hydroxyurea has been researched along with Cancer of Gastrointestinal Tract in 6 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxyurea (HU) is a ribonucleotide reductase inhibitor which blocks DNA excision-repair by the depletion of intracellular ribonucleotides." | 6.67 | A phase II study of high-dose hydroxyurea and dacarbazine (DTIC) in the treatment of metastatic malignant melanoma. ( Carmichael, J; Ganesan, TA; Harris, AL; Philip, PA; Tonkin, K, 1994) |
| " We were not able to increase 5FU weekly dosage above 700 mg/m2 due to the occurrence of grade 3-4 gastrointestinal toxicity." | 6.67 | Weekly levofolinic acid and 5-fluorouracil plus hydroxyurea in metastatic gastrointestinal adenocarcinomas. ( Buccellato, C; Cipolla, C; Comande, S; Curto, G; Gebbia, N; Gebbia, V; Latteri, M; Testa, A; Valenza, R, 1994) |
| "Hydroxyurea (HU) is a ribonucleotide reductase inhibitor which blocks DNA excision-repair by the depletion of intracellular ribonucleotides." | 2.67 | A phase II study of high-dose hydroxyurea and dacarbazine (DTIC) in the treatment of metastatic malignant melanoma. ( Carmichael, J; Ganesan, TA; Harris, AL; Philip, PA; Tonkin, K, 1994) |
| " We were not able to increase 5FU weekly dosage above 700 mg/m2 due to the occurrence of grade 3-4 gastrointestinal toxicity." | 2.67 | Weekly levofolinic acid and 5-fluorouracil plus hydroxyurea in metastatic gastrointestinal adenocarcinomas. ( Buccellato, C; Cipolla, C; Comande, S; Curto, G; Gebbia, N; Gebbia, V; Latteri, M; Testa, A; Valenza, R, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Philip, PA | 1 |
| Carmichael, J | 1 |
| Tonkin, K | 1 |
| Ganesan, TA | 1 |
| Harris, AL | 1 |
| Gebbia, V | 1 |
| Valenza, R | 1 |
| Testa, A | 1 |
| Cipolla, C | 1 |
| Latteri, M | 1 |
| Curto, G | 1 |
| Comande, S | 1 |
| Buccellato, C | 1 |
| Gebbia, N | 1 |
| Di Costanzo, F | 1 |
| el-Taani, H | 1 |
| Parriani, D | 1 |
| Tagliaventi, M | 1 |
| Bartolucci, R | 1 |
| Valenti, L | 1 |
| Manzione, L | 1 |
| Madejewicz, S | 1 |
| Savage, DG | 1 |
| Antman, KH | 1 |
| Lokich, JJ | 1 |
| Pitman, SW | 1 |
| Skarin, AT | 1 |
| Berk, PD | 1 |
| Goldberg, JD | 1 |
| Donovan, PB | 1 |
| Fruchtman, SM | 1 |
| Berlin, NI | 1 |
| Wasserman, LR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised Multicentre Phase IV Study to Compare Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec® in Combination With Interferon Alpha at Low Doses in the Treatment of Newly-Diagnosed Chronic-Phase Chronic Myeloid Leukaemia[NCT00390897] | Phase 4 | 360 participants | Interventional | 2003-07-31 | Completed | ||
| Multicenter Phase 2 Study of Efficacy and Safety of Pegylated Interferon-alfa 2a in Polycythemia Vera Patients[NCT00241241] | Phase 2 | 40 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyurea and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Imatinib mesylate--a new oral targeted therapy.
Topics: Administration, Oral; Antineoplastic Agents; Benzamides; Clinical Trials as Topic; Drug Resistance; | 2002 |
4 trials available for hydroxyurea and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
A phase II study of high-dose hydroxyurea and dacarbazine (DTIC) in the treatment of metastatic malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Dacarbazine; Female; Ga | 1994 |
Weekly levofolinic acid and 5-fluorouracil plus hydroxyurea in metastatic gastrointestinal adenocarcinomas.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Sch | 1994 |
Hydroxyurea may increase the activity of fluorouracil plus folinic acid in advanced gastrointestinal cancer: phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Female; Fluorouracil; G | 1996 |
Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols.
Topics: Acute Disease; Age Factors; Bloodletting; Chlorambucil; Combined Modality Therapy; False Positive Re | 1986 |
1 other study available for hydroxyurea and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Combined 5-fluorouracil and hydroxyurea therapy for gastrointestinal cancer.
Topics: Administration, Oral; Ataxia; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Gastrointe | 1975 |