hydroxyurea has been researched along with Abnormalities, Drug-Induced in 58 studies
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exposure to hydroxyurea caused a dose-dependent increase in fetal deaths that was not affected by hSOD1 expression; hydroxyurea decreased fetal weights in litters from wild-type but not hemizygous dams." | 3.75 | The impact of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea. ( Hales, BF; Larouche, G, 2009) |
| "On day 10 of pregnancy NMRI mice received an intraperitoneal injection of either 500 mg/kg hydroxyurea (HU) or 500 mg/kg HU plus 500, 700, 800, or 900 mg/kg deoxycytidine monophosphate (dCMP)." | 3.67 | The influence of deoxycytidine monophosphate (dCMP) on the cytotoxicity of hydroxyurea in the embryonic spinal cord of the mouse. ( Herken, R, 1984) |
| "Aspirin (ASS) was the most frequently used drug in 47 of 93 recorded cases (51%)." | 2.39 | Essential thrombocythemia and pregnancy. ( Griesshammer, M; Heimpel, H; Pearson, TC, 1996) |
| " From the dosage or exposure of laboratory animals, embryonic and maternal concentrations of the xenobiotic are calculated using a physiologically based pharmacokinetic (PBPK) model." | 1.30 | Mathematical analysis for teratogenic sensitivity. ( Luecke, RH; Wosilait, WD; Young, JF, 1997) |
| " Dose-response data of 6-MPr (s." | 1.30 | Combined prenatal toxicity of 6-mercaptopurine riboside and hydroxyurea in mice. ( Platzek, T; Schwabe, R, 1999) |
| "Hydroxyurea (HU) is a swiftly acting cytotoxic teratogen and an inhibitor of DNA synthesis." | 1.28 | The nature of the embryo-protective interaction of propyl gallate with hydroxyurea. ( DeSesso, JM; Goeringer, GC, 1990) |
| "Hydroxyurea (HU) is a potent teratogen that causes a characteristic, rapidly occurring episode of embryonic cell death 2 to 4 h after subcutaneously injecting 650 mg/kg of HU into pregnant New Zealand White rabbits on gestational day 12." | 1.28 | Ethoxyquin and nordihydroguaiaretic acid reduce hydroxyurea developmental toxicity. ( DeSesso, JM; Goeringer, GC, 1990) |
| "For cycloheximide, the values were 1." | 1.27 | Analysis of the activity of DNA, RNA, and protein synthesis inhibitors on Xenopus embryo development. ( Bantle, JA; Courchesne, CL, 1985) |
| "Timed-pregnant Fischer 344 rats were dosed by gavage with aniline hydrochloride (10, 30, or 100 mg/kg/day), a positive control agent (hydroxyurea, 200 mg/kg/day), or vehicle (distilled water) on gestational days (gd) 7 through 20 or gd 7 through parturition." | 1.27 | Teratologic and postnatal evaluation of aniline hydrochloride in the Fischer 344 rat. ( Ledoux, TA; Marks, TA; Paschke, LL; Price, CJ; Reel, JR; Tyl, RW, 1985) |
| " In our experimental conditions, the dose level of 300 mg/kg is regarded as a suitable positive control dosage in teratological testing of new molecules by oral route." | 1.26 | Hydroxyurea as a reference standard in teratological screening. Comparison of the embryotoxic and teratogenic effects following single intraperitoneal or repeated oral administrations to pregnant rats. ( Aliverti, V; Bonanomi, L; Giavini, E, 1980) |
| "Aspirin was administered in single oral doses of 500 and 625 mg/kg on d 10; hydroxyurea was injected ip at 500 mg/kg on d 11." | 1.26 | Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains. ( DePass, LR; Weaver, EV, 1982) |
