hydroxyproline has been researched along with Scleroderma, Systemic in 77 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the immune regulatory and anti-fibrosis function of thalidomide (Thal) in systemic sclerosis (SSc), we investigated the effects of Thal on: (a) Th17 and Treg cell production; (b) related factors expression; and (c) transforming growth factor (TGF)-β1/Smad3 pathway, using a mouse model of SSc." | 3.96 | Effects of thalidomide on Th17, Treg cells and TGF-β1/Smad3 pathway in a mouse model of systemic sclerosis. ( Lei, L; Li, X; Lu, Y; Tao, Z; Wen, J; Zhao, C; Zheng, L, 2020) |
| " The purpose of this study was to test in vivo the antifibrotic activity of Bosutinib (SKI-606), a second generation c-Abl and Src kinase inhibitor, on TGF-β induced cutaneous and pulmonary fibrosis." | 3.88 | Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib). ( Jimenez, SA; Wermuth, PJ, 2018) |
| "Bleomycin was subcutaneously injected every day in WBB6F1-W/W(V) and their normal littermate WBB6F1-+/+ mice for 4 weeks, and mice were analyzed for histological sclerosis, mast cell number, plasma histamine level, and hydroxyproline content." | 3.70 | Animal model of sclerotic skin. II. Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1-W/W(V) mice. ( Katayama, I; Nishioka, K; Takagawa, S; Takahashi, Y; Yamamoto, T, 1999) |
| "The most dominant feature of systemic sclerosis (SSc) is fibrosis, which is caused by overproduction of collagen by fibroblasts." | 1.42 | 2-Methoxyestradiol inhibits bleomycin-induced systemic sclerosis through suppression of fibroblast activation. ( Li, M; Song, Y; Zhu, L, 2015) |
| "The tight skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of the human disease including tight skin, fibrosis, extracellular matrix abnormalities, and reported antinuclear antibodies (ANA)." | 1.40 | Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. ( Artlett, CM; Blankenhorn, EP; Long, KB, 2014) |
| "Reduced fibrosis is due to deregulated fibroblast function, as the inflammatory response induced by bleomycin was similar in wild-type and Smad3(-/-) mice." | 1.32 | Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. ( Chen, SJ; DiPietro, LA; Ferreira, AM; Han, G; Lakos, G; Masuda, K; Takagawa, S; Varga, J; Wang, XJ, 2004) |
| "Although no single animal model of systemic sclerosis (SSc) faithfully reproduces all features of the human disease, certain animal models that display some of the features of SSc are potentially useful as they may be helpful in gaining a better understanding of the pathogenesis of SSc as well as developing novel therapeutic interventions." | 1.32 | Animal models of scleroderma. ( Lakos, G; Takagawa, S; Varga, J, 2004) |
