hydroxyurea and Carcinoma, Epidermoid studies

Research Excerpts

Excerpt	Relevance	Reference
"A 68-year-old women with polycythemia vera was treated with hydroxyurea for 8 years and developed painful ulcers on her lower legs, multiple hypertrophic actinic keratoses and a squamous cell carcinoma."	7.75	[Cutaneous side effects of hydroxyurea treatment for polycythemia vera]. ( Akanay-Diesel, S; Hanneken, S; Hoff, NP; Pippirs, U; Schulte, KW, 2009)
"Hydroxyurea (HU) is an antineoplastic drug used in the treatment of chronic myeloproliferative neoplasms (MPNs)."	5.40	Successful treatment of hydroxyurea-associated chronic leg ulcers associated with squamous cell carcinoma. ( Antar, A; El-Majzoub, N; Ghosn, S; Ishak, RS; Mahfouz, R; Otrock, ZK; Taher, AT, 2014)
"Hydroxyurea (HU) is commonly used for the treatment of chronic myelogenous leukaemia, polycythemia vera and essential thrombocythaemia."	4.82	Oral squamous cell carcinoma during long-term treatment with hydroxyurea. ( De Benedittis, M; Favia, G; Giardina, C; Lo Muzio, L; Petruzzi, M; Serpico, R, 2004)
"Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers."	3.78	A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma. ( Berger, A; Blumberg, S; Chen, W; McMeeking, A; O'Neill, D; Pastar, I; Ross, F; Stone, T, 2012)
" The patient was on long-term therapy with hydroxyurea (HU) for polycythemia vera."	3.77	Concurrent basal cell and squamous cell carcinomas associated with hydroxyurea therapy. ( Batinac, T; Hadžisejdić, I; Jonjić, N; Načinović-Duletić, A; Radić, J; Valković, T, 2011)
" In the absence of evidence of a dose-response curve for platinum, the lower dosage schedules that can be used with acceptable toxicity on an outpatient basis should be selected."	3.75	Chemotherapy for squamous cell carcinoma of the head and neck: a progress report. ( Glick, JH; Taylor, SG; Zehngebot, LM, 1980)
"A 68-year-old women with polycythemia vera was treated with hydroxyurea for 8 years and developed painful ulcers on her lower legs, multiple hypertrophic actinic keratoses and a squamous cell carcinoma."	3.75	[Cutaneous side effects of hydroxyurea treatment for polycythemia vera]. ( Akanay-Diesel, S; Hanneken, S; Hoff, NP; Pippirs, U; Schulte, KW, 2009)
"Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation."	3.74	Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject. ( Chimenti, S; Saraceno, R; Teoli, M, 2008)
" The direct cytotoxicity of piroxicam indomethacin, and aspirin against 4 canine tumor cell lines (transitional cell carcinoma, squamous cell carcinoma, melanoma, and soft tissue sarcoma) was determined in short-term growth rate assays and in clonogenic assays."	3.69	Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells. ( Chan, TC; Knapp, DW; Kuczek, T; Park, B; Reagan, WJ, 1995)
"Thirty-two patients with resectable (clinical stage IIa, n = 17; IIb, n = 1; III, n = 14) squamous cell cancer (n = 15) or adenocarcinoma (n = 17) were treated with neoadjuvant chemotherapy (cisplatin, 5-fluorouracil, leukovorin), resection, and postoperative chemoradiotherapy (hydroxyurea, 5-fluorouracil; 50-66 Gy)."	3.69	Intensive multimodality therapy for carcinoma of the esophagus and gastroesophageal junction. ( Drinkard, LC; Ferguson, MK; Haraf, DJ; Hoffman, PC; Reeder, LB; Vokes, EE, 1995)
" This report outlines the results of cell kinetic studies of normal and abnormal squamous epithelium of the female genital tract and presents preliminary results of a regimen utilizing methotrexate, hydroxyurea, and vincristine in patients with far-advanced squamous-cell cancer of the vulva, vagina, and cervix."	3.65	Cell kinetics and programmed chemotherapy for gynecologic cancer. I. Squamous-cell carcinoma. ( Averette, HE; Ford, JH; Girtanner, RE; Hoskins, WJ; Ramos, R; Weinstein, GD, 1976)
"Eligible patients had newly diagnosed HNSCC."	2.76	A randomized phase II study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and T4N0-1 head and neck cancers. ( Blair, EA; Cohen, EE; Haraf, DJ; Kunnavakkam, R; Salama, JK; Seiwert, T; Stenson, KM; Vokes, EE; Williams, R; Witt, ME, 2011)
"Full-dose reirradiation combined with chemotherapy after salvage surgery significantly improved DFS, but had no significant impact on OS."	2.73	Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma. ( Bardet, E; Benhamou, E; Bensadoun, RJ; Bourhis, J; Castaing, M; de Raucourt, D; Dolivet, G; Ferron, C; Géry, B; Grégoire, V; Hamoir, M; Janot, F; Julieron, M, 2008)
"Participants had biopsy-proven, untreated squamous cell carcinoma of the oral cavity, oropharynx (stage IV) and hypopharynx (stages II-IV)."	2.73	Phase II clinical trial of parenteral hydroxyurea and hyper-fractionated, accelerated external beam radiation therapy in patients with advanced squamous cell carcinoma of the head and neck: toxicity and efficacy with continuous ribonucleoside reductase in ( Beitler, JJ; Mazumdar, M; Owen, RP; Silver, CE; Smith, RV; Wadler, S, 2007)
"Patients with recurrent squamous cell carcinoma or a second primary arising in a previously irradiated field were eligible."	2.73	Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. ( Ang, KK; Harris, J; Machtay, M; Meredith, R; Rotman, M; Schultz, C; Spanos, W; Spencer, SA; Wheeler, RH, 2008)
"Patients with intermediate-stage squamous cell carcinoma of the head and neck traditionally have been treated with initial surgical resection followed by radiotherapy (RT) alone or chemoradiotherapy."	2.72	High survival and organ function rates after primary chemoradiotherapy for intermediate-stage squamous cell carcinoma of the head and neck treated in a multicenter phase II trial. ( Brockstein, B; Cohen, EE; Haraf, DJ; Kies, MS; Kocherginsky, M; List, MA; Mittal, BB; Rosen, F; Stenson, KM; Vokes, EE; Williams, R; Witt, ME, 2006)
"Patients with stage III or IV squamous carcinoma of the oral cavity, oropharynx, or hypopharynx were eligible."	2.71	Preliminary results of Radiation Therapy Oncology Group 97-03: a randomized phase ii trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck. ( Cooper, JS; Demas, W; Forastiere, AA; Garden, AS; Glisson, BS; Gore, E; Harris, J; Horwitz, EM; Jones, C; Nabell, L; Ridge, JA; Vokes, EE, 2004)
"Treatment of locoregionally advanced nasopharyngeal cancer with induction chemotherapy followed by concomitant chemoradiotherapy resulted in excellent overall survival with acceptable toxicity."	2.71	Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal cancer. ( Haraf, DJ; Kies, MS; Mittal, BB; Oh, JL; Vokes, EE; Weichselbaum, RR; Witt, ME, 2003)
"Full dose reirradiation combined with chemotherapy after salvage surgery in high risk patients with HNC was feasible with an "acceptable" toxicity and led to a relatively good 5-year survival rate."	2.70	Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma. ( Bobin, S; Bourhis, J; De Crevoisier, R; Domenge, C; Eschwege, F; Janot, F; Koscielny, S; Luboinski, B; Lusinchi, A; Wibault, P, 2001)
"Patients with recurrent squamous cell cancer of the head and neck (SCH&N) are generally treated with systemic chemotherapy."	2.70	RTOG 96-10: reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck. ( Harris, J; Machtay, M; Meredith, R; Rotman, M; Schultz, C; Spanos, W; Spencer, SA; Wheeler, RH, 2001)
"Oral hydroxyurea (HU) is a potent radiation sensitizer, but in vitro studies have suggested that prolonged exposure to HU by way of continuous parenteral infusion would enhance clinical efficacy."	2.70	Phase I clinical trial of parenteral hydroxyurea in combination with pelvic and para-aortic external radiation and brachytherapy for patients with advanced squamous cell cancer of the uterine cervix. ( Anderson, P; Beitler, JJ; Fields, A; Goldberg, G; Haynes, H; Runowicz, CD; Sood, B; Vikram, B; Wadler, S, 2002)
"The majority of patients with head and neck cancer die of locoregional recurrence of disease following surgery and/or radiotherapy."	2.67	Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. ( Haraf, DJ; McEvilly, JM; Mick, R; Panje, WR; Vokes, EE; Weichselbaum, RR, 1992)
"Thirty-nine patients with head and neck cancer were entered into Phase I-II study of simultaneous radiation therapy with continuous infusion fluorouracil at 800 mg/m2/day and escalating doses of hydroxyurea."	2.67	Survival and analysis of failure following hydroxyurea, 5-fluorouracil and concomitant radiation therapy in poor prognosis head and neck cancer. ( Haraf, DJ; Panje, WR; Vokes, EE; Weichselbaum, RR, 1991)
