, Volume: 63

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BCG Vaccine; Chronic Disease; Crotalid Venoms; Cro

2013
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).
    The hematology journal : the official journal of the European Haematology Association, 2003, Volume: 4, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Capillary Leak Syndrome; Combined Modality Th

2003
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ascitic Fluid; Benzothiazoles; D

2007
Induction of unscheduled DNA synthesis in hairless mouse epidermis by ultraviolet light.
    The Journal of toxicological sciences, 2000, Volume: 25, Issue:1

    Topics: Animals; DNA; DNA Damage; Dose-Response Relationship, Radiation; Edema; Epidermis; Erythema; Female;

2000
Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2

    Topics: Administration, Oral; Administration, Topical; Animals; Arthus Reaction; beta-Alanine; Dermatitis; E

2002
5-lipoxygenase inhibitory activity of zileuton.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase;

1991
Granulocyte-mediated airway edema in guinea pigs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 60, Issue:4

    Topics: Animals; Edema; Evans Blue; Granulocytes; Guinea Pigs; Hydroxyurea; Male; Toluene 2,4-Diisocyanate;

1986