hydroxyproline has been researched along with Hypoxia in 49 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A polymeric prodrug of the proline analogue cis-4-hydroxy-l-proline (CHOP), poly(ethylene glycol)-lysine-CHOP or CHOP-PEG, prevents hypoxic pulmonary hypertension in rats by inhibiting collagen accumulation." | 7.73 | Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats. ( Belinka, B; Lu, SE; Pachence, J; Poiani, GJ; Riley, DJ; Simon, PM; Tozzi, CA, 2006) |
| " Inflammation and fibrosis were evaluated by transaminases, myeloperoxidase activity, hydroxyproline, and histological evaluation." | 4.12 | Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease. ( Abrante, B; Abreu-González, P; de la Barreda, R; Díaz-Flores, F; González-Paredes, FJ; Hernández-Bustabad, A; Hernández-Guerra, M; Morales-Arraez, D; Quintero, E, 2022) |
| "The oxygen-dependent hydroxylation of proline residues in the alpha subunit of hypoxia-inducible transcription factor (HIFalpha) is central to the hypoxic response in animals." | 3.75 | Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. ( Chowdhury, R; Domene, C; Flashman, E; Hewitson, KS; Loenarz, C; McDonough, MA; Mecinović, J; Schofield, CJ, 2009) |
| "A polymeric prodrug of the proline analogue cis-4-hydroxy-l-proline (CHOP), poly(ethylene glycol)-lysine-CHOP or CHOP-PEG, prevents hypoxic pulmonary hypertension in rats by inhibiting collagen accumulation." | 3.73 | Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats. ( Belinka, B; Lu, SE; Pachence, J; Poiani, GJ; Riley, DJ; Simon, PM; Tozzi, CA, 2006) |
| "Both 764-3 and ligustrazine significantly inhibited the increase of pulmonary arterial pressure and elevation of hydroxyproline content in extrapulmonary arterial wall during chronic hypoxia." | 3.69 | [Effect of 764-3 and ligustrazine on collagen content of extrapulmonary arteries during chronic hypoxia]. ( Chen, X; Sun, R; Yan, Y, 1996) |
| " Cardiomegaly has been produced in rats by sideropenic anaemia, by isoprenaline or thyroxine or by the application of both drugs, by artificial increase in resistance to blood flow and by long-term adaptation to hypoxia and physical stress." | 3.65 | The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly. ( Bartosová, D; Chvapil, M; Korecký, B; Poupa, O; Rakusan, K; Turek, Z; Vízek, M, 1969) |
| "Triamcinolone treatment (12 mg/kg intraperitoneally, once daily for 3 days) reduced mean right ventricular pressure (11 +/- 1 versus 14 +/- 1 mm Hg) and protein content of pulmonary arteries (1." | 1.29 | Effect of glucocorticoids on collagen accumulation in pulmonary vascular remodeling in the rat. ( Choe, JK; Poiani, GJ; Riley, DJ; Thakker-Varia, S; Tozzi, CA, 1994) |
| "Lung hydroxyproline content was measured as an index of lung dry weight." | 1.28 | Regional alveolar hypoxia does not affect air embolism-induced pulmonary edema. ( Bishop, MJ; Cheney, FW; Eisenstein, BL; Overand, PT, 1989) |
