hydroxysafflor-yellow-a has been researched along with Hyperglycemia* in 1 studies
1 other study(ies) available for hydroxysafflor-yellow-a and Hyperglycemia
| Article | Year |
|---|---|
Protective Effects of Two Safflower Derived Compounds, Kaempferol and Hydroxysafflor Yellow A, on Hyperglycaemic Stress-Induced Podocyte Apoptosis via Modulating of Macrophage M1/M2 Polarization.
The primary initiating mechanism in diabetes nephropathy (DN) is hyperglycemia-induced inflammation in which macrophage and podocyte play important roles. The present research is aimed at exploring the effects of kaempferol (Ka) and hydroxysafflor yellow A (HSYA) on classically activated (M1)/alternatively activated (M2) macrophage polarization and podocyte apoptosis under hyperglycaemic conditions. (1) RAW264.7 cells were treated with 11.1 mM glucose (NG), 33.3 mM glucose (HG), Ka 4-8 . (1) Compared to the HG group, the Ka and HSYA 100 . The protective effects of Ka and HSYA on podocyte apoptosis under hyperglycemic stress are related to their modulation on M1/M2 polarization and the lowering effects on TNF- Topics: Animals; Apoptosis; Carthamus tinctorius; Cell Differentiation; Cells, Cultured; Chalcone; Cytokines; Humans; Hyperglycemia; Immunomodulation; Kaempferols; Macrophages; Mice; Podocytes; Quinones; RAW 264.7 Cells; Stress, Physiological; Th1 Cells; Th2 Cells | 2020 |