"Misonidazole was given in a dose of 1 gm/m2 in the same schedule, not to exceed 12 gm/m2."	2.66	A randomized trial of hydroxyurea versus misonidazole adjunct to radiation therapy in carcinoma of the cervix. A preliminary report of a Gynecologic Oncology Group study. ( Bundy, BN; Creasman, WT; Currie, JL; Keys, H; Mortel, R; Stehman, FB, 1988)
"Hydroxyurea was substituted for bleomycin when the accumulative dose of bleomycin reached 400 units."	2.65	Continuous intravenous infusion combination chemotherapy for head and neck squamous cell carcinoma. ( Gonzalez, MF; Sartiano, GP; Valdivieso, JG, 1984)
"Nonmelanoma skin cancer is the most common malignant tumor in the fair skin population, with each year several millions of diagnosed cases."	2.61	Nonmelanoma skin cancer associated with Hydroxyurea treatment: Overview of the literature and our own experience. ( Cantisani, C; Cantoresi, F; Carmosino, I; Cartoni, C; Kiss, N; Naqeshbandi, AF; Tofani, S; Tosti, G, 2019)
"The systemic therapy of head and neck cancer has gained momentum in recent years."	2.42	Intensive concurrent chemoradiotherapy for head and neck cancer with 5-Fluorouracil- and hydroxyurea-based regimens: reversing a pattern of failure. ( Argiris, A; Haraf, DJ; Kies, MS; Vokes, EE, 2003)
"At diagnosis of head and neck cancer, over half of all patients show advanced stages."	2.40	[Chemoradiotherapy for patients with advanced head and neck cancer]. ( Tsukuda, M, 1997)
"This paper presents an overview of studies of therapy of head and neck squamous cell carcinoma in which chemotherapy was combined with other modalities."	2.35	Current concepts of chemotherapy combined with other modalities for head and neck cancer. ( DeWys, WD, 1975)
"We analyzed data of mspHNSCC patients collected from the Taiwan Cancer Registry database."	1.46	Survival prognostic factors for metachronous second primary head and neck squamous cell carcinoma. ( Chang, CL; Chen, JH; Chen, TM; Lai, MT; Lee, FP; Lin, KC; Wu, CC; Wu, SY; Yen, YC; Yuan, KS, 2017)
"We report a case that exemplifies the cutaneous adverse effects of chronic hydroxyurea therapy."	1.46	A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea. ( Aires, D; Neill, B; Neill, J; Rajpara, A; Ryser, T, 2017)
"In this study, using HNSCC cell lines, we examined the anti-cancer effects and the mechanisms of action of docosahexaenoyl ethanolamide (DHEA) and N-arachidonoyl-L-alanine (NALA), which are polyunsaturated fatty acid (PUFA)-based ethanolamides like AEA."	1.43	5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells. ( Hah, JH; Jeong, WJ; Oh, SM; Park, SW; Sung, MW, 2016)
"Hydroxyurea (HU) is an antineoplastic drug used in the treatment of chronic myeloproliferative neoplasms (MPNs)."	1.40	Successful treatment of hydroxyurea-associated chronic leg ulcers associated with squamous cell carcinoma. ( Antar, A; El-Majzoub, N; Ghosn, S; Ishak, RS; Mahfouz, R; Otrock, ZK; Taher, AT, 2014)
" However, no epidemiologic information about the occurrence of the most clinically significant HU-associated adverse events is yet available."	1.38	Hydroxyurea-related toxicity in 3,411 patients with Ph'-negative MPN. ( Antonioli, E; Baccarani, M; Barbui, T; Bertozzi, I; Bosi, A; Cacciola, E; Cacciola, R; Cazzola, M; De Stefano, V; Elli, E; Finazzi, G; Finazzi, M; Guglielmelli, P; Luigia Randi, M; Martinelli, V; Passamonti, F; Pieri, L; Pogliani, E; Rambaldi, A; Rodeghiero, F; Rossi, E; Ruggeri, M; Rumi, E; Vannucchi, AM; Vianelli, N; Za, T, 2012)
"Oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide (NQO) show substantial overexpression of cyclooxygenase-2 (COX-2) when compared with adjacent phenotypically normal oral tissues."	1.36	Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. ( Horn, TL; Johnson, WD; Lubet, RA; McCormick, DL; Phillips, JM; Steele, VE, 2010)
"Here we report two cases of squamous cell carcinoma of the skin, which appeared in the photo-exposed areas in two elderly patients treated for advanced chronic myeloid leukemia with imatinib."	1.32	Squamous cutaneous epithelial cell carcinoma in two CML patients with progressive disease under imatinib treatment. ( Audring, H; Baskaynak, G; Dörken, B; Kreuzer, KA; le Coutre, P; Riess, H; Schwarz, M; Zuber, J, 2003)
"Hydroxyurea has some dermatological side-effects."	1.32	Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy. ( Altaner, S; Demir, M; Pamuk, GE; Tek, M; Turgut, B; Vural, O, 2003)
"Hydroxyurea is a treatment of myeloproliferative syndromes."	1.31	[Secondary cutaneous effects of hydroxyurea: prospective study of 26 patients from a dermatologic consultation]. ( Bernard, P; Leborgne, G; Potron, G; Salmon-Ehr, V; Vilque, JP, 2000)
"Clinical examination revealed a squamous cell carcinoma leading to amputation of a finger."	1.31	[Multiple skin and mouth squamous cell carcinomas related to long-term treatment with hydroxyurea]. ( Estève, E; Georgescu, V; Heitzmann, P; Martin, L, 2001)
"An 8-year-old girl had stage 4 squamous cell carcinoma of the tongue (T4N2M0), causing severe trismus and dysphagia."	1.31	Stage 4 squamous cell carcinoma of the tongue in a child: complete response to chemoradiotherapy. ( Beitler, JJ; Edelman, M; Radel, E; Sattenberg, R; Smith, RV; Soni, S; Wadler, S, 2001)
"Since squamous cell carcinoma is a malignant cutaneous neoplasm that can metastatize, the surveillance of skin changes is advisable during hydroxyurea treatment."	1.30	Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea. ( De Simone, C; Guerriero, C; Guidi, B; Rotoli, M; Tartaglione, R; Venier, A, 1998)
"The association of multiple cutaneous cancers and long-term use of hydroxyurea is now being recognized."	1.30	Multiple skin cancers associated with hydroxyurea therapy. ( Best, PJ; Petitt, RM, 1998)
"A 67-year-old patient with chronic myeloid leukemia for 4 years rapidly developed multiple squamous-cell carcinomas on the scalp."	1.29	Multiple squamous-cell carcinomas of the scalp and chronic myeloid leukemia. ( Andrac, L; Angeli-Besson, C; Jacquet, P; Koeppel, MC; Sayag, J, 1995)
"Hydroxyurea is an active single agent in squamous cell cancer of the head and neck."	1.28	Hydroxyurea with concomitant radiotherapy for locally advanced head and neck cancer. ( Haraf, DJ; Panje, WR; Schilsky, RL; Vokes, EE; Weichselbaum, RR, 1992)
"Patients with cancer of nasopharynx had a better survival than those with other primaries (P = 0."	1.28	Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region. ( Daniilidis, J; Destouni-Salem, E; Fountzilas, G; Kalogera-Fountzila, A; Sombolos, K; Sridhar, KS; Tourkantonis, A; Vritsios, A; Zaramboukas, T, 1990)
"In the human squamous carcinoma cell line SCC-9, the expression of two markers of keratinocyte differentiation, involucrin and transglutaminase, was greatly stimulated when growing cultures reached confluence."	1.27	Suppression of keratinocyte differentiation in SSC-9 human squamous carcinoma cells by benzo[a]pyrene, 12-O-tetradecanoylphorbol-13-acetate and hydroxyurea. ( Chakravarty, R; Rice, RH; Rong, XH, 1988)
"Fifty-five patients with squamous cell carcinoma of the cervix uteri metastatic to high common iliac or periaortic lymph nodes underwent biopsy of the left scalene fat pad as part of a prospective clinical trial."	1.27	Biopsy of the scalene fat pad in carcinoma of the cervix uteri metastatic to the periaortic lymph nodes. ( Abdulhay, G; Bundy, BN; Fowler, WC; Hanjani, P; Stehman, FB; Whitney, CW, 1987)
"Thirty-two patients with squamous cell carcinoma of head and neck not amenable to surgery or radiotherapy were treated with a combination of methotrexate 0."	1.26	Combined chemotherapy of head and neck squamous cell carcinomas with methotrexate, bleomycin, and hydroxyurea. ( Alberto, P; Lehmann, W; Medenica, R, 1981)
"Sixty-six patients with advanced head and neck cancer 57 of whom had failed to respond to prior irradiation, were treated according to two protocols."	1.26	[Chemotherapy of advanced head and neck cancer with a combination of bleomycin, vincristine, methotrexate and hydroxyuree or cis-dichloro-diamino-platinium. Analysis of local and general parameters of prognosis (author's transl)]. ( Asselin, B; Bataini, JP; Brugère, J; Garcia-Giralt, E; Jaulerry, M; Jouve, M; Palangie, T; Pouillart, P, 1980)
"Multiple lesions of Bowen's disease and squamous cell carcinoma on the penis and pubic areas developed in a 32-year-old patient with psoriasis who was undergoing treatment with psoralen and long-wave ultraviolet radiation (PUVA)."	1.26	Bowen's disease and squamous cell carcinoma. Occurrence in a patient with psoriasis after topical, systemic, and PUVA therapy. ( Tam, DW; Urbach, F; Van Scott, EJ, 1979)