| " Dose-response curves to prostaglandin F2 alpha, (PGF2 alpha), angiotensin II (ANG II), and norepinephrine (NE) and responses to a depolarizing concentration of KCl were obtained on rings of pulmonary artery from normal rats, chronically hypoxic (10% O2 for 10 days) rats, and chronically hypoxic rats treated with cis-4-hydroxy-L-proline (cHyp), an agent that blocks collagen accumulation." | 1.28 | Vascular collagen affects reactivity of hypertensive pulmonary arteries of the rat. ( Edelman, NH; Poiani, GJ; Riley, DJ; Tozzi, CA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (46.94) | 18.7374 |
| 1990's | 9 (18.37) | 18.2507 |
| 2000's | 10 (20.41) | 29.6817 |
| 2010's | 5 (10.20) | 24.3611 |
| 2020's | 2 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Hernández-Bustabad, A | 1 |
| Morales-Arraez, D | 1 |
| González-Paredes, FJ | 1 |
| Abrante, B | 1 |
| Díaz-Flores, F | 1 |
| Abreu-González, P | 1 |
| de la Barreda, R | 1 |
| Quintero, E | 1 |
| Hernández-Guerra, M | 1 |
| Hu, S | 1 |
| He, W | 1 |
| Wu, G | 1 |
| Armitage, EG | 1 |
| Kotze, HL | 1 |
| Allwood, JW | 1 |
| Dunn, WB | 1 |
| Goodacre, R | 1 |
| Williams, KJ | 1 |
| Tian, L | 1 |
| Wang, Z | 3 |
| Liu, Y | 1 |
| Eickhoff, JC | 2 |
| Eliceiri, KW | 1 |
| Chesler, NC | 4 |
| Yuan, W | 1 |
| Liu, W | 1 |
| Cai, H | 1 |
| Sun, X | 1 |
| Yang, D | 1 |
| Xu, F | 1 |
| Jin, C | 1 |
| Estrada, KD | 1 |
| Asif, MH | 1 |
| Trivedi, PK | 1 |
| Misra, P | 1 |
| Nath, P | 1 |
| Ahn, DR | 1 |
| Kim, SY | 1 |
| Lee, MJ | 1 |
| Yang, EG | 1 |
| Chowdhury, R | 1 |
| McDonough, MA | 1 |
| Mecinović, J | 1 |
| Loenarz, C | 1 |
| Flashman, E | 1 |
| Hewitson, KS | 1 |
| Domene, C | 1 |
| Schofield, CJ | 2 |
| Ooi, CY | 1 |
| Tabima, DM | 1 |
| Zadorozhnyi, AV | 1 |
| Popkov, VL | 1 |
| Galenko-Yaroshevskii, VP | 1 |
| Antelava, AV | 1 |
| Chikobava, EA | 1 |
| Sukoyan, GV | 1 |
| Meladze, VN | 1 |
| Simon, PM | 1 |
| Pachence, J | 1 |
| Belinka, B | 1 |
| Poiani, GJ | 5 |
| Lu, SE | 1 |
| Tozzi, CA | 6 |
| Riley, DJ | 7 |
| Farkas, GA | 1 |
| McCormick, KM | 1 |
| Gosselin, LE | 1 |
| McKenzie, JC | 1 |
| Klein, RM | 1 |
| Kerr, JS | 2 |
| Frank, MM | 1 |
| Trelstad, RL | 1 |
| Frankel, HM | 2 |
| Genovese, A | 2 |
| Latte, S | 1 |
| Bozzaotre, M | 1 |
| Chiariello, M | 1 |
| Sun, R | 2 |
| Yan, Y | 2 |
| Chen, X | 2 |
| Si, Q | 1 |
| Li, H | 1 |
| Thakker-Varia, S | 1 |
| Choe, JK | 2 |
| Kemnitzer, JE | 1 |
| Fox, JD | 1 |
| Kohn, J | 1 |
| Pelouch, V | 2 |
| Kolár, F | 2 |
| Ost'ádal, B | 1 |
| Milerová, M | 1 |
| Cihák, R | 1 |
| Widimský, J | 1 |
| Perhonen, M | 1 |
| Wang, W | 1 |
| Han, X | 1 |
| Ruskoaho, H | 1 |
| Takala, TE | 1 |
| Berg, JT | 1 |
| Breen, EC | 1 |
| Fu, Z | 1 |
| Mathieu-Costello, O | 1 |
| West, JB | 1 |
| Asemu, G | 1 |
| Neckár, J | 1 |
| Szárszoi, O | 1 |
| Papousek, F | 1 |
| Ostádal, B | 2 |
| Liu, Z | 1 |
| Cheng, X | 1 |
| Cai, R | 1 |
| Sun, B | 1 |
| Zhu, Y | 1 |
| Klinger, JR | 1 |
| Warburton, RR | 1 |
| Pietras, L | 1 |
| Oliver, P | 1 |
| Fox, J | 1 |
| Smithies, O | 1 |
| Hill, NS | 1 |
| Hon, WC | 1 |
| Wilson, MI | 1 |
| Harlos, K | 1 |
| Claridge, TD | 1 |
| Pugh, CW | 1 |
| Maxwell, PH | 1 |
| Ratcliffe, PJ | 1 |
| Stuart, DI | 1 |
| Jones, EY | 1 |
| Mirejovská, E | 2 |
| Mirejovský, P | 1 |
| Hurych, J | 2 |
| Forsberg, JO | 1 |
| Jiborn, H | 1 |
| Jung, B | 1 |
| del Río Vázquez, A | 1 |
| Rico Lenza, H | 1 |
| Cigüenza Gabriel, R | 1 |
| Espinós Pérez, D | 1 |
| Oikarinen, A | 1 |
| Anttinen, H | 1 |
| Kivirikko, KI | 1 |
| Gordon, HA | 1 |
| Rovin, S | 1 |
