hydroxyurea has been researched along with Abnormalities, Autosome in 115 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The leukemogenic risk attributed to therapy of polycythemia vera with radiophosphorus and alkylating drugs has led, over the last 20 years, to the increased use of myelosupressive nonmutagenic drugs, especially hydroxyurea." | 7.71 | Leukemic transformation of polycythemia vera after treatment with hydroxyurea with abnormalities of chromosome 17. ( Fricová, M; Guman, T; Hlebasková, M; Kafková, A; Nebesnáková, E; Raffac, S; Stecová, N; Svorcová, E; Tóthová, E, 2001) |
| "From 1981 to 1995, we diagnosed, followed and treated at our institution fifty-eight cases of essential thrombocythemia (ET), using hydroxyurea (HU) as first-line therapy in these patients." | 7.69 | Is treatment with hydroxyurea leukemogenic in patients with essential thrombocythemia? An analysis of three new cases of leukaemic transformation and review of the literature. ( Bordessoule, D; Brigaudeau, C; Desangles, F; Fermeaux, V; Liozon, E; Praloran, V; Trimoreau, F, 1997) |
| "Chromosomal aberrations and dihydrofolate reductase gene amplification are observed in L5178Y mouse lymphoma cells after treatment with hydroxyurea." | 7.67 | Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations. ( Hill, AB; Schimke, RT, 1985) |
| "Hydroxyurea (HU) is an agent that induces replicative stress by inhibiting ribonucleotide reductase (RNR), which synthesizes deoxyribonucleotide triphosphates (dNTPs) necessary for DNA replication and repair." | 5.42 | Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in Fanconi anemia cells. ( Altamirano-Lozano, M; Carnevale, A; Frias, S; Gómez, L; Marchetti, F; Molina, B; Ortiz, R; Ramos, S; Torres, L, 2015) |
| "Chromosomal aberrations were first measured after exposure to mitomicyn C (MMC) or hydroxyurea (HU)." | 5.35 | Differential expression of TP53 associated genes in Fanconi anemia cells after mitomycin C and hydroxyurea treatment. ( Acuña, H; Coleman, MA; Frias, S; Gómez, L; Hinz, JM; Jones, IM; Martinez, A; Molina, B, 2008) |
| " We describe the case of a 62-year-old man who developed precursor T-cell (pre-T) ALL 18 months after the diagnosis of an unclassifiable chronic myeloproliferative syndrome (CMPD, U), which had been treated with hydroxyurea (HU) over 12 months." | 3.74 | A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. ( Bacher, U; Haferlach, C; Haferlach, T; Harich, HD; Kern, W; Schnittger, S, 2007) |
| "The leukemogenic risk attributed to therapy of polycythemia vera with radiophosphorus and alkylating drugs has led, over the last 20 years, to the increased use of myelosupressive nonmutagenic drugs, especially hydroxyurea." | 3.71 | Leukemic transformation of polycythemia vera after treatment with hydroxyurea with abnormalities of chromosome 17. ( Fricová, M; Guman, T; Hlebasková, M; Kafková, A; Nebesnáková, E; Raffac, S; Stecová, N; Svorcová, E; Tóthová, E, 2001) |
| " Before the appearance of CMML, he received a total dose of 2,894 mg of nimustine for the treatment of a pontine glioma over 12 years." | 3.69 | Therapy-related chronic myelomonocytic leukaemia with bone marrow eosinophilia associated with der(11)t(1;11)(q21;q14). ( Amemiya, Y; Hatake, K; Miura, Y; Miyata, T; Muroi, K; Saito, M, 1996) |
| "From 1981 to 1995, we diagnosed, followed and treated at our institution fifty-eight cases of essential thrombocythemia (ET), using hydroxyurea (HU) as first-line therapy in these patients." | 3.69 | Is treatment with hydroxyurea leukemogenic in patients with essential thrombocythemia? An analysis of three new cases of leukaemic transformation and review of the literature. ( Bordessoule, D; Brigaudeau, C; Desangles, F; Fermeaux, V; Liozon, E; Praloran, V; Trimoreau, F, 1997) |
| "Chromosomal aberrations and dihydrofolate reductase gene amplification are observed in L5178Y mouse lymphoma cells after treatment with hydroxyurea." | 3.67 | Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations. ( Hill, AB; Schimke, RT, 1985) |
| "Patients with sickle cell anemia were treated with daily doses of hydroxyurea, to assess pharmacokinetics, toxicity, and increase in fetal hemoglobin (Hb) production in response to the drug." | 2.67 | Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia. ( Ballas, SK; Charache, S; Dover, GJ; Eckert, S; Koshy, M; Milner, PF; Moore, RD; Orringer, EP; Phillips, G; Platt, OS, 1992) |
| "Hydroxyurea (HU) is an anti-leukaemia and anti-tumour drug which has also found limited application in the treatment of dermatological disorders." | 2.35 | Hydroxyurea. ( Timson, J, 1975) |
| "Hydroxyurea is a medication frequently used in sickle-cell disease, different cancers and HIV infection." | 1.48 | Protective role of nimbolide against chemotherapeutic drug hydroxyurea induced genetic and oxidative damage in an animal model. ( Ahmad, MF; Ansari, MO; Jameel, S; Parveen, N; Shadab, GGHA; Siddique, HR; Wani, AL, 2018) |