Research

Studies (153)

Authors

Clinical Trials (13)

Trial Overview

Trial Outcomes

Distant Metastases

Timeframe	Studies, this research(%)	All Research%
pre-1990	66 (43.14)	18.7374
1990's	24 (15.69)	18.2507
2000's	38 (24.84)	29.6817
2010's	21 (13.73)	24.3611
2020's	4 (2.61)	2.80

Authors	Studies
Gambichler, T	1
Stockfleth, E	1
Susok, L	1
Song, Z	1
Chu, S	1
Tao, J	1
Qian, Y	1
Brown, H	1
Lamrock, E	1
Suzuki, M	1
Maezima, E	1
Ohnuma, T	1
Kawamura, T	1
Kirito, K	1
Neill, B	1
Ryser, T	1
Neill, J	1
Aires, D	1
Rajpara, A	1
Cantisani, C	1
Kiss, N	1
Naqeshbandi, AF	1
Tosti, G	1
Tofani, S	1
Cartoni, C	1
Carmosino, I	1
Cantoresi, F	1
Cheng, AN	1
Jiang, SS	1
Fan, CC	1
Lo, YK	1
Kuo, CY	1
Chen, CH	1
Liu, YL	1
Lee, CC	1
Chen, WS	1
Huang, TS	1
Wang, TY	1
Lee, AY	1
Cohen, EE	7
Karrison, TG	1
Kocherginsky, M	2
Mueller, J	1
Egan, R	1
Huang, CH	1
Brockstein, BE	6
Agulnik, MB	1
Mittal, BB	9
Yunus, F	1
Samant, S	1
Raez, LE	1
Mehra, R	1
Kumar, P	1
Ondrey, F	1
Marchand, P	1
Braegas, B	1
Seiwert, TY	3
Villaflor, VM	1
Haraf, DJ	23
Vokes, EE	26
Rose, PG	1
Java, JJ	1
Whitney, CW	2
Stehman, FB	3
Lanciano, R	1
Thomas, GM	1
Antar, A	1
Ishak, RS	1
Otrock, ZK	1
El-Majzoub, N	1
Ghosn, S	1
Mahfouz, R	1
Taher, AT	1
Sachdev, S	1
Refaat, T	1
Bacchus, ID	1
Sathiaseelan, V	1
Park, SW	1
Hah, JH	1
Oh, SM	1
Jeong, WJ	1
Sung, MW	1
Mokni, S	1
Fetoui Ghariani, N	1
Aounallah, A	1
Fathallah, N	1
Boussofara, L	1
Saidi, W	1
Ben Salem, C	1
Sriha, B	1
Belajouza, C	1
Denguezli, M	1
Ghariani, N	1
Nouira, R	1
Chen, JH	1
Yen, YC	1
Chen, TM	1
Yuan, KS	1
Lee, FP	1
Lin, KC	1
Lai, MT	1
Wu, CC	1
Chang, CL	1
Wu, SY	1
Salama, JK	7
Stenson, KM	7
Kistner, EO	1
Argiris, A	3
Witt, ME	13
Rosen, F	3
Saraceno, R	1
Teoli, M	1
Chimenti, S	1
Janot, F	3
de Raucourt, D	1
Benhamou, E	1
Ferron, C	1
Dolivet, G	1
Bensadoun, RJ	1
Hamoir, M	1
Géry, B	1
Julieron, M	2
Castaing, M	1
Bardet, E	1
Grégoire, V	1
Bourhis, J	2
Mijatovic, T	1
Jungwirth, U	1
Heffeter, P	1
Hoda, MA	1
Dornetshuber, R	1
Kiss, R	1
Berger, W	1
Hoff, NP	1
Akanay-Diesel, S	1
Pippirs, U	1
Schulte, KW	1
Hanneken, S	1
McCormick, DL	1
Phillips, JM	1
Horn, TL	1
Johnson, WD	1
Steele, VE	1
Lubet, RA	1
Pederson, AW	2
Blair, EA	5
Kao, J	2
Genden, EM	1
Gupta, V	1
Policarpio, EL	1
Burri, RJ	1
Rivera, M	1
Gurudutt, V	1
Som, PM	1
Teng, M	1
Packer, SH	1
Williams, R	2
Kunnavakkam, R	1
Seiwert, T	1
Schleußinger, TM	1
Dyall-Smith, D	1
Field, LM	1
Radić, J	1
Batinac, T	1
Hadžisejdić, I	1
Načinović-Duletić, A	1
Valković, T	1
Jonjić, N	1
Stone, T	1
Berger, A	1
Blumberg, S	1
O'Neill, D	1
Ross, F	1
McMeeking, A	1
Chen, W	1
Pastar, I	1
Budrukkar, A	1
Muttagi, S	1
Shahid, T	1
Chatturvedi, P	1
Banavali, S	1
Laskar, SG	1
Murthy, V	1
D'Cruz, A	1
Agarwal, JP	1
Antonioli, E	1
Guglielmelli, P	1
Pieri, L	1
Finazzi, M	1
Rumi, E	1
Martinelli, V	1
Vianelli, N	1
Luigia Randi, M	1
Bertozzi, I	1
De Stefano, V	1
Za, T	1
Rossi, E	1
Ruggeri, M	1
Elli, E	1
Cacciola, R	1
Cacciola, E	1
Pogliani, E	1
Rodeghiero, F	1
Baccarani, M	1
Passamonti, F	1
Finazzi, G	1
Rambaldi, A	1
Bosi, A	1
Cazzola, M	1
Barbui, T	1
Vannucchi, AM	1
Darga, T	1
Haraf, D	1
Stenson, K	7
Villaflor, V	1
Lingen, MW	1
Weichselbaum, RR	13
Rosen, FR	3
Kies, MS	7
Rademaker, AW	4
List, MA	4
Fung, BB	1
Portugal, L	4
Pelzer, H	6
Oh, JL	1
Baskaynak, G	1
Kreuzer, KA	1
Schwarz, M	1
Zuber, J	1
Audring, H	1
Riess, H	1
Dörken, B	1
le Coutre, P	1
Yang, WL	1
Yang-Biggs, G	1
Wu, Y	1
Ye, X	1
Gallos, G	1
Owen, RP	2
Ravikumar, TS	1
Pamuk, GE	1
Turgut, B	1
Vural, O	1
Demir, M	1
Tek, M	1
Altaner, S	1
BLOEDOW, CE	1
BICKERS, JN	1
HOWE, CD	1
SAMUELS, ML	3
Ozyar, E	1
Cengiz, M	1
Garden, AS	1
Harris, J	3
Forastiere, AA	1
Ridge, JA	1
Jones, C	1
Horwitz, EM	1
Glisson, BS	1
Nabell, L	1
Cooper, JS	1
Demas, W	1
Gore, E	1
Sanchez-Palacios, C	1
Guitart, J	1
De Benedittis, M	1
Petruzzi, M	1
Giardina, C	1
Lo Muzio, L	1
Favia, G	1
Serpico, R	1
Faivre, S	1
Marti, A	1
Rixe, O	1
Gatineau, M	1
Temam, S	1
Armand, JP	1
Domenge, C	2
Luboinski, B	2
Raymond, E	1
Li, N	1
Sood, S	1
Wang, S	1
Fang, M	1
Wang, P	1
Sun, Z	1
Yang, CS	1
Chen, X	1
Chmura, SJ	1
Milano, MT	1
Wong, AS	1
Soo, RA	1
Lu, JJ	1
Loh, KS	1
Tan, KS	1
Hsieh, WS	1
Shakespeare, TP	1
Chua, ET	1
Lim, HL	1
Goh, BC	1
Brockstein, B	2
Beitler, JJ	6
Smith, RV	5
Silver, CE	2
Mazumdar, M	1
Wadler, S	6
Spencer, SA	2
Wheeler, RH	2
Machtay, M	2
Schultz, C	2
Spanos, W	2
Rotman, M	2
Meredith, R	2
Ang, KK	1
Mauer, A	1
Dekker, A	1
Knab, BR	1
Solanki, A	1
Lerner, HJ	3
Beckloff, GL	2
Pouillart, P	1
Palangie, T	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy for HPV Negative Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma (REMATCH)[NCT05459415]		54 participants (Anticipated)	Interventional	2022-06-22	Active, not recruiting
A Phase II Study of Efficacy and Safety of Induction Modified TPF (mTPF) Followed by Concurrent Chemoradiotherapy (CCRT) in Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LASCCHN)[NCT05527782]	Phase 2	40 participants (Anticipated)	Interventional	2019-05-01	Recruiting
A Randomized Trial Comparing Induction Gemcitabine and Cisplatin Plus Intensity-modulated Radiotherapy With Concurrent Cisplatin Plus Intensity-modulated Radiotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma[NCT02460887]	Phase 3	236 participants (Anticipated)	Interventional	2015-06-30	Active, not recruiting
Neoadjuvant Tislelizumab With Afatinib for the Treatment of Resectable Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Trial (neoCHANCE-1 Trial)[NCT05517330]	Phase 2	23 participants (Anticipated)	Interventional	2022-12-20	Recruiting
Randomized Phase II Trial of Conventional vs IMRT Whole Brain Radiotherapy for Brain Metastases[NCT01890278]		60 participants (Anticipated)	Interventional	2013-06-30	Recruiting
Phase II Study of Concomitant Fluorouracil, Hydroxyurea, Cetuximab and Hyperfractionated Intensity Modulated Radiation Therapy for Locally Advanced Head and Neck Cancer[NCT00462735]	Phase 2	33 participants (Actual)	Interventional	2007-02-28	Completed
The Effect of Prophylactic Swallowing Exercises on Head and Neck Cancer Patients[NCT01349309]		26 participants (Actual)	Interventional	2007-06-30	Completed
Efficacy and Safety of Avatrombopag in Cancer Patients With Thrombocytopenia Induced by Targeted Therapy and Immunotherapy Combination Treatment[NCT04896528]	Phase 2	30 participants (Anticipated)	Interventional	2021-06-06	Recruiting
Phase II Randomized Trial Comparing Paclitaxel Combined With DDP Plus Concurrent Chemoradiotherapy With DDP Plus Concurrent Chemoradiotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma[NCT03047265]	Phase 2	164 participants (Anticipated)	Interventional	2017-02-04	Active, not recruiting
Phase I/II Dose Escalation Trial of Induction and Concomitant Erlotinib and Celecoxib With Radiation Therapy for Treatment of Poor Prognosis Head and Neck Cancer, Including Reirradiation[NCT00970502]	Phase 1/Phase 2	15 participants (Actual)	Interventional	2007-02-28	Completed
Hyperfractionated Radiotherapy With Concomitant Fluorouracil and Hydroxurea for Intermediate Stage Cancer of the Head and Neck[NCT00002951]	Phase 2	53 participants (Actual)	Interventional	1996-06-30	Completed
Safety and Efficacy of Gemcitabine Based Neoadjuvant Chemotherapy Followed by Chemoradiation in Locally Advanced Cervical Cancer Patients and Association With Human Equilibrative Nucleoside Transporter 1 (hENT1) Expression[NCT02309658]	Phase 2	50 participants (Actual)	Interventional	2013-09-30	Completed
Radiosensitization With a COX-2 Inhibitor (Celecoxib), With Chemoradiation for Cancer of the Head and Neck[NCT00581971]	Phase 1/Phase 2	30 participants (Actual)	Interventional	2002-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Percentage of participants who did not have distant control (NCT00462735)
Timeframe: 2 years