| "A new murine model of Systemic Sclerosis (SSc) has been developed by breeding the Tsk+/+pa tight skin mouse (TSK) and the autoimmune disease-prone NZB strain to produce an F1 hybrid displaying the connective tissue abnormalities of the TSK parent and the autoimmune abnormalities of the NZB parent." | 1.29 | Immunological characterization of (tight skin/NZB)F1 hybrid mice with connective tissue and autoimmune features resembling human systemic sclerosis. ( Bocchieri, MH; Christner, PJ; Henriksen, PD; Jimenez, SA, 1993) |
| "The hydroxyproline concentration was significantly increased (P less than 0." | 1.28 | Hydroxyproline in the oesophageal mucosa of patients with progressive systemic sclerosis during omeprazole-induced healing of reflux oesophagitis. ( Hendel, L, 1991) |
| "Rectal mucosa from 11 progressive systemic sclerosis patients, 5 patients with ulcerative colitis and 7 patients with various other diseases was analysed for collagen components." | 1.27 | Collagen components in the duodenal and rectal mucosa in progressive systemic sclerosis and other diseases. ( Ammitzbøll, T; Dirksen, K; Hendel, L; Petri, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (66.23) | 18.7374 |
| 1990's | 6 (7.79) | 18.2507 |
| 2000's | 8 (10.39) | 29.6817 |
| 2010's | 10 (12.99) | 24.3611 |
| 2020's | 2 (2.60) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuka, T | 1 |
| Kotani, T | 1 |
| Saito, T | 1 |
| Matsuda, S | 1 |
| Sato, T | 1 |
| Takeuchi, T | 1 |
| Fan, CF | 1 |
| Zhang, HX | 1 |
| Tang, YH | 1 |
| Xu, HH | 1 |
| Song, D | 1 |
| Lu, Y | 1 |
| Zhao, C | 3 |
| Lei, L | 3 |
| Tao, Z | 1 |
| Zheng, L | 1 |
| Wen, J | 1 |
| Li, X | 1 |
| Wermuth, PJ | 2 |
| Jimenez, SA | 4 |
| Mendoza, FA | 1 |
| Usategui, A | 1 |
| Criado, G | 1 |
| Del Rey, MJ | 1 |
| Faré, R | 1 |
| Pablos, JL | 1 |
| Long, KB | 1 |
| Artlett, CM | 1 |
| Blankenhorn, EP | 1 |
| Zhu, L | 1 |
| Song, Y | 1 |
| Li, M | 2 |
| Zhong, XN | 2 |
| He, ZY | 2 |
| Sun, XJ | 2 |
| Ohashi, T | 1 |
| Yamamoto, T | 4 |
| Ma, J | 1 |
| Chen, L | 1 |
| Liao, R | 1 |
| Xu, S | 1 |
| Xu, D | 1 |
| Li, W | 1 |
| Zhao, L | 1 |
| Xiao, K | 1 |
| Wang, H | 1 |
| Wang, Z | 1 |
| Sun, L | 1 |
| Zhang, F | 1 |
| Zhang, X | 1 |
| Tang, F | 1 |
| He, W | 1 |
| Hayashi, S | 1 |
| Ikeda, M | 1 |
| Kitamura, Y | 1 |
| Hamasaki, Y | 1 |
| Hatamochi, A | 1 |
| FLEISCHMAJER, R | 3 |
| ASBOE-HANSEN, G | 6 |
| NELLAS, CL | 1 |
| CRAWFORD, N | 1 |
| SCHERBEL, AL | 2 |
| Lakos, G | 2 |
| Takagawa, S | 5 |
| Chen, SJ | 1 |
| Ferreira, AM | 1 |
| Han, G | 1 |
| Masuda, K | 1 |
| Wang, XJ | 1 |
| DiPietro, LA | 1 |
| Varga, J | 2 |
| Kohno, S | 1 |
| Endo, H | 1 |
| Hashimoto, A | 1 |
| Hayashi, I | 1 |
| Murakami, Y | 1 |
| Kitasato, H | 1 |
| Kojima, F | 1 |
| Kawai, S | 1 |
| Kondo, H | 1 |
| Fineschi, S | 1 |
| Bongiovanni, M | 1 |
| Donati, Y | 1 |
| Djaafar, S | 1 |
| Naso, F | 1 |
| Goffin, L | 1 |
| Argiroffo, CB | 1 |
| Pache, JC | 1 |
| Dayer, JM | 1 |
| Ferrari-Lacraz, S | 1 |
| Chizzolini, C | 1 |
| Krol, S | 1 |
| Blumenkrantz, N | 6 |
| Hata, R | 1 |
| Sunada, H | 1 |
| Nagai, Y | 1 |
| Millan, A | 1 |
| Bashey, RI | 2 |
| Tan, EM | 1 |
| Ryhänen, L | 1 |
| Uitto, J | 6 |
| Bocchieri, MH | 1 |
| Christner, PJ | 1 |
