hydroxyproline has been researched along with Sensitivity and Specificity in 46 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "to observe the influence of aging on urinary secretion of 3-hydroxyproline (3-Hyp) in normal subjects and in cancer patients and study the effects of aging on the accuracy of urinary 3-Hyp as a general-purpose cancer screening test." | 7.69 | [Effects of aging on urinary secretion of 3-hydroxyproline and its importance for cancer screening in the elderly with ROC analysis]. ( Arai, M; Bos, AJ; Maruta, A; Matsuyama, S; Okazaki, I; Yuan, P, 1994) |
| "Treatment with pirfenidone significantly reduced the number of these cells compared with the corresponding BL group." | 5.32 | Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis. ( Abe, K; Fujii, T; Hayashi, T; Ishii, H; Kadota, J; Kakugawa, T; Kohno, S; Miyazaki, M; Mukae, H; Oku, H, 2004) |
| "to observe the influence of aging on urinary secretion of 3-hydroxyproline (3-Hyp) in normal subjects and in cancer patients and study the effects of aging on the accuracy of urinary 3-Hyp as a general-purpose cancer screening test." | 3.69 | [Effects of aging on urinary secretion of 3-hydroxyproline and its importance for cancer screening in the elderly with ROC analysis]. ( Arai, M; Bos, AJ; Maruta, A; Matsuyama, S; Okazaki, I; Yuan, P, 1994) |
| " An evaluation was made of deoxypyridinoline as well as other bone markets, such as alkaline phosphatase, tartrate resistant acid phosphatase, and hydroxyproline in patients with the diagnosis of osteoporosis." | 3.69 | [Deoxypyridinoline and other biochemical markers of bone resorption in distinct pathologies]. ( García Merlo, S; Grijalba Uche, A; Martínez Rodríguez, JL; Palacios Sarrasqueta, M; Rivero Marcotegui, A; Sorbet Zubiría, MJ, 1997) |
| " The validated method was successfully applied to a preclinical pharmacokinetic study of oxaceprol in rats." | 1.37 | Determination of oxaceprol in rat plasma by LC-MS/MS and its application in a pharmacokinetic study. ( Chen, N; Ding, G; Gu, J; Zhang, Z, 2011) |
| "Fibrosis is the final common pathway for various tissue lesions that lead to chronic progressive organ failure, and consequently effective antifibrotic drugs are strongly desired." | 1.36 | A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats. ( Kato, M; Mizuno, M; Sada, T; Terashima, H; Tsuchida, H; Yasumo, H, 2010) |
| "The hydroxyproline concentration was estimated relative to pipecolic acid, 3,4-dehydroproline and n-tetracosane as internal standards." | 1.32 | Quantitation of hydroxyproline in bone by gas chromatography-mass spectrometry. ( Delport, M; Laurens, JB; Maas, S; van der Merwe, SW, 2004) |
| "Treatment with pirfenidone significantly reduced the number of these cells compared with the corresponding BL group." | 1.32 | Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis. ( Abe, K; Fujii, T; Hayashi, T; Ishii, H; Kadota, J; Kakugawa, T; Kohno, S; Miyazaki, M; Mukae, H; Oku, H, 2004) |