Llocoregional Recurrence

Intervention	percentage of participants (Number)
Advanced Head and Neck Cancer	21

Percentage of Participants with Loco-regional recurrence. (NCT00462735)
Timeframe: 2 years

Long- Term Toxicity

UW-QOLR: Quality of Life Score

Intervention	Participants (Count of Participants)
Advanced Head and Neck Cancer	27

Intervention	events (Number)
Advanced Head and Neck Cancer	32

University of Washington Quality of Life (UW-QOLR) questionnaire - covers 12 domains - pain, appearance, activity, recreation, swallowing, chewing, speech, shoulder function, taste, saliva, mood and anxiety. Each domain have between 3 and 6 response options that are scaled evenly from 0 (worst) to 100 (best) according to the hierarchy of response and reported as one composite score from 0 (worst) to 100 (best). (NCT00462735)
Timeframe: 2 years

Survival

Intervention	units on a scale (Mean)
Advanced Head and Neck Cancer	80

Overall Survival - Percentage of Participants who survived Disease-Free Survival - measured from the initiation of nonsurgical treatment to either the last follow-up, disease progression, or death using intent-to-treat methodology (NCT00462735)
Timeframe: 2 years

Toxicity

Intervention	percentage of participants (Number)
	Overall Survival	Disease-Free Survival
Advanced Head and Neck Cancer	86	69

Number of participants with acute and late toxicity (NCT00970502)
Timeframe: 30 DAYS

Clinical Response

Intervention	participants (Number)
Celecoxib 200mg	0
Celecoxib 400mg	1
Celecoxib 600mg	2

Response to Concurrent Erlotinib, Celecoxib, and Reirradiation according to Response Evaluation Criteria in Solid Tumors - Complete Response (CR): Disappearance of all target lesions Partial Response (PR): At least a 30% decrease in the sum of the LD of target lesions, taking as reference the baseline sum LD Progressive Disease (PD): At least a 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions (NCT00970502)
Timeframe: 20 months

Locoregional Control, Progression-free Survival, Overall Survival and Late Toxicity

Intervention	Participants (Count of Participants)
	Complete Response(CR)	Pathologic partial response (pPR)	Progressive disease (PD)	No evidence of disease (NED)
Erlotinib + Celecoxib	6	1	5	2

At a median follow-up of 11 months, the 1 year locoregional control, progression-free survival, and overall survival rates. (NCT00970502)
Timeframe: 1 year

Locoregional Progression

Intervention	percentage of participants (Number)
	locoregional control	progress-free survival	overall survival rates	long term toxicity
Erlotinib + Celecoxib	60	37	55	0

Patients with locoregional and/or distant progression (NCT00970502)
Timeframe: 20 months

Response as Evaluated by Recurrence of Diseases

Intervention	participants (Number)
	free of disease	isolated locoregional progression	isolated distant progression	both locoregional and distant progression	no evidence of disease, died of comorbid illness
Erlotinib + Celecoxib	4	4	2	1	3

Evaluate the response to concurrent celecoxib, carboplatin, paclitaxel, and radiotherapy in the treatment of locally advanced SSC of the head and neck. Response is determined by local control only, local and distant metastasis, distant metastasis only, second primary, and surgical salvage. (NCT00581971)
Timeframe: 2 years from end of treatment (Radiation therapy)

Toxicity of Celecoxib With Concurrent Weekly Chemotherapy and Radiotherapy in the Treatment of Locally Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck.

