Page last updated: 2024-10-28

hydroxyurea and Anoxemia

hydroxyurea has been researched along with Anoxemia in 18 studies

Research Excerpts

ExcerptRelevanceReference
"Ischemic stroke is characterized by high morbidity, disability, and mortality."5.91Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke. ( Hong, Y; Hu, F; Jin, X; Ke, J; Li, S; Shang, X; Wang, K; Wen, L; Wu, X; Xu, Y; Yuan, H; Zhou, W, 2023)
"The root cause of sickle cell disease is a single beta-globin gene mutation coding for the sickle beta-hemoglobin chain."2.44Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches. ( Steinberg, MH, 2008)
"Ischemic stroke is characterized by high morbidity, disability, and mortality."1.91Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke. ( Hong, Y; Hu, F; Jin, X; Ke, J; Li, S; Shang, X; Wang, K; Wen, L; Wu, X; Xu, Y; Yuan, H; Zhou, W, 2023)
"Sickle cell anemia is a type of hemoglobinopathy characterized by a specific mutation in the beta globin gene with the consequent generation of an unstable hemoglobin that crystallizes in a state of hypoxia."1.62[Disease genotype, haplotypes, diagnosis and associated studies in sickle cell anemia]. ( Benavides-Benítez, E; Bernal, JE; Briceño-Balcázar, I; Díaz-Matallana, M; Márquez-Benítez, Y; Martínez-Lozano, JC, 2021)
" Our results showed, for the first time, a significantly increased expression of HIF-1α and VEGF genes in patients with SCA and an inverse dose-response relationship with hydroxyurea therapy."1.56Gene expression of HIF-1α and VEGF in response to hypoxia in sickle cell anaemia: Influence of hydroxycarbamide. ( Lemes, RPG; Pedrosa, AM, 2020)
"In cultured ovarian cancer cells, 5-LOX metabolites were increased under hypoxic conditons."1.42Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration. ( Fan, B; Gao, W; Li, B; Li, M; Liu, H; Qu, X; Shao, Q; Wang, Q; Wen, Z; Xie, Q; Yang, Y; Yu, J; Zhao, F, 2015)
"Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease."1.35Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea. ( Aygun, B; Koumbourlis, AC; Singh, SA, 2008)
"The EMH-related pleural effusion is rarely referred to in the literature of thalassemia."1.33Extramedullary hematopoiesis-related pleural effusion: the case of beta-thalassemia. ( Aessopos, A; Farmakis, D; Kati, M; Moyssakis, I; Polonifi, K; Tassiopoulos, S; Tsironi, M, 2006)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's0 (0.00)18.2507
2000's8 (44.44)29.6817
2010's4 (22.22)24.3611
2020's4 (22.22)2.80

Authors

AuthorsStudies
Díaz-Matallana, M1
Márquez-Benítez, Y1
Martínez-Lozano, JC1
Briceño-Balcázar, I1
Benavides-Benítez, E1
Bernal, JE1
Wang, K1
Zhou, W1
Jin, X1
Shang, X1
Wu, X1
Wen, L1
Li, S1
Hong, Y1
Ke, J1
Xu, Y1
Yuan, H1
Hu, F1
Pedrosa, AM1
Lemes, RPG1
Liguoro, I1
Arigliani, M1
Singh, B1
Rees, D1
Inusa, BPD1
Gupta, A1
Ip, H1
Kesse-Adu, R1
Howard, J1
Hart, N1
Wen, Z1
Liu, H1
Li, M1
Li, B1
Gao, W1
Shao, Q1
Fan, B1
Zhao, F1
Wang, Q1
Xie, Q1
Yang, Y1
Yu, J1
Qu, X1
Lopes, FC1
Ferreira, R1
Albuquerque, DM1
Silveira, AA1
Costa, R1
Soares, R1
Costa, FF1
Conran, N1
Steinberg, MH1
Economopoulou, M1
Langer, HF1
Celeste, A1
Orlova, VV1
Choi, EY1
Ma, M1
Vassilopoulos, A1
Callen, E1
Deng, C1
Bassing, CH1
Boehm, M1
Nussenzweig, A1
Chavakis, T1
Chernoff, N1
Rogers, JM1
Aessopos, A1
Tassiopoulos, S1
Farmakis, D1
Moyssakis, I1
Kati, M1
Polonifi, K1
Tsironi, M1
Singh, SA1
Koumbourlis, AC1
Aygun, B1
Bates, N1
Chimploy, K1
Tassotto, ML1
Mathews, CK1
Vacek, A1
Tacev, T1
Hofer, M1
Wetter, TJ1
Xiang, Z1
Sonetti, DA1
Haverkamp, HC1
Rice, AJ1
Abbasi, AA1
Meyer, KC1
Dempsey, JA1
Yamada, S1
Perot, PL1
Ducker, TB1
Gale, GR1
Dawson, KB1
Madoc-Jones, H1
Mauro, F1
Peacock, JH1

