hydroxyurea has been researched along with Di Guglielmo Disease in 25 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxyurea (HU) is a nonalkylating antineoplastic agent used in the treatment of hematological malignancies." | 1.51 | Hydroxyurea-induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F-positive human erythroleukemia cells. ( Bjelica, S; Čokić, VP; Diklić, M; Kovačić, M; Mitrović-Ajtić, O; Radojković, M; Santibanez, JF; Subotički, T; Đikić, D, 2019) |
| "The hydroxyurea-treated cells showed positive senescence associated-beta-galactosidase staining, a senescence index, and the accumulation of cdk (cyclin dependent kinase) inhibitors, such as p16INK4a, p21Waf1, and p27Kip1, implicated in cellular senescence." | 1.31 | Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell. ( Gao, YH; Han, JY; Jeong, JS; Kim, DI; Kim, IH; Park, JI; Park, SC; Rodgers, GP, 2000) |
| "HEL cells, a human erythroleukemia cell line, mainly express the fetal (gamma) globin gene and trace amount of the embryonic (epsilon) globin gene, but not adult (beta) globin gene." | 1.31 | Function of GATA transcription factors in hydroxyurea-induced HEL cells. ( Gui, CY; He, QY; Jiang, C; Qian, RL; Zhang, SB; Zhao, H, 2001) |
| "HEL cells, a human erythroleukemia cell line, expressing mainly the gamma-globin genes, small amount of epsilon-globin gene, but not beta-globin gene." | 1.30 | [Analysis of the binding of GATA factors to the regulatory elements of human beta-globin gene in hydroxyurea-induced and uninduced HEL cells]. ( Jiang, S; Qian, RL; Zhang, SB; Zhao, H, 1999) |
| "Hydroxyurea has been used to synchronize cultured cells to S-phase and used to treat patients with sickle-cell anemia." | 1.30 | The apoptosis of HEL cells induced by hydroxyurea. ( Gui, CY; Jiang, C; Qian, RL; Xie, HY, 1997) |
| "The HEL cells, a human erythroleukemia cell line, express mainly the fetal globin gene and small amount of the embryonic (epsilon) globin gene, but not the adult (beta) globin gene." | 1.30 | [The role of hydroxyurea in globin gene expression and cell differentiation of human erythroleukemia cell line]. ( Gui, CY; Jiang, C; Qian, RL, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (40.00) | 18.7374 |
| 1990's | 7 (28.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bjelica, S | 1 |
| Diklić, M | 1 |
| Đikić, D | 1 |
| Kovačić, M | 1 |
| Subotički, T | 1 |
| Mitrović-Ajtić, O | 1 |
| Radojković, M | 1 |
| Čokić, VP | 1 |
| Santibanez, JF | 1 |
| Aumont, C | 1 |
| Driss, F | 1 |
| Lazure, T | 1 |
| Picard, V | 1 |
| Creidy, R | 1 |
| De Botton, S | 1 |
| Saada, V | 1 |
| Lambotte, O | 1 |
| Bilhou-Nabera, C | 1 |
| Tertian, G | 1 |
| Michot, JM | 1 |
| Sharma, P | 1 |
| Dhingra, KK | 1 |
| Roy, S | 1 |
| Singh, T | 1 |
| Zhang, SB | 3 |
| Qian, RL | 5 |
| Zhao, H | 2 |
| Jiang, S | 1 |
| Iyamu, EW | 1 |
| Adunyah, SE | 1 |
| Fasold, H | 1 |
| Horiuchi, K | 1 |
| Baliga, S | 1 |
| Ohene-Frempong, K | 1 |
| Turner, EA | 1 |
| Asakura, T | 1 |
| Erard, F | 1 |
| Dean, A | 1 |
| Schechter, AN | 1 |