| "Hydroxyurea (HU) is an agent that induces replicative stress by inhibiting ribonucleotide reductase (RNR), which synthesizes deoxyribonucleotide triphosphates (dNTPs) necessary for DNA replication and repair." | 1.42 | Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in Fanconi anemia cells. ( Altamirano-Lozano, M; Carnevale, A; Frias, S; Gómez, L; Marchetti, F; Molina, B; Ortiz, R; Ramos, S; Torres, L, 2015) |
| "Eight patients with M3 (acute promyelocytic leukemia) were excluded from the study." | 1.38 | Induction chemotherapy versus palliative treatment for acute myeloid leukemia in a consecutive cohort of elderly patients. ( Atkinson, HD; Colovic, M; Colovic, N; Jankovic, G; Kraguljac, N; Radojkovic, M; Stanisavljevic, D; Suvajdzic, N; Tomin, D; Vidovic, A, 2012) |
| "Chromosomal aberrations were first measured after exposure to mitomicyn C (MMC) or hydroxyurea (HU)." | 1.35 | Differential expression of TP53 associated genes in Fanconi anemia cells after mitomycin C and hydroxyurea treatment. ( Acuña, H; Coleman, MA; Frias, S; Gómez, L; Hinz, JM; Jones, IM; Martinez, A; Molina, B, 2008) |
| "We report a rare case of eosinophilic leukemia transformation in a patient with polycythemia rubra vera on hydroxycarbamide (hydroxyurea) therapy only." | 1.33 | Eosinophilic leukemic transformation in polycythemia rubra vera (PRV). ( Chim, CS; Ma, SK, 2005) |
| "Acute leukemia is an uncommon complication of patients with essential thrombocythemia (ET)." | 1.33 | Acute biphenotypic leukemia arising in a patient with essential thrombocythemia. ( Lee, LH; Wong, GC, 2006) |
| "Mechanisms of chemoresistance in renal cell carcinoma include P-glycoprotein, overexpression of multidrug resistance-1 (mdr1) gene, and unstable chromosomal aberrations." | 1.31 | A pilot study of low dose hydroxyurea as a novel resistance modulator in metastatic renal cell cancer. ( Hao, D; Huan, SD; Segal, RJ; Stewart, DJ; Yau, JC, 2000) |
| "Bone marrow examinations reveal chromosomal abnormalities in 15-43% of PV patients and 5% of ET patients, but no specific recurring abnormality has been found to date." | 1.31 | Comparative genomic hybridization in polycythemia vera and essential thrombocytosis patients. ( Amiel, A; Bomstein, Y; Fejgin, MD; Gaber, E; Herishanu, Y; Kitay-Cohen, Y; Lishner, M, 2001) |
| "Hydroxyurea post-treatment potentiated the X-ray-induced aberration levels both in the normal and Werner's syndrome (KO375 and DJG) cell lines; in contrast caffeine was only effective in the normal cell line." | 1.30 | Lack of effect of caffeine post-treatment on X-ray-induced chromosomal aberrations in Werner's syndrome lymphoblastoid cell lines: a preliminary report. ( Franchitto, A; Mosesso, P; Palitti, F; Pichierri, P; Proietti De Santis, L, 1999) |
| "A strong increase of radiation-induced chromosomal aberrations was observed in normal and HzAT cells post-treated with ara-C, APC and HU, but not in the presence of BuPdG." | 1.29 | Lack of effect of inhibitors of DNA synthesis/repair on the ionizing radiation-induced chromosomal damage in G2 stage of ataxia telangiectasia cells. ( Antoccia, A; Catena, C; Palitti, F; Raggi, T; Tanzarella, C, 1994) |
| "The frequencies of chromosomal aberrations and sister chromatid exchanges (SCE) were studied in human peripheral lymphocytes after exposure of whole blood cultures to the antitumour agent m-AMSA." | 1.28 | The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA. ( Andersson, HC; Kihlman, BA, 1989) |
| "A high frequency of chromosome aberrations was induced in early spermatozoa to mid spermatids, while few chromosome aberrations were observed in early spermatids to late spermatocytes." | 1.28 | Mechanism of chromosome aberration induction in the mouse egg fertilized with sperm recovered from postmeiotic germ cells treated with methyl methanesulfonate. ( Maemori, M; Matsuda, Y; Seki, N; Tobari, I, 1989) |
| "Hydroxyurea (HU) is an inhibitor of DNA synthesis, which can inhibit the enzyme ribonucleotide reductase, reduce the syntheses of all four deoxyribonucleoside diphosphates (dNDP), and disturb the balance of the dNTP pool." | 1.27 | The effect of hydroxyurea on the expression of the common fragile site at 3p14. ( Li, XZ; Yan, ZA; Zhou, XT, 1987) |
| " Similar dose-response curves were established for Down's syndrome leukocytes and controls." | 1.26 | DNA repair and frequency of x-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome. ( Bui, TH; Funes-Cravioto, F; Hansson, K; Lambert, B; Lindsten, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (51.30) | 18.7374 |
| 1990's | 23 (20.00) | 18.2507 |
| 2000's | 23 (20.00) | 29.6817 |
| 2010's | 9 (7.83) | 24.3611 |
| 2020's | 1 (0.87) | 2.80 |
| Authors | Studies |
|---|---|
| Mus, LM | 1 |
| Van Haver, S | 1 |
| Popovic, M | 1 |
| Trypsteen, W | 1 |
| Lefever, S | 1 |
| Zeltner, N | 1 |
| Ogando, Y | 1 |
| Jacobs, EZ | 1 |
| Denecker, G | 1 |
| Sanders, E | 1 |
