hydroxyproline has been researched along with Multiple Myeloma in 34 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The simple postabsorptive urine hydroxyproline (Spot-HYPRO) with dialyzable and non-dialyzable (ND) fractions was measured in 28 patients with multiple myeloma." | 7.66 | The postabsorptive urinary hydroxyproline (spot-HYPRO) in patients with multiple myeloma. ( Neely, CL; Niell, HB; Palmieri, GM, 1981) |
| "Our data indicate that HOP in multiple myeloma at diagnosis is closely related to the extension of skeletal lesions and that during the clinical course it may be useful in the follow-up of bone disease." | 5.27 | Urinary hydroxyproline in multiple myeloma: correlation with clinical stages and bone disease. ( Bolzonella, S; Chiarion Sileni, V; De Besi, P; Fiorentino, MV; Paccagnella, A; Salvagno, L; Scalella, P, 1984) |
| "We evaluated the serum osteocalcin and alkaline phosphatase levels and the urinary hydroxyproline excretion in patients with blastic, lithic or mixed metastases, humoral malignant hypercalcemia (HMH) and myeloma." | 3.68 | [Bone turnover markers in tumor pathology with bone involvement]. ( Amado Señarís, JA; González Macías, J; Napal Lecumberri, J; Pesquera, C; Riancho, JA, 1990) |
| "In patients with multiple myeloma, with moderate and severe bone disease, the urinary hydroxyproline excretion was disproportionately elevated with respect to the activity of bone isoenzyme of alkaline phosphatase when compared with the relationship between the variables observed in 58 age- and sex-matched controls and in 50 healthy young subjects." | 3.67 | Biochemical assessment of bone disease in multiple myeloma. ( Formánková, J; Neuwirtová, R; Pacovský, V; Silinková-Málková, E; Stĕpán, JJ, 1984) |
| "Thirty-three patients with multiple myeloma were studied with serial skeletal surveys, serum immunoglobulin levels, and postabsorptive urinary hydroxyproline (Spot-HYPRO) determinations." | 3.67 | Skeletal surveys in multiple myeloma. Radiologic-clinical correlation. ( Niell, HB; Palmieri, GM; Reidy, TJ; Sebes, JI, 1986) |
| "The simple postabsorptive urine hydroxyproline (Spot-HYPRO) with dialyzable and non-dialyzable (ND) fractions was measured in 28 patients with multiple myeloma." | 3.66 | The postabsorptive urinary hydroxyproline (spot-HYPRO) in patients with multiple myeloma. ( Neely, CL; Niell, HB; Palmieri, GM, 1981) |
| "Markers of bone resorption are sensitive to changes in bone turnover induced by treatment." | 2.41 | Markers of bone turnover in bone metastases. ( Delmas, PD; Fontana, A, 2000) |
| "In 70 patients with stage III multiple myeloma (MM) the authors studied spontaneous and lipopolysaccharide-induced production of interleukin-1 (IL-1) and interleukin-6 (IL-6) by blood and bone marrow mononuclear cells, concentration of parathyroid hormone and vitamin D3 in the serum." | 1.29 | [The extratumor mechanisms of osteolysis in multiple myeloma and the means for their correction]. ( Golenkov, AK; Kliushnenkova, EN; Lutskaia, TD; Mitina, TA; Novikov, VE; Tishenina, RS; Valiulina, LS, 1996) |
| "The major mechanism of bone loss in myelomatosis is increased osteoclastic resorption but decreased bone formation contributes to bone loss with heavy plasma cell burdens." | 1.28 | Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. ( Beneton, MN; Greaves, M; Kanis, JA; McCloskey, EV; Rogers, S; Taube, T, 1992) |