| Foresti, M | 1 |
| Gaudio, L | 1 |
| Paoletti, I | 1 |
| Geraci, G | 1 |
| Shama, S | 1 |
| Avni, D | 1 |
| Frederickson, RM | 1 |
| Sonenberg, N | 1 |
| Meyuhas, O | 1 |
| Crespo, P | 1 |
| Delgado, MD | 1 |
| Gómez-Casares, MT | 1 |
| Cuadrado, MA | 1 |
| Richard, C | 1 |
| León, J | 1 |
| Pocsik, E | 1 |
| Mihalik, R | 1 |
| Penzes, M | 1 |
| Loetscher, H | 1 |
| Gallati, H | 1 |
| Aggarwal, BB | 1 |
| Gui, CY | 3 |
| Jiang, C | 3 |
| Xie, HY | 1 |
| Park, JI | 1 |
| Jeong, JS | 1 |
| Han, JY | 1 |
| Kim, DI | 1 |
| Gao, YH | 1 |
| Park, SC | 1 |
| Rodgers, GP | 1 |
| Kim, IH | 1 |
| Rodrigue, CM | 1 |
| Arous, N | 1 |
| Bachir, D | 1 |
| Smith-Ravin, J | 1 |
| Romeo, PH | 1 |
| Galacteros, F | 1 |
| Garel, MC | 1 |
| He, QY | 1 |
| Gambari, R | 1 |
| Terada, M | 1 |
| Bank, A | 1 |
| Rifkind, RA | 1 |
| Marks, PA | 1 |
| Leder, A | 1 |
| Orkin, S | 1 |
| Leder, P | 1 |
| Cheng, GH | 1 |
| Nandi, A | 1 |
| Clerk, S | 1 |
| Skoultchi, AI | 1 |
| Wanda, PE | 1 |
| Walker, MM | 1 |
| Brown, DT | 1 |
| Yang, YS | 1 |
| Sittman, DB | 1 |
| Ross, J | 1 |
| Peltz, SW | 1 |
| Kobs, G | 1 |
| Brewer, G | 1 |
| Kreja, L | 1 |
| Seidel, HJ | 1 |
| Gunz, FW | 1 |
| Levi, JA | 1 |
| Vincent, PC | 1 |
| Bloomfield, CD | 1 |
| Brunning, RD | 1 |
| Theologides, A | 1 |
| Kennedy, BJ | 1 |
25 other studies available for hydroxyurea and Di Guglielmo Disease
| Article | Year |
|---|---|
Hydroxyurea-induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F-positive human erythroleukemia cells.
Topics: Bystander Effect; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; | 2019 |
Myelodysplastic syndrome with clonal cytogenetic abnormalities followed by fatal erythroid leukemia after 14 years of exposure to hydroxyurea for sickle cell anemia.
Topics: Anemia, Sickle Cell; Antineoplastic Agents; Antisickling Agents; Chromosome Aberrations; Chromosomes | 2015 |
An acute myeloid leukemia M6b blast crisis with giant proerythroblasts in chronic myeloid leukemia.
Topics: Antineoplastic Agents; Blast Crisis; Blood Transfusion; Child; Erythroblasts; Female; Humans; Hydrox | 2009 |
The interaction between the human beta-globin locus control region and nuclear matrix.
Topics: Binding Sites; DNA; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Globins; Histones; | 2002 |
[Analysis of the binding of GATA factors to the regulatory elements of human beta-globin gene in hydroxyurea-induced and uninduced HEL cells].
Topics: Cell Differentiation; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; GATA1 Transcript | 1999 |
Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line.
Topics: Cell Division; Fetal Hemoglobin; Humans; Hydroxyurea; K562 Cells; Leukemia, Erythroblastic, Acute; M | 2003 |
Inhibitors of cell division reversibly modify hemoglobin concentration in human erythroleukemia K562 cells.
Topics: Cell Transformation, Neoplastic; Culture Media; Glutamine; Hemin; Hemoglobins; Humans; Hydroxyurea; | 1981 |
Inhibition of erythroid differentiation in MEL cells by UV irradiation. Cell cycle and DNA repair activity.