| Bruckner, G | 1 |
| Hollenberg, M | 1 |
| Honbo, N | 1 |
| Samorodin, AJ | 1 |
| Yohn, SE | 1 |
| Accinni, A | 1 |
| Spadaro, G | 1 |
| Quattrin, S | 1 |
| Condorelli, M | 1 |
| Adamson, IY | 1 |
| King, GM | 1 |
| Bowden, DH | 1 |
| Cheney, FW | 1 |
| Eisenstein, BL | 1 |
| Overand, PT | 1 |
| Bishop, MJ | 1 |
| Edelman, NH | 1 |
| Ruppert, CL | 1 |
| Neubauer, JA | 1 |
| Yu, SY | 1 |
| Debieu, D | 1 |
| Deschavanne, PJ | 1 |
| Midander, J | 1 |
| Larsson, A | 1 |
| Malaise, EP | 1 |
| Bartosová, D | 1 |
| Chvapil, M | 2 |
| Korecký, B | 1 |
| Poupa, O | 1 |
| Rakusan, K | 1 |
| Turek, Z | 1 |
| Vízek, M | 1 |
| Bing, OH | 1 |
| Matsushita, S | 1 |
| Fanburg, BL | 1 |
| Levine, HJ | 1 |
| McGrath, JJ | 1 |
| Procházka, J | 1 |
| Uitto, J | 1 |
| Prockop, DJ | 1 |
| Penttinen, R | 1 |
| Rantanen, J | 1 |
| Kulonen, E | 1 |
| Wilhjelm, B | 1 |
| Langgård, H | 1 |
| Helin, P | 1 |
| Lorenzen, I | 1 |
1 review available for hydroxyproline and Hypoxia
| Article | Year |
|---|---|
Hydroxyproline in animal metabolism, nutrition, and cell signaling.
Topics: Animals; Collagen; Dietary Proteins; Hydroxyproline; Hypoxia; Proline; Signal Transduction | 2022 |
48 other studies available for hydroxyproline and Hypoxia
| Article | Year |
|---|---|
Chronic intermittent hypoxia promotes early intrahepatic endothelial impairment in rats with nonalcoholic fatty liver disease.
Topics: Acetaminophen; Acetylcholine; Animals; Hydroxyproline; Hypoxia; Inflammation; Intercellular Adhesion | 2022 |
Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells.
Topics: Biomarkers; Cell Hypoxia; Cell Line, Tumor; HCT116 Cells; Humans; Hydroxyproline; Hypoxia; Hypoxia-I | 2015 |
Validation of an arterial constitutive model accounting for collagen content and crosslinking.
Topics: Aminopropionitrile; Animals; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Elasticity; | 2016 |
SB-431542, a specific inhibitor of the TGF-β type I receptor inhibits hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts.
Topics: Actins; Animals; Benzamides; Cell Proliferation; Cells, Cultured; Collagen; Cytokines; Dioxoles; Dow | 2016 |
Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia.
Topics: Animals; Biomechanical Phenomena; Collagen; Extracellular Matrix; Gene Expression Profiling; Gene Ex | 2009 |
Prolyl-4-hydroxylase (AtP4H1) mediates and mimics low oxygen response in Arabidopsis thaliana.
Topics: Animals; Arabidopsis; Arabidopsis Proteins; Gene Expression Profiling; Hydroxyproline; Hypoxia; Micr | 2009 |
HIF-1alpha peptide derivatives with modifications at the hydroxyproline residue as activators of HIF-1alpha.
Topics: Chemistry, Pharmaceutical; Drug Design; Elongin; HeLa Cells; Humans; Hydroxyproline; Hypoxia; Hypoxi | 2009 |
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
Topics: Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Humans; Hydroxylation; Hydroxypr | 2009 |
The role of collagen in extralobar pulmonary artery stiffening in response to hypoxia-induced pulmonary hypertension.
Topics: Animals; Biomechanical Phenomena; Blood Pressure; Chronic Disease; Collagen Type I; Collagen Type I, | 2010 |
Role of collagen content and cross-linking in large pulmonary arterial stiffening after chronic hypoxia.
