hydroxyproline has been researched along with Ureteral Obstruction in 11 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Ureteral Obstruction: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pirfenidone (PFD) is a novel anti-fibrotic agent that can prevent and even reverse extracellular matrix accumulation in several organs, as shown by experimental and clinical studies." | 5.30 | Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. ( Fukagawa, M; Hata, S; Kuroda, T; Kurokawa, K; Margolin, SB; Shimizu, T, 1998) |
| "Renal fibrosis is a well‑known cause for the progression of chronic kidney disease." | 1.43 | Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice. ( Baba, I; Egi, Y; Suzuki, K, 2016) |
| "Fibrosis is the final common pathway for various tissue lesions that lead to chronic progressive organ failure, and consequently effective antifibrotic drugs are strongly desired." | 1.36 | A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats. ( Kato, M; Mizuno, M; Sada, T; Terashima, H; Tsuchida, H; Yasumo, H, 2010) |
| "Obstruction-induced fibrosis is a leading cause of end-stage renal failure in children." | 1.34 | AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction. ( Eskild-Jensen, A; Frøkiaer, J; Nyengaard, JR; Olesen, P; Paulsen, LF; Pedersen, L; Wogensen, L, 2007) |
| "Fibrosis is a hallmark of progressive organ disease." | 1.34 | Blockade of IP-10/CXCR3 promotes progressive renal fibrosis. ( Furuichi, K; Gerard, C; Haino, M; Ishida, Y; Kaneko, S; Kawachi, H; Kitagawa, K; Kondo, T; Matsushima, K; Nakaya, I; Narumi, S; Sakai, N; Shimizu, F; Sugaya, T; Wada, T; Yokoyama, H, 2007) |
| "Pirfenidone (PFD) is a novel anti-fibrotic agent that can prevent and even reverse extracellular matrix accumulation in several organs, as shown by experimental and clinical studies." | 1.30 | Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. ( Fukagawa, M; Hata, S; Kuroda, T; Kurokawa, K; Margolin, SB; Shimizu, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, J | 1 |
| Zhang, J | 1 |
| Rudemiller, NP | 1 |
| Griffiths, R | 1 |
| Wen, Y | 1 |
| Lu, X | 2 |
| Privratsky, JR | 1 |
| Gunn, MD | 1 |
| Crowley, SD | 1 |
| Baba, I | 1 |
| Egi, Y | 1 |
| Suzuki, K | 1 |
| Fang, J | 1 |
| Wang, W | 1 |
| Sun, S | 1 |
| Wang, Y | 1 |
| Li, Q | 1 |
| Qiu, M | 1 |
| Zhang, Y | 1 |
| Terashima, H | 1 |
| Kato, M | 1 |
| Yasumo, H | 1 |
| Tsuchida, H | 1 |
| Mizuno, M | 1 |
| Sada, T | 1 |
| Nakanishi, T | 1 |
| Morokata, T | 1 |
| Noto, T | 1 |
| Kubo, K | 1 |
| Umeno, H | 1 |
| Kinugasa, F | 1 |
| Eikyu, Y | 1 |
| Kozuki, Y | 1 |
| Seki, N | 1 |
| Yuan, XP | 1 |
| Liu, LS | 1 |
| Fu, Q | 1 |
| Wang, CX | 1 |
| Eskild-Jensen, A | 1 |
| Paulsen, LF | 1 |
| Wogensen, L | 1 |
| Olesen, P | 1 |
| Pedersen, L | 1 |
| Frøkiaer, J | 1 |
| Nyengaard, JR | 1 |
| Nakaya, I | 1 |
| Wada, T | 1 |
| Furuichi, K | 1 |
| Sakai, N | 1 |
| Kitagawa, K | 1 |
| Yokoyama, H | 1 |
| Ishida, Y | 1 |
| Kondo, T | 1 |
| Sugaya, T | 1 |
| Kawachi, H | 1 |
| Shimizu, F | 1 |
| Narumi, S | 1 |
| Haino, M | 1 |
| Gerard, C | 1 |
| Matsushima, K | 1 |
| Kaneko, S | 1 |
| Bruno, NE | 1 |
| Yano, Y | 1 |
| Takei, Y | 1 |
| Gabazza, EC | 1 |
| Qin, L | 1 |
| Nagashima, M | 1 |
| Morser, J | 1 |
| D'Alessandro-Gabazza, CN | 1 |
| Taguchi, O | 1 |
| Sumida, Y | 1 |
| Na, Y | 1 |
| Zhang, XX | 1 |
| Zhang, XD | 1 |
| Yuan, HP | 1 |
| Hu, XL | 1 |
| Zheng, W | 1 |
| Li, G | 1 |
| Shimizu, T | 1 |
| Kuroda, T | 1 |
| Hata, S | 1 |
| Fukagawa, M | 1 |
| Margolin, SB | 1 |
| Kurokawa, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury[NCT02530359] | Phase 4 | 90 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for hydroxyproline and Ureteral Obstruction
| Article | Year |
|---|---|
Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis
Topics: Actins; Animals; Benzofurans; Collagen Type I; CX3C Chemokine Receptor 1; Disease Models, Animal; Ex | 2019 |
Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice.
Topics: Animals; Collagen Type I; Disease Models, Animal; Fibrosis; Gene Deletion; Heterozygote; Hydroxyprol | 2016 |
Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Blood Urea Nitrogen; Creatinine; Discr | 2016 |
A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzamides; Collagen; Collagen Type I; Collagen Ty | 2010 |
Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats.
Topics: Acridines; Animals; Chemokine CCL2; Chronic Disease; Collagen; Fibrosis; Hydroxyproline; IMP Dehydro | 2010 |
Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis.
Topics: Actins; Animals; Bone Morphogenetic Protein 7; Cell Line; Collagen; Connective Tissue Growth Factor; | 2012 |
AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Apoptosis; Benzi | 2007 |
Blockade of IP-10/CXCR3 promotes progressive renal fibrosis.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Chemokine CXCL10; Chemokines, CXC; Disease Progres | 2007 |
Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis.
Topics: Animals; Carboxypeptidase B2; Cytokines; Fibrinolysin; Fibrosis; Hydroxyproline; Kidney Diseases; Ma | 2008 |
[Effects of reduced glutathione on contents of hydroxyproline and oxidation stress reaction in kidney of unilateral ureteral obstruction in rat].
Topics: Animals; Disease Models, Animal; Female; Glutathione; Hydroxyproline; Kidney; Male; Malondialdehyde; | 2007 |
Pirfenidone improves renal function and fibrosis in the post-obstructed kidney.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Collagen; Disea | 1998 |