Topics: Animals; Cell Cycle; DNA; DNA Damage; DNA Repair; Erythroid Precursor Cells; Hydroxyurea; Leukemia, | 1993 |
Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.
Topics: 3T3 Cells; Animals; Aphidicolin; Cell Differentiation; Cell Division; Cross-Linking Reagents; Dinucl | 1995 |
Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells.
Topics: Apolipoproteins E; Cell Differentiation; Cytarabine; Humans; Hydroxyurea; Hypercholesterolemia; Leuk | 1993 |
Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors.
Topics: Cell Cycle; Demecolcine; DNA; Enzyme Inhibitors; Etoposide; G1 Phase; G2 Phase; HeLa Cells; Humans; | 1995 |
The apoptosis of HEL cells induced by hydroxyurea.
Topics: Apoptosis; Cell Nucleus; Chromatin; Flow Cytometry; Humans; Hydroxyurea; Leukemia, Erythroblastic, A | 1997 |
Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell.
Topics: Antineoplastic Agents; Apoptosis; beta-Galactosidase; Cell Differentiation; Cellular Senescence; Cyc | 2000 |
[The role of hydroxyurea in globin gene expression and cell differentiation of human erythroleukemia cell line].
Topics: Antineoplastic Agents; Cell Transformation, Neoplastic; DNA-Binding Proteins; Erythroid-Specific DNA | 1997 |
Resveratrol, a natural dietary phytoalexin, possesses similar properties to hydroxyurea towards erythroid differentiation.
Topics: Anemia, Sickle Cell; Antioxidants; Blotting, Western; Cell Differentiation; Cell Division; Cell Line | 2001 |
Function of GATA transcription factors in hydroxyurea-induced HEL cells.
Topics: Cell Differentiation; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; GATA1 Transcript | 2001 |
Synthesis of globin mRNA in relation to the cell cycle during induced murine erythroleukemia differentiation.
Topics: Acetamides; Animals; Cell Cycle; Cell Differentiation; Cells, Cultured; Diamines; Dimethyl Sulfoxide | 1978 |
Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis.
Topics: Butyrates; Cell Differentiation; Cell Line; Cytarabine; DNA Replication; DNA, Neoplasm; Hemoglobins; | 1975 |
Different 3'-end processing produces two independently regulated mRNAs from a single H1 histone gene.
Topics: Acetamides; Amino Acid Sequence; Animals; Base Sequence; Cell Cycle; Cell Line; DNA, Neoplasm; Gene | 1989 |
Hemoglobin induction by Ara-C in human erythroleukemic cells (K562) is cell-cycle dependent.
Topics: Cell Cycle; Cell Line; Cytarabine; Heme; Hemoglobins; Humans; Hydroxyurea; Interphase; Kinetics; Leu | 1989 |
Histone gene switching in murine erythroleukemia cells is differentiation specific and occurs without loss of cell cycle regulation.
Topics: Animals; Cell Cycle; Cell Differentiation; Cycloheximide; Dexamethasone; Gene Expression Regulation; | 1988 |
Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus.
Topics: Base Sequence; Cell Line; Cloning, Molecular; Cytarabine; DNA Replication; Genes; Histones; Humans; | 1986 |
On the role of the spleen in Friend virus (F-MuLV-P) erythroleukemia.
Topics: Animals; Dactinomycin; Endotoxins; Erythropoiesis; Female; Friend murine leukemia virus; Hematocrit; | 1985 |
The outlook for the adult with acute leukaemia, 1972.
Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Cytarabine; Drug Combinations; Female; | 1972 |
Daunorubicin-prednisone remission induction with hydroxyurea maintenance in acute non-lymphocytic leukemia.
Topics: Adult; Age Factors; Daunorubicin; Female; Humans; Hydroxyurea; Leukemia, Erythroblastic, Acute; Leuk | 1973 |