hydroxyurea has been researched along with Choriocarcinoma in 10 studies
Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously shown that treatment of choriocarcinoma cells with methotrexate or hydroxyurea leads to both cessation of cell growth, accompanied by repression of c-myc oncogene expression, and induction of genes associated with the placental phenotype, including both subunits of human chorionic gonadotropin (hCG) and placental alkaline phosphatase." | 7.68 | Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma. ( Arbiser, JL; Arbiser, ZK; Majzoub, JA, 1993) |
| "We have previously shown that treatment of choriocarcinoma cells with methotrexate or hydroxyurea leads to both cessation of cell growth, accompanied by repression of c-myc oncogene expression, and induction of genes associated with the placental phenotype, including both subunits of human chorionic gonadotropin (hCG) and placental alkaline phosphatase." | 3.68 | Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma. ( Arbiser, JL; Arbiser, ZK; Majzoub, JA, 1993) |
| "Treatment of choriocarcinoma cells (JAr line) for 24 hr with methotrexate, fluorodeoxyuridine, 1-beta-D-arabinofuranosylcytosine, or hydroxyurea, in doses that inhibit DNA synthesis, results in a 2." | 3.66 | Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis. ( Azizkhan, JC; Goode, D; Speeg, KV; Stromberg, K, 1979) |
| "Surgery combined with chemotherapy was applied in 34 out of 178 patients (19." | 1.29 | Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD). ( Kietlińska, Z; Sablińska, B; Zieliński, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bagshawe, KD | 5 |
| Arbiser, JL | 2 |
| Arbiser, ZK | 2 |
| Majzoub, JA | 2 |
| Sablińska, B | 1 |
| Kietlińska, Z | 1 |
| Zieliński, J | 1 |
| Bower, M | 1 |
| Rustin, GJ | 1 |
| Newlands, ES | 1 |
| Holden, L | 1 |
| Short, D | 1 |
| Foskett, M | 1 |
| Hardy, DB | 1 |
| Pereria, LE | 1 |
| Yang, K | 1 |
| Azizkhan, JC | 1 |
| Speeg, KV | 1 |
| Stromberg, K | 1 |
| Goode, D | 1 |
| Sharma, K | 1 |
| Southall, PJ | 1 |
| Boden, JA | 1 |
| Boxer, GM | 2 |
| Patridge, TA | 1 |
| Antoniw, P | 1 |
| Pedley, RB | 1 |
| Boden, J | 1 |
| Britton, DW | 1 |
| Green, A | 1 |
| Partridge, T | 1 |
| Pedley, B | 1 |
| Sharma, S | 1 |
| Southall, P | 1 |
1 review available for hydroxyurea and Choriocarcinoma
| Article | Year |
|---|---|
Treatment of high-risk choriocarcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin; Cycl | 1984 |
9 other studies available for hydroxyurea and Choriocarcinoma
| Article | Year |
|---|---|
Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma.
Topics: Choriocarcinoma; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases | 1993 |
Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD).
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chorioca | 1993 |
Chemotherapy for gestational trophoblastic tumours hastens menopause by 3 years.
Topics: Adult; Antineoplastic Agents; Choriocarcinoma; Dactinomycin; Etoposide; Female; Follow-Up Studies; H | 1998 |
Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Choriocarcinoma; Dinoprost; Dinoprostone; Enzyme Inhibitors; | 1999 |
Stimulation of human chorionic gonadotropin by JAr line choriocarcinoma after inhibition of DNA synthesis.
Topics: Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Cycloheximide; Cytarabine; DNA, Neoplasm; Dose-R | 1979 |
Regulation of gene expression in choriocarcinoma by methotrexate and hydroxyurea.
Topics: Choriocarcinoma; Chorionic Gonadotropin; DNA; Dose-Response Relationship, Drug; Gene Expression Regu | 1991 |
Selective uptake of toxic nucleoside (125IUdR) by resistant cancer.
Topics: Adenocarcinoma; Animals; Cell Line; Choriocarcinoma; Colon; Colonic Neoplasms; Cytarabine; Drug Resi | 1991 |
Radiochemotherapy with 125I-5-iodo-2-deoxyuridine.
Topics: Animals; Choriocarcinoma; Drug Resistance; Humans; Hydroxyurea; Idoxuridine; Iodine Radioisotopes; M | 1987 |
A cytotoxic DNA precursor is taken up selectively by human cancer xenografts.
Topics: Animals; Choriocarcinoma; Colon; DNA; Female; Fluorouracil; Humans; Hydroxyurea; Idoxuridine; Methot | 1987 |