| "Patients with Hodgkin's disease had elevated T, D, and ND HYPRO levels, and the D/ND ratio was in the range of patients with prostate cancer." | 1.27 | Total, dialyzable, and nondialyzable postabsorptive hydroxyproline. Values in patients with cancer. ( Hopkins, SC; Maxwell, TA; Neely, CL; Niell, HB; Palmieri, GM; Soloway, MS, 1983) |
| "Our data indicate that HOP in multiple myeloma at diagnosis is closely related to the extension of skeletal lesions and that during the clinical course it may be useful in the follow-up of bone disease." | 1.27 | Urinary hydroxyproline in multiple myeloma: correlation with clinical stages and bone disease. ( Bolzonella, S; Chiarion Sileni, V; De Besi, P; Fiorentino, MV; Paccagnella, A; Salvagno, L; Scalella, P, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (79.41) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Teng, Z | 1 |
| Lv, H | 1 |
| Zhang, Y | 2 |
| Guan, J | 1 |
| Chengyin, W | 1 |
| Borel, JP | 1 |
| Caranjot, JM | 1 |
| Jayle, MF | 1 |
| Delmas, PD | 2 |
| Charhon, S | 2 |
| Chapuy, MC | 2 |
| Vignon, E | 1 |
| Briancon, D | 1 |
| Edouard, C | 2 |
| Meunier, PJ | 2 |
| Paterson, AD | 1 |
| Kanis, JA | 2 |
| Cameron, EC | 1 |
| Douglas, DL | 1 |
| Beard, DJ | 1 |
| Preston, FE | 1 |
| Russell, RG | 1 |
| Valentin-Opran, A | 1 |
| Rosini, S | 1 |
| Siris, ES | 2 |
| Sherman, WH | 1 |
| Baquiran, DC | 1 |
| Schlatterer, JP | 1 |
| Osserman, EF | 1 |
| Canfield, RE | 2 |
| Stĕpán, JJ | 1 |
| Neuwirtová, R | 2 |
| Pacovský, V | 2 |
| Formánková, J | 2 |
| Silinková-Málková, E | 1 |
| Stĕpán, J | 1 |
| Jarolímková, E | 1 |
| Niell, HB | 3 |
| Palmieri, GM | 3 |
| Neely, CL | 2 |
| Maxwell, TA | 1 |
| Hopkins, SC | 1 |
| Soloway, MS | 1 |
| Bolzonella, S | 1 |
| Paccagnella, A | 1 |
| Salvagno, L | 1 |
| Chiarion Sileni, V | 1 |
| De Besi, P | 1 |
| Scalella, P | 1 |
| Fiorentino, MV | 1 |
| Kelleher, PC | 1 |
| Smith, CJ | 1 |
| Leone, G | 1 |
| Scuderi, F | 1 |
| Carlesimo, M | 1 |
| Crivelli, F | 1 |
| Mazières, B | 1 |
| Laroche, M | 1 |
| Cantagrel, A | 1 |
| Golenkov, AK | 1 |
| Lutskaia, TD | 1 |
| Kliushnenkova, EN | 1 |
| Tishenina, RS | 1 |
| Valiulina, LS | 1 |
| Novikov, VE | 1 |
| Mitina, TA | 1 |
| Fontana, A | 1 |
| Tomaszewski, J | 1 |
| Kowalewski, J | 1 |
| van Breukelen, FJ | 1 |
| Bijvoet, OL | 1 |
| van Oosterom, AT | 1 |
| Taube, T | 1 |
| Beneton, MN | 1 |
| McCloskey, EV | 1 |
| Rogers, S | 1 |
| Greaves, M | 1 |
| Rico, H | 1 |
| Hernandez, ER | 1 |
| Diaz-Mediavilla, J | 1 |
| Alvarez, A | 1 |
| Martinez, R | 1 |
| Espinos, D | 1 |
| Napal Lecumberri, J | 1 |
| Amado Señarís, JA | 1 |
| Pesquera, C | 1 |
| Riancho, JA | 1 |
| González Macías, J | 1 |
| Jacobs, TP | 1 |
| Sebes, JI | 1 |
| Reidy, TJ | 1 |
| Legendre, C | 1 |
| Bataille, R | 1 |
| Sany, J | 1 |
| Raab, W | 2 |
| Radom, S | 3 |
| Zulawski, M | 3 |
| Golebiowska, D | 1 |
| Dahlig, E | 1 |
| Sienczewska-Burzyńska, J | 1 |
| Jaruga-Dolińska, E | 1 |
| Zender, R | 1 |
| Courvoisier, B | 1 |
| Czitober, H | 1 |
| Carbone, PP | 1 |
| Zipkin, I | 1 |
| Sokoloff, L | 1 |
| Frazier, P | 1 |
| Cook, P | 1 |
| Mullins, F | 1 |
| Resnick, H | 1 |
| Lapp, NL | 1 |
| Morgan, WK | 1 |
| Guzzo, CE | 1 |
| Pachas, WN | 1 |
| Pinals, RS | 1 |
| Krant, MJ | 1 |
| Hosley, HF | 1 |
| Taft, EG | 1 |
| Olson, KB | 1 |
| Gates, S | 1 |
| Beebe, RT | 1 |
2 reviews available for hydroxyproline and Multiple Myeloma
| Article | Year |
|---|---|
Collagen metabolites in the urine and serum of patients with cancer.