| Van Neste, C | 1 |
| Vanhauwaert, S | 1 |
| Decaesteker, B | 1 |
| Deforce, D | 1 |
| Van Nieuwerburgh, F | 1 |
| Mestdagh, P | 1 |
| Vandesompele, J | 1 |
| Menten, B | 1 |
| De Preter, K | 1 |
| Studer, L | 1 |
| Heindryckx, B | 1 |
| Durinck, K | 1 |
| Roberts, S | 1 |
| Speleman, F | 1 |
| Ahmad, MF | 1 |
| Ansari, MO | 1 |
| Jameel, S | 1 |
| Wani, AL | 1 |
| Parveen, N | 1 |
| Siddique, HR | 1 |
| Shadab, GGHA | 1 |
| Molina, B | 2 |
| Marchetti, F | 1 |
| Gómez, L | 2 |
| Ramos, S | 1 |
| Torres, L | 1 |
| Ortiz, R | 1 |
| Altamirano-Lozano, M | 1 |
| Carnevale, A | 1 |
| Frias, S | 2 |
| Aumont, C | 1 |
| Driss, F | 1 |
| Lazure, T | 1 |
| Picard, V | 1 |
| Creidy, R | 1 |
| De Botton, S | 1 |
| Saada, V | 1 |
| Lambotte, O | 1 |
| Bilhou-Nabera, C | 1 |
| Tertian, G | 1 |
| Michot, JM | 1 |
| Pai, GM | 1 |
| Zielinski, A | 1 |
| Koalick, D | 1 |
| Ludwig, K | 1 |
| Wang, ZQ | 1 |
| Borgmann, K | 1 |
| Pospiech, H | 1 |
| Rubio, I | 1 |
| Martinez, A | 1 |
| Hinz, JM | 1 |
| Acuña, H | 1 |
| Jones, IM | 1 |
| Coleman, MA | 1 |
| Shi, W | 1 |
| Feng, Z | 1 |
| Zhang, J | 2 |
| Gonzalez-Suarez, I | 1 |
| Vanderwaal, RP | 1 |
| Wu, X | 1 |
| Powell, SN | 2 |
| Roti Roti, JL | 1 |
| Gonzalo, S | 1 |
| McGann, PT | 1 |
| Howard, TA | 1 |
| Flanagan, JM | 1 |
| Lahti, JM | 1 |
| Ware, RE | 1 |
| Colovic, M | 1 |
| Colovic, N | 1 |
| Radojkovic, M | 1 |
| Stanisavljevic, D | 1 |
| Kraguljac, N | 1 |
| Jankovic, G | 1 |
| Tomin, D | 1 |
| Suvajdzic, N | 1 |
| Vidovic, A | 1 |
| Atkinson, HD | 1 |
| Pincheira, J | 1 |
| de la Torre, C | 2 |
| Rodríguez, N | 1 |
| Valenzuela, CY | 1 |
| Singh, M | 1 |
| Hunt, CR | 1 |
| Pandita, RK | 1 |
| Kumar, R | 1 |
| Yang, CR | 1 |
| Horikoshi, N | 1 |
| Bachoo, R | 1 |
| Serag, S | 1 |
| Story, MD | 1 |
| Shay, JW | 1 |
| Gupta, A | 1 |
| Jeffery, J | 1 |
| Pandita, S | 1 |
| Chen, BP | 1 |
| Deckbar, D | 1 |
| Löbrich, M | 1 |
| Yang, Q | 1 |
| Khanna, KK | 1 |
| Worman, HJ | 1 |
| Pandita, TK | 1 |
| Bernasconi, P | 1 |
| Boni, M | 1 |
| Cavigliano, PM | 1 |
| Calatroni, S | 1 |
| Brusamolino, E | 1 |
| Passamonti, F | 1 |
| Volpe, G | 1 |
| Pistorio, A | 1 |
| Giardini, I | 1 |
| Rocca, B | 1 |
| Caresana, M | 1 |
| Lazzarino, M | 1 |
| Bernasconi, C | 1 |
| Hochhaus, A | 1 |
| Berger, U | 1 |
| Reiter, A | 1 |
| Engelich, G | 1 |
| Lahaye, T | 1 |
| Kreil, S | 1 |
| Merx, K | 1 |
| Müller, MC | 1 |
| Hehlmann, R | 2 |
| Morel, F | 1 |
| Bris, MJ | 1 |
| Herry, A | 1 |
| Calvez, GL | 1 |
| Marion, V | 1 |
| Abgrall, JF | 1 |
| Berthou, C | 1 |
| Braekeleer, MD | 1 |
| Buesche, G | 1 |
| Hecker, H | 1 |
| Heimpel, H | 1 |
| Heinze, B | 1 |
| Schmeil, A | 1 |
| Pfirrmann, M | 1 |
| Gomez, G | 1 |
| Tobler, A | 1 |
| Herrmann, H | 1 |
| Kappler, M | 1 |
| Hasford, J | 1 |
| Buhr, T | 1 |
| Kreipe, HH | 1 |
| Georgii, A | 1 |
| Andreassen, PR | 1 |
| Lohez, OD | 1 |
| Margolis, RL | 1 |
| de Lima, PD | 1 |
| Cardoso, PC | 2 |
| Khayat, AS | 2 |
| Bahia, Mde O | 1 |
| Burbano, RR | 2 |
| Hopkins, KM | 1 |
| Auerbach, W | 1 |
| Wang, XY | 1 |
| Hande, MP | 1 |
| Hang, H | 1 |
| Wolgemuth, DJ | 1 |
| Joyner, AL | 1 |
| Lieberman, HB | 1 |
| Chim, CS | 2 |
| Ma, SK | 2 |
| Daskalakis, M | 1 |
| Mauritzson, N | 1 |
| Johansson, B | 2 |
| Bouabdallah, K | 1 |
| Onida, F | 1 |
| Kunzmann, R | 1 |
| Müller-Berndorff, H | 1 |
| Schmitt-Gräff, A | 1 |
| Lübbert, M | 1 |
| Antunes, LM | 1 |
| Guimarães, AC | 1 |
| Bahia, MO | 1 |
| Lemos, JA | 1 |
| Cabral, IR | 1 |
| Lima, PD | 1 |
| Amorim, MI | 1 |
| Smith, MA | 1 |
| Santos, RA | 1 |
| Wong, GC | 1 |
| Lee, LH | 1 |
| Ostro, D | 1 |
| Cheung, K | 1 |
| Kamel-Reid, S | 1 |
| Lipton, JH | 1 |
| Bacher, U | 1 |
| Haferlach, T | 1 |
| Kern, W | 1 |
| Harich, HD | 1 |
| Schnittger, S | 1 |
| Haferlach, C | 1 |
| Shimizu, N | 2 |
| Misaka, N | 1 |
| Utani, K | 1 |
| Hanada, K | 1 |
| Budzowska, M | 1 |
| Davies, SL | 1 |
| van Drunen, E | 1 |
| Onizawa, H | 1 |
| Beverloo, HB | 1 |
| Maas, A | 1 |
| Essers, J | 1 |
| Hickson, ID | 1 |
| Kanaar, R | 1 |
| Soukup, S | 1 |
| Takacs, E | 1 |
| Warkany, J | 1 |
| Sen, P | 1 |
| Hittelman, WN | 4 |
| Hansson, K | 3 |
| Hartley-Asp, B | 1 |
| Fleischer, J | 1 |
| Franke, WG | 1 |
| Kihlman, BA | 5 |
| Natarajan, AT | 3 |
| Andersson, HC | 2 |
| Zwanenburg, TS | 1 |
| Mullenders, LH | 1 |
| van Zeeland, AA | 1 |
| Palitti, F | 6 |
| Tanzarella, C | 5 |
| Degrassi, F | 2 |
| De Salvia, R | 2 |
| Fiore, M | 2 |
| Sono, A | 2 |
| Sakaguchi, K | 2 |
| Haas, OA | 1 |
| Schwarzmeier, JD | 2 |
| Nacheva, E | 1 |
| Fischer, P | 2 |
| Paietta, E | 2 |
| Tsutsui, T | 2 |
| Suzuki, N | 1 |
| Ohmori, M | 1 |
| Maizumi, H | 1 |
| Haas, O | 1 |
| Lindenhahn, M | 1 |
| Schubert, I | 1 |
| Hieber, L | 1 |
| Lücke-Huhle, C | 1 |
| Karlsson, MB | 1 |
| Sakaguchi, M | 1 |
| Yamada, H | 1 |
| Miyahara, T | 1 |
| Kozuka, H | 1 |
| Antoccia, A | 3 |
| Raggi, T | 2 |
| Catena, C | 2 |
| Wettergren, Y | 1 |
| Kullberg, A | 1 |
| Levan, G | 1 |
| Taylor, DL | 1 |
