hydroxyurea has been researched along with Blast Crisis in 40 studies
Blast Crisis: An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We present an unusual Ph-positive CML case, which developed lymphoid blast crisis in complete cytogenetic remission following interferon-alpha and hydroxyurea therapy." | 7.69 | Lymphoid blast crisis during complete cytogenetic remission following interferon-alpha and hydroxyurea therapy. ( Bose, S; Chowdhry, VP; Kucheria, K; Saxena, R, 1997) |
| "Treatment of the myeloid blast phase of chronic granulocytic leukemia is still a major problem in clinical hematology." | 5.28 | Therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea. ( Goudsmit, R; Ho, AD; Hunstein, W; Trümper, LH; van der Lelie, H, 1989) |
| "Six patients with either acceleration or blast crisis of transformed chronic myeloid leukemia (CML) were treated with high-dose interferon alpha in combination with hydroxyurea." | 5.08 | Successful treatment of accelerated and blastic phase of chronic myeloid leukemia with high-dose interferon alpha and hydroxyurea: a novel approach. ( Heinemann, V; Jehn, U; Pötscher, C, 1995) |
| " Indirubin and meisoindigo induced hematologic remission in patients with chronic phase (CP) CML as effective as hydroxyurea and busulfan, in addition, there were no significant differences in median duration of CP, median survival and blast crisis at 60 months from diagnosis in indirubin, meisoindigo, hydroxyurea and busulfan treated groups." | 4.81 | Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China. ( Hao, Y; Liu, B; Qian, L; Xiao, Z, 2002) |
| " We present an unusual Ph-positive CML case, which developed lymphoid blast crisis in complete cytogenetic remission following interferon-alpha and hydroxyurea therapy." | 3.69 | Lymphoid blast crisis during complete cytogenetic remission following interferon-alpha and hydroxyurea therapy. ( Bose, S; Chowdhry, VP; Kucheria, K; Saxena, R, 1997) |
| " Overexpression of P-170 without amplification of MDR-1 was found in four of 11 patients with chronic phase CML at diagnosis, seven of 16 patients treated with busulfan or hydroxyurea in chronic phase and four of 15 patients in blast crisis." | 3.68 | The role of the MDR-1/P-170 mechanism in the development of multidrug resistance in chronic myeloid leukemia. ( Dowding, C; Goldman, J; Paulsen, W; Weide, R, 1990) |
| "The clinical course of 196 patients with chronic myelocytic leukemia (CML) was studied." | 2.67 | [Evaluation of 196 patients with chronic myeloid leukemia based on a standard prognosis model]. ( Anger, B; Carbonell, F; Ganser, A; Heimpel, H; Robertson, J; Schmeiser, T; Sokal, JE, 1990) |
| "Several reports have described intracranial hemorrhage during the accelerated phase or blast crisis of CML, but few have described this complication during the chronic phase." | 1.62 | [Chronic-phase chronic myeloid leukemia with intracranial hemorrhage complicated with tumor lysis syndrome]. ( Aoki, T; Arakawa, Y; Ikeda, Y; Isobe, K; Koh, K; Kubota, Y; Kurihara, J; Mori, M; Oyama, C, 2021) |
