hydroxyurea has been researched along with Adult Premature Aging Syndrome in 8 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " We show here that antisense suppression of WRN in two human glioma cell lines reproduces hallmarks of the drug cytotoxicity profile of WS cells, namely, hypersensitivity to 4-nitroquinoline 1-oxide, camptothecin and hydroxyurea." | 3.72 | The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. ( Blank, A; Bobola, MS; D Kolstoe, D; Gold, B; Loeb, LA; Meade, EH; Rabinovitch, PS; Silber, JR; Varadarajan, S, 2004) |
| "Werner syndrome is a genetic disorder characterized by genomic instability, elevated recombination and replication defects." | 1.32 | In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. ( Brosh, RM; Sharma, S; Sommers, JA, 2004) |
| "Bloom's syndrome (BS) and Werner's syndrome (WS) are genetic disorders in which an increased rate of chromosomal aberration is detected." | 1.30 | Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. ( Furuichi, Y; Goto, M; Ikeda, H; Kato, J; Shimamoto, A; Yamagata, K, 1998) |
| "Hydroxyurea post-treatment potentiated the X-ray-induced aberration levels both in the normal and Werner's syndrome (KO375 and DJG) cell lines; in contrast caffeine was only effective in the normal cell line." | 1.30 | Lack of effect of caffeine post-treatment on X-ray-induced chromosomal aberrations in Werner's syndrome lymphoblastoid cell lines: a preliminary report. ( Franchitto, A; Mosesso, P; Palitti, F; Pichierri, P; Proietti De Santis, L, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pichierri, P | 3 |
| Rosselli, F | 1 |
| Franchitto, A | 3 |
| Blank, A | 1 |
| Bobola, MS | 1 |
| Gold, B | 1 |
| Varadarajan, S | 1 |
| D Kolstoe, D | 1 |
| Meade, EH | 1 |
| Rabinovitch, PS | 1 |
| Loeb, LA | 1 |
| Silber, JR | 1 |
| Sharma, S | 1 |
| Sommers, JA | 1 |
| Brosh, RM | 1 |
| Stewart, E | 1 |
| Chapman, CR | 1 |
| Al-Khodairy, F | 1 |
| Carr, AM | 1 |
| Enoch, T | 1 |
| Yamagata, K | 1 |
| Kato, J | 1 |
| Shimamoto, A | 1 |
| Goto, M | 1 |
| Furuichi, Y | 1 |
| Ikeda, H | 1 |
| Proietti De Santis, L | 1 |
| Mosesso, P | 2 |
| Palitti, F | 2 |
| Onoda, F | 1 |
| Seki, M | 1 |
| Miyajima, A | 1 |
| Enomoto, T | 1 |
8 other studies available for hydroxyurea and Adult Premature Aging Syndrome
| Article | Year |
|---|---|
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.
Topics: Ataxia Telangiectasia Mutated Proteins; Camptothecin; Cell Cycle Proteins; Cell Nucleus Structures; | 2003 |
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.
Topics: 4-Nitroquinoline-1-oxide; Adenine; Alkylating Agents; Antineoplastic Agents; Apoptosis; Camptothecin | 2004 |
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication.
Topics: Adenosine Triphosphatases; Catalytic Domain; Cell Cycle; Cells, Cultured; Conserved Sequence; DNA He | 2004 |
rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Bloom Syndrome; DNA Helicases; DNA Replication; Exod | 1997 |
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.
Topics: Base Sequence; Bloom Syndrome; DNA; DNA Helicases; Humans; Hydroxyurea; Mutation; Recombination, Gen | 1998 |
Lack of effect of caffeine post-treatment on X-ray-induced chromosomal aberrations in Werner's syndrome lymphoblastoid cell lines: a preliminary report.
Topics: Caffeine; Cell Line, Transformed; Cell Transformation, Viral; Chromosome Aberrations; Chromosomes, H | 1999 |
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.
Topics: Alleles; Bloom Syndrome; DNA Helicases; Dose-Response Relationship, Drug; Genetic Complementation Te | 2000 |
Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.
Topics: Apoptosis; Camptothecin; Cells, Cultured; Comet Assay; DNA Damage; DNA Helicases; DNA Nucleotidyltra | 2001 |