| Kerwick, AM | 1 |
| Elliott, SL | 1 |
| Rodwell, RL | 1 |
| Wright, SJ | 1 |
| Marlton, PV | 1 |
| Veleba, AR | 1 |
| Taylor, KM | 1 |
| Kanda, T | 1 |
| Wahl, GM | 2 |
| Chessa, L | 1 |
| Ricordy, R | 1 |
| Fioretos, T | 1 |
| Billström, R | 1 |
| Mitelman, F | 1 |
| Martinelli, G | 1 |
| Testoni, N | 1 |
| Zuffa, E | 1 |
| Visani, G | 1 |
| Zinzani, PL | 1 |
| Zaccaria, A | 1 |
| Farabegoli, P | 1 |
| Arpinati, M | 1 |
| Amabile, M | 1 |
| Tura, S | 1 |
| Muroi, K | 1 |
| Miyata, T | 1 |
| Saito, M | 1 |
| Hatake, K | 1 |
| Amemiya, Y | 1 |
| Miura, Y | 1 |
| Liozon, E | 1 |
| Brigaudeau, C | 1 |
| Trimoreau, F | 1 |
| Desangles, F | 1 |
| Fermeaux, V | 1 |
| Praloran, V | 1 |
| Bordessoule, D | 1 |
| Slamenová, D | 1 |
| Gábelová, A | 1 |
| Ruzeková, L | 1 |
| Chalupa, I | 1 |
| Horváthová, E | 1 |
| Farkasová, T | 1 |
| Bozsakyová, E | 1 |
| Stĕtina, R | 1 |
| Tatebayashi, K | 1 |
| Kato, J | 1 |
| Ikeda, H | 1 |
| Greenwood, SK | 1 |
| Armstrong, MJ | 1 |
| Hill, RB | 1 |
| Bradt, CI | 1 |
| Johnson, TE | 1 |
| Hilliard, CA | 1 |
| Galloway, SM | 1 |
| Tefferi, A | 1 |
| Maloisel, F | 1 |
| Uettwiller, F | 1 |
| Laplace, A | 1 |
| Lioure, B | 1 |
| Herbrecht, R | 1 |
| Mark, M | 1 |
| Dufour, P | 1 |
| Franchitto, A | 1 |
| Proietti De Santis, L | 1 |
| Pichierri, P | 1 |
| Mosesso, P | 1 |
| Hao, D | 1 |
| Huan, SD | 1 |
| Stewart, DJ | 1 |
| Segal, RJ | 1 |
| Yau, JC | 1 |
| Pelayo, HR | 1 |
| Lastres, P | 1 |
| Herishanu, Y | 1 |
| Lishner, M | 1 |
| Bomstein, Y | 1 |
| Kitay-Cohen, Y | 1 |
| Fejgin, MD | 1 |
| Gaber, E | 1 |
| Amiel, A | 1 |
| Tóthová, E | 1 |
| Fricová, M | 1 |
| Stecová, N | 1 |
| Hlebasková, M | 1 |
| Kafková, A | 1 |
| Raffac, S | 1 |
| Guman, T | 1 |
| Svorcová, E | 1 |
| Nebesnáková, E | 1 |
| Rybaczek, D | 1 |
| Polit, J | 1 |
| Luchniak, P | 1 |
| Maszewski, J | 1 |
| Garber, PM | 1 |
| Rine, J | 1 |
| Brinkley, BR | 1 |
| Sognier, MA | 2 |
| Rao, PN | 1 |
| Lambert, B | 1 |
| Bui, TH | 1 |
| Funes-Cravioto, F | 1 |
| Lindsten, J | 1 |
| Popescu, NC | 1 |
| Turnbull, D | 1 |
| DiPaolo, JA | 1 |
| Barrett, JC | 1 |
| Ts'o, PO | 1 |
| Timson, J | 1 |
| Brodsky, I | 1 |
| Fuscaldo, KE | 1 |
| Kahn, SB | 1 |
| Conroy, JF | 1 |
| Lamping, CG | 1 |
| Whang-Peng, J | 2 |
| Broder, S | 1 |
| Lee, E | 1 |
| Young, RC | 2 |
| Collins, AR | 1 |
| Schor, SL | 1 |
| Johnson, RT | 1 |
| Reddy, MM | 1 |
| Miller, MW | 1 |
| Weissfeld, AS | 1 |
| Rouse, H | 1 |
| Coutinho, V | 1 |
| Bottura, C | 1 |
| Alexander, B | 1 |
| Berger, R | 1 |
| Day, LM | 1 |
| Hogarth, PM | 1 |
| Feneziani, A | 1 |
| Cook, WD | 1 |
| Charache, S | 1 |
| Dover, GJ | 1 |
| Moore, RD | 1 |
| Eckert, S | 1 |
| Ballas, SK | 1 |
| Koshy, M | 1 |
| Milner, PF | 1 |
| Orringer, EP | 1 |
| Phillips, G | 1 |
| Platt, OS | 1 |
| Jelmert, O | 1 |
| Hansteen, IL | 1 |
| Langård, S | 1 |
| Von Hoff, DD | 1 |
| McGill, JR | 1 |
| Forseth, BJ | 1 |
| Davidson, KK | 1 |
| Bradley, TP | 1 |
| Van Devanter, DR | 1 |
| Darroudi, F | 1 |
| van der Schans, GP | 1 |
| Löfvenberg, E | 1 |
| Nordenson, I | 1 |
| Wahlin, A | 1 |
| Mateos, S | 2 |
| Piñero, J | 2 |
| Ortiz, T | 2 |
| Cortés, F | 2 |
| Matsuda, Y | 2 |
| Maemori, M | 2 |
| Tobari, I | 2 |
| Seki, N | 1 |
| Banga, SS | 1 |
| Shenkar, R | 1 |
| Boyd, JB | 1 |
| Pelliccia, F | 1 |
| Belloni, G | 1 |
| Bosi, A | 1 |
| Micheli, A | 1 |
| Olivieri, G | 1 |
| Sherwood, SW | 1 |
| Schumacher, RI | 1 |
| Schimke, RT | 3 |
| Yan, ZA | 1 |
| Li, XZ | 1 |
| Zhou, XT | 1 |
| Landaw, SA | 1 |
| Hahn, P | 1 |
| Kapp, LN | 1 |
| Morgan, WF | 1 |
| Painter, RB | 1 |
| Kantarjian, HM | 1 |
| Smith, TL | 1 |
| McCredie, KB | 1 |
| Keating, MJ | 1 |
| Walters, RS | 1 |
| Talpaz, M | 1 |
| Hester, JP | 1 |
| Bligham, G | 1 |
| Gehan, E | 1 |
| Freireich, EJ | 1 |
| Hill, A | 1 |
| Johnston, RN | 1 |
| Hill, AB | 1 |
| Karon, M | 1 |
| Benedict, WF | 1 |
| Canellos, GP | 2 |
| Hartley, B | 1 |
| Ottolenghi, F | 1 |
| Andreassi, L | 1 |
| Bender, MA | 1 |
| Griggs, HG | 1 |
| Bedford, JS | 1 |
| Parrington, JM | 1 |
| Delhanty, JD | 1 |
| Baden, HP | 1 |
| De Vita, VT | 1 |
| Schein, P | 1 |
| Chabner, B | 1 |
| Stryckmans, PA | 1 |
| Sarkar, S | 1 |
| Chowdhury, JR | 1 |
| Fahmy, OG | 1 |
| Fahmy, MJ | 1 |
| Wolff, S | 1 |
| Prempree, T | 1 |
| Merz, T | 1 |
| Long, DL | 1 |
| Pierre, RV | 1 |
| Yu, CK | 1 |
| Sinclair, WK | 1 |
| Kaung, DT | 1 |
| Swartzendruber, AA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH)[NCT00000586] | Phase 3 | 0 participants | Interventional | 1992-01-31 | Completed | ||
| Evaluation of Potential Synergy of Combining Hydroxyurea With Nitric Oxide Donors on Fetal Hemoglobin Synthesis in Patients With Sickle Cell Anemia[NCT00056433] | Phase 1 | 39 participants (Actual) | Interventional | 2003-03-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for hydroxyurea and Abnormalities, Autosome
| Article | Year |
|---|---|
[Current therapy concepts in chronic myeloid leukemia. Study IV of the German CML Study Group].
