Page last updated: 2024-11-06

hydroxyproline and Osteogenesis Imperfecta

hydroxyproline has been researched along with Osteogenesis Imperfecta in 52 studies

Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.

Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.

Research Excerpts

Excerpt	Relevance	Reference
"Recessive mutations that prevent 3-hydroxyproline formation in type I collagen have been shown to cause forms of osteogenesis imperfecta."	3.77	Insights on the evolution of prolyl 3-hydroxylation sites from comparative analysis of chicken and Xenopus fibrillar collagens. ( Eyre, DR; Hudson, DM; Weis, M, 2011)
" The patients were divided into two groups comparable in sex, age, height, and clinical severity of OI; seven patients (three boys) were treated for 12 months with hGH at a dosage of 0."	1.29	Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type I collagen synthesis. ( Antoniazzi, F; Bertoldo, F; Mottes, M; Sirpresi, S; Tató, L; Valentini, R; Valli, M; Zamboni, G, 1996)

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (73.08)	18.7374
1990's	6 (11.54)	18.2507
2000's	5 (9.62)	29.6817
2010's	3 (5.77)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Yao, X	1
Carleton, SM	1
Kettle, AD	1
Melander, J	1
Phillips, CL	1
Wang, Y	1
Gjaltema, RA	1
Bank, RA	2
Hasegawa, K	1
Kataoka, K	1
Inoue, M	1
Seino, Y	2
Morishima, T	1
Tanaka, H	1
Hudson, DM	1
Weis, M	1
Eyre, DR	1
GOIDANICH, IF	1
LENZI, L	1
SILVA, E	1
Radmer, RJ	1
Klein, TE	1
Ha-Vinh, R	1
Alanay, Y	1
Campos-Xavier, AB	1
Zankl, A	1
Superti-Furga, A	1
Bonafé, L	1
Guillot, PV	1
Abass, O	1
Bassett, JH	1
Shefelbine, SJ	1
Bou-Gharios, G	1
Chan, J	1
Kurata, H	1
Williams, GR	1
Polak, J	1
Fisk, NM	1
Krane, SM	1
Fraser, J	1
Lancaster, GA	1
Scriver, CR	2
Sbyrakis, S	1
Mengreli, C	1
Côté, GB	1
Morakis, A	1
Hata, R	1
Sunada, H	1
Nagai, Y	1
Duterque, M	1
Crouzet, J	1
Kouri, N	1
Nishi, Y	1
Hyodo, S	1
Yoshimitsu, K	1
Sawano, K	1
Yamaoka, K	1
Usui, T	1
Herbage, D	1
Borsali, F	1
Buffevant, C	1
Flandin, F	1
Aguercif, M	1
Smith, R	3
Mainardi, CL	1
Kang, AH	1
Lehmann, HW	1
Rimek, D	1
Bodo, M	1
Brenner, RE	1
Vetter, U	1
Wörsdörfer, O	1
Karbowski, A	1
Müller, PK	1
Minisola, S	1
Piccioni, AL	1
Rosso, R	1
Romagnoli, E	1
Pacitti, MT	1
Scarnecchia, L	1
Mazzuoli, G	1
Antoniazzi, F	1
Bertoldo, F	1
Mottes, M	1
Valli, M	2
Sirpresi, S	1
Zamboni, G	1
Valentini, R	1
Tató, L	1
Scott, JE	1
Dyne, KM	1
Thomlinson, AM	1
Ritchie, M	1
Bateman, J	1
Cetta, G	1
Prockop, DJ	1
Cepollaro, C	1
Gonnelli, S	1
Pondrelli, C	1
Montagnani, A	1
Martini, S	1
Bruni, D	1
Gennari, C	2
Uitto, J	1
Lichtenstein, JR	1
Rico Lenza, H	2
del Río Vázquez, A	2
Serrano Garijo, P	1
Espinós Pérez, D	2
Rosenberg, E	1
Lang, R	1
Boisseau, V	1
Rojanasathit, S	1
Avioli, LV	1
August, GP	1
Shapiro, J	1
Hung, W	1
Lancaster, G	1
Goldman, H	1
Gold, RJ	1
Wong, I	1
Francis, MJ	2
Bauze, RJ	1
Kruse, HP	2
Kuhlencordt, F	2
Gage, JP	1
Whitaker, GE	1
Bonaventure, J	1
Cohen-Solal, L	1
Lasselin, C	1
Allain, JC	1
Maroteaux, P	1
Oxlund, H	1
Pedersen, U	1
Danielsen, CC	1
Oxlund, I	1
Elbrøond, O	1
Castells, S	2
Lu, C	1
Baker, RK	2
Wallach, S	2
Hirthe, D	2
Mühlbach, R	3
Langness, U	3
Behnke, H	3
Kaiser, G	1
Kyselka, R	2
Beck, O	2
Schramm, G	2
Lindenhayn, K	1
Bleckmann, H	1
Kresse, H	1
Wollensak, J	1
Buddecke, E	1
Lozano-Tonkin, C	1
Schneider, C	1
Sommer, E	1
Goldfield, EB	1
Braiker, BM	1
Prendergast, JJ	1
Kolb, FO	1
Eastoe, JE	1
Martens, P	1
Thomas, NR	1
Riley, FC	1
Jowsey, J	1
Brown, DM	1
Inamdar, S	1
Kocher, P	1
Segrest, JP	1
Cunningham, LW	1
Czitober, H	1
Raab, W	1
Rubegni, M	1
Forconi, S	1
Romano, S	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Impact of Topical Prostaglandin Analogs on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma[NCT02388360]			Phase 4	35 participants (Actual)	Interventional	2013-05-06	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for hydroxyproline and Osteogenesis Imperfecta

