hydroxyurea has been researched along with Ataxia Telangiectasia in 6 studies
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability of a mec1 disruption." | 1.29 | TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. ( Collins, FS; Hieter, P; Morrow, DM; Shiloh, Y; Tagle, DA, 1995) |
| "A strong increase of radiation-induced chromosomal aberrations was observed in normal and HzAT cells post-treated with ara-C, APC and HU, but not in the presence of BuPdG." | 1.29 | Lack of effect of inhibitors of DNA synthesis/repair on the ionizing radiation-induced chromosomal damage in G2 stage of ataxia telangiectasia cells. ( Antoccia, A; Catena, C; Palitti, F; Raggi, T; Tanzarella, C, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Franchitto, A | 1 |
| Pichierri, P | 1 |
| Morrow, DM | 1 |
| Tagle, DA | 1 |
| Shiloh, Y | 1 |
| Collins, FS | 1 |
| Hieter, P | 1 |
| Antoccia, A | 2 |
| Palitti, F | 1 |
| Raggi, T | 1 |
| Catena, C | 1 |
| Tanzarella, C | 2 |
| Chessa, L | 1 |
| Ricordy, R | 1 |
| Chen, MJ | 1 |
| Lin, YT | 1 |
| Lieberman, HB | 1 |
| Chen, G | 1 |
| Lee, EY | 1 |
| Feijoo, C | 1 |
| Hall-Jackson, C | 1 |
| Wu, R | 1 |
| Jenkins, D | 1 |
| Leitch, J | 1 |
| Gilbert, DM | 1 |
| Smythe, C | 1 |
6 other studies available for hydroxyurea and Ataxia Telangiectasia
| Article | Year |
|---|---|
Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.
Topics: Apoptosis; Ataxia Telangiectasia; Cell Line, Tumor; Cell Nucleolus; Checkpoint Kinase 1; Comet Assay | 2004 |
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.
Topics: Ataxia Telangiectasia; Base Sequence; Bleomycin; Cloning, Molecular; DNA Damage; Fungal Proteins; Ga | 1995 |
Lack of effect of inhibitors of DNA synthesis/repair on the ionizing radiation-induced chromosomal damage in G2 stage of ataxia telangiectasia cells.
Topics: Ataxia Telangiectasia; Chromosome Aberrations; DNA Repair; DNA-Directed DNA Polymerase; G2 Phase; Hu | 1994 |
Modulation of radiation-induced chromosomal damage by inhibitors of DNA repair and flow cytometric analysis in ataxia telangiectasia cells with 'intermediate radiosensitivity'.
Topics: Aphidicolin; Ataxia Telangiectasia; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes | 1995 |
ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; DNA- | 2001 |
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.
Topics: Alkaloids; Animals; Aphidicolin; Ataxia Telangiectasia; Caffeine; Cell Fractionation; Cell Line; Cel | 2001 |