hydroxyurea has been researched along with Down Syndrome in 4 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Similar dose-response curves were established for Down's syndrome leukocytes and controls." | 1.26 | DNA repair and frequency of x-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome. ( Bui, TH; Funes-Cravioto, F; Hansson, K; Lambert, B; Lindsten, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, AA | 1 |
| Smoczer, C | 1 |
| Pace, B | 1 |
| Patterson, D | 1 |
| Cress Cabelof, D | 1 |
| Wei, CH | 1 |
| Yu, IT | 1 |
| Tzeng, CH | 1 |
| Fan, FS | 1 |
| Hsieh, RK | 1 |
| Chiou, TJ | 1 |
| Liu, JH | 1 |
| Chen, PM | 1 |
| Lambert, B | 1 |
| Hansson, K | 1 |
| Bui, TH | 1 |
| Funes-Cravioto, F | 1 |
| Lindsten, J | 1 |
| Standen, G | 1 |
| Philip, MA | 1 |
| Fletcher, J | 1 |
4 other studies available for hydroxyurea and Down Syndrome
| Article | Year |
|---|---|
Loss of DNA polymerase β induces cellular senescence.
Topics: Animals; Cells, Cultured; Cellular Senescence; DNA Breaks, Double-Stranded; DNA Polymerase beta; Dow | 2018 |
Trisomy 21 in acute myeloid leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Down Syndrome; Humans; Hydroxyure | 1996 |
DNA repair and frequency of x-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome.
Topics: Adult; Chromosome Aberrations; Chromosomes; DNA Repair; DNA Replication; Dose-Response Relationship, | 1976 |
Reduced number of peripheral blood granulocytic progenitor cells in patients with Down's syndrome.
Topics: Adolescent; Adult; Cell Survival; Colony-Forming Units Assay; Down Syndrome; Female; Granulocytes; H | 1979 |