hydroxyurea has been researched along with Bronchial Hyperreactivity in 6 studies
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to determine whether zileuton, an inhibitor of 5-lipoxygenase, attenuated bronchial hyperresponsiveness (BHR) in asthmatic subjects who had marked BHR during maintenance treatment with inhaled corticosteroids (ICS)." | 9.08 | Effects of single-dose zileuton on bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticosteroids. ( Bootsma, GP; Dekhuijzen, PN; Festen, J; van den Berg, LR; van Herwaarden, CL; Wielders, PL, 1997) |
| "From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit leukotrienes (LT), the hypothesis has emerged that leukotrienes are important mediators of airway obstruction and other symptoms in aspirin-intolerant asthma (AIA)." | 9.08 | Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. ( Bochenek, G; Boodhoo, TI; Dahlén, B; Dahlén, SE; Dubé, LM; Kumlin, M; Mastalerz, L; Nizankowska, E; Pinis, G; Swanson, LJ; Szczeklik, A; Wright, S; Zetterström, O, 1998) |
| " We investigated the effects of zileuton, an inhibitor of 5-lipoxygenase (5-LO), on airway responsiveness to cold, dry air in patients with moderate asthma." | 5.08 | Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects. ( Awni, WM; Cohn, J; Drazen, JM; Fischer, AR; Frantz, R; Israel, E; McFadden, CA, 1995) |
| "The aim of the study was to determine whether zileuton, an inhibitor of 5-lipoxygenase, attenuated bronchial hyperresponsiveness (BHR) in asthmatic subjects who had marked BHR during maintenance treatment with inhaled corticosteroids (ICS)." | 5.08 | Effects of single-dose zileuton on bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticosteroids. ( Bootsma, GP; Dekhuijzen, PN; Festen, J; van den Berg, LR; van Herwaarden, CL; Wielders, PL, 1997) |
| "From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit leukotrienes (LT), the hypothesis has emerged that leukotrienes are important mediators of airway obstruction and other symptoms in aspirin-intolerant asthma (AIA)." | 5.08 | Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. ( Bochenek, G; Boodhoo, TI; Dahlén, B; Dahlén, SE; Dubé, LM; Kumlin, M; Mastalerz, L; Nizankowska, E; Pinis, G; Swanson, LJ; Szczeklik, A; Wright, S; Zetterström, O, 1998) |
| "RBx 7796, a 5-lipoxygenase inhibitor, was evaluated in in vivo efficacy models, in vitro ADME and in vivo pharmacokinetic models." | 1.35 | Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor. ( Dastidar, SG; Kakar, S; Paliwal, JK; Ray, A; Salman, M; Sattigeri, V; Sharma, P; Shirumalla, RK; Singh Saini, G; Varshney, B, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Connes, P | 1 |
| Machado, R | 1 |
| Hue, O | 1 |
| Reid, H | 1 |
| Shirumalla, RK | 1 |
| Sharma, P | 1 |
| Dastidar, SG | 1 |
| Paliwal, JK | 1 |
| Kakar, S | 1 |
| Varshney, B | 1 |
| Singh Saini, G | 1 |
| Sattigeri, V | 1 |
| Salman, M | 1 |
| Ray, A | 1 |
| Fischer, AR | 1 |
| McFadden, CA | 1 |
| Frantz, R | 1 |
| Awni, WM | 1 |
| Cohn, J | 1 |
| Drazen, JM | 1 |
| Israel, E | 1 |
| Dekhuijzen, PN | 1 |
| Bootsma, GP | 1 |
| Wielders, PL | 1 |
| van den Berg, LR | 1 |
| Festen, J | 1 |
| van Herwaarden, CL | 1 |
| Dahlén, B | 1 |
| Nizankowska, E | 1 |
| Szczeklik, A | 1 |
| Zetterström, O | 1 |
| Bochenek, G | 1 |
| Kumlin, M | 1 |
| Mastalerz, L | 1 |
| Pinis, G | 1 |
| Swanson, LJ | 1 |
| Boodhoo, TI | 1 |
| Wright, S | 1 |
| Dubé, LM | 1 |
| Dahlén, SE | 1 |
| Abraham, WM | 1 |
| Ahmed, A | 1 |
| Cortes, A | 1 |
| Sielczak, MW | 1 |
| Hinz, W | 1 |
| Bouska, J | 1 |
| Lanni, C | 1 |
| Bell, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aerobic Physical Fitness and Health-related Quality of Life in Children With Sickle Cell Disease.[NCT05995743] | 72 participants (Actual) | Observational | 2021-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyurea and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia.
Topics: Adaptation, Physiological; Anemia, Sickle Cell; Arterial Occlusive Diseases; Bronchial Hyperreactivi | 2011 |
3 trials available for hydroxyurea and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects.
Topics: Adult; Arachidonate 5-Lipoxygenase; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; | 1995 |
Effects of single-dose zileuton on bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticosteroids.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchial Hyperreactivity; Bronc | 1997 |
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics.
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Hyperr | 1998 |
2 other studies available for hydroxyurea and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor.
Topics: Animals; Arachidonate 5-Lipoxygenase; Bronchial Hyperreactivity; Calcimycin; Dogs; Humans; Hydroxyur | 2008 |
The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep.
Topics: Administration, Oral; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage F | 1992 |