Compounds > hydroxyurea
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hydroxyurea and Carcinoma, Ehrlich Tumor

hydroxyurea has been researched along with Carcinoma, Ehrlich Tumor in 40 studies

Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Research Excerpts

ExcerptRelevanceReference
"In the cytosol fraction of either Ehrlich ascites tumor, Yoshida ascites sarcoma or regenerating rat liver after partial hepatectomy, UDP reduction activity, in contrast to CDP reduction activity, is not sensitive to hydroxyurea."1.27Uridine diphosphate reductase of Ehrlich ascites tumor is insensitive to hydroxyurea. ( Fujimura, S; Fukui, N; Morita, T; Moriyama, Y; Murayama, J, 1985)
" This investigation demonstrated that: (1) Data from untouched animals cannot serve as proper controls because treatment with SAL altered the level of the MI, but only during the diurnal, not the nocturnal, phase of the circadian cycle; (2) the presence of the EAC depressed the level of the MI, but this inhibition was only detected during the diurnal period; (3) treatment with 500 mg/kg HU injected at 0500 caused more perturbation in this rhythm than did treatment with 500 mg/kg HU at 1700; (4) when 500 mg/kg HU was given at 2000 and 0100 and 0500, the perturbation of the rhythm was greater than when 500 mg/kg HU was given at 0900 and 1400 and 1700; (5) when 3000 mg/kg HU was given at 1700 and compared to 500 mg/kg HU at 1700, little difference in the overall circadian profiles of these rhythms was observed, indicating that the circadian control mechanisms operating on the MI exerted a greater influence than did a dosage change from 500 to 3000 mg/kg HU; and (6) a comparison of the practice of plotting experimental and control data as "hours after treatment" versus using a "time of day" plot for the same data demonstrated that the "hours after treatment" plot is very misleading because it fails to account for the significant circadian oscillation in this in vivo system."1.26Circadian rhythm in mitotic index of corneal epithelium: presence of Ehrlich ascites carcinoma and treatment with saline or hydroxyurea. ( Burns, ER, 1981)
" The dosage of ADM was 2."1.26Experimental investigations on a sequential combination chemotherapy protocol. ( Akokan, G; Christian, E; Coerper, C; Klein, HO; Lennartz, KJ; Toermer, HJ, 1980)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199035 (87.50)18.7374
1990's5 (12.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
GALE, GR5
Langen, P2
Lehmann, W1
Graetz, H1
Böhmer, FD1
Grosse, R1
Burns, ER3
Vassilev, L2
Russev, G2
Sato, A3
Cory, JG3
Lasater, L2
Klein, HO2
Toermer, HJ1
Christian, E1
Coerper, C1
Lennartz, KJ2
Akokan, G1
Tsanev, R1
Fehér, I1
Gidali, J1
Forýtková, L1
Hrazdira, I1
Mornstein, V1
Lassmann, G2
Curtis, J1
Liermann, B2
Mason, RP1
Eling, TE1
Mlejnek, P1
Kozubek, S1
Sur, P1
Bag, SP1
Sur, B1
Khanam, JA1
Bossa, R1
Galatulas, I1
Leotta, L1
Tofanetti, O1
Adler, D1
Doering, M1
Klein, PJ1
Hoshino, J1
Frahm, J1
Kröger, H1
Li, JC1
Kaminskas, E1
Satyamoorthy, K1
Chitnis, MP1
Pradhan, SG1
Murayama, J1
Morita, T1
Fukui, N1
Moriyama, Y1
Fujimura, S1
Chiu, ML1
Irvin, JL2
Seidel, HJ1
Frankfurt, OS1
Probst, H1
Ullrich, A1
Krauss, G1
Nicolini, C1
Baserga, R1
Malec, J1
Kornacka, L1
Wojnarowska, M1
Mościcka, M1
Sarkar, S1
Chowdhury, JR1
Puschendorf, B1
Grunicke, H1
Horikawa, M1
Fukuhara, M1
Suzuki, F1
Nikaido, O1
Sugahara, T1
Levine, RL1
Kretchmer, N1
Sugiura, K1
Chae, CB1
Williams, A1
Krasny, H1
Piantadosi, C1
Smith, AB1
Hynes, JB1
Turner, MK1
Abrams, R1
Lieberman, I1