| Henriksen, PD | 1 |
| Hatakeyama, A | 1 |
| Kasturi, KN | 1 |
| Wolf, I | 1 |
| Phelps, RG | 1 |
| Bona, CA | 1 |
| Katayama, I | 2 |
| Mizushima, Y | 1 |
| Nishioka, K | 3 |
| Takahashi, Y | 1 |
| Kuroda, M | 1 |
| Saito, E | 1 |
| Fujimoto, M | 1 |
| Hasegawa, M | 1 |
| Komura, K | 1 |
| Hamaguchi, Y | 1 |
| Kaburagi, Y | 1 |
| Nagaoka, T | 1 |
| Takehara, K | 1 |
| Tedder, TF | 1 |
| Sato, S | 1 |
| Asboe-Hanson, G | 1 |
| Sano, S | 1 |
| Shinkai, H | 1 |
| Yonemasu, K | 1 |
| Howitz, P | 1 |
| Kreysel, HW | 5 |
| Bauer, EA | 1 |
| Buckingham, RB | 1 |
| Prince, RK | 1 |
| Rodnan, GP | 2 |
| Taylor, F | 1 |
| Widjaja, V | 1 |
| Nissen, HP | 1 |
| Lipinski, E | 1 |
| Luksick, J | 1 |
| Fedorova, EG | 1 |
| Lashmanova, AP | 1 |
| Dabrowski, J | 1 |
| Stachow, A | 1 |
| Jabłońska, S | 1 |
| Walski, M | 1 |
| Punzi, L | 1 |
| Schivo, P | 1 |
| Gambari, PF | 1 |
| Todesco, S | 1 |
| Blonck-Kranold, D | 1 |
| Osborn, H | 1 |
| Kimmig, J | 1 |
| Harris, ED | 1 |
| Hoffman, GS | 1 |
| McGuire, JL | 1 |
| Strosberg, JM | 1 |
| Jayson, MI | 2 |
| Bailey, AJ | 2 |
| Black, C | 1 |
| Jones, KL | 1 |
| Kawaguchi, Y | 1 |
| Harigai, M | 1 |
| Kitani, A | 1 |
| Suzuki, K | 1 |
| Kawakami, M | 1 |
| Ishizuka, T | 1 |
| Hidaka, T | 1 |
| Hara, M | 1 |
| Kawagoe, M | 1 |
| Nakamura, H | 1 |
| Hendel, L | 2 |
| Ammitzbøll, T | 1 |
| Dirksen, K | 1 |
| Petri, M | 1 |
| Kucharz, EJ | 1 |
| Sierakowski, SJ | 1 |
| Majamaa, K | 1 |
| Sasaki, T | 1 |
| Serup, J | 1 |
| Ocaña, J | 1 |
| Pérez de Vargas, I | 1 |
| Wilhelmi, ML | 1 |
| Crespo, V | 1 |
| Pastor, R | 1 |
| Fajardo, FS | 1 |
| Delgado, ML | 1 |
| Francès, C | 1 |
| Branchet, MC | 1 |
| Blétry, O | 1 |
| Lefevre, C | 1 |
| Boisnic, S | 1 |
| Kern, P | 1 |
| Godeau, P | 1 |
| Osborn, TG | 1 |
| Moore, TL | 1 |
| Fischer, VW | 1 |
| Helin, G | 1 |
| Helin, P | 2 |
| Lorenzen, I | 3 |
| Herbert, CM | 1 |
| Lindberg, KA | 1 |
| Christiansen, AH | 1 |
| Ullman, S | 1 |
| Leroy, EC | 1 |
| Emmrich, R | 1 |
| Grant, ME | 1 |
| Prockop, DJ | 1 |
| Ohlenschlaeger, K | 1 |
| Nusgens, B | 1 |
| Lapiere, CM | 1 |
| Köhler, N | 1 |
| Rau, R | 1 |
| Pandurovic, L | 1 |
| Böni, A | 1 |
| Keiser, HR | 1 |
| Stein, HD | 1 |
| Sjoerdsma, A | 1 |
| McCormack, LJ | 1 |
| Layle, JK | 1 |
| Bienenstock HKIBRICK, AC | 1 |
| Segrest, JP | 1 |
| Cunningham, LW | 1 |
| Rasmussen, O | 1 |
| Black, MM | 1 |
| Bottoms, E | 1 |
| Shuster, S | 1 |
| Neldner, KH | 1 |
| Jones, JD | 1 |
| Winkelmann, RK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273529] | Phase 2 | 100 participants (Anticipated) | Interventional | 2020-02-20 | Not yet recruiting | ||
| The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273581] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-02-18 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for hydroxyproline and Scleroderma, Systemic
| Article | Year |
|---|---|
Methods for analysis of connective-tissue macromolecules by determination of certain constituents.