Topics: Animals; Biomechanical Phenomena; Chronic Disease; Collagen; Cross-Linking Reagents; Elastic Modulus | 2012 |
Effect of richlocaine alone or in combination with energostim on the severity of endotoxemia and survival of the skin under conditions of reduced blood flow.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cell Survival; Cytochromes | 2003 |
Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Hydroxyproline; Hypertension, Pulmonary; | 2006 |
Episodic hypoxia exacerbates respiratory muscle dysfunction in DMD(mdx) mice.
Topics: Animals; Diaphragm; Hydroxyproline; Hypoxia; In Vitro Techniques; Isotonic Contraction; Male; Mice; | 2007 |
Protein synthesis in the rat pulmonary trunk during the early development of hypoxia-induced pulmonary hypertension.
Topics: Animals; Cardiomegaly; Collagen; Glycine; Hematocrit; Hydroxyproline; Hypertension, Pulmonary; Hypox | 1983 |
Reduction of chronic hypoxic pulmonary hypertension in the rat by beta-aminopropionitrile.
Topics: Aminopropionitrile; Animals; Body Weight; Chronic Disease; Heart Ventricles; Hematocrit; Hemodynamic | 1984 |
Response of the left ventricular connective tissue to hypoxia.
Topics: Aerobiosis; Altitude; Animals; Collagen; Connective Tissue; Heart; Heart Ventricles; Hydroxyproline; | 1983 |
Role of collagen metabolism changes in the pathogenesis of pulmonary hypertension in rats and its reversibility.
Topics: Animals; Blood Pressure; Collagen; Drugs, Chinese Herbal; Hydroxyproline; Hypertension, Pulmonary; H | 1994 |
Effect of glucocorticoids on collagen accumulation in pulmonary vascular remodeling in the rat.
Topics: Analysis of Variance; Animals; Collagen; Dose-Response Relationship, Drug; Hemodynamics; Hydroxyprol | 1994 |
Polymeric carrier of proline analogue with antifibrotic effect in pulmonary vascular remodeling.
Topics: Amylopectin; Animals; Cells, Cultured; Collagen; Drug Carriers; Endothelium, Vascular; Hydroxyprolin | 1997 |
Regression of chronic hypoxia-induced pulmonary hypertension, right ventricular hypertrophy, and fibrosis: effect of enalapril.
Topics: Altitude Sickness; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Chronic Disease; | 1997 |
Right ventricular collagen type III and IV gene expression increases during early phases of endurance training in hypobaric hypoxic condition.
Topics: Animals; Atmosphere Exposure Chambers; Atmospheric Pressure; Blotting, Northern; Cardiomegaly; Colla | 1997 |
[Effect of 764-3 and ligustrazine on collagen content of extrapulmonary arteries during chronic hypoxia].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Drugs, Chinese Herbal; Hydroxyproline; H | 1996 |
Alveolar hypoxia increases gene expression of extracellular matrix proteins and platelet-derived growth factor-B in lung parenchyma.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Capillaries; Collagen; Endothelial Growt | 1998 |
Effects of adaptation to intermittent high altitude hypoxia on ischemic ventricular arrhythmias in rats.
Topics: Adaptation, Physiological; Altitude; Animals; Body Weight; Heart; Hydroxyproline; Hypoxia; In Vitro | 2000 |
[Effects of 764-3 on collagen deposition in hypertensive pulmonary arteries in hypoxic rats].
Topics: Aminopropionitrile; Animals; Collagen; Drugs, Chinese Herbal; Hydroxyproline; Hypertension, Pulmonar | 1998 |
Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Carotid Arteries; Disease Progression; Guanylate C | 2002 |
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Elongin; Humans; Hydr | 2002 |
Effect of hyperbarism on collagenous protein metabolism in granulation tissue.
Topics: Animals; Atmospheric Pressure; Collagen; Granulation Tissue; Hydroxyproline; Hyperbaric Oxygenation; | 1975 |
Protective effect of hypoxia against radiation induced fibrosis in the rat gut.
Topics: Animals; Hydroxyproline; Hypoxia; Ileum; Intestinal Mucosa; Male; Microspheres; Radiation Dosage; Ra | 1979 |
[Urinary excretion of hydroxyproline in patients with chronic respiratory insufficiency (author's transl)].
