hydroxyurea has been researched along with Adult Spinal Muscular Atrophy in 8 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxyurea (HU) has recently been shown to increase full-length SMN transcript in cultured lymphocytes from patients with SMA." | 1.37 | Hydroxyurea enhances SMN2 gene expression through nitric oxide release. ( Chen, X; Ganta, M; Grzeschik, SM; Wang, CH; Xu, C, 2011) |
| "Hydroxyurea treatment resulted in a time-related and dose-dependent increase in the ratio of full-length to truncated SMN messenger RNA." | 1.33 | Hydroxyurea enhances SMN2 gene expression in spinal muscular atrophy cells. ( Ganta, M; Grzeschik, SM; Heavlin, WD; Prior, TW; Wang, CH, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, P | 1 |
| Liew, WK | 1 |
| Darras, BT | 1 |
| Mattis, VB | 1 |
| Butchbach, ME | 1 |
| Lorson, CL | 1 |
| Bönnemann, CG | 1 |
| Finkel, RS | 1 |
| Chen, TH | 1 |
| Chang, JG | 2 |
| Yang, YH | 1 |
| Mai, HH | 1 |
| Liang, WC | 2 |
| Wu, YC | 1 |
| Wang, HY | 2 |
| Huang, YB | 1 |
| Wu, SM | 1 |
| Chen, YC | 2 |
| Yang, SN | 1 |
| Jong, YJ | 2 |
| Xu, C | 1 |
| Chen, X | 1 |
| Grzeschik, SM | 2 |
| Ganta, M | 2 |
| Wang, CH | 2 |
| Also-Rallo, E | 1 |
| Alías, L | 1 |
| Martínez-Hernández, R | 1 |
| Caselles, L | 1 |
| Barceló, MJ | 1 |
| Baiget, M | 1 |
| Bernal, S | 1 |
| Tizzano, EF | 1 |
| Prior, TW | 1 |
| Heavlin, WD | 1 |
| Yuo, CY | 1 |
| Chang, YF | 1 |
| Ju, YH | 1 |
| Chiou, SS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Placebo-Controlled Trial of Hydroxyurea in Spinal Muscular Atrophy[NCT00485511] | Phase 2/Phase 3 | 0 participants | Interventional | 2007-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyurea and Adult Spinal Muscular Atrophy
| Article | Year |
|---|---|
Current advances in drug development in spinal muscular atrophy.
Topics: Animals; Child; Child, Preschool; Disease Models, Animal; Drug Design; Female; Genetic Therapy; Huma | 2013 |
2 trials available for hydroxyurea and Adult Spinal Muscular Atrophy
| Article | Year |
|---|---|
Randomized, double-blind, placebo-controlled trial of hydroxyurea in spinal muscular atrophy.
Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; F | 2010 |
The effect of hydroxyurea in spinal muscular atrophy cells and patients.
Topics: Adolescent; Adult; Cells, Cultured; Child; Child, Preschool; Cyclic AMP Response Element-Binding Pro | 2008 |
5 other studies available for hydroxyurea and Adult Spinal Muscular Atrophy
| Article | Year |
|---|---|
Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cells, Cultured; Disease | 2008 |
Linking SMN to SMA: an assay for the rescuer.
Topics: Cell Survival; Central Nervous System Agents; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyurea | 2008 |
Hydroxyurea enhances SMN2 gene expression through nitric oxide release.
Topics: Base Sequence; Cell Line; Cyclic N-Oxides; DNA Primers; Free Radical Scavengers; Gene Expression; Hu | 2011 |
Treatment of spinal muscular atrophy cells with drugs that upregulate SMN expression reveals inter- and intra-patient variability.
Topics: Cell Line, Transformed; Cells, Cultured; Drug Resistance; Female; Fibroblasts; Frameshift Mutation; | 2011 |
Hydroxyurea enhances SMN2 gene expression in spinal muscular atrophy cells.
Topics: Blotting, Western; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; En | 2005 |