hydroxyurea has been researched along with Astrocytoma in 14 studies
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The parallel effects of simvastatin on cell cycle and PKC activity in rat C6 glioma cells were investigated." | 7.69 | PKC activity in rat C6 glioma cells: changes associated with cell cycle and simvastatin treatment. ( Baetta, R; Battaini, F; Bergamaschi, S; Davegna, C; De Renzis, MR; Fumagalli, R; Govoni, S; Soma, MR, 1994) |
| "Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole." | 7.67 | 5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984) |
| "In an attempt to improve the primary treatment of malignant gliomas we used a concomitant 6-week course of chemoradiotherapy with 5 fluorouracil (5 FU) and hydroxyurea (HU) in 24 adults with anaplastic astrocytoma (AA) (7 cases) or glioblastomas (GLB) (17 cases)." | 5.07 | Pilot study of 6 weeks of chemoradiotherapy with 5 FU and hydroxyurea in malignant gliomas. ( Armand, JP; Cioloca, C; Constans, JP; Cvitkovic, FB; Haie-Meder, C; Maugis, N; Papadimitrakopoulou, V, 1993) |
| "The parallel effects of simvastatin on cell cycle and PKC activity in rat C6 glioma cells were investigated." | 3.69 | PKC activity in rat C6 glioma cells: changes associated with cell cycle and simvastatin treatment. ( Baetta, R; Battaini, F; Bergamaschi, S; Davegna, C; De Renzis, MR; Fumagalli, R; Govoni, S; Soma, MR, 1994) |
| "Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole." | 3.67 | 5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984) |
| "The imatinib mesylate dose was 500 mg twice a day for patients on enzyme inducing anti-epileptic drugs (EIAEDs) and 400 mg once a day for those not on EIAEDs." | 2.73 | Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas. ( Desjardins, A; Dowell, JM; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; McLendon, RE; Provenzale, JM; Quinn, JA; Reardon, DA; Rich, JN; Salvado, A; Sampson, JH; Sathornsumetee, S; Vredenburgh, JJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reardon, DA | 2 |
| Desjardins, A | 2 |
| Vredenburgh, JJ | 2 |
| Herndon, JE | 2 |
| Coan, A | 1 |
| Gururangan, S | 2 |
| Peters, KB | 1 |
| McLendon, R | 1 |
| Sathornsumetee, S | 2 |
| Rich, JN | 2 |
| Lipp, ES | 1 |
| Janney, D | 1 |
| Friedman, HS | 2 |
| Quinn, JA | 1 |
| Friedman, AH | 1 |
| McLendon, RE | 1 |
| Provenzale, JM | 1 |
| Sampson, JH | 1 |
| Dowell, JM | 1 |
| Salvado, A | 1 |
| Levin, VA | 3 |
| Edwards, MS | 1 |
| Wara, WM | 2 |
| Allen, J | 1 |
| Ortega, J | 1 |
| Vestnys, P | 1 |
| Chicoine, MR | 1 |
| Silbergeld, DL | 1 |
| Soma, MR | 1 |
| Baetta, R | 1 |
| Bergamaschi, S | 1 |
| De Renzis, MR | 1 |
| Davegna, C | 1 |
| Battaini, F | 1 |
| Fumagalli, R | 1 |
| Govoni, S | 1 |
| Cvitkovic, FB | 1 |
| Haie-Meder, C | 1 |
| Papadimitrakopoulou, V | 1 |
| Armand, JP | 1 |
| Cioloca, C | 1 |
| Maugis, N | 1 |
| Constans, JP | 1 |
| Vokes, EE | 1 |
| Dolan, ME | 1 |
| Krishnasamy, S | 1 |
| Mick, R | 1 |
| Ratain, MJ | 1 |
| Berezin, F | 1 |
| Brachman, D | 1 |
| Whitman, G | 1 |
| Schilsky, RL | 1 |
| Charette, J | 1 |
| Hong, FD | 1 |
| Chen, J | 1 |
| Donovan, S | 1 |
| Schneider, N | 1 |
| Nisen, PD | 1 |
| Wilson, CB | 1 |
| Davis, R | 1 |
| Pischer, TL | 1 |
| Irwin, L | 1 |
| Zänker, KS | 1 |
| Stavrou, D | 1 |
| Osterkamp, U | 1 |
| Wriedt-Lübbe, I | 1 |
| Blümel, G | 1 |
| Pendergrass, TW | 1 |
| Milstein, JM | 1 |
| Geyer, JR | 1 |
| Mulne, AF | 1 |
| Kosnik, EJ | 1 |
| Morris, JD | 1 |
| Heideman, RL | 1 |
| Ruymann, FB | 1 |
| Stuntz, JT | 1 |
| Bleyer, WA | 1 |
| Chastagner, P | 1 |
| Olive, D | 1 |
| Philip, T | 1 |
| Zucker, JM | 1 |
| Czorny, A | 1 |
| Lapras, C | 1 |
| Brunat-Mentigny, M | 1 |
| Lerner, HJ | 1 |
| Beckloff, GL | 1 |
| Godwin, MC | 1 |
1 review available for hydroxyurea and Astrocytoma
| Article | Year |
|---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
5 trials available for hydroxyurea and Astrocytoma
| Article | Year |
|---|---|
Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemother | 2012 |
Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Benzamide | 2007 |
Pilot study of 6 weeks of chemoradiotherapy with 5 FU and hydroxyurea in malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined | 1993 |
5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chemotherapy, Adjuvant; Dr | 1993 |
A phase III comparison of BCNU, hydroxyurea, and radiation therapy to BCNU and radiation therapy for treatment of primary malignant gliomas.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Cobalt Radioisotope | 1979 |
8 other studies available for hydroxyurea and Astrocytoma
| Article | Year |
|---|---|
5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bra | 1984 |
Assessment of brain tumor cell motility in vivo and in vitro.
Topics: Amidines; Animals; Astrocytoma; Brain Neoplasms; Cell Movement; Clone Cells; Cytochalasin B; Fibrone | 1995 |
PKC activity in rat C6 glioma cells: changes associated with cell cycle and simvastatin treatment.
Topics: Animals; Astrocytoma; Cell Cycle; Demecolcine; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitor | 1994 |
Taxol, vincristine or nocodazole induces lethality in G1-checkpoint-defective human astrocytoma U373MG cells by triggering hyperploid progression.
Topics: Astrocytoma; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Division; Cyclin-Dependent Kinase Inh | 1999 |
Fibrinolysis induced by rat glioma cells. A mitosis-triggered process?
Topics: Animals; Astrocytoma; Cell Line; Dactinomycin; Fibrin Fibrinogen Degradation Products; Fibrinolysis; | 1978 |
Eight drugs in one day chemotherapy for brain tumors: experience in 107 children and rationale for preradiation chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Cisplatin; Comb | 1987 |
[Efficacy of the "8 drugs in a day" protocol in brain tumors in children].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cer | 1988 |
Treatment of astrocytoma with hydroxyurea and irradiation: report of six patients with 18-month follow-up.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Female; Follow-Up Studies; Humans; Hydroxyurea; Male; Mid | 1970 |