Other Studies

40 other studies available for hydroxyurea and Carcinoma, Ehrlich Tumor

ArticleYear
EFFECT OF HYDROXYUREA ON THE INCORPORATION OF THYMIDINE INTO EHRLICH ASCITES TUMOR CELLS.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Hydroxyurea

1964
Is ribonucleotide reductase in Ehrlich ascites mammary tumour cells the target of a growth inhibitor purified from bovine mammary gland?
    Biomedica biochimica acta, 1984, Volume: 43, Issue:12

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cattle; Cells, Cultured; Cytidine; Deoxycytidine; Deoxyuridine; E

1984
Induction of differences in the circadian profiles of DNA synthesis between normal and neoplastic cell populations by hydroxyurea without perturbation of the normal circadian rhythms.
    Oncology, 1983, Volume: 40, Issue:6

    Topics: Animals; Ascitic Fluid; Carcinoma, Ehrlich Tumor; Cells, Cultured; Circadian Rhythm; DNA; Esophagus;

1983
Hydroxyurea treatment does not prevent initiation of DNA synthesis in Ehrlich ascites tumour cells and leads to the accumulation of short DNA fragments containing the replication origins.
    Biochimica et biophysica acta, 1984, Feb-24, Volume: 781, Issue:1-2

    Topics: Animals; Carcinoma, Ehrlich Tumor; DNA Replication; DNA, Neoplasm; Hydroxyurea; Mice; Molecular Weig

1984
Evaluation of combinations of drugs that inhibit Ehrlich tumor cell ribonucleotide reductase.
    Cancer research, 1981, Volume: 41, Issue:5

    Topics: Aldehydes; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Deoxyadenine Nucleotides; Deoxy

1981
Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.
    Biochemical pharmacology, 1981, May-01, Volume: 30, Issue:9

    Topics: Animals; Carcinoma, Ehrlich Tumor; Chelating Agents; Deferoxamine; Edetic Acid; Female; Guanazole; H

1981
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy.
    Advances in enzyme regulation, 1980, Volume: 19

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Interactions; Drug Synergism; Female;

1980
Circadian rhythm in mitotic index of corneal epithelium: presence of Ehrlich ascites carcinoma and treatment with saline or hydroxyurea.
    The Anatomical record, 1981, Volume: 199, Issue:4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Circadian Rhythm; Cornea; Corneal Diseases; Dose-Response Relatio

1981
Experimental investigations on a sequential combination chemotherapy protocol.
    Journal of cancer research and clinical oncology, 1980, Volume: 96, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Diploidy; DNA, Neoplasm; Do

1980
Histone exchange in chromatin of hydroxyurea-blocked Ehrlich ascites tumour cells.
    Nature, 1980, Jun-19, Volume: 285, Issue:5766

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatin; DNA; DNA Replication; Histones; Hydro

1980
Protection of cycling CFUs against hydroxyurea by low doses of actinomycin D.
    Cell and tissue kinetics, 1980, Volume: 13, Issue:4

    Topics: Animals; Autoradiography; Carcinoma, Ehrlich Tumor; Cell Division; Colony-Forming Units Assay; Dacti

1980
Effect of ultrasound on DNA synthesis in tumor cells.
    Ultrasound in medicine & biology, 1995, Volume: 21, Issue:4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Cold Temperature; DNA; DNA Repair; DNA Replication

1995
ESR studies on reactivity of protein-derived tyrosyl radicals formed by prostaglandin H synthase and ribonucleotide reductase.
    Archives of biochemistry and biophysics, 1993, Volume: 300, Issue:1

