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hydroxyurea and Alzheimer Disease

hydroxyurea has been researched along with Alzheimer Disease in 7 studies

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"5-Lipoxygenase (5LO) is upregulated in Alzheimer's disease (AD) and in vivo modulates the amyloidotic phenotype of amyloid precursor protein transgenic mice."1.40Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease. ( Chu, J; Giannopoulos, PF; Joshi, YB; Kirby, LG; Li, JG; Praticò, D; Sperow, M, 2014)
"Zileuton treatment did not induce any change in the steady state levels of amyloid-β precursor protein (APP), BACE1 or ADAM10."1.37Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase. ( Chu, J; Praticò, D, 2011)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, JG3
Barrero, C1
Merali, S1
Praticò, D5
Brose, RD1
Lehrmann, E1
Zhang, Y1
Reeves, RH1
Smith, KD1
Mattson, MP1
Giannopoulos, PF1
Chu, J3
Joshi, YB1
Sperow, M1
Kirby, LG1
Di Meco, A1
Lauretti, E1
Vagnozzi, AN1
Smith, TA1
Neary, D1
Itzhaki, RF1

Other Studies

7 other studies available for hydroxyurea and Alzheimer Disease

ArticleYear
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
    Scientific reports, 2017, 04-06, Volume: 7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Diet; DNA Methylation; Female;

2017
Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease.
    Neurobiology of aging, 2018, Volume: 72

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cells, Cultured; Disease Models

2018
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
    Molecular psychiatry, 2014, Volume: 19, Issue:4

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arachidonate 5-Lipoxygenase

2014
Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein

2013
Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice.
    Neurobiology of aging, 2014, Volume: 35, Issue:11

    Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Amyloidogenic Proteins; Animals; Arachidona

2014
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.
    The American journal of pathology, 2011, Volume: 178, Issue:4

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Fe

2011
DNA repair in lymphocytes from young and old individuals and from patients with Alzheimer's disease.
    Mutation research, 1987, Volume: 184, Issue:2

    Topics: Adult; Aged; Aging; Alzheimer Disease; Cell Survival; DNA; DNA Repair; Female; Gamma Rays; Humans; H

1987
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