Topics: Animals; Autoanalysis; Collagen; Colorimetry; Connective Tissue; Glycosaminoglycans; Humans; Hydroxy | 1977 |
Collagen in cutaneous diseases.
Topics: Collagen; Ehlers-Danlos Syndrome; Epidermolysis Bullosa; Glucocorticoids; Humans; Hydroxylysine; Hyd | 1979 |
Increased collagen accumulation in dermal fibroblast cultures from patients with progressive systemic sclerosis (scleroderma).
Topics: Adolescent; Adult; Ascorbic Acid; Cells, Cultured; Collagen; Culture Media; Female; Fibroblasts; Hum | 1978 |
[Metabolism of collagen in progressive scleroderma and dermatomyositis].
Topics: Blood Proteins; Chemical Phenomena; Chemistry; Collagen; Dermatomyositis; Humans; Hydroxyproline; Mi | 1976 |
[Metabolism of the connective tissue in generalized scleroderma].
Topics: Collagen; Connective Tissue; Glycosaminoglycans; Humans; Hydroxyproline; Scleroderma, Systemic; Skin | 1989 |
Localized scleroderma (morphoea). Clinical, physiological, biochemical and ultrastructural studies with particular reference to quantitation of scleroderma.
Topics: Amino Acids; Blood Vessels; Cell Nucleus; Collagen; Connective Tissue; Cornea; Cytoplasm; Elasticity | 1986 |
The biosynthesis of collagen. 3.
Topics: Aging; Amino Acid Sequence; Animals; Chemical Phenomena; Chemistry; Chick Embryo; Collagen; Collagen | 1972 |
1 trial available for hydroxyproline and Scleroderma, Systemic
| Article | Year |
|---|---|
Effect of prolyl 4-hydroxylase inhibitor on fibroblast collagen production in vitro: an approach to the treatment of systemic sclerosis.
Topics: Blotting, Northern; Collagen; Cysteine; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibronectins | 1992 |
69 other studies available for hydroxyproline and Scleroderma, Systemic
| Article | Year |
|---|---|
Therapeutic effects of adipose-derived mesenchymal stem/stromal cells with enhanced migration ability and hepatocyte growth factor secretion by low-molecular-weight heparin treatment in bleomycin-induced mouse models of systemic sclerosis.
Topics: Actins; Animals; Anti-Inflammatory Agents; Bleomycin; Collagen; Disease Models, Animal; Fibrosis; He | 2022 |
[Preventive and therapeutic effects of safflower water extract on systemic scleroderma in mice and its mechanism].
Topics: Animals; Bleomycin; Carthamus tinctorius; Connective Tissue Growth Factor; Disease Models, Animal; H | 2019 |
Effects of thalidomide on Th17, Treg cells and TGF-β1/Smad3 pathway in a mouse model of systemic sclerosis.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Fibrosis; Hydroxyproline; Immunosuppressive Agen | 2020 |
Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib).
Topics: Aniline Compounds; Animals; Hydroxyproline; Imatinib Mesylate; Lung; Mice; Mice, Transgenic; Nitrile | 2018 |
Abrogation of transforming growth factor-β-induced tissue fibrosis in mice with a global genetic deletion of Nox4.