Topics: Aged; Bone and Bones; Chronic Disease; Collagen; Female; Humans; Hydroxyproline; Hypercapnia; Hypoxi | 1979 |
Further studies on the effect of the collagen triple-helix formation on the hydroxylation of lysine and the glycosylations of hydroxylysine in chick-embryo tendon and cartilage cells.
Topics: Animals; Cartilage; Chick Embryo; Collagen; Dithiothreitol; Hydroxylation; Hydroxylysine; Hydroxypro | 1977 |
Blood flow, collagen components of oral tissue and salivary kallikrein in young to senescent, germfree and conventional rats. A study on the etiologic factors of periodontal disease.
Topics: Aging; Animals; Collagen; Germ-Free Life; Gingiva; Hydroxyproline; Hypoxia; Kallikreins; Ligation; M | 1978 |
Effects of hypoxia on cardiac growth in neonatal rat.
Topics: Animals; Animals, Newborn; Autoradiography; Body Weight; DNA; Heart; Heart Ventricles; Hematocrit; H | 1976 |
An antifibrotic agent reduces blood pressure in established pulmonary hypertension in the rat.
Topics: Animals; Arterioles; Blood Viscosity; Collagen; Hematocrit; Hemodynamics; Hydroxyproline; Hypertensi | 1990 |
Myocardial hypertrophy in rats exposed to simulated high altitude.
Topics: Altitude; Animals; Atmospheric Pressure; Cardiomegaly; Hemodynamics; Hydroxyproline; Hypoxia; In Vit | 1985 |
Collagen breakdown during acute lung injury.
Topics: Acute Disease; Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, Animal; E | 1988 |
Regional alveolar hypoxia does not affect air embolism-induced pulmonary edema.
Topics: Animals; Blood Pressure; Carbon Dioxide; Dogs; Embolism, Air; Female; Hemodynamics; Hydroxyproline; | 1989 |
Vascular collagen affects reactivity of hypertensive pulmonary arteries of the rat.
Topics: Angiotensin II; Animals; Collagen; Dinoprost; Hydroxyproline; Hypertension, Pulmonary; Hypoxia; Male | 1989 |
Reduction of chronic hypoxic pulmonary hypertension in the rat by an inhibitor of collagen production.
Topics: Animals; Arterioles; Cardiac Output; Chronic Disease; Collagen; Heart Ventricles; Hematocrit; Hydrox | 1987 |
Survival curves of glutathione synthetase deficient human fibroblasts: correlation between radiosensitivity in hypoxia and glutathione synthetase activity.
Topics: Cell Survival; Cells, Cultured; Gamma Rays; Glutathione; Glutathione Synthase; Humans; Hydroxyprolin | 1985 |
The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly.
Topics: Anemia, Hypochromic; Animals; Cardiomegaly; Collagen; Hydroxyproline; Hypertension; Hypertrophy; Hyp | 1969 |
Mechanical properties of rat cardiac muscle during experimental hypertrophy.
Topics: Animals; Aorta, Thoracic; Cardiomegaly; Constriction; Disease Models, Animal; Elasticity; Heart; Hyd | 1971 |
Physiological responses of rats to intermittent high-altitude stress: effects of age.
Topics: Age Factors; Altitude; Animals; Atmosphere Exposure Chambers; Body Weight; Cardiomegaly; Hemoglobino | 1973 |
Biosynthesis of cartilage procollagen. Influence of chain association and hydroxylation of prolyl residues on the folding of the polypeptides into the triple-helical conformation.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Cartilage; Chick Embryo; Chromatography, Gel; Collagen | 1974 |
Fracture healing at reduced atmospheric pressure. A biochemical study with rats.
Topics: Altitude; Animals; Atmospheric Pressure; Bone Matrix; Bone Regeneration; Calcium; Carbohydrate Metab | 1972 |
Effect of long-term hypoxia on protein synthesis in granuloma and in some organs in rats.
Topics: Animals; Carbon Isotopes; Collagen; Female; Granuloma; Hydroxyproline; Hypoxia; Intestine, Small; Li | 1970 |
Effects of phenobarbital, phenytoin, and anoxia on connective tissue of mice.
Topics: Animals; Collagen; Connective Tissue; Electrolytes; Fats; Hydroxyproline; Hypoxia; Liver; Mice; Phen | 1968 |
Arteriosclerosis in rabbit aorta induced by systemic hypoxia. Biochemical and morphologic studies.
Topics: Albumins; Animals; Aorta; Aorta, Thoracic; Arteriosclerosis; Blood Pressure; Body Weight; Bone and B | 1969 |