| "Hydroxyurea is a cytotoxic agent used in the management of chronic granulocytic leukemia." | 1.26 | Effects of hydroxyurea on hemodynamics of pregnant rabbits: a maternally mediated mechanism of embryotoxicity. ( Clark, KE; DeSesso, JM; Kleinman, LI; Millicovsky, G, 1981) |
| "Hydroxyurea (HU) is a potent teratogen which caused 100% embryotoxic effects in New Zealand white rabbits when injected sc on gestational day 12." | 1.26 | Amelioration of teratogenesis. I. Modification of hydroxyurea-induced teratogenesis by the antioxidant propyl gallate. ( DeSesso, JM, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (70.69) | 18.7374 |
| 1990's | 5 (8.62) | 18.2507 |
| 2000's | 7 (12.07) | 29.6817 |
| 2010's | 5 (8.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Banh, S | 1 |
| Hales, BF | 4 |
| Guan, Z | 1 |
| Wang, X | 1 |
| Dong, Y | 1 |
| Xu, L | 1 |
| Zhu, Z | 1 |
| Wang, J | 1 |
| Zhang, T | 1 |
| Niu, B | 1 |
| Larouche, G | 1 |
| Chernoff, N | 1 |
| Rogers, JM | 1 |
| Pérez-Pastén, R | 1 |
| Martínez-Galero, E | 1 |
| Chamorro-Cevallos, G | 1 |
| Schlisser, AE | 1 |
| Yan, J | 2 |
| MURPHY, ML | 2 |
| CHAUBE, S | 2 |
| Green, AR | 1 |
| Vassiliou, GS | 1 |
| Curtin, N | 1 |
| Campbell, PJ | 1 |
| Woo, GH | 1 |
| Katayama, K | 1 |
| Bak, EJ | 1 |
| Ueno, M | 1 |
| Yamauchi, H | 1 |
| Uetsuka, K | 1 |
| Nakayama, H | 1 |
| Doi, K | 1 |
| Meyappan, JD | 1 |
| Lampl, M | 1 |
| Hsu, LL | 1 |
| Paul, SR | 1 |
| Balasooriya, U | 1 |
| Banerjee, T | 1 |
| Soukup, S | 1 |
| Takacs, E | 1 |
| Warkany, J | 1 |
| Ritter, EJ | 6 |
| Scott, WJ | 6 |
| Wilson, JG | 5 |
| Mathinos, PR | 1 |
| Randall, JL | 1 |
| Bertoli, D | 1 |
| Borelli, G | 1 |
| Herken, R | 2 |
| Warner, CW | 1 |
| Sadler, TW | 2 |
| Shockey, J | 1 |
| Smith, MK | 1 |
| Baumann, M | 1 |
| Sander, K | 1 |
| Skalko, RG | 2 |
| Kwasigroch, TE | 2 |
| Aliverti, V | 1 |
| Bonanomi, L | 1 |
| Giavini, E | 1 |
| Sugrue, SP | 1 |
| Desesso, JM | 6 |
| DePass, LR | 1 |
| Weaver, EV | 1 |
| Millicovsky, G | 1 |
| Kleinman, LI | 1 |
| Clark, KE | 1 |
| Barr, M | 1 |
| Beaudoin, AR | 1 |
| Griesshammer, M | 1 |
| Heimpel, H | 1 |
| Pearson, TC | 1 |
| Luecke, RH | 1 |
| Wosilait, WD | 1 |
| Young, JF | 1 |
| Platzek, T | 1 |
| Schwabe, R | 1 |
| Khera, KS | 1 |
| Theisen, CT | 1 |
| Brunner, RL | 1 |
| McLean, M | 1 |
| Vorhees, CV | 1 |
| Butcher, RE | 2 |
| Jordan, RL | 1 |
| Cardell, RR | 1 |
| Krowke, R | 1 |
| Bochert, G | 1 |
| Goeringer, GC | 2 |
| Courchesne, CL | 1 |
| Bantle, JA | 2 |
| Dawson, DA | 1 |
| Asano, Y | 1 |
| Okaniwa, A | 1 |
| Moore, EC | 1 |
| Hurlbert, RB | 1 |
| Price, CJ | 1 |
| Tyl, RW | 1 |
| Marks, TA | 1 |
| Paschke, LL | 1 |
| Ledoux, TA | 1 |
| Reel, JR | 1 |
| Stoll, R | 1 |
| Bodit, F | 1 |
| Maraud, R | 1 |
| Roll, R | 1 |
| Bär, F | 1 |
| Hervet, E | 1 |
| Barrat, J | 1 |
| Darbois, Y | 1 |
| Faguer, C | 1 |
| Jusko, WJ | 1 |
| Kazmaier, K | 1 |
| von Kreybig, T | 3 |
| Schreiner, L | 1 |
| Roba, J | 1 |
| Lambelin, G | 1 |
| Buu-Hoï, NP | 1 |
| Preussmann, R | 1 |
| Schmidt, W | 1 |
6 reviews available for hydroxyurea and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Hypoxia and the Edema Syndrome: elucidation of a mechanism of teratogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Blister; Chick Embryo; Cocaine; Edema; Epinephrine; Hematoma; | 2010 |
Management of the myeloproliferative disorders : distinguishing data from dogma.