Topics: Animals; DNA Damage; Fibrosis; Gene Knockout Techniques; Hydroxyproline; Lung; Mice; Mice, Inbred C5 | 2019 |
Topical vitamin D analogue calcipotriol reduces skin fibrosis in experimental scleroderma.
Topics: Administration, Topical; Animals; Bleomycin; Calcitriol; Collagen; Cytokines; Dermatologic Agents; D | 2014 |
Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis.
Topics: Age Factors; Animals; Carrier Proteins; Collagen; Extracellular Matrix; Fibrosis; Fluorescent Antibo | 2014 |
2-Methoxyestradiol inhibits bleomycin-induced systemic sclerosis through suppression of fibroblast activation.
Topics: 2-Methoxyestradiol; Adolescent; Adult; Animals; Bleomycin; Cell Differentiation; Cell Proliferation; | 2015 |
IL-21 induction of CD4+ T cell differentiation into Th17 cells contributes to bleomycin-induced fibrosis in mice.
Topics: Animals; Bleomycin; CD4-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Female | 2015 |
Elevated frequencies of CD4(+) IL-21(+) T, CD4(+) IL-21R(+) T and IL-21(+) Th17 cells, and increased levels of IL-21 in bleomycin-induced mice may be associated with dermal and pulmonary inflammation and fibrosis.
Topics: Animals; Bleomycin; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Disease Model | 2016 |
Antifibrotic effect of lysophosphatidic acid receptors LPA1 and LPA3 antagonist on experimental murine scleroderma induced by bleomycin.
Topics: Animals; Bleomycin; Cell Count; Chemokine CCL3; Collagen Type I; Connective Tissue Growth Factor; Di | 2015 |
[Effects of artemether and dihydroarteannuin on mouse model of scleroderma].
Topics: Animals; Artemether; Artemisinins; Collagen; Female; Hydroxyproline; Lung; Mice; Mice, Inbred BALB C | 2009 |
Thalidomide has a therapeutic effect on interstitial lung fibrosis: evidence from in vitro and in vivo studies.
Topics: Actins; Animals; Bleomycin; Blotting, Western; Cell Differentiation; Cells, Cultured; Collagen Type | 2009 |
Thalidomide has a therapeutic effect on interstitial lung fibrosis: evidence from in vitro and in vivo studies.
Topics: Actins; Animals; Bleomycin; Blotting, Western; Cell Differentiation; Cells, Cultured; Collagen Type | 2009 |
Thalidomide has a therapeutic effect on interstitial lung fibrosis: evidence from in vitro and in vivo studies.
Topics: Actins; Animals; Bleomycin; Blotting, Western; Cell Differentiation; Cells, Cultured; Collagen Type | 2009 |
Thalidomide has a therapeutic effect on interstitial lung fibrosis: evidence from in vitro and in vivo studies.
Topics: Actins; Animals; Bleomycin; Blotting, Western; Cell Differentiation; Cells, Cultured; Collagen Type | 2009 |
UVA irradiation following treatment with topical 8-methoxypsoralen improves bleomycin-induced scleroderma in a mouse model, by reducing the collagen content and collagen gene expression levels in the skin.
Topics: Administration, Cutaneous; Animals; Bleomycin; Collagen Type I; Collagen Type III; Disease Models, A | 2012 |
THE COLLAGEN IN SCLERODERMA.
Topics: Amino Acids; Collagen; Connective Tissue; Histocytochemistry; Humans; Hydroxyproline; Scleroderma, L | 1964 |
DERMATOLOGIC ASPECTS OF MAST CELL ACTIVITY.
Topics: Chondroitin; Coloring Agents; Cushing Syndrome; Dermatology; Erythema Multiforme; Heparin; Hexosamin | 1964 |
PANCREATIC COLLAGENASE THERAPY FOR SEVERE, PROGRESSIVE SYSTEMIC SCLEROSIS. EFFECT ON SKIN AND ON HYDROXYPROLINE CONTENT IN URINE.
