hydroxyurea and Alzheimer Disease
hydroxyurea has been researched along with Alzheimer Disease in 7 studies
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"5-Lipoxygenase (5LO) is upregulated in Alzheimer's disease (AD) and in vivo modulates the amyloidotic phenotype of amyloid precursor protein transgenic mice." | 1.40 | Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease. ( Chu, J; Giannopoulos, PF; Joshi, YB; Kirby, LG; Li, JG; Praticò, D; Sperow, M, 2014) |
"Zileuton treatment did not induce any change in the steady state levels of amyloid-β precursor protein (APP), BACE1 or ADAM10." | 1.37 | Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase. ( Chu, J; Praticò, D, 2011) |
Research
Studies (7)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (14.29) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 6 (85.71) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Li, JG | 3 |
Barrero, C | 1 |
Merali, S | 1 |
Praticò, D | 5 |
Brose, RD | 1 |
Lehrmann, E | 1 |
Zhang, Y | 1 |
Reeves, RH | 1 |
Smith, KD | 1 |
Mattson, MP | 1 |
Giannopoulos, PF | 1 |
Chu, J | 3 |
Joshi, YB | 1 |
Sperow, M | 1 |
Kirby, LG | 1 |
Di Meco, A | 1 |
Lauretti, E | 1 |
Vagnozzi, AN | 1 |
Smith, TA | 1 |
Neary, D | 1 |
Itzhaki, RF | 1 |
Other Studies
7 other studies available for hydroxyurea and Alzheimer Disease
Article | Year |
---|---|
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Diet; DNA Methylation; Female; | 2017 |
Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cells, Cultured; Disease Models | 2018 |
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arachidonate 5-Lipoxygenase | 2014 |
Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2013 |
Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Amyloidogenic Proteins; Animals; Arachidona | 2014 |
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Fe | 2011 |
DNA repair in lymphocytes from young and old individuals and from patients with Alzheimer's disease.
Topics: Adult; Aged; Aging; Alzheimer Disease; Cell Survival; DNA; DNA Repair; Female; Gamma Rays; Humans; H | 1987 |