| "We report a patient with Philadelphia chromosome positive (Ph +ve) chronic myelogenous leukemia (CML), treated with hydroxyurea alone, who upon disease progression developed an additional Ph - ve clone containing chromosomal abnormalities typical of myelodysplastic syndrome (MDS)." | 1.31 | Coexistence of independent myelodysplastic and Philadelphia chromosome positive clones in a patient treated with hydroxyurea. ( Flamm, MJ; Murty, VV; Nichols, GL; Rao, PH, 2002) |
| "Transformed chronic myeloid leukemia (CML) has a dismal prognosis, and treatment with a variety of chemotherapeutic agents is extremely disappointing." | 1.30 | Successful treatment of accelerated and blastic phase of chronic myeloid leukemia with high-dose interferon-alpha combined with hydroxyurea. ( Heinemann, V; Jehn, U, 1998) |
| "Essential thrombocythemia is a myeloproliferative disorder that infrequently evolves into acute leukemia." | 1.29 | Acute lymphoblastic leukemia in a case of essential thrombocythemia. ( Litz, CE; Woronzoff-Dashkoff, KK, 1996) |
| "Treatment of the myeloid blast phase of chronic granulocytic leukemia is still a major problem in clinical hematology." | 1.28 | Therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea. ( Goudsmit, R; Ho, AD; Hunstein, W; Trümper, LH; van der Lelie, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (17.50) | 18.7374 |
| 1990's | 14 (35.00) | 18.2507 |
| 2000's | 13 (32.50) | 29.6817 |
| 2010's | 4 (10.00) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Assi, R | 1 |
| Kantarjian, H | 1 |
| Keating, M | 1 |
| Pemmaraju, N | 1 |
| Verstovsek, S | 1 |
| Garcia-Manero, G | 1 |
| Ravandi, F | 1 |
| Borthakur, G | 1 |
| Dahl, J | 1 |
| Jabbour, E | 1 |
| Cortes, JE | 1 |
| Oyama, C | 1 |
| Arakawa, Y | 1 |
| Ikeda, Y | 1 |
| Aoki, T | 1 |
| Kubota, Y | 1 |
| Isobe, K | 1 |
| Mori, M | 1 |
| Kurihara, J | 1 |
| Koh, K | 1 |
| Andriani, A | 1 |
| Elli, E | 1 |
| Trapè, G | 1 |
| Villivà, N | 1 |
| Fianchi, L | 1 |
| Di Veroli, A | 1 |
| Niscola, P | 1 |
| Centra, A | 1 |
| Anaclerico, B | 1 |
| Montanaro, G | 1 |
| Martini, V | 1 |
| Aroldi, A | 1 |
| Carmosino, I | 1 |
| Voso, MT | 1 |
| Breccia, M | 1 |
| Montanaro, M | 1 |
| Foà, R | 1 |
| Latagliata, R | 1 |
| Itzykson, R | 1 |
| Itzkson, R | 1 |
| Fenaux, P | 1 |
| Solary, E | 1 |
| Huang, CT | 1 |
| Kuo, PH | 1 |
| Yao, M | 1 |
| Tsai, YJ | 1 |
| Yang, PC | 1 |
| Sharma, P | 1 |
| Dhingra, KK | 1 |
| Roy, S | 1 |
| Singh, T | 1 |
| Tolo-Diebkilé, A | 1 |
| Koffi, KG | 1 |
| Sawadogo, GD | 1 |
| Ndiaye, FS | 1 |
| Nanho, DC | 1 |
| Sékongo, YM | 1 |
| Kouakou, B | 1 |
| Méité, N | 1 |
| Ayemou, R | 1 |
| Sanogo, I | 1 |
| Kobayashi, Y | 1 |
| Tanaka, T | 1 |
| Kawata, E | 1 |
| Akaogi, T | 1 |
| Huang, PH | 1 |
| You, JY | 1 |
| Hsu, HC | 1 |
| Wisløff, F | 1 |
| Brinch, L | 1 |
| Hammerstrøm, J | 1 |
| Liu, NS | 1 |
| O'Brien, S | 1 |
| Morel, F | 1 |
| Bris, MJ | 1 |
| Herry, A | 1 |
| Calvez, GL | 1 |
| Marion, V | 1 |
| Abgrall, JF | 1 |
| Berthou, C | 1 |
| Braekeleer, MD | 1 |
| Xiao, Z | 1 |
| Hao, Y | 1 |
| Liu, B | 1 |
| Qian, L | 1 |
| Prabhash, K | 1 |
| Loknath, D | 1 |
| Babu, KG | 1 |
| Hasib, AG | 1 |
| Biswas, S | 1 |
| Bapsy, PP | 1 |
| Hehlmann, R | 2 |
| Heimpel, H | 3 |
| Hasford, J | 2 |
| Kolb, HJ | 2 |
| Pralle, H | 2 |
| Hossfeld, DK | 2 |
| Queisser, W | 3 |
| Löffler, H | 2 |
| Hochhaus, A | 1 |
| Heinze, B | 2 |
| Goldman, JM | 2 |
| Shibata, A | 1 |
| Georgii, A | 1 |
| Oikawa, H | 1 |
| Utsugisawa, T | 1 |
| Murai, K | 1 |