| "Hydroxyproline was derivatized using 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole; separation and detection were accomplished using HPLC with coulometric electrochemical detection." | 1.29 | Coulometric electrochemical detection of hydroxyproline using 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole. ( Acworth, I; Levine, M; Welch, RW, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.52) | 18.7374 |
| 1990's | 15 (32.61) | 18.2507 |
| 2000's | 17 (36.96) | 29.6817 |
| 2010's | 11 (23.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, Y | 1 |
| Zhao, J | 1 |
| Shi, Y | 1 |
| Chen, C | 1 |
| Chen, X | 1 |
| Lv, C | 1 |
| Zhang, N | 1 |
| Zhu, Q | 1 |
| Gong, M | 1 |
| Inoue, Y | 1 |
| Kuwahara, A | 1 |
| Ohmori, K | 1 |
| Sunayama, H | 1 |
| Ooya, T | 1 |
| Takeuchi, T | 1 |
| Pester, JK | 1 |
| Stumpfe, ST | 1 |
| Steinert, S | 1 |
| Marintschev, I | 1 |
| Plettenberg, HK | 1 |
| Aurich, M | 1 |
| Hofmann, GO | 1 |
| da Silva, CM | 1 |
| Spinelli, E | 1 |
| Rodrigues, SV | 1 |
| Ahmed, U | 1 |
| Anwar, A | 1 |
| Savage, RS | 1 |
| Costa, ML | 1 |
| Mackay, N | 1 |
| Filer, A | 1 |
| Raza, K | 1 |
| Watts, RA | 1 |
| Winyard, PG | 1 |
| Tarr, J | 1 |
| Haigh, RC | 1 |
| Thornalley, PJ | 1 |
| Rabbani, N | 1 |
| Liu, F | 1 |
| Chen, L | 1 |
| Rao, HY | 1 |
| Teng, X | 1 |
| Ren, YY | 1 |
| Lu, YQ | 1 |
| Zhang, W | 1 |
| Wu, N | 1 |
| Liu, FF | 1 |
| Wei, L | 1 |
| Xu, Y | 1 |
| Fang, L | 1 |
| Wang, E | 1 |
| Yang, ZR | 1 |
| Kassira, N | 1 |
| Glassberg, MK | 1 |
| Jones, C | 1 |
| Pincus, DJ | 1 |
| Elliot, SJ | 1 |
| Fritz, JR | 1 |
| Karl, M | 1 |
| Thaller, S | 1 |
| Terashima, H | 1 |
| Kato, M | 1 |
| Yasumo, H | 1 |
| Tsuchida, H | 1 |
| Mizuno, M | 1 |
| Sada, T | 1 |
| Gavina, JM | 1 |
| White, CE | 1 |
| Finan, TM | 1 |
| Britz-McKibbin, P | 1 |
| Gu, J | 1 |
| Chen, N | 1 |
| Ding, G | 1 |
| Zhang, Z | 1 |
| Ye, X | 1 |
| Wang, L | 1 |
| Dang, Y | 1 |
| Liu, B | 1 |
| Zhao, D | 1 |
| Steen, H | 1 |
| Mann, M | 1 |
| Långsjö, TK | 1 |
| Rieppo, J | 1 |
| Pelttari, A | 1 |
| Oksala, N | 1 |
| Kovanen, V | 1 |
| Helminen, HJ | 1 |
| Stern, S | 1 |
| Lindenhayn, K | 1 |
| Perka, C | 1 |
| Delport, M | 1 |
| Maas, S | 1 |
| van der Merwe, SW | 1 |
| Laurens, JB | 1 |
| Grainger, DJ | 1 |
| Aitken, S | 1 |
| Kakugawa, T | 1 |
| Mukae, H | 1 |
| Hayashi, T | 1 |
| Ishii, H | 1 |
| Abe, K | 1 |
| Fujii, T | 1 |
| Oku, H | 1 |
| Miyazaki, M | 1 |
| Kadota, J | 1 |
| Kohno, S | 1 |
| Hagiyama, M | 1 |
| Arata, J | 1 |
| Tanioku, K | 1 |
| Tuckerman, JR | 1 |
| Zhao, Y | 1 |
| Hewitson, KS | 1 |
| Tian, YM | 1 |
| Pugh, CW | 1 |
| Ratcliffe, PJ | 1 |
| Mole, DR | 1 |
| Moorhead, JF | 1 |
| Varghese, Z | 1 |
| Tatler, GL | 1 |
| Baillod, RA | 1 |
| Wills, MR | 1 |
| Gorgulu, S | 1 |
| Yagci, G | 1 |
| Kaymakcioglu, N | 1 |
| Ozkara, M | 1 |
| Kurt, B | 1 |
| Ozcan, A | 1 |
| Kaya, O | 1 |
| Sadir, S | 1 |
| Tufan, T | 1 |
| Attallah, AM | 1 |
| Toson, EA | 1 |
| Shiha, GE | 1 |
| Omran, MM | 1 |
| Abdel-Aziz, MM | 1 |
| El-Dosoky, I | 1 |
| Silsand, T | 1 |
| Reine, A | 1 |
| Dugal, S | 1 |
| Lunde, T | 1 |
| Smedsrud, B | 1 |
| Seeberg, T | 1 |
| Bianchi, V | 1 |
| Mazza, L | 1 |
| Bos, AJ | 1 |
| Yuan, P | 1 |
| Maruta, A | 2 |
| Matsuyama, S | 2 |
| Arai, M | 1 |
| Okazaki, I | 2 |
| Kataoka, H | 1 |
| Nabeshima, N | 1 |