Topics: Abnormalities, Drug-Induced; Adult; Aged; Anticoagulants; Contraindications; Female; Humans; Hydroxy | 2004 |
Essential thrombocythemia and pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Aspirin; Busulfan; Combined Modality Therapy; Di | 1996 |
Digital abnormalities in monkeys and rats.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Cell Division; Cell Survival; Cytarabine; DNA; | 1977 |
The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Ce | 1985 |
[Carcinogenesis and teratogenesis. Comparative studies from the viewpoint of teratology].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Cycloph | 1970 |
52 other studies available for hydroxyurea and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Hydroxyurea exposure triggers tissue-specific activation of p38 mitogen-activated protein kinase signaling and the DNA damage response in organogenesis-stage mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Cell Nucleus; Cytoplasm; DNA; DNA Damage; Dose-Response Relati | 2013 |
dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development.
Topics: Abnormalities, Drug-Induced; Animals; Apoptosis; Brain; Caspase 3; Cell Proliferation; Deoxyribonucl | 2015 |
The impact of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Disease Models, Animal; Enzyme Inhibitors; Fem | 2009 |
Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Cytoprotection; Dose-Response Relationship, Drug | 2010 |
Teratogen-induced oxidative stress targets glyceraldehyde-3-phosphate dehydrogenase in the organogenesis stage mouse embryo.
Topics: Abnormalities, Drug-Induced; Aldehydes; Animals; Aspartate Aminotransferase, Mitochondrial; Cell Nuc | 2010 |
PRELIMINARY SURVEY OF HYDROXYUREA (NSC-32065) AS A TERATOGEN.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Data Collection; Echinodermata; Embryo, Mammalia | 1964 |
Effects of prenatal hydroxyurea-treatment on mouse offspring.
Topics: Abnormalities, Drug-Induced; Animals; Apoptosis; Female; Fetus; Hydroxyurea; Male; Mice; Mice, Inbre | 2004 |
Parents' assessment of risk in sickle cell disease treatment with hydroxyurea.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; Child; Chi | 2005 |
Fisher information matrix of the Dirichlet-multinomial distribution.
Topics: Abnormalities, Drug-Induced; Animals; Biometry; Data Interpretation, Statistical; Female; Hydroxyure | 2005 |
Depletion of glutathione induces 4-hydroxynonenal protein adducts and hydroxyurea teratogenicity in the organogenesis stage mouse embryo.
Topics: Abnormalities, Drug-Induced; Aldehydes; Animals; Buthionine Sulfoximine; DNA; Embryo, Mammalian; Fem | 2006 |
Chromosome changes in embryos treated with various teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure | 1967 |
Potentiative interactions between caffeine and various teratogenic agents.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Caffeine; Cycloheximide; Dactinomycin; Dose-Res | 1982 |
[Teratogenic action of Rifaximin in the rat and rabbit and its effect on perinatal development in the rat].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Hydroxyurea; Pregnancy; Prenatal Exposure Delay | 1984 |
The influence of deoxycytidine monophosphate (dCMP) on the cytotoxicity of hydroxyurea in the embryonic spinal cord of the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Drug I | 1984 |
A comparison of the in vivo and in vitro response of mammalian embryos to a teratogenic insult.
Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Embryo, Mammalian; Female; Gestational Age | 1983 |
Bipartite axiation follows incomplete epiboly in zebrafish embryos treated with chemical teratogens.
Topics: Abnormalities, Drug-Induced; Amanitins; Animals; Cell Differentiation; Cell Division; Cycloheximide; | 1984 |
The interaction of chemicals during pregnancy: an update.
Topics: Abnormalities, Drug-Induced; Animals; Bromodeoxyuridine; Caffeine; Drug Interactions; Female; Fetus; | 1983 |
Hydroxyurea as a reference standard in teratological screening. Comparison of the embryotoxic and teratogenic effects following single intraperitoneal or repeated oral administrations to pregnant rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Embryo, Mammalian; Female; Gestational A | 1980 |
Altered glycosaminoglycan composition of rat forelimb-buds during hydroxyurea teratogenesis: an indication of repair.
Topics: Abnormalities, Drug-Induced; Animals; Cell Survival; Female; Forelimb; Glycosaminoglycans; Hydroxyur | 1982 |
Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Hydroxyurea; Pregnancy; Rats; Rats, Inbred F3 | 1982 |
Effects of hydroxyurea on hemodynamics of pregnant rabbits: a maternally mediated mechanism of embryotoxicity.
Topics: Abnormalities, Drug-Induced; Animals; Blood Pressure; Female; Heart Rate; Hydroxyurea; Pregnancy; Pr | 1981 |
Amelioration of teratogenesis. I. Modification of hydroxyurea-induced teratogenesis by the antioxidant propyl gallate.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Female; Gallic Acid; Gestational Age; Hydroxyu | 1981 |
An exploration of the role of hydroxyurea injection time in fetal growth and teratogenesis in rats.
Topics: Abnormalities, Drug-Induced; Animals; Circadian Rhythm; Female; Fetal Resorption; Fetus; Growth; Hyd | 1981 |
Mathematical analysis for teratogenic sensitivity.
Topics: Abnormalities, Drug-Induced; Animals; Computer Simulation; Dose-Response Relationship, Drug; Embryon | 1997 |
Combined prenatal toxicity of 6-mercaptopurine riboside and hydroxyurea in mice.
Topics: Abnormalities, Drug-Induced; Animals; DNA; Dose-Response Relationship, Drug; Female; Hydroxyurea; Li | 1999 |
The use of newer asthma and allergy medications during pregnancy. The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI).
Topics: Abnormalities, Drug-Induced; Acetates; Administration, Inhalation; Administration, Intranasal; Admin | 2000 |
A teratogenicity study on hydroxyurea and diphenylhydantoin in cats.
Topics: Abnormalities, Drug-Induced; Animals; Cats; Dose-Response Relationship, Drug; Drug Evaluation, Precl | 1979 |
Effects of hydroxyurea during final neuronal DNA synthesis in dorsal root ganglia of rats.
Topics: Abnormalities, Drug-Induced; Animals; Cell Cycle; Cell Division; DNA; Dose-Response Relationship, Dr | 1979 |
A comparison of behavioral and anatomical measures of hydroxyurea induced abnormalities.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Birth Weight; Brain; Dose-Response Relations | 1978 |
Drug-induced limb dysplasias in fetal rabbits.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Animals; Ectoderm; Extremities; | 1977 |
Ultrastructural alterations in neuroepithelial cells of mouse embryos exposed to cytotoxic doses of hydroxyurea.
Topics: Abnormalities, Drug-Induced; Animals; Central Nervous System; Fetus; Hydroxyurea; Mice | 1977 |
Inhibition of RNA synthesis, a possible mode of the embryotoxic action of hydroxyurea.