| Narigasawa, Y | 1 |
| Miyairi, Y | 1 |
| Shimosegawa, K | 1 |
| Suzuki, T | 1 |
| Kuriya, S | 1 |
| Jehn, U | 2 |
| Pötscher, C | 1 |
| Heinemann, V | 2 |
| Woronzoff-Dashkoff, KK | 1 |
| Litz, CE | 1 |
| Martinelli, G | 1 |
| Testoni, N | 1 |
| Zuffa, E | 1 |
| Visani, G | 1 |
| Zinzani, PL | 1 |
| Zaccaria, A | 1 |
| Farabegoli, P | 1 |
| Arpinati, M | 1 |
| Amabile, M | 1 |
| Tura, S | 1 |
| Carulli, G | 1 |
| Papineschi, F | 1 |
| Azzarà, A | 1 |
| Ambrogi, F | 1 |
| Bose, S | 1 |
| Chowdhry, VP | 1 |
| Saxena, R | 1 |
| Kucheria, K | 1 |
| Tabata, M | 1 |
| Imagawa, S | 1 |
| Tarumoto, T | 1 |
| Ohmine, K | 1 |
| Hatake, K | 1 |
| Miura, Y | 1 |
| Ozawa, K | 1 |
| Thiesing, JT | 1 |
| Ohno-Jones, S | 1 |
| Kolibaba, KS | 1 |
| Druker, BJ | 1 |
| Gancberg, D | 1 |
| Dargent, JL | 1 |
| Verhest, A | 1 |
| Kentos, A | 1 |
| Feremans, W | 1 |
| Lohrisch, C | 1 |
| Kornreich, A | 1 |
| Al-Rayes, HM | 1 |
| Al-Shaikh, AA | 1 |
| Halim, MA | 1 |
| Al-Qurashi, FS | 1 |
| Al-Jurf, MM | 1 |
| Flamm, MJ | 1 |
| Murty, VV | 1 |
| Rao, PH | 1 |
| Nichols, GL | 1 |
| Liang, R | 1 |
| Chan, TK | 1 |
| Chiu, E | 1 |
| Todd, D | 1 |
| Anger, B | 2 |
| Schmeiser, T | 1 |
| Robertson, J | 1 |
| Sokal, JE | 1 |
| Ganser, A | 1 |
| Carbonell, F | 1 |
| Weide, R | 1 |
| Dowding, C | 1 |
| Paulsen, W | 1 |
| Goldman, J | 1 |
| Koller, CA | 1 |
| Miller, DM | 1 |
| Allan, NC | 2 |
| Shepherd, PC | 1 |
| Trümper, LH | 1 |
| Ho, AD | 1 |
| Hunstein, W | 1 |
| van der Lelie, H | 1 |
| Goudsmit, R | 1 |
| Ueki, K | 1 |
| Tsuchida, A | 1 |
| Murakami, H | 1 |
| Karasawa, M | 1 |
| Kobayashi, N | 1 |
| Omine, M | 1 |
| Naruse, T | 1 |
| Herrmann, F | 1 |
| Lindemann, A | 1 |
| Hiddemann, W | 1 |
| Krey, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chart Review Study of Chronic Myelogenous Leukemia (CML) Patients Treated With Imatinib Outside of a Clinical Trial[NCT00816114] | 3,000 participants (Anticipated) | Observational | 2005-06-08 | Recruiting | |||
| Efficacy and Safety of Pegylated Proline Interferon Alpha 2b (AOP2014) in Maintaining Deep Molecular Remissions in Patients With Chronic Myeloid Leukemia (CML) Who Discontinue ABL-Kinase Inhibitor Therapy - a Randomized Phase III, Multicenter Trial With P[NCT03117816] | Phase 3 | 214 participants (Actual) | Interventional | 2017-05-04 | Completed | ||
| Randomised Multicentre Phase IV Study to Compare Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec® in Combination With Interferon Alpha at Low Doses in the Treatment of Newly-Diagnosed Chronic-Phase Chronic Myeloid Leukaemia[NCT00390897] | Phase 4 | 360 participants | Interventional | 2003-07-31 | Completed | ||
| Nilotinib Combined by Chemotherapy for Myeloid Blastic Phase of Chronic Myeloid Leukemia or Bcr-abl Positive Acute Myeloid Leukemia[NCT01690065] | Phase 2 | 46 participants (Anticipated) | Interventional | 2012-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for hydroxyurea and Blast Crisis
| Article | Year |
|---|---|
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Topics: Allografts; Antineoplastic Agents; Blast Crisis; Female; Humans; Hydroxyurea; Leukemia, Myelogenous, | 2013 |
Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Blast Crisis; China; Dose-Response Rela | 2002 |
Management of chronic myeloid leukaemia.