Reviews

2 reviews available for hydroxyurea and Anoxemia

ArticleYear
Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches.
    TheScientificWorldJournal, 2008, Dec-25, Volume: 8

    Topics: alpha-Thalassemia; Anemia, Sickle Cell; Erythrocyte Membrane; Female; Hemoglobin, Sickle; Humans; Hy

2008
Hypoxia and the Edema Syndrome: elucidation of a mechanism of teratogenesis.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2010, Volume: 89, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Blister; Chick Embryo; Cocaine; Edema; Epinephrine; Hematoma;

2010

Other Studies

16 other studies available for hydroxyurea and Anoxemia

ArticleYear
[Disease genotype, haplotypes, diagnosis and associated studies in sickle cell anemia].
    Revista medica de Chile, 2021, Volume: 149, Issue:9

    Topics: Anemia, Sickle Cell; Haplotypes; Humans; Hydroxyurea; Hypoxia

2021
Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke.
    Nanoscale, 2023, Jul-13, Volume: 15, Issue:27

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Endothelial Cells; Hydroxyurea; Hypoxia; Ischem

2023
Gene expression of HIF-1α and VEGF in response to hypoxia in sickle cell anaemia: Influence of hydroxycarbamide.
    British journal of haematology, 2020, Volume: 190, Issue:1

    Topics: Adolescent; Adult; Aged; Anemia, Sickle Cell; Antisickling Agents; Case-Control Studies; Female; Gen

2020
Long-term oxygen therapy in children with sickle cell disease and hypoxaemia.
    Archives of disease in childhood, 2021, Volume: 106, Issue:3

    Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Case-Control Studies; Child; Chronic Disease;

2021
Low flow nocturnal oxygen therapy does not suppress haemoglobin levels or increase painful crises in sickle cell disease.
    British journal of haematology, 2013, Volume: 161, Issue:3

    Topics: Adult; Anemia, Sickle Cell; Antisickling Agents; Erythropoiesis; Erythropoietin; Female; Hemoglobins

2013
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.
    Oncogene, 2015, Mar-05, Volume: 34, Issue:10

    Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Cell Line, Tumor; Chemotaxis, Leukocyte; Disease Mo

2015
In vitro and in vivo anti-angiogenic effects of hydroxyurea.
    Microvascular research, 2014, Volume: 94

    Topics: Anemia, Sickle Cell; Angiogenesis Inhibitors; Animals; Cell Movement; Cell Proliferation; Human Umbi

2014
Histone H2AX is integral to hypoxia-driven neovascularization.
    Nature medicine, 2009, Volume: 15, Issue:5

    Topics: Animals; DNA Damage; Endothelium, Vascular; Gene Deletion; Hindlimb; Histones; Humans; Hydroxyurea;

2009
Extramedullary hematopoiesis-related pleural effusion: the case of beta-thalassemia.
    The Annals of thoracic surgery, 2006, Volume: 81, Issue:6

    Topics: Adult; Atrial Fibrillation; beta-Thalassemia; Blood Transfusion; Chest Tubes; Combined Modality Ther

2006
Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:6

    Topics: Anemia, Sickle Cell; Antisickling Agents; Child; Chronic Disease; Female; Humans; Hydroxyurea; Hypox

2008
Hydroxycarbamide (hydroxyurea) toxicity in dogs.
    The Journal of small animal practice, 2008, Volume: 49, Issue:4

    Topics: Animals; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxyurea; Hypox

2008
Ribonucleotide reductase, a possible agent in deoxyribonucleotide pool asymmetries induced by hypoxia.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Animals; Cells, Cultured; Cricetinae; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguan

2000
Modulation of radioprotective effects of respiratory hypoxia by changing the duration of hypoxia before irradiation and by combining hypoxia and administration of hemopoiesis-stimulating agents.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2001, Volume: 177, Issue:9

    Topics: Adaptation, Physiological; Animals; Antineoplastic Agents; Cobalt Radioisotopes; Dextran Sulfate; Fe

2001
Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:1

    Topics: Adult; Cell Count; Exercise; Female; Histamine H1 Antagonists; Humans; Hydroxyurea; Hypoxia; Inflamm

2002
Effect of prolonged continuous intracarotid arterial perfusion of hydroxyurea on the normal monkey brain.
    The American surgeon, 1974, Volume: 40, Issue:4

    Topics: Animals; Brain; Carotid Arteries; Glioblastoma; Haplorhini; Hydroxyurea; Hypoxia; Macaca; Methods; P

1974
Studies on the radiobiology of a rat sarcoma treated in situ and assayed in vitro.
    European journal of cancer, 1973, Volume: 9, Issue:1

    Topics: Animals; Cell Survival; Cells, Cultured; Clone Cells; Hydroxyurea; Hypoxia; Neoplasm Transplantation

1973