Topics: Antibodies; Biopsy; Clinical Laboratory Techniques; Collagenases; Drug Therapy; Endopeptidases; Huma | 1965 |
Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma.
Topics: Actins; Animals; Bleomycin; Blotting, Western; Cells, Cultured; Collagen; Connective Tissue Growth F | 2004 |
Animal models of scleroderma.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Disease Models, Animal; Flow Cytometry; Graft vs Ho | 2004 |
Inhibition of skin sclerosis by 15deoxy delta12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma.
Topics: Animals; Bleomycin; Connective Tissue Growth Factor; Disease Models, Animal; Female; Fibroblasts; Hi | 2006 |
In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
Topics: Animals; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Collagen Type I; Fibrosis; Hydroxypr | 2008 |
Chemical synthesis of the dermis in scleroderma.
Topics: Aldehydes; Electrophoresis; Gelatin; Hexosamines; Hexoses; Humans; Hydroxyproline; Scleroderma, Syst | 1967 |
Variation of urinary acid glycosaminoglycan and collagen metabolite excretion with disease activity in generalized scleroderma.
Topics: Adult; Aged; Collagen; Female; Follow-Up Studies; Glutamine; Glycosaminoglycans; Humans; Hydralazine | 1980 |
Biochemical analysis of dermis and urine in generalized scleroderma.
Topics: Adult; Aged; Connective Tissue; Female; Humans; Hydroxylysine; Hydroxyproline; Male; Middle Aged; Pr | 1980 |
Sodium ion modulates collagen types in human fibroblastic cells in culture.
Topics: Adult; Cells, Cultured; Collagen; Fibroblasts; Humans; Hydroxyproline; Microbial Collagenase; Muscle | 1983 |
Scleroderma-like alterations in collagen metabolism occurring in the TSK (tight skin) mouse.
Topics: Animals; Collagen; Disease Models, Animal; DNA; Hydroxyproline; Mice; Mice, Mutant Strains; Organ Cu | 1984 |
Proline analogues inhibit human skin fibroblast growth and collagen production in culture.
Topics: Azetidinecarboxylic Acid; Azetines; Cell Adhesion; Cell Division; Cells, Cultured; Collagen; Depress | 1983 |
Immunological characterization of (tight skin/NZB)F1 hybrid mice with connective tissue and autoimmune features resembling human systemic sclerosis.
Topics: Animals; Autoantibodies; Collagen; Connective Tissue; Cytokines; Disease Models, Animal; Hydroxyprol | 1993 |
Correlation between the concentration of serum anti-topoisomerase I autoantibodies and histological and biochemical alterations in the skin of tight skin mice.
Topics: Animals; Autoantibodies; Collagen; DNA Topoisomerases, Type I; Hydroxyproline; Mice; Mice, Inbred C5 | 1996 |
Effect of superoxide dismutase on bleomycin-induced dermal sclerosis: implications for the treatment of systemic sclerosis.
Topics: Animals; Bleomycin; Disease Models, Animal; Hydroxyproline; Injections, Intravenous; Mannitol; Mice; | 1999 |
Animal model of sclerotic skin. II. Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1-W/W(V) mice.
Topics: Animals; Antibiotics, Antineoplastic; Biopsy; Bleomycin; Cell Count; Disease Models, Animal; Female; | 1999 |
Effect of interferon-gamma on experimental scleroderma induced by bleomycin.
Topics: Animals; Bleomycin; Female; Hydroxyproline; Interferon-gamma; Mice; Mice, Inbred BALB C; Pulmonary F | 2000 |
CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, CD19; Antigens, Differe | 2002 |
Subhydroxylated collagen in scleroderma.
Topics: Collagen; Humans; Hydroxylation; Hydroxylysine; Hydroxyproline; Proline; Scleroderma, Systemic; Skin | 1978 |
Immunobiological aspects of Clq in sera of patients with cutaneous vasculitis and collagen diseases.
