hydroxyurea has been researched along with Chromosomal Instability in 9 studies
Chromosomal Instability: An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A major driver of cancer chromosomal instability is replication stress, the slowing or stalling of DNA replication." | 1.72 | Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses. ( Bakker, B; Boemo, MA; De Angelis, S; Foijer, F; Johnson, SC; Maniati, E; Mazzagatti, A; McClelland, SE; Shaikh, N; Spierings, DCJ; Wang, J; Wardenaar, R, 2022) |
| "In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7DNp53) were employed to investigate the relationship between induction of genotoxic stress, activation of cyclin-A/Cdk2 and Aurora-A oncogenic signalings and development of centrosome amplification." | 1.39 | Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells. ( Billadeau, D; D'Assoro, AB; Galanis, E; Ingle, J; Leontovich, AA; McCubrey, J; Salisbury, JL; Tallarita, T; Veroux, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Shaikh, N | 1 |
| Mazzagatti, A | 1 |
| De Angelis, S | 1 |
| Johnson, SC | 1 |
| Bakker, B | 1 |
| Spierings, DCJ | 1 |
| Wardenaar, R | 1 |
| Maniati, E | 1 |
| Wang, J | 1 |
| Boemo, MA | 1 |
| Foijer, F | 1 |
| McClelland, SE | 1 |
| Leontovich, AA | 1 |
| Salisbury, JL | 1 |
| Veroux, M | 1 |
| Tallarita, T | 1 |
| Billadeau, D | 1 |
| McCubrey, J | 1 |
| Ingle, J | 1 |
| Galanis, E | 1 |
| D'Assoro, AB | 1 |
| Hu, L | 1 |
| Kim, TM | 1 |
| Son, MY | 1 |
| Kim, SA | 1 |
| Holland, CL | 1 |
| Tateishi, S | 1 |
| Kim, DH | 1 |
| Yew, PR | 1 |
| Montagna, C | 1 |
| Dumitrache, LC | 1 |
| Hasty, P | 1 |
| Wilhelm, T | 1 |
| Magdalou, I | 1 |
| Barascu, A | 1 |
| Técher, H | 1 |
| Debatisse, M | 1 |
| Lopez, BS | 1 |
| Wakabayashi, M | 1 |
| Saijyou, N | 1 |
| Hatakeyama, S | 1 |
| Inoue, H | 1 |
| Tanaka, S | 1 |
| de Lahondès, R | 1 |
| Ribes, V | 1 |
| Arcangioli, B | 1 |
| Howlett, NG | 1 |
| Taniguchi, T | 1 |
| Durkin, SG | 1 |
| D'Andrea, AD | 1 |
| Glover, TW | 1 |
| Lentini, L | 1 |
| Iovino, F | 1 |
| Amato, A | 1 |
| Di Leonardo, A | 1 |
| Hanada, K | 1 |
| Budzowska, M | 1 |
| Davies, SL | 1 |
| van Drunen, E | 1 |
| Onizawa, H | 1 |
| Beverloo, HB | 1 |
| Maas, A | 1 |
| Essers, J | 1 |
| Hickson, ID | 1 |
| Kanaar, R | 1 |
9 other studies available for hydroxyurea and Chromosomal Instability
| Article | Year |
|---|---|
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses.
Topics: Aphidicolin; Chromatin; Chromosomal Instability; Chromosomes; DNA; DNA Copy Number Variations; Human | 2022 |
Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells.
Topics: Aurora Kinase A; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Centrosome; Chromosomal Instability | 2013 |
Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes.
Topics: Animals; Base Sequence; Chromosomal Instability; Chromosome Breakage; Chromosomes, Mammalian; DNA Br | 2013 |
Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.
Topics: Animals; Aphidicolin; Cell Line; Centrosome; Chromosomal Instability; Chromosome Segregation; Cricet | 2014 |
Neurospora mrc1 homologue is involved in replication stability and is required for normal cell growth and chromosome integrity in mus-9 and mus-21 mutants.
Topics: Cell Cycle; Chromosomal Instability; DNA Damage; DNA Repair; DNA Replication; DNA, Fungal; Fungal Pr | 2012 |
Fission yeast Sap1 protein is essential for chromosome stability.
Topics: Anaphase; Benzimidazoles; Blotting, Southern; Blotting, Western; Cell Division; Centromere; Chromati | 2003 |
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.
Topics: Aphidicolin; Chromosomal Instability; Chromosome Fragile Sites; DNA Replication; Fanconi Anemia; Fan | 2005 |
Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.
Topics: Aneuploidy; Animals; Cell Line; Cells, Cultured; Centrosome; Chromosomal Instability; Fibroblasts; H | 2006 |
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.
Topics: Animals; Aphidicolin; Cell Cycle; Cells, Cultured; Chromosomal Instability; Chromosome Aberrations; | 2007 |