hydroxyproline has been researched along with Iron Overload in 3 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Iron Overload: An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study sought to determine whether excess hepatic iron potentiates liver injury in the methionine choline-deficient (MCD) model of non-alcoholic fatty liver disease (NAFLD)." | 3.73 | Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease. ( Hall, Pde L; Kirsch, R; Marais, AD; Sijtsema, HP; Tlali, M, 2006) |
| "Hepatic iron overload was associated with induction of heme oxygenase-1, a sensitive indicator of oxidative stress, and with modest increases in hydroxyproline and procollagen I mRNA levels without histologically evident fibrosis, all of which were unaffected by dietary fat." | 3.72 | Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. ( Brown, KE; Brunt, EM; Dennery, PA; Fimmel, CJ; Kladney, RD; Ridnour, LA; Spitz, DR, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 2 |
| Xie, Y | 1 |
| Gao, Y | 1 |
| Ma, J | 1 |
| Yuan, J | 1 |
| Li, J | 1 |
| Wang, J | 1 |
| Li, L | 1 |
| Zhang, J | 1 |
| Chu, L | 1 |
| Brown, KE | 1 |
| Dennery, PA | 1 |
| Ridnour, LA | 1 |
| Fimmel, CJ | 1 |
| Kladney, RD | 1 |
| Brunt, EM | 1 |
| Spitz, DR | 1 |
| Kirsch, R | 1 |
| Sijtsema, HP | 1 |
| Tlali, M | 1 |
| Marais, AD | 1 |
| Hall, Pde L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.[NCT03453918] | 41 participants (Actual) | Interventional | 2018-04-09 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for hydroxyproline and Iron Overload
| Article | Year |
|---|---|
Multitargeted inhibition of hepatic fibrosis in chronic iron-overloaded mice by Salvia miltiorrhiza.
Topics: Animals; Collagen Type I; Collagen Type III; Down-Regulation; Hydroxyproline; Interleukin-1alpha; Ir | 2013 |
Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats.
Topics: Animals; Collagen Type I; Cysteine; Dietary Fats, Unsaturated; Dipeptides; Glutathione; Heme Oxygena | 2003 |
Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Fatty Liver; | 2006 |