    Topics: Animals; Anisoles; Carcinoma, Ehrlich Tumor; Cyclooxygenase Inhibitors; Electron Spin Resonance Spec

1993
Protective effect of adenine on DNA synthesis in irradiated Ehrlich ascites tumor cells.
    Radiation research, 1997, Volume: 147, Issue:4

    Topics: Adenine; Animals; Carcinoma, Ehrlich Tumor; DNA Replication; DNA, Neoplasm; Gamma Rays; Hydroxyurea;

1997
Chloroaceto hydroxamic acid as antitumor agent against Ehrlich ascites carcinoma in mice.
    Neoplasma, 1997, Volume: 44, Issue:3

    Topics: Alkaline Phosphatase; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; DNA,

1997
Effect of various antitumor drugs on energetic processes.
    Pharmacological research communications, 1976, Volume: 8, Issue:4

    Topics: Animals; Antineoplastic Agents; Bleomycin; Brain; Carcinoma, Ehrlich Tumor; Carmustine; Cytarabine;

1976
Investigations on pharmacologic induction of partial synchronization of tumor cell proliferation: its relevance for cytostatic therapy.
    Cancer treatment reports, 1976, Volume: 60, Issue:12

    Topics: Adolescent; Adult; Aged; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cyclophosphamide; Drug Ad

1976
Quenching of tyrosine radicals of M2 subunit from ribonucleotide reductase in tumor cells by different antitumor agents: an EPR study.
    Free radical biology & medicine, 1990, Volume: 9, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Electron Spin Resonance Spectroscopy; Enzy

1990
Suppression of nuclear ADP-ribosyltransferase activity in Ehrlich ascites tumor cells by 5-azacytidine and its analogs.
    Biochemical and biophysical research communications, 1987, Jan-30, Volume: 142, Issue:2

    Topics: Animals; Azacitidine; Carcinoma, Ehrlich Tumor; Cell Nucleus; Cytosine; DNA; Female; Hydroxyurea; Me

1987
Progressive formation of DNA lesions in cultured Ehrlich ascites tumor cells treated with hydroxyurea.
    Cancer research, 1987, Jun-01, Volume: 47, Issue:11

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Deoxyribonucleosides; Deoxyribonucleotides; DNA; DNA D

1987
Biological time and the effects of hydroxyurea on DNA synthetic activity of bone marrow and tumor cells in mice bearing the Ehrlich ascites carcinoma.
    The American journal of anatomy, 1987, Volume: 179, Issue:3

    Topics: Animals; Bone Marrow; Carcinoma, Ehrlich Tumor; Cell Cycle; Circadian Rhythm; DNA; DNA Replication;

1987
Potentiation of hydroxyurea cytotoxicity by iron-chelating agent in murine tumor models in vitro.
    Cancer drug delivery, 1986,Summer, Volume: 3, Issue:3

    Topics: 2,2'-Dipyridyl; Animals; Carcinoma, Ehrlich Tumor; Cell Line; DNA, Neoplasm; Drug Synergism; Hydroxy

1986
Uridine diphosphate reductase of Ehrlich ascites tumor is insensitive to hydroxyurea.
    Biochemical and biophysical research communications, 1985, Feb-15, Volume: 126, Issue:3

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cytosol; Hydroxyurea; Male; Mice; Mice, Inbred Strains; Ribonucle

1985
Effect of inhibition of DNA synthesis on histone synthesis, turnover, and deposition in the rat testis.
    Archives of biochemistry and biophysics, 1985, Volume: 236, Issue:1

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Cytarabine; DNA; Histones; Hydroxyurea; Hypophysect

1985
[Estimation of tumor sensitivity in vitro. II. Studies with the solid Ehrlich carcinoma of the mouse and the GW 77, a heterotransplanted human carcinoma].
    Zeitschrift fur Krebsforschung, 1970, Volume: 74, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Autoradiography; Carcinoma; Carcinoma, Ehrlich Tumor; Colonic

1970
Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.
    Cancer research, 1973, Volume: 33, Issue:5