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Chromosome Aberrations; Fusion Proteins, | 2002 |
G2 and spindle assembly checkpoint adaptation, and tetraploidy arrest: implications for intrinsic and chemically induced genomic instability.
Topics: Cell Cycle Proteins; Cell Division; Chromosome Aberrations; DNA Damage; DNA Replication; G1 Phase; G | 2003 |
[Chromosome analysis and TdT determination: important prognostic parameters of blastic crises in chronic myelocytic leukemia].
Topics: Busulfan; Chromosome Aberrations; Cytarabine; DNA Nucleotidylexotransferase; DNA Nucleotidyltransfer | 1982 |
Ultrastructure of mammalian chromosome aberrations.
Topics: Alkylating Agents; Aminopterin; Animals; Bleomycin; Cell Line; Cell Nucleolus; Cells, Cultured; Chro | 1975 |
Hydroxyurea.
Topics: Animals; Chromosome Aberrations; DNA; DNA Repair; DNA Replication; Humans; Hydroxyurea; Mice; Mitosi | 1975 |
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.
Topics: Alkylating Agents; Animals; Caffeine; Chromosome Aberrations; Cyanides; Cytarabine; Deoxyadenosines; | 1974 |
Current concepts in chronic myelogenous leukemia.
Topics: Alkaline Phosphatase; Blood; Bone Marrow Cells; Bone Marrow Examination; Busulfan; Cell Division; Ce | 1974 |
3 trials available for hydroxyurea and Abnormalities, Autosome
| Article | Year |
|---|---|
Marrow fibrosis, indicator of therapy failure in chronic myeloid leukemia - prospective long-term results from a randomized-controlled trial.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Biopsy; Bone Marrow; Bone Mar | 2003 |
Chronic myelogenous leukemia: a clinical and experimental evaluation of splenectomy and intensive chemotherapy.
Topics: Adult; Antineoplastic Agents; Busulfan; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Cli | 1975 |
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.
Topics: Adult; Alanine Transaminase; Anemia, Sickle Cell; Chromosome Aberrations; Chromosome Disorders; Dose | 1992 |
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.
Topics: Adult; Alanine Transaminase; Anemia, Sickle Cell; Chromosome Aberrations; Chromosome Disorders; Dose | 1992 |
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.
Topics: Adult; Alanine Transaminase; Anemia, Sickle Cell; Chromosome Aberrations; Chromosome Disorders; Dose | 1992 |
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.
Topics: Adult; Alanine Transaminase; Anemia, Sickle Cell; Chromosome Aberrations; Chromosome Disorders; Dose | 1992 |
105 other studies available for hydroxyurea and Abnormalities, Autosome
| Article | Year |
|---|---|
Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions.
Topics: Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Chromosome Aberrations; Chromosomes | 2021 |
Protective role of nimbolide against chemotherapeutic drug hydroxyurea induced genetic and oxidative damage in an animal model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Chromosome Aberrations; Disease Models, Animal; Hydrox | 2018 |
Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in Fanconi anemia cells.
Topics: Cell Line; Chromosome Aberrations; Cytogenetic Analysis; Drug Synergism; Fanconi Anemia; G2 Phase; H | 2015 |
Myelodysplastic syndrome with clonal cytogenetic abnormalities followed by fatal erythroid leukemia after 14 years of exposure to hydroxyurea for sickle cell anemia.
Topics: Anemia, Sickle Cell; Antineoplastic Agents; Antisickling Agents; Chromosome Aberrations; Chromosomes | 2015 |
TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.
Topics: Animals; Cell Cycle; Cell Death; Cells, Cultured; Chromosome Aberrations; DNA Damage; DNA Replicatio | 2016 |
Differential expression of TP53 associated genes in Fanconi anemia cells after mitomycin C and hydroxyurea treatment.
Topics: Cell Line; Chromosome Aberrations; Cross-Linking Reagents; DNA Damage; Fanconi Anemia; Gene Expressi | 2008 |
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest.
Topics: Blotting, Western; Cell Line, Tumor; Chromosome Aberrations; Comet Assay; DNA Damage; Genomic Instab | 2010 |
Chromosome damage and repair in children with sickle cell anaemia and long-term hydroxycarbamide exposure.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; Cells, Cultured; Child; Child, Preschoo | 2011 |
Induction chemotherapy versus palliative treatment for acute myeloid leukemia in a consecutive cohort of elderly patients.
Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Blood Compon | 2012 |
Response of the G2-prophase checkpoint to genotoxic drugs in lymphocytes from healthy individuals.
Topics: Adult; Antibiotics, Antineoplastic; Chromosome Aberrations; Cytarabine; DNA Damage; Doxorubicin; Fem | 2012 |
Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest.
Topics: Animals; Cell Line; Cell Line, Tumor; Chromosome Aberrations; DNA Damage; DNA Repair; DNA Replicatio | 2013 |
Acute myeloid leukemia (AML) having evolved from essential thrombocythemia (ET): distinctive chromosome abnormalities in patients treated with pipobroman or hydroxyurea.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Chromosome Aberrations; Female; Humans; H | 2002 |
Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib.
Topics: Aneuploidy; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast | 2003 |
Evaluation of the mutagenic activity of hydroxyurea on the G1-S-G2 phases of the cell cycle: an in vitro study.