Intervention	Participants (Number)
	Local Control Only	Local Control and Distant Metastasis	Distant Metastatsis Only	Secondary Primary - Site Unknown	Surgical Salvage
Recurrence	6	2	1	2	3

Particpants experiencing Acute Toxicities > Grade 3 (NCT00581971)
Timeframe: 2 years from radiation therapy

Article	Year
Nonmelanoma skin cancer associated with Hydroxyurea treatment: Overview of the literature and our own experience. Dermatologic therapy, 2019, Volume: 32, Issue:5 Topics: Carcinoma, Squamous Cell; Cohort Studies; Female; Humans; Hydroxyurea; Male; Photochemotherapy; Poly	2019
Intensive concurrent chemoradiotherapy for head and neck cancer with 5-Fluorouracil- and hydroxyurea-based regimens: reversing a pattern of failure. The oncologist, 2003, Volume: 8, Issue:4 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; C	2003
Hydroxyurea-associated squamous dysplasia. Journal of the American Academy of Dermatology, 2004, Volume: 51, Issue:2 Topics: Aged; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Keratosis; Male; Precancerous Conditions; Skin	2004
Oral squamous cell carcinoma during long-term treatment with hydroxyurea. Clinical and experimental dermatology, 2004, Volume: 29, Issue:6 Topics: Aged; Carcinoma, Squamous Cell; Drug Administration Schedule; Humans; Hydroxyurea; Male; Nucleic Aci	2004
Chemotherapy for squamous cell carcinoma of the head and neck: a progress report. American journal of otolaryngology, 1980, Volume: 1, Issue:4 Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil; Clinical Trials as Topic;	1980
Changing role of chemotherapy in treatment of head and neck cancer. The American journal of medicine, 1982, Volume: 73, Issue:4 Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Drug Therapy, Combination; Fl	1982
[Chemoradiotherapy for patients with advanced head and neck cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:14 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Cisplatin; Co	1997
Chemoradiation for carcinoma of the cervix: advances and opportunities. Radiation research, 2000, Volume: 154, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Chemotherapy, A	2000
[Concomitant radiochemotherapy in cancer of the cervix uteri: modifications of the standards]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2000, Volume: 4 Suppl 1 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin;	2000
Current concepts of chemotherapy combined with other modalities for head and neck cancer. Canadian journal of otolaryngology, 1975, Volume: 4, Issue:2 Topics: Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Fluorouracil; Head; Head and Neck Neoplasms;	1975
The integration of chemotherapy into a combined modality approached to cancer therapy. V. Squamous cell cancer of the head and neck. Cancer treatment reviews, 1975, Volume: 2, Issue:2 Topics: Bleomycin; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Therapy, Combination; Fluoro	1975
Use of a trypsin, Peru balsam, and castor oil spray on the oral mucosa: case report and review of the literature. Pharmacotherapy, 1989, Volume: 9, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Balsams; Carcinoma, Squamous Cell; Castor Oil	1989
Clinical use of radiation sensitizing agents. Cancer treatment reviews, 1974, Volume: 1, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura	1974
Lung cancer: perspectives and prospects. Annals of internal medicine, 1970, Volume: 73, Issue:6 Topics: Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyc	1970

Article	Year
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Sep-01, Volume: 32, Issue:25 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2014
Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels. Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:10 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;	2008
Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Dec-01, Volume: 26, Issue:34 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Disease Progression; Fem	2008
Phase 2 trial of concurrent 5-fluorouracil, hydroxyurea, cetuximab, and hyperfractionated intensity-modulated radiation therapy for locally advanced head and neck cancer. Cancer, 2011, Jan-15, Volume: 117, Issue:2 Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C	2011
Phase 2 trial of concurrent 5-fluorouracil, hydroxyurea, cetuximab, and hyperfractionated intensity-modulated radiation therapy for locally advanced head and neck cancer. Cancer, 2011, Jan-15, Volume: 117, Issue:2 Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C	2011
Phase 2 trial of concurrent 5-fluorouracil, hydroxyurea, cetuximab, and hyperfractionated intensity-modulated radiation therapy for locally advanced head and neck cancer. Cancer, 2011, Jan-15, Volume: 117, Issue:2 Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C	2011
Phase 2 trial of concurrent 5-fluorouracil, hydroxyurea, cetuximab, and hyperfractionated intensity-modulated radiation therapy for locally advanced head and neck cancer. Cancer, 2011, Jan-15, Volume: 117, Issue:2 Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C	2011
A randomized phase II study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and T4N0-1 head and neck cancers. Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemother	2011
A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation. Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiothe	2013
Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinoma, Squamous Cell; Ci	2003
Multicenter randomized Phase II study of paclitaxel (1-hour infusion), fluorouracil, hydroxyurea, and concomitant twice daily radiation with or without erythropoietin for advanced head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous	2003
Preliminary results of Radiation Therapy Oncology Group 97-03: a randomized phase ii trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jul-15, Volume: 22, Issue:14 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous	2004
Preliminary results of Radiation Therapy Oncology Group 97-03: a randomized phase ii trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jul-15, Volume: 22, Issue:14 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous	2004
Preliminary results of Radiation Therapy Oncology Group 97-03: a randomized phase ii trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jul-15, Volume: 22, Issue:14 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous	2004
Preliminary results of Radiation Therapy Oncology Group 97-03: a randomized phase ii trial of concurrent radiation and chemotherapy for advanced squamous cell carcinomas of the head and neck. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jul-15, Volume: 22, Issue:14 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous	2004
Paclitaxel, 5-fluorouracil and hydroxyurea concurrent with radiation in locally advanced nasopharyngeal carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:7 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Moda	2006
High survival and organ function rates after primary chemoradiotherapy for intermediate-stage squamous cell carcinoma of the head and neck treated in a multicenter phase II trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jul-20, Volume: 24, Issue:21 Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamo	2006
Phase II clinical trial of parenteral hydroxyurea and hyper-fractionated, accelerated external beam radiation therapy in patients with advanced squamous cell carcinoma of the head and neck: toxicity and efficacy with continuous ribonucleoside reductase in Head & neck, 2007, Volume: 29, Issue:1 Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Dose Fractionation, R	2007
Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head & neck, 2008, Volume: 30, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous	2008
A phase I trial of docetaxel based induction and concomitant chemotherapy in patients with locally advanced head and neck cancer. Cancer investigation, 2007, Volume: 25, Issue:6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Docetaxel; Fe	2007
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Intensified concomitant chemoradiotherapy with and without filgrastim for poor-prognosis head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Co	1994
Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:8 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplat	1998
A phase I clinical trial of prolonged infusion of hydroxyurea in combination with hyperfractionated, accelerated, external radiation therapy in patients with advanced squamous cell cancer of the head and neck. Investigational new drugs, 1998, Volume: 16, Issue:2 Topics: Adult; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose Fractionation, Radiation; Dos	1998
Radiation therapy with concomitant hydroxyurea and fluorouracil in stage II and III head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:2 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamo	1999
Paclitaxel, 5-fluorouracil, hydroxyurea, and concomitant radiation therapy for poor-prognosis head and neck cancer. Seminars in radiation oncology, 1999, Volume: 9, Issue:2 Suppl 1 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali	1999
Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Apr-01, Volume: 19, Issue:7 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamo	2001
Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma. Cancer, 2001, Jun-01, Volume: 91, Issue:11 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cel	2001
RTOG 96-10: reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck. International journal of radiation oncology, biology, physics, 2001, Dec-01, Volume: 51, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality T	2001
Phase I clinical trial of parenteral hydroxyurea in combination with pelvic and para-aortic external radiation and brachytherapy for patients with advanced squamous cell cancer of the uterine cervix. International journal of radiation oncology, biology, physics, 2002, Mar-01, Volume: 52, Issue:3 Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality Therapy;	2002
Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:3 Topics: Bone Marrow; Carcinoma, Squamous Cell; Clinical Trials as Topic; Female; Humans; Hydroxyurea; Pelvic	1979
Combination chemotherapy of advanced lung cancer: a randomized trial. Cancer, 1976, Volume: 38, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Small Cell;	1976
Clinical report of the treatment of locally advanced lung cancer. Cancer, 1977, Volume: 40, Issue:1 Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Dose-Response Relation	1977
Clinical research on the treatment of locally advanced lung cancer: final report of VALG Protocol 13 Limited. Cancer, 1978, Volume: 42, Issue:3 Topics: Adenocarcinoma; Bone Marrow; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Clinical Trials as Top	1978
A combination of adriamycin, CCNU and hydroxyurea in the treatment of disseminated bronchogenic carcinoma. European journal of cancer, 1975, Volume: 11, Issue:11 Topics: Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Clinical Trials as Topic; Doxorubicin; Drug Thera	1975
Gynecologic Oncology Group Reports I and II. Gynecologic oncology, 1975, Volume: 3, Issue:3 Topics: Carcinoma, Squamous Cell; Female; Genital Neoplasms, Female; Humans; Hydroxyurea; Interprofessional	1975
Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. Journal of the National Cancer Institute, 1992, Jun-03, Volume: 84, Issue:11 Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma; Carcinoma, Squamous Cell; Cisp	1992
Survival and analysis of failure following hydroxyurea, 5-fluorouracil and concomitant radiation therapy in poor prognosis head and neck cancer. American journal of clinical oncology, 1991, Volume: 14, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carc	1991
A randomized study of methotrexate, bleomycin, hydroxyurea with versus without cisplatin in patients with previously untreated and recurrent squamous cell carcinoma of the head and neck. European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Ci	1987
Induction chemotherapy with cisplatinum, 5-fluorouracil, bleomycin, mitomycin C and hydroxyurea for previously untreated locally advanced squamous cell carcinomas of the head and neck. Archives of oto-rhino-laryngology, 1989, Volume: 246, Issue:5 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squam	1989
Hydroxyurea plus pelvic irradiation versus placebo plus pelvic irradiation in nonsurgically staged stage IIIB cervical cancer. Journal of surgical oncology, 1989, Volume: 42, Issue:2 Topics: Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Combined Modality Therapy; Double-Blind Method; Fe	1989
A randomized trial of hydroxyurea versus misonidazole adjunct to radiation therapy in carcinoma of the cervix. A preliminary report of a Gynecologic Oncology Group study. American journal of obstetrics and gynecology, 1988, Volume: 159, Issue:1 Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Combined Modality T	1988
Advanced lung cancer: A clinical trial of radiotherapy plus two drug combination regimens. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Nov-24, Volume: 47, Issue:46 Topics: Adenocarcinoma; Amides; Antineoplastic Agents; Carcinoma; Carcinoma, Small Cell; Carcinoma, Squamous	1973
Split-course irradiation compared to split-course irradiation plus hydroxyurea in inoperable bronchogenic carcinoma--a randomized study of 53 patients. Cancer, 1974, Volume: 34, Issue:5 Topics: Adenocarcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cobalt Radioisotopes; Esophagitis	1974
Hydroxyurea (NSC-32065) with irradiation for cervical carcinoma--preliminary report. Cancer chemotherapy reports, 1968, Volume: 52, Issue:5 Topics: Carcinoma, Squamous Cell; Clinical Trials as Topic; Female; Humans; Hydroxyurea; Uterine Cervical Ne	1968