    Topics: Animals; Body Weight; Carcinoma, Ehrlich Tumor; Cell Count; Floxuridine; Fluorouracil; Hydroxyurea;

1973
Newly synthesized mammalian cell DNA: studies on the reasons for the increased affinity to nitrocellulose.
    Biochimica et biophysica acta, 1971, Nov-29, Volume: 254, Issue:1

    Topics: Alcohols; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cellulose; Centrifugation, Density Gra

1971
RNA-nascent DNA complexes in Ehrlich ascites tumor cells in vivo.
    Experimental and molecular pathology, 1974, Volume: 21, Issue:1

    Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Centrifugation, Density Gradient; Chromatog

1974
The relationship between DNA synthesis and incorporation of (14C)lysine into different histone fractions in Ehrlich ascites tumour cells.
    Acta biochimica Polonica, 1974, Volume: 21, Issue:1

    Topics: Animals; Arginine; Aspartic Acid; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cell Nucleus; DNA;

1974
Effect of hydroxyurea on the chromosomes of tumour cells.
    Indian journal of cancer, 1972, Volume: 9, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Chromosome Aberrations; Chromosomes; Diploidy; Hydroxyurea; Leuke

1972
Effect of hydroxyurea and trisethyleneiminobenzoquinone (Trenimon) on the methylation of DNA in Ehrlich ascites tumor cells.
    Biochimica et biophysica acta, 1972, Jun-22, Volume: 272, Issue:1

    Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chromatography, Paper; Cytidine; Cytosine Nucleo

1972
Comparative studies on induction and rejoining of DNA single-strand breaks by radiation and chemical carcinogen in mammalian cells in vitro.
    Experimental cell research, 1972, Volume: 70, Issue:2

    Topics: Animals; Bromodeoxyuridine; Carcinogens; Carcinoma, Ehrlich Tumor; Cells, Cultured; Centrifugation,

1972
Conversion of carbamoyl phosphate to hydroxyurea. An assay for carbamoylphosphate synthetase.
    Analytical biochemistry, 1971, Volume: 42, Issue:2

    Topics: Animals; Bicarbonates; Carbamates; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cattle; Cell Line; Cer

1971
Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and two related compounds on a spectrum of tumors.
    Cancer research, 1967, Volume: 27, Issue:3 Pt 2

    Topics: Adenocarcinoma; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Fibrosarcoma; Glioma; Hydroxy

1967
Hydroxyurea derivatives: oxamyl hydroxamic acid.
    Cancer research, 1966, Volume: 26, Issue:11

    Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA,

1966
Hydroxyurea derivatives: acetoxyoxamide.
    Journal of the National Cancer Institute, 1967, Volume: 38, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; DNA, Bacterial; Escherichia coli; Hemoglob

1967
Inhibition of thymidine phosphorylation and DNA and histone synthesis in Ehrlich ascites carcinoma.
    Cancer research, 1970, Volume: 30, Issue:11

    Topics: Aldehydes; Animals; Arginine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chromatography, Thin Layer;

1970
Hydroxyurea derivatives--1-methyl-1-hydroxyurea and 1-ethyl-1-hydroxyurea.
    Biochemical pharmacology, 1968, Volume: 17, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Depression, Chemical; DNA, Neoplasm; Drug Antagonism; Hydroxyurea

1968
Hydroxyurea derivatives: 1-hydroxybiuret and 3-hydroxybiuret.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 127, Issue:4

    Topics: Animals; Antimetabolites; Carcinoma, Ehrlich Tumor; Depression, Chemical; DNA, Neoplasm; Hydroxyurea

1968
Meso-alpha, beta-diphenylsuccinate and hydroxyurea as inhibitors of deoxycytidylate synthesis in extracts of Ehrlich ascites and L cells.
    The Journal of biological chemistry, 1966, Dec-25, Volume: 241, Issue:24

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cytosine Nucleotides; Hydroxyurea; In Vitr

1966