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hydroxyurea and Agranulocytosis

hydroxyurea has been researched along with Agranulocytosis in 9 studies

Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Research Excerpts

ExcerptRelevanceReference
"Hydroxyurea is an old drug that is often used to control essential thrombocythemia and polycythemia vera in patients with high-risk disease."8.83Hydroxyurea: The drug of choice for polycythemia vera and essential thrombocythemia. ( Dingli, D; Tefferi, A, 2006)
"Hydroxyurea is an old drug that is often used to control essential thrombocythemia and polycythemia vera in patients with high-risk disease."4.83Hydroxyurea: The drug of choice for polycythemia vera and essential thrombocythemia. ( Dingli, D; Tefferi, A, 2006)
"To see whether circulating granulocytes are of importance in mediating endotoxin-induced pulmonary failure with similar characteristics to the human adult respiratory distress syndrome (ARDS), we made pigs granulocytopenic by injecting hydroxyurea via a central venous line for 10 days."3.67Prevention by granulocyte depletion of endotoxin-induced adult respiratory distress syndrome. An experimental study in pigs. ( Modig, J; Samuelsson, T, 1987)
"Twenty-six Holstein calves were treated with hydroxyurea in order to induce neutropenia."3.67Neutrophil depletion of calves with hydroxyurea: methods and clinical and pathologic effects. ( Derksen, FJ; Ingersoll, R; Malark, J; Robinson, NE; Slocombe, RF, 1986)
"Hydroxyurea has documented laboratory efficacy with increases in Hb and HbF; treatment also significantly reduces the number of painful episodes, acute chest syndrome, transfusions, and hospitalizations."2.49Hydroxycarbamide: clinical aspects. ( Ware, RE, 2013)
"All rabbits died of respiratory failure with pulmonary edema, and although chemotherapy decreased the number of neutrophils in the lungs by greater than 90%, it did not influence survival time or extravascular lung water content."1.27Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs. ( Bland, RD; Hazinski, TA; Raj, JU, 1985)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19906 (66.67)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ware, RE1
Dingli, D1
Tefferi, A1
Hinson, JM1
Hutchison, AA1
Ogletree, ML1
Brigham, KL1
Snapper, JR1
Lo, SK1
Garcia-Szabo, RR1
Malik, AB1
Modig, J1
Samuelsson, T1
Slocombe, RF1
Malark, J1
Ingersoll, R1
Derksen, FJ1
Robinson, NE1
Vacca, M1
De Gori, N1
Del Carmine, R1
Navarra, PL1
Preziosi, P1
Raj, JU1
Hazinski, TA1
Bland, RD1
Rickard, KA1
Morley, A1
Howard, D1
Stohlman, F1

Reviews

2 reviews available for hydroxyurea and Agranulocytosis

ArticleYear
Hydroxycarbamide: clinical aspects.
    Comptes rendus biologies, 2013, Volume: 336, Issue:3

    Topics: Agranulocytosis; Anemia, Sickle Cell; Antisickling Agents; Clinical Trials as Topic; Developing Coun

2013
Hydroxyurea: The drug of choice for polycythemia vera and essential thrombocythemia.
    Current hematologic malignancy reports, 2006, Volume: 1, Issue:2

    Topics: Aged; Agranulocytosis; Alkylating Agents; Clinical Trials as Topic; Combined Modality Therapy; Disea

2006

Other Studies

7 other studies available for hydroxyurea and Agranulocytosis

ArticleYear
Effect of granulocyte depletion on altered lung mechanics after endotoxemia in sheep.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1983, Volume: 55, Issue:1 Pt 1

    Topics: Agranulocytosis; Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Endotoxins; Escher

1983
Leukocyte repletion reverses protective effect of neutropenia in thrombin-induced increase in lung vascular permeability.
    The American journal of physiology, 1990, Volume: 259, Issue:1 Pt 2

    Topics: Agranulocytosis; Animals; Capillary Permeability; Hydroxyurea; Leukocyte Count; Leukocytes; Lung; Ly

1990
Prevention by granulocyte depletion of endotoxin-induced adult respiratory distress syndrome. An experimental study in pigs.
    Resuscitation, 1987, Volume: 15, Issue:3

    Topics: Agranulocytosis; Animals; Endotoxins; Escherichia coli; Female; Granulocytes; Hemodynamics; Hydroxyu

1987
Neutrophil depletion of calves with hydroxyurea: methods and clinical and pathologic effects.
    American journal of veterinary research, 1986, Volume: 47, Issue:10

    Topics: Agranulocytosis; Animals; Bone Marrow; Cattle; Cattle Diseases; Hydroxyurea; Male; Neutropenia

1986
Replacement therapy against increased hydroxyurea toxicity in pituitary or adrenal ablated rats.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1985, Volume: 8

    Topics: Adrenalectomy; Agranulocytosis; Animals; Corticosterone; Cosyntropin; Desoxycorticosterone; Drug The

1985
Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1985, Volume: 58, Issue:3

    Topics: Agranulocytosis; Animals; Blood Pressure; Capillary Permeability; Cardiac Output; Hydroxyurea; Lung;

1985
The in vitro colony-forming cell and the response to neutropenia.
    Blood, 1971, Volume: 37, Issue:1

    Topics: Agranulocytosis; Animals; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Clone Cells; Culture

1971