hydroxyurea has been researched along with Drug Overdose in 4 studies
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "female, with essential thrombocythemia, who was admitted to our clinic because of double suicidal ingestion of hydroxycarbamide." | 1.38 | Double, suicidal intoxication with hydroxycarbamide--a case report. ( Kabata, P; Sein Anand, J; Waldman, W, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nnebe-Agumadu, U | 1 |
| Adebayo, IA | 1 |
| Nnodu, O | 1 |
| Adekile, A | 1 |
| Litt, E | 1 |
| Thomas, B | 1 |
| Smyth, J | 1 |
| Desoysa, L | 1 |
| Watson, D | 1 |
| Miller, ST | 1 |
| Rey, K | 1 |
| He, J | 1 |
| Flanagan, J | 1 |
| Fish, BJ | 1 |
| Rogers, ZR | 1 |
| Wang, WC | 1 |
| Ware, RE | 1 |
| Waldman, W | 1 |
| Kabata, P | 1 |
| Sein Anand, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG)[NCT00006400] | Phase 3 | 193 participants (Actual) | Interventional | 2000-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
DTPA GFR was originally a co-primary efficacy outcome for the study. Later in May 29, 2009, this measurement was discontinued because of statistical futility (an extremely small chance that the difference between treatment groups would be statistically significant for this outcome) and the small risk posed by the radiation exposure involved with performing the DTPA GFR test. Subjects who had missing data at baseline or 2 years measurement were excluded from the analysis (29 subjects from the hydroxurea, and 31 subjects from the placebo group excluded). (NCT00006400)
Timeframe: Before initiation of treatment and at 2 years
| Intervention | mL/min/1.73m^2 (Mean) |
|---|---|
| Hydroxyurea | 22.56 |
| Placebo | 20.74 |
GFR was calculated using new Schwartz formula: 39.1× [height (cm)/serum creatinine (mg/dL)]0.516 × [1.8/cystatin C]0.294 × [30/blood urea nitrogen]0.169 × [1.099]if male × [height(m)/1.4]0.188. Children with missing baseline or 2 years GFR were excluded from the analysis. (NCT00006400)
Timeframe: Before initiation of treatment and at 2 years
| Intervention | mL/min/1.73m^2 (Mean) |
|---|---|
| Hydroxyurea | 10.57 |
| Placebo | 14.33 |
Schwartz formula used to calculate GFR is: 0.55× height (cm)/serum creatinine (mg/dL). Where height is in cm and serum creatinine is in mg/dL. Children with missing baseline or 2 years GFR were excluded from the analysis. (NCT00006400)
Timeframe: Before initiation of treatment and at 2 years
| Intervention | mL/min/1.73m^2 (Mean) |
|---|---|
| Hydroxyurea | 28.65 |
| Placebo | 33.36 |
1 trial available for hydroxyurea and Drug Overdose
| Article | Year |
|---|---|
Massive accidental overdose of hydroxyurea in a young child with sickle cell anemia.
Topics: Anemia, Sickle Cell; Antisickling Agents; Child, Preschool; Drug Overdose; Female; Humans; Hydroxyur | 2012 |
3 other studies available for hydroxyurea and Drug Overdose
| Article | Year |
|---|---|
Accidental hydroxyurea overdosage in a child with sickle cell anemia: An African experience.
Topics: Anemia, Sickle Cell; Antisickling Agents; Child, Preschool; Dose-Response Relationship, Drug; Drug O | 2020 |
Deliberate hydroxycarbamide overdose in an adult with essential thrombocythaemia.
Topics: Critical Care; Drug Overdose; Female; Humans; Hydroxyurea; Middle Aged; Nucleic Acid Synthesis Inhib | 2013 |
Double, suicidal intoxication with hydroxycarbamide--a case report.
Topics: Adult; Complex Mixtures; Diazepam; Drug Overdose; Ethanol; Female; Humans; Hydroxyurea; Paroxetine; | 2012 |