Topics: Bone Neoplasms; Breast Neoplasms; Collagen; Colorimetry; Female; Humans; Hydroxylysine; Hydroxyproli | 1982 |
Markers of bone turnover in bone metastases.
Topics: Alkaline Phosphatase; Biomarkers; Bone Development; Bone Neoplasms; Bone Resorption; Collagen; Human | 2000 |
4 trials available for hydroxyproline and Multiple Myeloma
| Article | Year |
|---|---|
Long-term effects of dichloromethylene diphosphonate (CI2MDP) on skeletal lesions in multiple myeloma.
Topics: Biopsy; Bone and Bones; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Humans; Hydroxypro | 1982 |
Effects of dichloromethylene diphosphonate on skeletal mobilization of calcium in multiple myeloma.
Topics: Adult; Aged; Bone and Bones; Bone Resorption; Calcium; Clinical Trials as Topic; Clodronic Acid; Dip | 1980 |
Dichloromethylene diphosphonate action in hematologic and other malignancies.
Topics: Administration, Oral; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clinical Tr | 1987 |
Circadian rhythm of total urinary hydroxyproline excretion and 3-H hydroxyproline test.
Topics: Adult; Aged; Bone Neoplasms; Breast Neoplasms; Circadian Rhythm; Clinical Trials as Topic; Female; H | 1972 |
28 other studies available for hydroxyproline and Multiple Myeloma
| Article | Year |
|---|---|
Development of a Fluorescent Labeling Reagent for Determination of Proline and Hydroxyproline in Myeloma Patient Plasma by HPLC-FLD.
Topics: Blood Chemical Analysis; Carbazoles; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; | 2016 |
[A method of fractionating urinary peptides containing hydroxyproline].
Topics: Acromegaly; Arthritis, Rheumatoid; Bone Neoplasms; Chemistry, Clinical; Chromatography, Ion Exchange | 1967 |
The use of dichloromethylene diphosphonate for the management of hypercalcaemia in multiple myeloma.
Topics: Aged; Alkaline Phosphatase; Calcium; Clodronic Acid; Creatinine; Diphosphonates; Female; Humans; Hyd | 1983 |
[Treatment of hypercalcemia of myelomatous origin with intravenous diphosphonates].
Topics: Aged; Calcium; Diphosphonates; Female; Humans; Hydroxyproline; Hypercalcemia; Ilium; Injections, Int | 1983 |
Biochemical assessment of bone disease in multiple myeloma.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Bone and Bones; Bone Diseases; Female; Humans; Hydrox | 1984 |
[Biochemical monitoring of bone involvement in multiple myeloma].
Topics: Alkaline Phosphatase; Bone Resorption; Humans; Hydroxyproline; Multiple Myeloma; Osteolysis | 1983 |
Total, dialyzable, and nondialyzable postabsorptive hydroxyproline. Values in patients with cancer.
Topics: Bone Neoplasms; Breast Neoplasms; Collagen; Dialysis; Female; Hodgkin Disease; Humans; Hydroxyprolin | 1983 |
Urinary hydroxyproline in multiple myeloma: correlation with clinical stages and bone disease.