Article	Year
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease. Critical reviews in biochemistry and molecular biology, 2017, Volume: 52, Issue:1 Topics: Animals; Arthrogryposis; Connective Tissue Diseases; Ehlers-Danlos Syndrome; Fibrillar Collagens; Gl	2017
The importance of proline residues in the structure, stability and susceptibility to proteolytic degradation of collagens. Amino acids, 2008, Volume: 35, Issue:4 Topics: Amino Acid Sequence; Animals; Collagen; Glycine; Humans; Hydroxyproline; Mice; Models, Biological; M	2008
Collagen and disorders of bone. Clinical science (London, England : 1979), 1980, Volume: 59, Issue:4 Topics: Adolescent; Bone Diseases; Bone Matrix; Collagen; Humans; Hydroxylysine; Hydroxyproline; Osteogenesi	1980
Hopkins Memorial Medal lecture. Pleasant surprises en route from the biochemistry of collagen to attempts at gene therapy. Biochemical Society transactions, 1999, Volume: 27, Issue:2 Topics: Amino Acid Sequence; Animals; Awards and Prizes; Biochemistry; Collagen; Computer Simulation; Geneti	1999
Defects in the biochemistry of collagen in diseases of connective tissue. The Journal of investigative dermatology, 1976, Volume: 66, Issue:02 Topics: Aortic Diseases; Bone and Bones; Brain Diseases; Collagen; Connective Tissue; Cutis Laxa; Ehlers-Dan	1976

Trials

1 trial available for hydroxyproline and Osteogenesis Imperfecta

Article	Year
Effects of synthetic salmon calcitonin in osteogenesis imperfecta. Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:1 Topics: Adolescent; Animals; Bone Resorption; Calcitonin; Calcium; Calcium Radioisotopes; Child; Child, Pres	1974