Topics: Adolescent; Adult; Blood Cell Count; Blood Platelets; Collagen Diseases; Complement C1; Complement C | 1979 |
Urinary proline to hydroxyproline ratio varies with age.
Topics: Adolescent; Adult; Age Factors; Child; Dwarfism; Humans; Hydroxyproline; Myositis Ossificans; Prolin | 1979 |
[Morphology, biochemistry and function of proteoglycans in the skin].
Topics: Adolescent; Adult; Binding Sites; Cell Membrane Permeability; Child; Collagen; Collagen Diseases; Co | 1975 |
[Determination of ceruloplasmin activity in plasma in progressive scleroderma].
Topics: Adolescent; Adult; Age Factors; Ceruloplasmin; Child; Child, Preschool; Humans; Hydroxyproline; Immu | 1977 |
Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma.
Topics: Acromegaly; Adolescent; Adult; Aged; Biopsy; Collagen; Female; Humans; Hydroxyproline; Male; Middle | 1979 |
[Dynamics of hydroxyproline content as the indicator of the severity of the course and the effectiveness of treatment of focal scleroderma].
Topics: Adolescent; Adult; Aged; Circadian Rhythm; Female; Humans; Hydroxyproline; Male; Middle Aged; Sclero | 1978 |
[Ultrastructural and biochemical study of collagen in scleroderma].
Topics: Collagen; Connective Tissue; Humans; Hydroxyproline; Scleroderma, Localized; Scleroderma, Systemic | 1978 |
Urinary hydroxyproline excretion in comparison with other immunoinflammatory indices in progressive systemic sclerosis.
Topics: Adult; Alkaline Phosphatase; Blood Proteins; Blood Sedimentation; Collagen; Complement System Protei | 1978 |
Discussion paper: methodology and techniques in the evaluation of dimethyl sulfoxide for connective tissue disorders.
Topics: Administration, Topical; Dimethyl Sulfoxide; Humans; Hydroxyproline; Plethysmography; Scleroderma, S | 1975 |
Colchicine: effects upon urinary hydroxyproline excretion in patients with scleroderma.
Topics: Adult; Colchicine; Collagen; Dose-Response Relationship, Drug; Female; Galactose; Glucose; Humans; H | 1975 |
Collagen studies in acro-osteolysis.
Topics: Adult; Biopsy; Bone Resorption; Collagen; Fingers; Humans; Hydroxyproline; Male; Osteolysis; Proline | 1976 |
Hydroxyproline in the oesophageal mucosa of patients with progressive systemic sclerosis during omeprazole-induced healing of reflux oesophagitis.
Topics: Adult; Aged; Biopsy; Esophagitis, Peptic; Esophagus; Female; Fibrosis; Humans; Hydroxyproline; Male; | 1991 |
Collagen components in the duodenal and rectal mucosa in progressive systemic sclerosis and other diseases.
Topics: Adolescent; Adult; Aged; Collagen; Duodenum; Female; Humans; Hydroxylysine; Hydroxyproline; Intestin | 1986 |
Inhibition of prolyl hydroxylation during collagen biosynthesis in human skin fibroblast cultures by ethyl 3,4-dihydroxybenzoate.
Topics: Cells, Cultured; Humans; Hydroxybenzoates; Hydroxyproline; Procollagen; Procollagen-Proline Dioxygen | 1987 |
[Sclerodermiform porphyria cutanea tarda. Ultrastructural study].
Topics: Aged; Animals; Bicarbonates; Cricetinae; Diabetes Complications; Diagnosis, Differential; Hemorrhage | 1985 |
Skin collagen from scleroderma patients before and after cyclosporin A treatment.
Topics: Adult; Aged; Collagen; Cyclosporins; Humans; Hydroxyproline; Middle Aged; Scleroderma, Systemic; Ski | 1988 |
Collagenous abnormalities in the heart of the tight-skin mouse.