Topics: Actuarial Analysis; Adolescent; Adult; Aged; Blast Crisis; Bone Marrow Transplantation; Busulfan; Ch | 1994 |
Treatment of chronic myeloid leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Busulfan; Dose-Response Relationship, | 1987 |
Therapeutic options in chronic myeloid leukaemia.
Topics: Blast Crisis; Bone Marrow Transplantation; Busulfan; Humans; Hydroxyurea; Leukemia, Myelogenous, Chr | 1989 |
4 trials available for hydroxyurea and Blast Crisis
| Article | Year |
|---|---|
Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML Study Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blast Crisis; Busulfan; Cross-Over Studies; Drug Resista | 1994 |
Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group.
Topics: Blast Crisis; Busulfan; Drug Resistance; Female; Humans; Hydroxyurea; Leukemia, Myelogenous, Chronic | 1993 |
Successful treatment of accelerated and blastic phase of chronic myeloid leukemia with high-dose interferon alpha and hydroxyurea: a novel approach.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antineoplastic Agents; Antineoplastic Combined | 1995 |
[Evaluation of 196 patients with chronic myeloid leukemia based on a standard prognosis model].
Topics: Biomarkers, Tumor; Blast Crisis; Busulfan; Clinical Trials as Topic; Female; Follow-Up Studies; Huma | 1990 |
31 other studies available for hydroxyurea and Blast Crisis
| Article | Year |
|---|---|
Management of chronic myeloid leukemia during pregnancy among patients treated with a tyrosine kinase inhibitor: a single-Center experience.
Topics: Blast Crisis; Female; Humans; Hydroxyurea; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; P | 2021 |
[Chronic-phase chronic myeloid leukemia with intracranial hemorrhage complicated with tumor lysis syndrome].
Topics: Adolescent; Blast Crisis; Humans; Hydroxyurea; Intracranial Hemorrhages; Leukemia, Myelogenous, Chro | 2021 |
Treatment of Philadelphia-negative myeloproliferative neoplasms in accelerated/blastic phase with azacytidine. Clinical results and identification of prognostic factors.
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Blast Crisis; Female; Humans; Hydroxyurea; Leuke | 2019 |
Pleural effusion heralds acute leukemic transformation of chronic myelomonocytic leukemia.
Topics: Blast Crisis; Bone Marrow; Disease Progression; Fatal Outcome; Female; Humans; Hydroxyurea; Leukemia | 2008 |
An acute myeloid leukemia M6b blast crisis with giant proerythroblasts in chronic myeloid leukemia.
Topics: Antineoplastic Agents; Blast Crisis; Blood Transfusion; Child; Erythroblasts; Female; Humans; Hydrox | 2009 |
[Therapeutic impact of alpha interferon in chronic myelogenous leukaemia].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cytarabine; Female; Fusion Prot | 2010 |
Chronic myelogenous leukemia in the chronic phase with lymph node swelling which represented extramedullary involvement composed of cells at different stages of maturation.
Topics: Benzamides; Blast Crisis; Fatal Outcome; Humans; Hydroxyurea; Imatinib Mesylate; Leukemia, Myeloid, | 2011 |
Extensive pulmonary infiltration by leukemic blasts successfully treated with hydroxyurea--a case report.
Topics: Acute Disease; Adult; Antineoplastic Agents; Blast Crisis; Diagnosis, Differential; Humans; Hydroxyu | 2002 |
[National guidelines for treatment of chronic myelogenous leukemia].