Topics: Adult; Aged; Bone Diseases; Female; Fractures, Bone; Humans; Hydroxyproline; Male; Middle Aged; Mult | 1984 |
Myelofibrosis associated with IgG myeloma.
Topics: Female; Humans; Hydroxyproline; Immunoglobulin G; Middle Aged; Multiple Myeloma; Primary Myelofibros | 1982 |
The postabsorptive urinary hydroxyproline (spot-HYPRO) in patients with multiple myeloma.
Topics: Bone Resorption; Creatinine; Dialysis; Follow-Up Studies; Humans; Hydroxyproline; Kidney Diseases; M | 1981 |
[Biphosphonates and multiple myeloma].
Topics: Animals; Bone Neoplasms; Calcium; Diphosphonates; Humans; Hydroxyproline; Hypercalcemia; Multiple My | 1993 |
[The extratumor mechanisms of osteolysis in multiple myeloma and the means for their correction].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Bone Marrow; Cholecalcife | 1996 |
High-molecular-weight hydroxyproline-protein in relation to immunoglobulins M (IgM) in human blood serum.
Topics: Adult; Aged; Blood Proteins; Chronic Disease; Female; gamma-Globulins; Glomerulonephritis; Hepatitis | 1975 |
Inhibition of osteolytic bone lesions by (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.).
Topics: Bone Resorption; Breast Neoplasms; Calcium; Creatinine; Diphosphonates; Female; Humans; Hydroxyproli | 1979 |
Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption.
Topics: Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Density; Bone Development; Bone Remodeling; Bone | 1992 |
Treatment of multiple myeloma with nasal spray calcitonin: a histomorphometric and biochemical study.
Topics: Administration, Intranasal; Adult; Age Factors; Aged; Aged, 80 and over; Alkaline Phosphatase; Calci | 1990 |
[Bone turnover markers in tumor pathology with bone involvement].
Topics: Adult; Aged; Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Neoplasms; Female; Humans; Hydro | 1990 |
Skeletal surveys in multiple myeloma. Radiologic-clinical correlation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Female; Humans; Hydroxyproline; Immu | 1986 |
[Are measurements of the urinary excretion of fasting calcium, phosphorus and hydroxyproline usefull in myeloma?].
Topics: Calcium; Fasting; Female; Humans; Hydroxyproline; Male; Middle Aged; Multiple Myeloma; Phosphorus | 1985 |
[The clinical significance of urinary hydroxyproline determinations (author's transl)].
Topics: Alkaline Phosphatase; Animals; Arthritis, Rheumatoid; Bone Diseases; Bone Neoplasms; Burns; Carbon R | 1972 |
Urinary hydroxyproline, serum alkaline phosphatase, calcium and phosphorus in patients with bone neoplasms.
Topics: Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; Calcium; Carcinoma, Intraductal, Noninfiltra | 1972 |
[Creatinine-hydroxyproline index in healthy subjects, in hyperthyroidism and in bone neoplasms].
Topics: Adult; Aged; Bone Neoplasms; Creatinine; Female; Graves Disease; Humans; Hydroxyproline; Hyperthyroi | 1971 |
[Plasma free amino acids in malignant bone tumors and in healthy subjects].
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Amino Acids; Bone Neoplasms; Calcium; Chromatography; | 1970 |
[Urinary hydroxyproline excretion in generalized bone diseases].
Topics: Adult; Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Bone Diseases; Bone Neoplasms; Female; Hum | 1967 |
Fluoride effect on bone in plasma cell myeloma.
Topics: Bone and Bones; Bone Neoplasms; Calcium; Cyclophosphamide; Fluorides; Humans; Hydroxyproline; Ilium; | 1968 |
Urinary hydroxyproline excretion in coalworkers' pneumoconiosis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Coal Mining; Collagen; Female; Humans; Hydroxyprolin | 1969 |
Urinary hydroxyproline excretion in patients with cancer.
Topics: Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; Calcium; Collagen; Creatine; Female; Humans; | 1969 |
Hydroxyproline excretion in malignant neoplastic disease.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; Carcinoma, Bronchogenic; Female | 1966 |