Topics: Analysis of Variance; Antineoplastic Agents; Chromosome Aberrations; Endpoint Determination; G1 Phas | 2003 |
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality.
Topics: Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Chromosome Aberrations; DNA Da | 2004 |
Eosinophilic leukemic transformation in polycythemia rubra vera (PRV).
Topics: Aged; Chromosome Aberrations; Cytogenetic Analysis; Humans; Hydroxyurea; Hypereosinophilic Syndrome; | 2005 |
Der(8)t(1;8) in myeloblastic transformation of ET with hydroxyurea as the sole prior treatment.
Topics: Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Hu | 2005 |
Trisomy 19 as the sole chromosomal abnormality in proliferative chronic myelomonocytic leukemia.
Topics: Aged; Azacitidine; Chromosome Aberrations; Chromosomes, Human, Pair 19; Cytarabine; Cytogenetic Anal | 2006 |
Cytotoxic and genotoxic monitoring of sickle cell anaemia patients treated with hydroxyurea.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; Case-Control Studies; Child; Chromosome | 2006 |
Acute biphenotypic leukemia arising in a patient with essential thrombocythemia.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Chromosomes, | 2006 |
Chromosomal abnormalities in chronic myeloid leukemia: evidence of a hierarchy in imatinib treated cells.
Topics: Adult; Antineoplastic Agents; Benzamides; Bone Marrow Cells; Chromosome Aberrations; Cytogenetics; H | 2007 |
A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia.
Topics: Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Banding; Chromosome Painting; Di | 2007 |
Nonselective DNA damage induced by a replication inhibitor results in the selective elimination of extrachromosomal double minutes from human cancer cells.
Topics: Cell Division; Chromatin; Chromosome Aberrations; Colorectal Neoplasms; DNA Damage; DNA Repair; DNA | 2007 |
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.
Topics: Animals; Aphidicolin; Cell Cycle; Cells, Cultured; Chromosomal Instability; Chromosome Aberrations; | 2007 |
Chromosome changes in embryos treated with various teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure | 1967 |
Induction of chromosome damage by Neurospora endonuclease in repair-inhibited quiescent normal human fibroblasts.
Topics: Cell Line; Chromosome Aberrations; Cytarabine; DNA Repair; Endonucleases; Fibroblasts; HeLa Cells; H | 1984 |
Potentiation by hydroxyurea in G2-prophase of thiotepa- and bleomycin-induced chromosomal aberrations in Chinese hamster cells.
Topics: Animals; Bleomycin; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Drug Synergism; Hydro | 1981 |
[Diagnosis and therapy of chronic monocytic leukemia].
Topics: Aged; Chromosome Aberrations; Colloids; Diagnosis, Differential; Female; Humans; Hydroxyurea; Indium | 1981 |
Potentiation of chromosomal alterations by inhibitors of DNA repair.
Topics: Animals; Anti-Bacterial Agents; Chromatids; Chromosome Aberrations; Deoxyadenosines; DNA Repair; Flo | 1984 |
High frequencies of chromatid aberrations produced during G2 in human lymphocytes by very low doses (0.025-0.4 Gy) of X-rays in combination with inhibitors of DNA synthesis.
Topics: Chromatids; Chromosome Aberrations; Cytarabine; Deoxyadenosines; DNA Replication; Dose-Response Rela | 1984 |
DNA lesions, chromosomal aberrations and G2 delay in CHO cells cultured in medium containing bromo- or chloro-deoxyuridine.
Topics: Animals; Benzamides; Bromodeoxyuridine; Caffeine; Cell Survival; Chromosome Aberrations; Cricetinae; | 1984 |
Enhancement of induced sister chromatid exchange and chromosomal aberrations by inhibitors of DNA repair processes.
Topics: Animals; Aphidicolin; Caffeine; Chromosome Aberrations; Cricetinae; Cricetulus; Diterpenes; DNA; DNA | 1984 |
Potentiation of induced sister chromatid exchanges and chromatid-type aberrations by inhibitors of DNA synthesis and repair in G2.
Topics: Aphidicolin; Caffeine; Cells, Cultured; Chromosome Aberrations; Diterpenes; DNA Repair; DNA Replicat | 1984 |
Inhibition of protein synthesis antagonizes induction of sister-chromatid exchanges by exogenous agents.
Topics: Animals; Bromodeoxyuridine; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Crossing Over | 1981 |
Investigations on karyotype evolution in patients with chronic myeloid leukemia (CML).
Topics: Adult; Aged; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Female; Humans; Hydroxyurea; K | 1984 |
Cytotoxicity, chromosome aberrations and unscheduled DNA synthesis in cultured human diploid fibroblasts induced by sodium fluoride.
Topics: Cell Survival; Cells, Cultured; Chromosome Aberrations; DNA; DNA Repair; Humans; Hydroxyurea; Mutati | 1984 |
On the origin of hydroxyurea-induced chromatid aberrations in G2 chromosomes with BrdUrd in only one of the sister chromatids.
Topics: Bromodeoxyuridine; Chromosome Aberrations; Crossing Over, Genetic; Hydroxyurea; Plants; Sister Chrom | 1983 |
PCC technique reveals severe chromatin lesions and repair in G2-arrested cells after alpha irradiation.
Topics: Alpha Particles; Animals; Caffeine; Cell Line; Chromatin; Chromosome Aberrations; Cricetinae; DNA Re | 1983 |
Potentiation of x-ray and streptonigrin-induced chromosomal aberrations in human lymphocytes by post-treatments with hydroxyurea and caffeine.
Topics: Caffeine; Cells, Cultured; Chromosome Aberrations; DNA Repair; Drug Synergism; Humans; Hydroxyurea; | 1982 |
Antagonizing effect of triphenyltin chloride on cytosine-1-beta-D-arabinofuranoside potentiation of chromosome aberrations induced by mitomycin C.
Topics: Animals; Caffeine; CHO Cells; Chromosome Aberrations; Cricetinae; Cytarabine; Drug Antagonism; Drug | 1994 |
Lack of effect of inhibitors of DNA synthesis/repair on the ionizing radiation-induced chromosomal damage in G2 stage of ataxia telangiectasia cells.
Topics: Ataxia Telangiectasia; Chromosome Aberrations; DNA Repair; DNA-Directed DNA Polymerase; G2 Phase; Hu | 1994 |
Drug-specific rearrangements of chromosome 12 in hydroxyurea-resistant mouse SEWA cells: support for chromosomal breakage model of gene amplification.
Topics: Animals; Chromosome Aberrations; Drug Resistance; Gene Amplification; Hydroxyurea; Mice; Models, Gen | 1994 |
Discordant neutrophil alkaline phosphatase activity and cytogenetic response in chronic myeloid leukemia treated with alpha-interferon.