Article	Year
Aggressive cutaneous squamous cell carcinoma in a hydroxyurea- and ruxolitinib-pretreated patient with polycythaemia vera. Journal of the European Academy of Dermatology and Venereology : JEADV, 2022, Volume: 36 Suppl 1 Topics: Aged, 80 and over; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Male; Nitriles; Polycythemia Vera;	2022
Successful management of hydroxyurea-induced multiple actinic keratoses and cutaneous squamous cell carcinomas with combination treatment. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2023, Volume: 21, Issue:2 Topics: Carcinoma, Squamous Cell; Humans; Hydroxyurea; Keratosis, Actinic; Skin Neoplasms	2023
Hydroxyurea-induced squamous cell carcinoma. The Australasian journal of dermatology, 2021, Volume: 62, Issue:1 Topics: Aged, 80 and over; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea; Neoplasms, Multiple Primar	2021
[Development of skin squamous cell carcinoma on the scalp in a hydroxycarbamide-treated polycythemia vera patient]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2020, Volume: 61, Issue:12 Topics: Aged; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Polycythemia Vera; Scalp; Thrombocythemia, Esse	2020
A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea. Dermatology online journal, 2017, Nov-15, Volume: 23, Issue:11 Topics: Aged; Biopsy; Carcinoma, Squamous Cell; Dermatomyositis; Humans; Hydroxyurea; Keratosis; Male; Polyc	2017
Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents. Cancer letters, 2013, Sep-01, Volume: 337, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Camptothecin; Carcinoma, Squamous Cell; Cell Cy	2013
Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in gynecologic oncology group trials of cisplatin-based chemoradiation. Gynecologic oncology, 2014, Volume: 135, Issue:2 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Adenosquamous; Car	2014
Successful treatment of hydroxyurea-associated chronic leg ulcers associated with squamous cell carcinoma. Hematology/oncology and stem cell therapy, 2014, Volume: 7, Issue:4 Topics: Carcinoma, Squamous Cell; Chronic Disease; Female; Humans; Hydroxyurea; Leg Ulcer; Middle Aged; Skin	2014
Age most significant predictor of requiring enteral feeding in head-and-neck cancer patients. Radiation oncology (London, England), 2015, Apr-18, Volume: 10 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcino	2015
5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells. BMC cancer, 2016, 07-13, Volume: 16 Topics: Alanine; Antineoplastic Agents; Apoptosis; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Azoles; B	2016
[Dermatologic complications of long-term hydroxyurea therapy]. Therapie, 2017, Volume: 72, Issue:3 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Keratosis, Actinic; Male; Midd	2017
Survival prognostic factors for metachronous second primary head and neck squamous cell carcinoma. Cancer medicine, 2017, Volume: 6, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;	2017
Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject. Clinical therapeutics, 2008, Volume: 30, Issue:7 Topics: Aged, 80 and over; Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Hydroxy	2008
The Na+/K+-ATPase is the Achilles heel of multi-drug-resistant cancer cells. Cancer letters, 2009, Sep-08, Volume: 282, Issue:1 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma, Non-Small-Cell	2009
[Cutaneous side effects of hydroxyurea treatment for polycythemia vera]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2009, Volume: 60, Issue:10 Topics: Aged; Antisickling Agents; Carcinoma, Squamous Cell; Drug Eruptions; Female; Humans; Hydroxyurea; Le	2009
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:1 Topics: Animals; Carcinoma, Squamous Cell; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Gene Expr	2010
Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue. Head & neck, 2010, Volume: 32, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopl	2010
Concurrent chemotherapy and intensity-modulated radiotherapy for organ preservation of locoregionally advanced oral cavity cancer. American journal of clinical oncology, 2011, Volume: 34, Issue:4 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carc	2011
Hydroxyurea-associated squamous dysplasia in a monozygotic twin. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:3 Topics: Aged, 80 and over; Carcinoma, Squamous Cell; Diseases in Twins; Facial Dermatoses; Female; Hand Derm	2011
Concurrent basal cell and squamous cell carcinomas associated with hydroxyurea therapy. Acta dermatovenerologica Croatica : ADC, 2011, Volume: 19, Issue:3 Topics: Aged; Antimetabolites; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea;	2011
A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma. International wound journal, 2012, Volume: 9, Issue:3 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Chronic Disease; Debridement; Female; Humans; Hydro	2012
Second primary head and neck squamous cell cancers with aggressive behavior in patients with chronic myeloid leukaemia. The British journal of oral & maxillofacial surgery, 2012, Volume: 50, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Benzamides; Carcinoma, Squamous Cell; Cause of Death; Disease-Fr	2012
Hydroxyurea-related toxicity in 3,411 patients with Ph'-negative MPN. American journal of hematology, 2012, Volume: 87, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Carcinoma, Squamous Cell; Drug Eruptions; Female; F	2012
Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jan-15, Volume: 21, Issue:2 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;	2003
Squamous cutaneous epithelial cell carcinoma in two CML patients with progressive disease under imatinib treatment. European journal of haematology, 2003, Volume: 70, Issue:4 Topics: Age Factors; Aged; Antineoplastic Agents; Benzamides; Carcinoma, Squamous Cell; Cocarcinogenesis; Co	2003
Development of cross-resistance between heat and cisplatin or hydroxyurea treatments in FaDu squamous carcinoma cells. The Journal of surgical research, 2003, May-01, Volume: 111, Issue:1 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Survival; Cisplatin; Drug Resistance, Neoplasm	2003
Metastatic squamous cell carcinoma of the skin in chronic myeloid leukaemia: complication of hydroxyurea therapy. Clinical and laboratory haematology, 2003, Volume: 25, Issue:5 Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Leukemia, Myelogenous, C	2003
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MISCELLANEOUS TUMORS. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Carcinom	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CARCINOMA OF THE LUNG. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Adult; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Drug Therapy; Humans; Hydroxyurea	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: UROLOGIC AND GYNECOLOGIC NEOPLASMS. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Adenocarcinoma; Anemia; Anemia, Aplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Ther	1964
Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Dec-01, Volume: 9, Issue:16 Pt 1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;	2003
With regard to "Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal cancer" by Oh et al. (AnnOnc 2003; 14: 464-569). Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:4 Topics: Carcinoma, Squamous Cell; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Disease-Fr	2004
Preoperative sequential chemotherapy in locally advanced squamous cell carcinoma of the head and neck. Head & neck, 2005, Volume: 27, Issue:4 Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; An	2005
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Mar-01, Volume: 11, Issue:5 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogen	2005
Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma. International journal of radiation oncology, biology, physics, 2006, Feb-01, Volume: 64, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Camptothecin; Carcinoma, Squamous Cell; Cisplatin; Combined Modality	2006
Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:9 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Squamous C	2008
Combined chemotherapy and radiotherapy. Preliminary results of clinical trial of hydroxyurea and x-irradiation in the treatment of epidermoid cancers of the head and neck. The American surgeon, 1967, Volume: 33, Issue:3 Topics: Adult; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea; Male; Middle Ag	1967
[Chemotherapy of advanced head and neck cancer with a combination of bleomycin, vincristine, methotrexate and hydroxyuree or cis-dichloro-diamino-platinium. Analysis of local and general parameters of prognosis (author's transl)]. Bulletin du cancer, 1980, Volume: 67, Issue:3 Topics: Bleomycin; Carcinoma; Carcinoma, Squamous Cell; Cisplatin; Drug Therapy, Combination; Head and Neck	1980
Sequential combination chemotherapy of advanced head and neck carcinoma: re-evaluation of a highly effective regimen. Strahlentherapie, 1981, Volume: 157, Issue:4 Topics: Adult; Aged; Bleomycin; Carcinoma, Squamous Cell; Doxorubicin; Female; Fluorouracil; Head and Neck N	1981
Combined chemotherapy of head and neck squamous cell carcinomas with methotrexate, bleomycin, and hydroxyurea. Cancer chemotherapy and pharmacology, 1981, Volume: 5, Issue:3 Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Drug Therapy, Combination; Head and Neck	1981
Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A Southwest Oncology Group Study. Journal of surgical oncology, 1982, Volume: 20, Issue:4 Topics: Adult; Aged; Bleomycin; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Therapy, Combin	1982
Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: a preliminary report. Gynecologic oncology, 1980, Volume: 9, Issue:2 Topics: Animals; Carcinoma, Squamous Cell; Doxorubicin; Female; Humans; Hydroxyurea; Mice; Mice, Nude; Neopl	1980
Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells. American journal of veterinary research, 1995, Volume: 56, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma, Squamou	1995
Intensive multimodality therapy for carcinoma of the esophagus and gastroesophageal junction. Annals of surgical oncology, 1995, Volume: 2, Issue:2 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cel	1995
Severe radiation morbidity in carcinoma of the cervix: impact of pretherapy surgical staging and previous surgery. International journal of radiation oncology, biology, physics, 1995, Feb-15, Volume: 31, Issue:4 Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; Female; Humans; Hyd	1995
PUVA and cancer: a case-control study. The British journal of dermatology, 1993, Volume: 129, Issue:1 Topics: Adult; Aged; Arsenic; Carcinoma, Squamous Cell; Case-Control Studies; Coal Tar; Combined Modality Th	1993
Multiple skin tumors on light-exposed areas during long-term treatment with hydroxyurea. Journal of the American Academy of Dermatology, 1993, Volume: 28, Issue:3 Topics: Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Leukemia, Myelogenous, C	1993
Multiple squamous-cell carcinomas of the scalp and chronic myeloid leukemia. Dermatology (Basel, Switzerland), 1995, Volume: 191, Issue:4 Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Hydr	1995
Multiple actinic keratosis and skin tumors secondary to hydroxyurea treatment. Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:2 Topics: Aged; Antineoplastic Agents; Busulfan; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Hydr	1998
Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea. European journal of dermatology : EJD, 1998, Volume: 8, Issue:2 Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Face; Humans; Hydroxyurea; Leukemia, Myelogen	1998
Multiple skin cancers associated with hydroxyurea therapy. Mayo Clinic proceedings, 1998, Volume: 73, Issue:10 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea; Middle Aged; Neoplasms	1998
[How toxic and effective is simultaneous radiochemotherapy with hydroxyurea, 5-FU and cisplatin in cervix carcinoma?]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1998, Volume: 174, Issue:11 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chem	1998
Pharyngeal transport dysfunction consequent to an organ-sparing protocol. Archives of otolaryngology--head & neck surgery, 1999, Volume: 125, Issue:4 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Clinical Trials, Phase I as Topic; Deg	1999
[Secondary cutaneous effects of hydroxyurea: prospective study of 26 patients from a dermatologic consultation]. La Revue de medecine interne, 2000, Volume: 21, Issue:1 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Hydroxyurea; Leg Ulcer; Myeloproliferative	2000
Long-term swallowing problems after organ preservation therapy with concomitant radiation therapy and intravenous hydroxyurea: initial results. Archives of otolaryngology--head & neck surgery, 2000, Volume: 126, Issue:3 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Combined Modal	2000
The cutaneous side-effects of hydroxyurea. Clinical and laboratory haematology, 2000, Volume: 22, Issue:4 Topics: Aged; Alopecia; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea; Keratosis; Polycythemia Vera;	2000
Multiple squamous epitheliomas during long-term treatment with hydroxyurea. Journal of the European Academy of Dermatology and Venereology : JEADV, 2001, Volume: 15, Issue:1 Topics: Carcinoma, Squamous Cell; Humans; Hydroxyurea; Male; Middle Aged; Nucleic Acid Synthesis Inhibitors;	2001
[Multiple skin and mouth squamous cell carcinomas related to long-term treatment with hydroxyurea]. Annales de dermatologie et de venereologie, 2001, Volume: 128, Issue:8-9 Topics: Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea; Mouth Neoplasms; Neo	2001
Stage 4 squamous cell carcinoma of the tongue in a child: complete response to chemoradiotherapy. Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:9 Topics: Adult; Antineoplastic Agents, Alkylating; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose	2001
[The cell-cycle phase-specific effect of bleomycin on squamous-cell carcinomas following synchronization with hydroxyurea]. Fortschritte der Kiefer- und Gesichts-Chirurgie, 1976, Volume: 21 Topics: Bleomycin; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cytological Techniques; Dose-Resp	1976
Intravenous bleomycin infusion as a potential syncronizing agent in human disseminated malignancies: a preliminary report. Cancer, 1976, Volume: 38, Issue:4 Topics: Adult; Bleomycin; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Drug Therapy, Combination;	1976
Bowen's disease and squamous cell carcinoma. Occurrence in a patient with psoriasis after topical, systemic, and PUVA therapy. Archives of dermatology, 1979, Volume: 115, Issue:2 Topics: Adult; Carcinoma, Squamous Cell; Coal Tar; Cocarcinogenesis; Glucocorticoids; Humans; Hydroxyurea; M	1979
New polychemotherapy regimen for head and neck tumors: pilot study. Cancer treatment reports, 1979, Volume: 63, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Administration	1979
Concomitant hydroxyurea and irradiation. Clinical experience with 100 patients with advanced head and neck cancer at Pennsylvania hospital. American journal of surgery, 1977, Volume: 134, Issue:4 Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; DNA, Neoplasm; Head and Neck Neoplasms; Humans;	1977
Cell kinetics and programmed chemotherapy for gynecologic cancer. I. Squamous-cell carcinoma. American journal of obstetrics and gynecology, 1976, Apr-15, Volume: 124, Issue:8 Topics: Carcinoma, Squamous Cell; Cell Division; DNA, Neoplasm; Female; Genital Neoplasms, Female; Humans; H	1976