| Nagao, K | 1 |
| Makita, M | 1 |
| Welch, RW | 1 |
| Acworth, I | 1 |
| Levine, M | 1 |
| Mazzi, G | 1 |
| Fioravanzo, F | 1 |
| Burti, E | 1 |
| Mubay, I | 1 |
| Mbuyi-Muamba, JM | 1 |
| Kalala-Lunganza, R | 1 |
| Dequeker, J | 1 |
| Last, JA | 1 |
| Pinkerton, KE | 1 |
| Koyano, Y | 1 |
| Hämmerle, H | 1 |
| Mollenhauer, J | 1 |
| Le Boucher, J | 1 |
| Charret, C | 1 |
| Coudray-Lucas, C | 1 |
| Giboudeau, J | 1 |
| Cynober, L | 1 |
| Rivero Marcotegui, A | 1 |
| Palacios Sarrasqueta, M | 1 |
| Grijalba Uche, A | 1 |
| Martínez Rodríguez, JL | 1 |
| Sorbet Zubiría, MJ | 1 |
| García Merlo, S | 1 |
| Tsuruta, Y | 3 |
| Inoue, H | 3 |
| Iguchi, H | 1 |
| Kono, A | 1 |
| Ye, Q | 1 |
| Zünd, G | 1 |
| Jockenhoevel, S | 1 |
| Hoerstrup, SP | 1 |
| Schoeberlein, A | 1 |
| Grunenfelder, J | 1 |
| Turina, M | 1 |
| Vouyouka, AG | 1 |
| Pfeiffer, BJ | 1 |
| Liem, TK | 1 |
| Taylor, TA | 1 |
| Mudaliar, J | 1 |
| Phillips, CL | 1 |
| Iguch, H | 1 |
| Kouno, A | 1 |
| Schmolke, B | 1 |
| Vestergaard, P | 1 |
| Hermann, AP | 1 |
| Gram, J | 1 |
| Jensen, LB | 1 |
| Eiken, P | 1 |
| Abrahamsen, B | 1 |
| Brot, C | 1 |
| Kolthoff, N | 1 |
| Sørensen, OH | 1 |
| Beck Nielsen, H | 1 |
| Pors Nielsen, S | 1 |
| Charles, P | 1 |
| Mosekilde, L | 1 |
| Walsh, BJ | 1 |
| Thornton, SC | 1 |
| Penny, R | 1 |
| Breit, SN | 1 |
| Suzuki, F | 1 |
| Maruyama, K | 1 |
| Kubochi, K | 1 |
| Yoshino, K | 1 |
| Kobayashi, Y | 1 |
| Abe, O | 1 |
| Tsuchiya, M | 1 |
| Coulton, LA | 1 |
| Preston, CJ | 1 |
| Couch, M | 1 |
| Kanis, JA | 1 |
1 review available for hydroxyproline and Sensitivity and Specificity
| Article | Year |
|---|---|
Hydroxyprolinuria in normal Zairean children.
Topics: Adolescent; Age Distribution; Child; Child, Preschool; Democratic Republic of the Congo; Developing | 1996 |
45 other studies available for hydroxyproline and Sensitivity and Specificity
| Article | Year |
|---|---|
Simple determination of L-hydroxyproline in idiopathic pulmonary fibrosis lung tissues of rats using non-extractive high-performance liquid chromatography coupled with fluorescence detection after pre-column derivatization with novel synthetic 9-acetylimi
Topics: Animals; Carbazoles; Chromatography, High Pressure Liquid; Hydroxyproline; Idiopathic Pulmonary Fibr | 2017 |
Rapid determination of free prolyl dipeptides and 4-hydroxyproline in urine using flow-gated capillary electrophoresis.
Topics: Adult; Dipeptides; Electrophoresis, Capillary; Humans; Hydroxyproline; Male; Reproducibility of Resu | 2017 |
Fluorescent molecularly imprinted polymer thin films for specific protein detection prepared with dansyl ethylenediamine-conjugated O-acryloyl L-hydroxyproline.
Topics: Animals; Biosensing Techniques; Cattle; Dansyl Compounds; Ethylenediamines; Fluorescent Dyes; Humans | 2013 |
[Histological, biochemical and spectroscopic changes of articular cartilage in osteoarthritis: is there a chance for spectroscopic evaluation?].
Topics: Aged; Aged, 80 and over; Biomarkers; Cartilage, Articular; Female; Humans; Hydroxyproline; Male; Mid | 2014 |
Fast and sensitive collagen quantification by alkaline hydrolysis/hydroxyproline assay.