Other Studies

46 other studies available for hydroxyproline and Osteogenesis Imperfecta

Article	Year
Gender-dependence of bone structure and properties in adult osteogenesis imperfecta murine model. Annals of biomedical engineering, 2013, Volume: 41, Issue:6 Topics: Animals; Biomechanical Phenomena; Carbonates; Disease Models, Animal; Elastic Modulus; Female; Hydro	2013
Impaired pyridinoline cross-link formation in patients with osteogenesis imperfecta. Journal of bone and mineral metabolism, 2008, Volume: 26, Issue:4 Topics: Amino Acids; Case-Control Studies; Child; Child, Preschool; Collagen Type I; Cross-Linking Reagents;	2008
Insights on the evolution of prolyl 3-hydroxylation sites from comparative analysis of chicken and Xenopus fibrillar collagens. PloS one, 2011, May-03, Volume: 6, Issue:5 Topics: Amino Acid Motifs; Animals; Binding Sites; Chickens; Collagen; Collagen Type III; Cross-Linking Reag	2011
URINARY HYDROXYPROLINE EXCRETION IN NORMAL SUBJECTS AND IN PATIENTS AFFECTED WITH PRIMARY DISEASES OF BONE. Clinica chimica acta; international journal of clinical chemistry, 1965, Volume: 11 Topics: Adolescent; Amino Acids; Body Fluids; Bone Diseases; Child; Fibrous Dysplasia of Bone; Fluids and Se	1965
Severity of osteogenesis imperfecta and structure of a collagen-like peptide modeling a lethal mutation site. Biochemistry, 2004, May-11, Volume: 43, Issue:18 Topics: Amino Acid Sequence; Amino Acid Substitution; Collagen; Collagen Type I; Computer Simulation; Genes,	2004
Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2. American journal of medical genetics. Part A, 2004, Dec-01, Volume: 131, Issue:2 Topics: Abnormalities, Multiple; Amino Acid Sequence; Child, Preschool; Collagen; Consanguinity; Contracture	2004
Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice. Blood, 2008, Feb-01, Volume: 111, Issue:3 Topics: Animals; Female; Fetal Stem Cells; Fractures, Bone; Gene Expression Regulation; Humans; Hydroxyproli	2008
Secreted collagen ratios in normal human and osteogenesis imperfecta skin fibroblasts. Connective tissue research, 1983, Volume: 11, Issue:1 Topics: Adolescent; Adult; Age Factors; Cells, Cultured; Child; Child, Preschool; Chromatography, DEAE-Cellu	1983
Vitamin D and related research in osteogenesis imperfecta. Progress in clinical and biological research, 1982, Volume: 104 Topics: Alkaline Phosphatase; Calcium; Child; Child, Preschool; Dihydroxycholecalciferols; Diphosphates; Fem	1982
Sodium ion modulates collagen types in human fibroblastic cells in culture. Biochemical and biophysical research communications, 1983, Nov-30, Volume: 117, Issue:1 Topics: Adult; Cells, Cultured; Collagen; Fibroblasts; Humans; Hydroxyproline; Microbial Collagenase; Muscle	1983
[Sclerodermiform lesions in Lobstein's disease]. Annales de dermatologie et de venereologie, 1984, Volume: 111, Issue:8 Topics: Adult; Collagen; Diagnosis, Differential; Female; Humans; Hydroxyproline; Male; Middle Aged; Osteoge	1984
Vitamin D metabolism in osteogenesis imperfecta during calcitonin therapy. Pediatrics, 1984, Volume: 73, Issue:4 Topics: Adolescent; Alkaline Phosphatase; Calcitonin; Calcitriol; Calcium; Child, Preschool; Female; Humans;	1984
Composition, cross-linking and thermal stability of bone and skin collagens in patients with osteogenesis imperfecta. Metabolic bone disease & related research, 1982, Volume: 4, Issue:2 Topics: Adolescent; Bone and Bones; Calorimetry, Differential Scanning; Child; Child, Preschool; Collagen; D	1982
Collagen disease: a new perspective. The American journal of medicine, 1981, Volume: 71, Issue:6 Topics: Collagen; Collagen Diseases; Ehlers-Danlos Syndrome; Extracellular Space; Genes; Humans; Hydroxylysi	1981
Hydroxylation of collagen type I: evidence that both lysyl and prolyl residues are overhydroxylated in osteogenesis imperfecta. European journal of clinical investigation, 1995, Volume: 25, Issue:5 Topics: Adolescent; Adult; Body Height; Cells, Cultured; Child; Child, Preschool; Collagen; Female; Fibrobla	1995