Hydroxyurea with concomitant radiotherapy for locally advanced head and neck cancer. Seminars in oncology, 1992, Volume: 19, Issue:3 Suppl 9 Topics: Administration, Oral; Bone Marrow; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Fluorouracil; H	1992
Enhancement of the loss of multiple drug resistance by hydroxyurea. Seminars in oncology, 1992, Volume: 19, Issue:3 Suppl 9 Topics: Carcinoma, Squamous Cell; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance; Gene Amplifi	1992
Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells. Cancer research, 1991, Dec-01, Volume: 51, Issue:23 Pt 1 Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing);	1991
Induction chemotherapy with a new regimen alternating cisplatin, fluorouracil with mitomycin, hydroxyurea and bleomycin in carcinomas of nasopharynx or other sites of the head and neck region. Cancer, 1990, Oct-01, Volume: 66, Issue:7 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Ci	1990
Platinum-based induction chemotherapy followed by radiation as definitive treatment for patients with locally advanced cancer of the oral cavity, oropharynx and hypopharynx. A retrospective analysis of 32 cases. Journal of chemotherapy (Florence, Italy), 1991, Volume: 3, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell;	1991
Induction chemotherapy with methotrexate, bleomycin and hydroxyurea with or without cisplatin in advanced squamous cell carcinoma of the head and neck: a study of the Swiss Group for Clinical Cancer Research (SAKK). Progress in clinical and biological research, 1985, Volume: 201 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Ci	1985
[Combined therapy of locally advanced squamous epithelial cancers in the area of the head and neck]. Laryngologie, Rhinologie, Otologie, 1988, Volume: 67, Issue:4 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squam	1988
Suppression of keratinocyte differentiation in SSC-9 human squamous carcinoma cells by benzo[a]pyrene, 12-O-tetradecanoylphorbol-13-acetate and hydroxyurea. Carcinogenesis, 1988, Volume: 9, Issue:10 Topics: Benzo(a)pyrene; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line; Enzyme Induction; Epiderm	1988
Cisplatin with high-dose infusions of hydroxyurea to inhibit DNA repair. A phase II study in non-small-cell lung cancer. Cancer chemotherapy and pharmacology, 1989, Volume: 23, Issue:4 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carc	1989
Postcricoid carcinoma: a retrospective study of 13 patients. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1985, Volume: 11, Issue:1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Co	1985
Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer: a phase I-II study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carcino	1989
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma. The Journal of investigative dermatology, 1987, Volume: 88, Issue:1 Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Deoxyuracil Nucleotides; Depression, Chemical; DNA Rep	1987
cis-platinum, 5-fluorouracil, and hydroxyurea in the treatment of advanced non-small-cell lung cancer. A phase II study. American journal of clinical oncology, 1987, Volume: 10, Issue:3 Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung	1987
Biopsy of the scalene fat pad in carcinoma of the cervix uteri metastatic to the periaortic lymph nodes. Surgery, gynecology & obstetrics, 1987, Volume: 165, Issue:6 Topics: Adipose Tissue; Adult; Aged; Aorta, Abdominal; Biopsy, Needle; Carcinoma, Squamous Cell; Cisplatin;	1987
Phase II study of a combination of hydroxyurea, fluorouracil and mitomycin in previously treated squamous cell carcinoma of the head and neck. European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Drug Evaluati	1986
Chemotherapy in head and neck cancer. JAMA, 1971, Jul-26, Volume: 217, Issue:4 Topics: Administration, Oral; Antineoplastic Agents; Arteries; Carcinoma, Squamous Cell; Head; Head and Neck	1971
The role of chemotherapy in the treatment of carcinoma of the oral cavity. Otolaryngologic clinics of North America, 1972, Volume: 5, Issue:2 Topics: Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous	1972
Chemotherapy of cancer of the head and neck. Cancer, 1973, Volume: 31, Issue:5 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Catheteriza	1973
Chemotherapy of lung cancer: the experience of the National Cancer Institute of Milan. Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2 Topics: Adenocarcinoma; Bleomycin; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Doxorubicin; Fluoroura	1973
Chemotherapy in recurrent heat and neck cancer. Otolaryngologic clinics of North America, 1974, Volume: 7, Issue:1 Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Cytarabine; Drug Thera	1974
Proceedings: Carcinoma of the oral cavity--general principles of therapy. Journal of surgical oncology, 1974, Volume: 6, Issue:4 Topics: Azirines; Bleomycin; Carcinoma, Squamous Cell; Cryosurgery; Dactinomycin; Doxorubicin; Head and Neck	1974
Combined chemotherapy, radiotherapy, and surgery in the treatment of advanced but localized solid malignant tumours. The Australian and New Zealand journal of surgery, 1974, Volume: 44, Issue:4 Topics: Adult; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cystadenocarcinoma; Drug Th	1974
Chemotherapy of induced skin tumors in mice. Gan, 1968, Volume: 59, Issue:5 Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Benz(a)Anthracenes; Busulfan; Ca	1968
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. Journal of virology, 1974, Volume: 14, Issue:1 Topics: Amino Acids; Autoradiography; Carbon Radioisotopes; Carcinoma, Squamous Cell; Cell Line; Cells, Cult	1974
Six year survival in the combined treatment of far advanced head and neck cancer under a combined therapy program. American journal of surgery, 1973, Volume: 126, Issue:4 Topics: Carcinoma, Squamous Cell; Evaluation Studies as Topic; Head and Neck Neoplasms; Humans; Hydroxyurea;	1973
Systemic chemotherapy for carcinoma of the cervix. American journal of obstetrics and gynecology, 1967, Mar-15, Volume: 97, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Fema	1967
Clinical evaluation of the adjunctive use of hydroxyurea (NSC-32065) in radiation therapy of carcinoma of the lung. A comparative study. Radiologia clinica et biologica, 1967, Volume: 36, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea	1967
[Basic principles of percutaneous radiotherapy in cervical lymph node metastases]. Strahlentherapie, 1971, Volume: 141, Issue:5 Topics: Carcinoma, Squamous Cell; Cesium Isotopes; Cobalt Isotopes; Electrons; Fluorouracil; Head and Neck N	1971
Combined hydroxyurea and radiotherapy: a new dosage schedule. Southern medical journal, 1972, Volume: 65, Issue:2 Topics: Adult; Aged; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Head; Head and Neck Neoplasms;	1972
Three-year observation of combined treatment for far advanced cancer of the head and neck. American journal of surgery, 1969, Volume: 118, Issue:5 Topics: Carcinoma, Squamous Cell; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Mouth Neoplasms	1969
Hydroxyurea in nasopharyngeal cancer. JAMA, 1969, Dec-29, Volume: 210, Issue:13 Topics: Carcinoma, Squamous Cell; Eye Neoplasms; Humans; Hydroxyurea; Male; Middle Aged; Nasopharyngeal Neop	1969
Oral carcinoma and hypercalcemia. Archives of otolaryngology (Chicago, Ill. : 1960), 1970, Volume: 92, Issue:2 Topics: Adult; Autopsy; Blood Chemical Analysis; Carcinoma, Squamous Cell; Cobalt Isotopes; Humans; Hydrocor	1970
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole. Cancer research, 1970, Volume: 30, Issue:9 Topics: Adenine; Animals; Azaguanine; Carbon Isotopes; Carcinoma, Squamous Cell; Culture Techniques; DNA, Ne	1970

hydroxyurea and Carcinoma, Epidermoid