Topics: Animals; Biological Assay; Collagen; Colorimetry; Fasting; Hydrogen-Ion Concentration; Hydrolysis; H | 2015 |
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.
Topics: Adult; Aged; Algorithms; Area Under Curve; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Chroma | 2015 |
Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy.
Topics: Animals; Automation, Laboratory; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; Hydroxypr | 2017 |
Successful establishment of MEKC with electrochemiluminescence detection based on one functionalized ionic liquid.
Topics: Chromatography, Micellar Electrokinetic Capillary; Electrochemistry; Hydroxyproline; Imidazoles; Ion | 2009 |
Predict collagen hydroxyproline sites using support vector machines.
Topics: Algorithms; Amino Acid Sequence; Artificial Intelligence; Collagen; Hydroxyproline; Mathematics; Mod | 2009 |
Estrogen deficiency and tobacco smoke exposure promote matrix metalloproteinase-13 activation in skin of aging B6 mice.
Topics: Animals; Disease Models, Animal; Enzyme Activation; Estradiol; Estrogens; Female; Hydroxyproline; Ma | 2009 |
A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzamides; Collagen; Collagen Type I; Collagen Ty | 2010 |
Determination of 4-hydroxyproline-2-epimerase activity by capillary electrophoresis: A stereoselective platform for inhibitor screening of amino acid isomerases.
Topics: Amino Acid Isomerases; Bacterial Proteins; Cystic Fibrosis; Electrophoresis, Capillary; Enzyme Inhib | 2010 |
Determination of oxaceprol in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.
Topics: Acetates; Acetonitriles; Administration, Oral; Animals; Chemistry Techniques, Analytical; Chromatogr | 2011 |
Investigation of the 1064 nm Q-switched Nd:YAG laser on collagen expression in an animal model.
Topics: Animals; Blotting, Western; Collagen; Female; Hydroxyproline; Lasers, Solid-State; Low-Level Light T | 2012 |
Analysis of bromotryptophan and hydroxyproline modifications by high-resolution, high-accuracy precursor ion scanning utilizing fragment ions with mass-deficient mass tags.
Topics: Animals; Conotoxins; Hydroxyproline; Ions; Mass Spectrometry; Mollusca; Mollusk Venoms; Sensitivity | 2002 |
Collagenase-induced changes in articular cartilage as detected by electron-microscopic stereology, quantitative polarized light microscopy and biochemical assays.
Topics: Animals; Cartilage, Articular; Cattle; Collagen; Collagenases; Hydroxyproline; Microscopy, Electron; | 2002 |
Human intervertebral disc cell culture for disc disorders.
Topics: Biomarkers; Cell Movement; Cells, Cultured; DNA; Female; Humans; Hydroxyproline; Intervertebral Disc | 2004 |
Quantitation of hydroxyproline in bone by gas chromatography-mass spectrometry.
Topics: Animals; Bone and Bones; Calibration; Gas Chromatography-Mass Spectrometry; Hydroxyproline; Rats; Se | 2004 |
A microtitre format assay for proline in human serum or plasma.
Topics: Buffers; Humans; Hydroxyproline; Isatin; Kinetics; Proline; Reference Standards; Sensitivity and Spe | 2004 |
Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Bleomycin; Disease Models, Animal; HSP70 Heat-Shock P | 2004 |
The effects of castration and testosterone administration on mast cells and hydroxyproline in rat skin.
Topics: Animals; Castration; Cells, Cultured; Disease Models, Animal; Female; Hydroxyproline; Japan; Male; M | 1977 |
Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Catalysis; Cell Extracts; Cell Hypoxia; Cell Line; Huma | 2004 |
Comparison of biochemical with radiological findings in renal osteodystrophy.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Calcium; Chronic Kidney Disease-Mineral and Bone Disord | 1975 |
Hyperbaric oxygen enhances the efficiency of 5-aminosalicylic acid in acetic acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Colitis, Ulcerative; Combined Modality Therapy; Disease Models, Animal; Female | 2006 |
Evaluation of serum procollagen aminoterminal propeptide III, laminin, and hydroxyproline as predictors of severe fibrosis in patients with chronic hepatitis C.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Collagen Type III; Diagnosis, Differential; | 2007 |
Urinary concentration of a specific peptide of type I collagen of bone (CrossLaps): correlation to hydroxyproline.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Bone and Bones; Collagen; Female; Humans; Hydroxyproline | 1995 |
Rapid reversed-phase high-performance liquid chromatographic method with double derivatization for the assay of urinary hydroxyproline.