Topics: Animals; Collagen; Creatine Kinase; Disease Models, Animal; Hexosamines; Hydroxyproline; Mice; Mice, | 1987 |
Connective tissue in scleroderma. A biochemical study on the correlation of fractionated glycosaminoglycans and collagen in human skin.
Topics: Carbon Isotopes; Chondroitin; Collagen; Connective Tissue; Glycosaminoglycans; Humans; Hydrolysis; H | 1971 |
Biosynthesis and maturation of skin collagen in scleroderma, and effect of D-penicillamine.
Topics: Adolescent; Adult; Age Factors; Aged; Amino Acids; Animals; Biopsy; Collagen; Culture Techniques; Fe | 1974 |
Hydralazine-induced Lupoid syndrome. Biochemical and immunological studies.
Topics: Adult; Biopsy; Blood Sedimentation; Chemical Precipitation; Complement System Proteins; DNA; Fluores | 1974 |
Connective tissue synthesis by scleroderma skin fibroblasts in cell culture.
Topics: Cell Count; Cells, Cultured; Collagen; DNA; Fibroblasts; Galactosamine; Glycoproteins; Glycosaminogl | 1972 |
Hydroxyproline and collagen metabolism. Clinical implications.
Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Child; Child, Preschool; Collagen; Female; Gelatin; | 1965 |
[Hydroxyproline excretion in urine in chronic connective tissue disease].
Topics: Adrenocorticotropic Hormone; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Collagen | 1970 |
D-penicillamine in progressive scleroderma.
Topics: Adult; Aged; Biopsy; Blood Proteins; Blood Sedimentation; Collagen; Female; Hemoglobins; Humans; Hyd | 1972 |
The relationship between proline and hydroxyproline urinary excretion in human as an index of collagen catabolism.
Topics: Adolescent; Adult; Aging; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Chromatogra | 1973 |
[Clinical significance of urinary hydroxyproline excretion].
Topics: Dermatomyositis; Humans; Hydroxyproline; Lupus Erythematosus, Systemic; Middle Aged; Pseudoxanthoma | 1973 |
[Clinical aspects of collagen like protein in sera (author's transl)].
Topics: Blood Proteins; Collagen; Collagen Diseases; Dermatomyositis; Humans; Hydroxyproline; Pseudoxanthoma | 1974 |
[Gestagen therapy of scleroderma. 10 cases].
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Biopsy; Caproates; Chemical and Drug Induc | 1972 |
Increased protocollagen proline hydroxylase activity in sclerodermatous skin.
Topics: Adolescent; Adult; Aged; Biopsy; Child; Collagen; Female; Humans; Hydroxyproline; Male; Middle Aged; | 1971 |
Further observations on the effect of dimethyl sulfoxide in patients with generalized scleroderma. (Progressive systemic sclerosis).
Topics: Adult; Aged; Biopsy; Calcinosis; Collagen; Dimethyl Sulfoxide; Female; Fingers; Humans; Hydroxyproli | 1967 |
Urinary excretion of prolylhydroxyproline in rheumatic diseases.
Topics: Adolescent; Adult; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Collagen; Dermatomyositis; Dip | 1969 |
Variations in human urinary O-hydroxylysyl glycoside levels and their relationship to collagen metabolism.
Topics: Achondroplasia; Adolescent; Adult; Aged; Amino Acids; Arthritis, Rheumatoid; Bone and Bones; Bronchi | 1970 |
Skin collagen in patients with scleroderma: biosynthesis and maturation in vitro, and the effect of D-penicillamine.
Topics: Adult; Aged; Biopsy; Carbon Isotopes; Collagen; Female; Humans; Hydroxyproline; In Vitro Techniques; | 1970 |
Skin collagen content and thickness in systemic sclerosis.
Topics: Adult; Aged; Biopsy; Collagen; Diagnosis, Differential; Female; Humans; Hydroxyproline; Middle Aged; | 1970 |
Scleroderma: dermal amino acid composition with particular reference to hydroxyproline.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Female; Humans; Hydroxyproline; In Vitro Techniques; Mal | 1966 |