Reduced serum levels of carboxy-terminal propeptide of human type I procollagen in a family with type I-A osteogenesis imperfecta. Metabolism: clinical and experimental, 1994, Volume: 43, Issue:10 Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Bone Density; Bone Reso	1994
Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type I collagen synthesis. The Journal of pediatrics, 1996, Volume: 129, Issue:3 Topics: Alkaline Phosphatase; Bone Density; Calcium; Child; Child, Preschool; Collagen; Female; Growth; Grow	1996
Human cells unable to express decoron produced disorganized extracellular matrix lacking "shape modules" (interfibrillar proteoglycan bridges). Experimental cell research, 1998, Aug-25, Volume: 243, Issue:1 Topics: Adult; Cells, Cultured; Child, Preschool; Collagen; Decorin; Extracellular Matrix; Extracellular Mat	1998
Osteogenesis imperfecta: bone turnover, bone density, and ultrasound parameters. Calcified tissue international, 1999, Volume: 65, Issue:2 Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Amino Acids; Bone and Bones; Bone Density; Bone	1999
[Osteogenesis imperfecta tarda: the value of the determination of the urinary excretion of hydroxyprolyne (author's transl)]. Medicina clinica, 1979, Jun-25, Volume: 73, Issue:2 Topics: Adolescent; Arm; Child; Female; Foot; Hand; Humans; Hydroxyproline; Leg; Male; Osteogenesis Imperfec	1979
Effect of long-term calcitonin therapy on the clinical course of osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:2 Topics: Acid Phosphatase; Age Factors; Alkaline Phosphatase; Animals; Calcitonin; Calcium; Child; Child, Pre	1977
Calcitonin therapy of children with osteogenesis imperfecta. The Journal of pediatrics, 1977, Volume: 91, Issue:6 Topics: Adolescent; Animals; Calcitonin; Child, Preschool; Female; Humans; Hydroxyproline; Hypokalemia; Hypo	1977
[Hydroxyprolinuria, index of severity in osteogenesis imperfecta tarda]. La Nouvelle presse medicale, 1978, Dec-02, Volume: 7, Issue:43 Topics: Adolescent; Child; Female; Humans; Hydroxyproline; Male; Osteogenesis Imperfecta; Prognosis	1978
Dominantly inherited osteogenesis imperfecta in man: an examination of collagen biosynthesis. Pediatric research, 1975, Volume: 9, Issue:2 Topics: Adolescent; Adult; Carbon Radioisotopes; Child; Child, Preschool; Chromatography, Gel; Chromatograph	1975
Osteogenesis imperfecta. A clinical and biochemical study of a generalized connective tissue disorder. The Quarterly journal of medicine, 1975, Volume: 44, Issue:176 Topics: Adolescent; Adult; Age Factors; Aged; Alkaline Phosphatase; Biopsy; Bone Diseases; Bony Callus; Calc	1975
On an attempt to treat primary and secondary osteoporosis with human growth hormone. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1975, Volume: 7, Issue:6 Topics: Adult; Alkaline Phosphatase; Calcium; Follow-Up Studies; Growth Hormone; Humans; Hydroxyproline; Mal	1975
Dentine is biochemically abnormal in osteogenesis imperfecta. Clinical science (London, England : 1979), 1986, Volume: 70, Issue:4 Topics: Amino Acids; Dentin; Glycine; Humans; Hydroxyproline; Lysine; Osteogenesis Imperfecta	1986
Abnormal procollagen synthesis in fibroblasts from three patients of the same family with a severe form of osteogenesis imperfecta (type III). Biochimica et biophysica acta, 1986, Oct-31, Volume: 889, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Collagen; Electrophoresis, Polyacrylamide Gel; Female; F	1986
Reduced strength of skin in osteogenesis imperfecta. European journal of clinical investigation, 1985, Volume: 15, Issue:6 Topics: Adult; Collagen; Female; Humans; Hydroxyproline; Male; Osteogenesis Imperfecta; Skin; Tensile Streng	1985
[Differential diagnosis of congenital systemic diseases of the skeleton based on biochemical changes in the body fluids]. Beitrage zur Orthopadie und Traumatologie, 1968, Volume: 15, Issue:11 Topics: Bone Diseases; Calcium; Cystic Fibrosis; Diagnosis, Differential; Glycosaminoglycans; Humans; Hydrox	1968
[Biochemical studies on osteogenesis imperfecta]. Deutsche medizinische Wochenschrift (1946), 1970, Jan-30, Volume: 95, Issue:5 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Collagen; Connective Tissue; Female; Femur	1970