Topics: Adult; Alkaline Phosphatase; Chromosome Aberrations; Female; Gene Rearrangement; Genes, abl; Humans; | 1993 |
Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA.
Topics: Cell Fractionation; Centromere; Chromosome Aberrations; DNA Probes; Enzyme Inhibitors; Gene Amplific | 1996 |
Modulation of radiation-induced chromosomal damage by inhibitors of DNA repair and flow cytometric analysis in ataxia telangiectasia cells with 'intermediate radiosensitivity'.
Topics: Aphidicolin; Ataxia Telangiectasia; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes | 1995 |
Abberant cytogenetic evolution pattern of Philadelphia-positive chronic myeloid leukemia treated with interferon-alpha.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; | 1996 |
FLANG (fludarabine + cytosine arabinoside + novantrone + G-CSF) induces partial remission in lymphoid blast transformation of Ph+chronic myelogenous leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bone Marrow; Bone Marrow Transplantati | 1996 |
Therapy-related chronic myelomonocytic leukaemia with bone marrow eosinophilia associated with der(11)t(1;11)(q21;q14).
Topics: Antineoplastic Agents; Bone Marrow; Brain Neoplasms; Child; Chromosome Aberrations; Eosinophilia; Fa | 1996 |
Is treatment with hydroxyurea leukemogenic in patients with essential thrombocythemia? An analysis of three new cases of leukaemic transformation and review of the literature.
Topics: Aged; Antisickling Agents; Cell Transformation, Neoplastic; Chromosome Aberrations; Female; Humans; | 1997 |
Detection of MNNG-induced DNA lesions in mammalian cells; validation of comet assay against DNA unwinding technique, alkaline elution of DNA and chromosomal aberrations.
Topics: Animals; Cell Line; Child; Chromatids; Chromosome Aberrations; Cricetinae; Cytarabine; DNA; DNA Dama | 1997 |
Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis.
Topics: Cell Cycle Proteins; Chromosome Aberrations; DNA Repair; Fungal Proteins; Genes, Fungal; Hydroxyurea | 1998 |
Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53.
Topics: Alkylating Agents; Antineoplastic Agents; Aphidicolin; Apoptosis; B-Lymphocytes; Cell Division; Cell | 1998 |
Is hydroxyurea leukemogenic in essential thrombocythemia?
Topics: Acute Disease; Antineoplastic Agents, Alkylating; Bone Marrow; Busulfan; Chromosome Aberrations; Chr | 1998 |
Emergence of unusual cytogenetic abnormalities under interferon-alpha therapy in patients with chronic myelogenous leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Busulfan; Chromosome Aberrations; Chromo | 1999 |
Lack of effect of caffeine post-treatment on X-ray-induced chromosomal aberrations in Werner's syndrome lymphoblastoid cell lines: a preliminary report.
Topics: Caffeine; Cell Line, Transformed; Cell Transformation, Viral; Chromosome Aberrations; Chromosomes, H | 1999 |
A pilot study of low dose hydroxyurea as a novel resistance modulator in metastatic renal cell cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B | 2000 |
Replication and G2 checkpoints: their response to caffeine.
Topics: Caffeine; Cell Cycle; Chromosome Aberrations; Chromosomes; DNA Repair; DNA Replication; Flow Cytomet | 2001 |
Comparative genomic hybridization in polycythemia vera and essential thrombocytosis patients.
Topics: Aged; Aged, 80 and over; Chromosome Aberrations; Female; Humans; Hydroxyurea; Male; Middle Aged; Nuc | 2001 |
Leukemic transformation of polycythemia vera after treatment with hydroxyurea with abnormalities of chromosome 17.
Topics: Antineoplastic Agents; Bone Marrow Cells; Chromosome Aberrations; Chromosomes, Human, Pair 17; Disea | 2001 |
Induction of premature mitosis in root meristem cells of Vicia faba and Pisum sativum by various agents is correlated with an increased level of protein phosphorylation.
Topics: Antibodies, Monoclonal; Caffeine; Cell Nucleus; Chromosome Aberrations; Chromosomes; DNA, Plant; Flu | 2002 |
Overlapping roles of the spindle assembly and DNA damage checkpoints in the cell-cycle response to altered chromosomes in Saccharomyces cerevisiae.
Topics: Calcium-Binding Proteins; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Chromosome Aberrations; | 2002 |
Effect of DNA repair inhibitors on the induction and repair of bleomycin-induced chromosome damage.
Topics: Animals; Bleomycin; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; Cricetinae; Cr | 1979 |
The repair of bleomycin-induced DNA damage and its relationship to chromosome aberration repair.
Topics: Animals; Anti-Bacterial Agents; Bleomycin; Cell Line; Chromosome Aberrations; Chromosomes; Cricetina | 1979 |
DNA repair and frequency of x-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome.
Topics: Adult; Chromosome Aberrations; Chromosomes; DNA Repair; DNA Replication; Dose-Response Relationship, | 1976 |
Sister chromatid exchange and chromosome aberration analysis with the use of several carcinogens and noncarcinogens.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acridines; Benzop | 1977 |
Morphological transformation, DNA damage, and chromosomal aberrations induced by a direct DNA perturbation of synchronized Syrian hamster embryo cells.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultu | 1979 |
Unusual clonal evolution in a case of chronic myelogenous leukemia.
Topics: Adult; Chromosome Aberrations; Clone Cells; Humans; Hydroxyurea; Leukemia, Myeloid; Male; Translocat | 1976 |
The inhibition of repair in UV irradiated human cells.
Topics: Cell Division; Centrifugation, Density Gradient; Chromosome Aberrations; Chromosomes; DNA Repair; DN | 1977 |
X-ray induction of chromosome and chromatid aberrations in the same cells after treatment with hydroxyurea.
Topics: Chromatids; Chromosome Aberrations; DNA Replication; Hydroxyurea; Plant Physiological Phenomena; Pla | 1977 |
Arginine deprivation in KB cells. II. Characterization of the DNA synthesized during starvation.
Topics: Arginine; Cell Line; Centrifugation, Isopycnic; Chromosome Aberrations; DNA; DNA Replication; Hydrox | 1977 |
[Cytogenetics of megaloblast transformation].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; C | 1976 |
Tumor-associated karyotypic lesions coselected with in vitro macrophage differentiation.
Topics: Abelson murine leukemia virus; Animals; Azacitidine; Biomarkers, Tumor; Bromodeoxyuridine; Cell Adhe | 1992 |
The yield of fission neutron-induced chromatid aberrations in G2-stage human lymphocytes: effect of caffeine, hydroxyurea and cytosine arabinoside post-irradiation.