Topics: Adult; Aged; Antineoplastic Agents; Blast Crisis; Humans; Hydroxyurea; Interferon-alpha; Leukemia, M | 2003 |
Spontaneous reversion from blast to chronic phase after withdrawal of imatinib mesylate in a patient with chronic myelogenous leukemia.
Topics: Aged; Benzamides; Blast Crisis; Cytogenetic Analysis; Drug Resistance, Neoplasm; Female; Humans; Hyd | 2002 |
Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib.
Topics: Aneuploidy; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast | 2003 |
Chronic myeloid leukemia with osteolytic bone involvement.
Topics: Adult; Antineoplastic Agents; Blast Crisis; Disease Progression; Humans; Hydroxyurea; Leukemia, Myel | 2003 |
[Clinical study of chronic myelogenous leukemia].
Topics: Blast Crisis; Bone Marrow Transplantation; Busulfan; Granulocytes; Humans; Hydroxyurea; Interferon-a | 1993 |
Tetrasomy of Philadelphia chromosome in myeloblastic crisis of chronic myelogenous leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Fatal Outcome; Humans; Hydroxyurea; Im | 1995 |
Acute lymphoblastic leukemia in a case of essential thrombocythemia.
Topics: Aged; Antigens, CD; Blast Crisis; Bone Marrow; Female; Humans; Hydroxyurea; Lymphocyte Activation; P | 1996 |
FLANG (fludarabine + cytosine arabinoside + novantrone + G-CSF) induces partial remission in lymphoid blast transformation of Ph+chronic myelogenous leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bone Marrow; Bone Marrow Transplantati | 1996 |
Alpha-2a-interferon administration and Fc gamma RIII expression on neutrophils from chronic myeloid leukemia.
Topics: Blast Crisis; Humans; Hydroxyurea; Interferon alpha-2; Interferon-alpha; Leukemia, Myelogenous, Chro | 1996 |
Lymphoid blast crisis during complete cytogenetic remission following interferon-alpha and hydroxyurea therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Female; Humans; Hydroxyurea; In Situ H | 1997 |
Successful treatment of accelerated and blastic phase of chronic myeloid leukemia with high-dose interferon-alpha combined with hydroxyurea.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Female; Humans; Hydroxyur | 1998 |
Essential thrombocythemia transformed to acute myelogenous leukemia with t(3;17)(p24; q12), del(5)(q13q34) after treatment with carboquone and hydroxyurea.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Carbazilquinone; Chromosomes, Human, P | 2000 |
Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells.
Topics: Antineoplastic Agents; Benzamides; Blast Crisis; Cell Division; Cell Survival; Cytarabine; Daunorubi | 2000 |
Near haploid blast phase in a chronic myeloid leukemia detected by fluorescence in situ hybridization using a BCR-ABL probe.
Topics: Antineoplastic Agents; Blast Crisis; Genes, abl; Haploidy; Humans; Hydroxyurea; In Situ Hybridizatio | 2001 |
Leukemic synovitis as a presentation of myelomonocytic blast crisis of chronic myeloid leukemia.
Topics: Adult; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Blast Crisis; Combined M | 2001 |
Coexistence of independent myelodysplastic and Philadelphia chromosome positive clones in a patient treated with hydroxyurea.
Topics: Aged; Antineoplastic Agents; Blast Crisis; Cell Differentiation; Chronic Disease; Female; Humans; Hy | 2002 |
Non-aggressive therapy for chronic myeloid leukaemia in blastic transformation.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Prot | 1992 |
The role of the MDR-1/P-170 mechanism in the development of multidrug resistance in chronic myeloid leukemia.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Busulfan; Drug Resistance; Ge | 1990 |
Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; DNA; Drug Administration Schedu | 1986 |
Current treatment of chronic myelogenous leukemia.
Topics: Blast Crisis; Bone Marrow Transplantation; Busulfan; Humans; Hydroxyurea; Interferons; Leukemia, Mye | 1989 |
Therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Female; Humans; Hydroxyur | 1989 |
[Myeloid crisis of chronic myelogenous leukemia showing dramatic response to mithramycin and hydroxyurea combination].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Female; Humans; Hydroxyurea; Le | 1989 |
Therapy of the blast phase of chronic granulocytic leukemia with mithramycin and hydroxyurea.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Female; Follow-Up Studies | 1988 |