Topics: Chromatography, High Pressure Liquid; Humans; Hydroxyproline; o-Phthalaldehyde; p-Dimethylaminoazobe | 1995 |
[Effects of aging on urinary secretion of 3-hydroxyproline and its importance for cancer screening in the elderly with ROC analysis].
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers, Tumor; Female; Humans; Hydroxyproline; Male; Mass | 1994 |
Selective and sensitive determination of urinary total proline and hydroxyproline by gas chromatography with flame photometric detection.
Topics: Chromatography, Gas; Humans; Hydroxyproline; Photometry; Proline; Sensitivity and Specificity | 1993 |
Coulometric electrochemical detection of hydroxyproline using 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Ascorbic Acid; Cattle; Cells, Cultured; Collagen; Electrochem | 1993 |
New marker of bone resorption: hydroxyproline-containing peptide. High-performance liquid chromatographic assay without hydrolysis as an alternative to hydroxyproline determination: a preliminary report.
Topics: Adult; Amino Acids; Biomarkers; Bone Resorption; Chromatography, High Pressure Liquid; Female; Fluor | 1996 |
Chronic exposure of rats to ozone and sulfuric acid aerosol: biochemical and structural responses.
Topics: Aerosols; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hydroxyproline; Lung; Male; Ozo | 1997 |
Analysis of 3H-proline-labeled protein by rapid filtration in multiwell plates for the study of collagen metabolism.
Topics: Animals; Cartilage, Articular; Cattle; Cells, Cultured; Chickens; Collagen; Electrophoresis, Polyacr | 1997 |
Amino acid determination in biological fluids by automated ion-exchange chromatography: performance of Hitachi L-8500A.
Topics: Amino Acids; Automation; Body Fluids; Buffers; Calibration; Chromatography, High Pressure Liquid; Ch | 1997 |
[Deoxypyridinoline and other biochemical markers of bone resorption in distinct pathologies].
Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Resorption; Female; Hum | 1997 |
4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride as a fluorescent labeling reagent for determination of amino acids in high-performance liquid chromatography and its application for determination of urinary free hydroxyproline.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Hydroxyproline; Phthali | 1998 |
Highly sensitive determination of N-terminal prolyl dipeptides, proline and hydroxyproline in urine by high-performance liquid chromatography using a new fluorescent labelling reagent, 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride.
Topics: Chromatography, High Pressure Liquid; Dipeptides; Fluorescent Dyes; Humans; Hydroxyproline; Phthalim | 1999 |
Tissue engineering in cardiovascular surgery: new approach to develop completely human autologous tissue.
Topics: Analysis of Variance; Aorta, Thoracic; Cardiovascular Surgical Procedures; Cells, Cultured; Collagen | 2000 |
The role of type I collagen in aortic wall strength with a homotrimeric.
Topics: Analysis of Variance; Animals; Aorta; Biomechanical Phenomena; Collagen; Culture Techniques; Hydroxy | 2001 |
Fluorometric determination of N-terminal prolyl dipeptides, proline and hydroxyproline in human serum by pre-column high-performance liquid chromatography using 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsufonyl chloride.
Topics: Chromatography, High Pressure Liquid; Dipeptides; Fluorescent Dyes; Humans; Hydroxyproline; Phthalim | 2001 |
[Laboratory diagnosis of osteoporosis].
Topics: Adult; Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone and Bones; Bone Resorption; Child; | 2001 |
Evaluation of methods for prediction of bone mineral density by clinical and biochemical variables in perimenopausal women.
Topics: Alkaline Phosphatase; Biomarkers; Bone Density; Climacteric; Creatinine; Cross-Sectional Studies; Fe | 2001 |
Microplate reader-based quantitation of collagens.
Topics: Acetylcholinesterase; Azo Compounds; Cell Line; Collagen; Colorimetry; Coloring Agents; Elastin; Hum | 1992 |
Endogenous urinary 3-hydroxyproline has 96% specificity and 44% sensitivity for cancer screening.
Topics: Adult; Aged; Biomarkers, Tumor; Creatinine; Female; Humans; Hydroxyproline; Male; Middle Aged; Neopl | 1992 |
An evaluation of serum osteocalcin in Paget's disease of bone and its response to diphosphonate treatment.
Topics: Alkaline Phosphatase; Calcium-Binding Proteins; Diphosphonates; Female; Humans; Hydroxyproline; Male | 1988 |