Topics: Caffeine; Chromosome Aberrations; Cytarabine; DNA Damage; DNA Repair; G2 Phase; Humans; Hydroxyurea; | 1992 |
Enhanced cytogenetic detection of previous in vivo exposure to mutagens in human lymphocytes after treatment with inhibitors of DNA synthesis and DNA repair in vitro.
Topics: Adult; Caffeine; Cells, Cultured; Chromosome Aberrations; DNA Repair; DNA Replication; Humans; Hydro | 1992 |
Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Chromosome Disorders; Extrachromosomal Inheritance; G | 1992 |
Biochemical and cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6. VI. The correlation between UV-induced DNA lesions and chromosomal aberrations, and their modulations with inhibitors of DNA repair synth
Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Cytarabine; DNA; DNA Damage; DNA | 1990 |
Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Aberrations; Chronic Disease; Female; Humans; Hydroxyurea | 1990 |
G2 effects of DNA-repair inhibitors on chromatid-type aberrations in root-tip cells treated with maleic hydrazide and mitomycin C.
Topics: Caffeine; Cell Cycle; Chromosome Aberrations; Chromosomes; Cytarabine; DNA Damage; DNA Repair; Floxu | 1989 |
The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA.
Topics: Amsacrine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes; Culture Media; Cytarabi | 1989 |
Relationship between cell cycle stage in the fertilized egg of mice and repair capacity for X-ray-induced damage in the sperm.
Topics: Animals; Benzamides; Caffeine; Cell Cycle; Chromosome Aberrations; Cytarabine; DNA Damage; DNA Repai | 1989 |
Mechanism of chromosome aberration induction in the mouse egg fertilized with sperm recovered from postmeiotic germ cells treated with methyl methanesulfonate.
Topics: Animals; Benzamides; Caffeine; Chromosome Aberrations; Cytarabine; Female; Hydroxyurea; Male; Meiosi | 1989 |
Effects of caffeine and inhibitors of DNA synthesis on chromatid-type aberrations induced by acetaldehyde in root-tip cells.
Topics: Acetaldehyde; Caffeine; Cells, Cultured; Chromatids; Chromosome Aberrations; Cytarabine; DNA Replica | 1987 |
The influence of a protein synthesis inhibitor on sister-chromatid exchange in the plant Vicia faba.
Topics: Chromosome Aberrations; Cycloheximide; DNA Replication; Fabaceae; Hydroxyurea; Mitomycin; Mitomycins | 1986 |
Hypersensitivity of Drosophila mei-41 mutants to hydroxyurea is associated with reduced mitotic chromosome stability.
Topics: Animals; Chromosome Aberrations; DNA Replication; Drosophila melanogaster; Hydroxyurea; Larva; Mitos | 1986 |
Studies on chromosome aberrations induced by incorporated tritium: effect of post-treatment with hydroxyurea and caffeine in G2.
Topics: Caffeine; Cells, Cultured; Chromosome Aberrations; DNA Damage; DNA Repair; Humans; Hydroxyurea; In V | 1988 |
Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Cycloheximide; DN | 1988 |
The effect of hydroxyurea on the expression of the common fragile site at 3p14.
Topics: Caffeine; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human | 1987 |
Acute leukemia in polycythemia vera.
Topics: Acute Disease; Antigens, Neoplasm; Bloodletting; Chlorambucil; Chromosome Aberrations; Chromosome Di | 1986 |
Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: implications for gene amplification.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes; Colchicine; Cric | 1986 |
Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival.
Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Basophils; Blood Cell Coun | 1985 |
Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneity.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; DNA; DNA Replication; Drug Resistance; Gene Amplif | 1985 |
Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations.
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; DNA; DNA Replication; Drug Resistan | 1985 |
Chromatid breakage: differential effect of inhibitors of DNA synthesis during G 2 phase.
Topics: Animals; Azacitidine; Azaguanine; Cell Line; Chromatids; Chromosome Aberrations; Cricetinae; Cytarab | 1972 |
Philadelphia-chromosome-positive preleukaemic state.
Topics: Adult; Blood Cell Count; Bone Marrow Cells; Bone Marrow Examination; Chromosome Aberrations; Cytarab | 1972 |
Hydroxyurea: effect on Cicia chromosomes previously exposed to x-rays or to radiomimetic chemicals.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antitubercular Agents; Caffeine; Chromosome Aber | 1967 |
[Limitations and risks of therapy of psoriasis with amethopterin and hydroxyurea].
Topics: Adult; Aged; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chromosome Aberrat | 1971 |
Unscheduled DNA synthesis, u.v.-induced chromosome aberrations and SV 40 transformation in cultured cells from xeroderma pigmentosum.
Topics: Adult; Autoradiography; Cell Transformation, Neoplastic; Cells, Cultured; Child; Chromosome Aberrati | 1971 |
Proceedings: The chronic leukemias: current therapeutic concepts.
Topics: Bromine; Busulfan; Cell Division; Chlorambucil; Chromosome Aberrations; Cyclophosphamide; Humans; Hy | 1972 |
Effect of hydroxyurea on the chromosomes of tumour cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Chromosome Aberrations; Chromosomes; Diploidy; Hydroxyurea; Leuke | 1972 |
Hydroxylamine and derivatives: cytotoxicity without mutagenicity in cellular genetic systems.
Topics: Animals; Antineoplastic Agents; Chromosome Aberrations; Chromosome Disorders; Drosophila melanogaste | 1970 |
The repair of x-ray-induced chromosome aberrations in stimulated and unstimulated human lymphocytes.
Topics: Amino Acids; Autoradiography; Chromosome Aberrations; Colchicine; Cycloheximide; DNA Repair; Humans; | 1972 |
Does hydroxyurea inhibit chromosome repair in cultured human lymphocytes?
Topics: Cell Transformation, Neoplastic; Chromosome Aberrations; Culture Techniques; Humans; Hydroxyurea; Ly | 1969 |
Autosomal monosomy mosaicism in human bone marrow aspirate. Report of a case.
Topics: Aged; Aneuploidy; Bone Marrow; Bone Marrow Cells; Carcinoma; Chromosome Aberrations; Chromosome Diso | 1968 |
Cytological effects on Chinese hamster cells of synchronizing concentrations of hydroxyurea.
Topics: Animals; Cell Division; Chromosome Aberrations; Chromosomes; Cricetinae; Culture Techniques; Hydroxy | 1968 |
Effect of chemotherapeutic agents on chromosomes of patients with lung cancer.
Topics: Adult; Antineoplastic Agents; Carcinoma, Bronchogenic; Chromosome Aberrations; Chromosomes; Cyclopho | 1969 |