[The significance of the excretion of amino acids and acid mucopolysaccharides in the urine in orthopedic diseases]. Beitrage zur Orthopadie und Traumatologie, 1969, Volume: 16, Issue:10 Topics: Adolescent; Adult; Amino Acids; Bone Diseases; Chromatography, Paper; Collagen; Glycosaminoglycans;	1969
[Glycosaminoglycan and collagen analyses in osteogenesis imperfecta]. Zeitschrift fur Kinderheilkunde, 1971, Volume: 110, Issue:1 Topics: Acetone; Aorta; Autoanalysis; Bone and Bones; Cartilage; Cartilage, Articular; Child, Preschool; Cho	1971
[Does the determination of acid mucopolysaccharides and hydroxyproline contribute to the differential diagnosis of fibrous dysplasia (Jaffé-Lichtenstein) and osteogenesis imperfecta congenita?]. Beitrage zur Orthopadie und Traumatologie, 1972, Volume: 19, Issue:12 Topics: Diagnosis, Differential; Fibrous Dysplasia of Bone; Fractures, Spontaneous; Glycosaminoglycans; Huma	1972
[Application of growth hormone in osteoporosis (author's transl)]. Klinische Wochenschrift, 1974, Dec-01, Volume: 52, Issue:23 Topics: Adult; Alkaline Phosphatase; Calcium; Growth Hormone; Humans; Hydroxyproline; Injections, Intramuscu	1974
Synthetic salmon calcitonin. Treatment of Paget's disease and osteogenesis imperfecta. JAMA, 1972, Sep-04, Volume: 221, Issue:10 Topics: Aged; Alkaline Phosphatase; Bone Resorption; Calcitonin; Calcium; Female; Humans; Hydroxyproline; Ma	1972
The amino-acid composition of human hard tissue collagens in osteogenesis imperfecta and dentinogenesis imperfecta. Calcified tissue research, 1973, May-09, Volume: 12, Issue:2 Topics: Alanine; Amino Acids; Bone and Bones; Child; Collagen; Dentin; Dentinogenesis Imperfecta; Glycine; H	1973
Osteogenesis imperfecta: morphologic and biochemical studies of connective tissue. Pediatric research, 1973, Volume: 7, Issue:9 Topics: Adolescent; Adult; Biopsy; Bone Regeneration; Bone Resorption; Child; Child, Preschool; Collagen; Co	1973
Effects of porcine calcitonin in osteogenesis imperfecta tarda. The Journal of pediatrics, 1972, Volume: 80, Issue:5 Topics: Animals; Bone Resorption; Calcitonin; Calcium; Child, Preschool; Female; Humans; Hydroxyproline; Inj	1972
[Study of urinary hydroxyproline in osteopathies]. Pathologie et biologie, 1966, Volume: 14, Issue:21 Topics: Acromegaly; Adult; Aged; Bone Neoplasms; Female; Humans; Hydroxyproline; Hyperparathyroidism; Hypert	1966
Variations in human urinary O-hydroxylysyl glycoside levels and their relationship to collagen metabolism. The Journal of clinical investigation, 1970, Volume: 49, Issue:8 Topics: Achondroplasia; Adolescent; Adult; Aged; Amino Acids; Arthritis, Rheumatoid; Bone and Bones; Bronchi	1970
Collagen metabolites in plasma and urine in osteogenesis imperfecta. Metabolism: clinical and experimental, 1971, Volume: 20, Issue:5 Topics: Adolescent; Adult; Blood Proteins; Child; Collagen; Creatinine; Female; Humans; Hydroxyproline; Male	1971
[Urinary hydroxyproline excretion in generalized bone diseases]. Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1967, Volume: 48, Issue:10 Topics: Adult; Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Bone Diseases; Bone Neoplasms; Female; Hum	1967
[Correlation between hydroxyprolinuria, alkaline phosphatasemia and Ca45 dynamics]. Bollettino della Societa italiana di biologia sperimentale, 1965, May-31, Volume: 41, Issue:10 Topics: Adult; Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Female; Humans; Hydroxyproline; Hyperpa	1965
[Hydroxyproline excretion as an index for the evaluation of metabolic bone changes]. Beitrage zur Orthopadie und Traumatologie, 1966, Volume: 13, Issue:10 Topics: Adult; Animals; Bone Neoplasms; Breast Neoplasms; Child; Female; Humans; Hydroxyproline; Metabolic D	1966
[Hydroxyproline elimination in urine in osteogenesis imperfecta]. Klinische Wochenschrift, 1966, Nov-15, Volume: 44, Issue:22 Topics: Adolescent; Adult; Child; Child, Preschool; Collagen; Female; Humans; Hydroxyproline; Male; Middle A	1966