Topics: Abnormalities, Drug-Induced; Animals; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Fema | 1975 |
The nature of the embryo-protective interaction of propyl gallate with hydroxyurea.
Topics: Abnormalities, Drug-Induced; Animals; DNA; Embryo, Mammalian; Female; Hydroxyurea; Injections; Necro | 1990 |
Ethoxyquin and nordihydroguaiaretic acid reduce hydroxyurea developmental toxicity.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Body Weight; Embryo, Mammalian; Ethoxyquin; Fema | 1990 |
Analysis of the activity of DNA, RNA, and protein synthesis inhibitors on Xenopus embryo development.
Topics: Abnormalities, Drug-Induced; Animals; Cycloheximide; Cytarabine; Dactinomycin; DNA Replication; Drug | 1985 |
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, N | 1987 |
In utero morphological effects of hydroxyurea on the fetal development in Sprague-Dawley rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Embryonic and Fetal Development; Female; Fetal De | 1987 |
Teratologic and postnatal evaluation of aniline hydrochloride in the Fischer 344 rat.
Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Animals, Newborn; Blood; Body Weight; Eryth | 1985 |
Ultrastructural changes in the neural tube of 10-day-old mouse embryos exposed to colchicine and hydroxyurea.
Topics: Abnormalities, Drug-Induced; Animals; Colchicine; Drug Administration Schedule; Drug Interactions; H | 1985 |
The teratogenic interaction of hydroxyurea and 5-bromodeoxyuridine examined with the aid of limb culture and image analysis.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Bromodeoxyuridine; Culture Techniques; Drug In | 1985 |
[On the action of some antimitotics resembling hydroxyurea and semicarbozide in the chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Hydrazines; Hydroxylamines; Hydroxyurea; Mitosis | 1967 |
DNA synthesis inhibition, cytotoxicity and their relationship to teratogenesis following administration of a nicotinamide antagonist, aminothiadiazole, to pregnant rats.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Cytarabine; Depression, Chemical; DNA; Female; F | 1973 |
[Studies on the teratogenic effect of hydroxyurea during the early and embryonic development of mice].
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Embryo, Mammalian; Encephalocele; Female; Fetal | 1969 |
[Letter: Teratogenic effects of medications].
Topics: Abnormalities, Drug-Induced; Adult; Chlorambucil; Female; Humans; Hydroxyurea; Leukemia, Lymphoid; M | 1974 |
Pharmacodynamic principles in chemical teratology: dose-effect relationships.
Topics: Abnormalities, Drug-Induced; Adsorption; Cyclophosphamide; Dose-Response Relationship, Drug; Drug-Re | 1972 |
Protective effect of deoxycytidylic acid (CdMP) on hydroxyurea-induced malformations in rats.
Topics: Abnormalities, Drug-Induced; Animals; Cytosine Nucleotides; Female; Fetus; Hydroxyurea; Pregnancy; R | 1973 |
Postnatal effects in rats of prenatal treatment with hydroxyurea.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Embryo, M | 1973 |
Relationship of temporal patterns of cell death and development to malformations in the rat limb. Possible mechanisms of teratogenesis with inhibitors of DNA synthesis.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Cell Survival; Cytarabine; DNA; Ectod | 1973 |
DNA synthesis inhibition and cell death associated with hydroxyurea teratogenesis in rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Cell Division; Central Nervous System; DNA; Embryo, Mammalian; | 1971 |
[Effect of cytostatics on the facial development of rats].
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Animals; Antineoplastic Agents; Cycloph | 1969 |
Teratological studies of p-butoxyphenylacethydroxamic acid (CP 1044 J3) in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Hydroxamic Acids; Hydr | 1970 |
[Chemical constitution and teratogenic effect in rats. I. Carbonic acid amides, carbonic acid hydrazides and hydroxamic acids].
Topics: Abnormalities, Drug-Induced; Amides; Animals; Brain; Embryo, Mammalian; Embryonic and Fetal Developm | 1968 |