hydroxyproline and Hypocalcemia studies

Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.

Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"This study investigated whether hydroxyproline, deoxypyridinoline, or the carboxyterminal telopeptide of type I collagen could be used as markers to provide evidence of bone resorption during hypocalcemia of dairy cows."	3.70	Comparison of bone resorption markers during hypocalcemia in dairy cows. ( Eicher, R; Liesegang, A; Riond, JL; Risteli, J; Sassi, ML; Wanner, M, 1998)
"Cows fed a balanced diet with the required amounts of calcium and phosphorus developed acute hypocalcemia and hypophosphatemia shortly after parturition, even in the presence of the a responsive parathyroid gland, when bone resorption was selectively inhibited by the prepartal administration of disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP)."	3.65	Experimental parturient hypocalcemia in cows following prepartal chemical inhibition of bone resportion. ( Black, HE; Capen, CC; Geho, WB; Potts, JT; Re, R; Yarrington, JT, 1976)
"24 patients with chronic renal failure (glomerular filtration-rate (G."	2.64	Controlled trial of 1apha-hydroxycholecalciferol in chronic renal failure. ( Brochner-Mortensen, J; Christensen, MS; Rodbro, P; Sorensen, AW; Sorensen, E; Tougaard, L, 1976)
"Hydroxyproline in plasma was greater during peripartal period in cows fed low-calcium diet."	1.26	Vitamin D metabolites in plasma of cows fed a prepartum low-calcium diet for prevention of parturient hypocalcemia. ( Beitz, DC; Green, HB; Horst, RL; Littledike, ET, 1981)
"8 patients with hypoparathyroidism have been treated successfully with 1,25-dihydroxycholecalciferol (0-25-1-0 mug/day) for 4-24 mo."	1.26	1,25-dihydroxycholecalciferol in hypoparathyroidism. ( Davies, M; Hill, LF; Stanbury, SW; Taylor, CM, 1977)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (88.89)	18.7374
1990's	3 (6.67)	18.2507
2000's	2 (4.44)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Davey, RA	1
Morris, HA	1
Parsons, V	1
Baum, M	1
Self, M	1
Reinhardt, TA	1
Conrad, HR	2
Fairney, A	1
Jacobs, TP	1
Siris, ES	1
Bilezikian, JP	1
Baquiran, DC	1
Shane, E	1
Canfield, RE	1
Jönsson, G	1
Pehrson, B	1
Lundström, K	1
Edqvist, LE	1
Blum, JW	1
Green, HB	1
Horst, RL	1
Beitz, DC	1
Littledike, ET	1
Vidal, MC	1
Bottasso, OA	1
Lehrer, A	1
Puche, RC	1
Liesegang, A	2
Sassi, ML	2
Risteli, J	2
Eicher, R	2
Wanner, M	2
Riond, JL	2
Tougaard, L	1
Sorensen, E	1
Brochner-Mortensen, J	1
Christensen, MS	1
Rodbro, P	1
Sorensen, AW	1
Davies, M	1
Taylor, CM	1
Hill, LF	1
Stanbury, SW	1
Yarrington, JT	2
Capen, CC	4
Black, HE	4
Re, R	2
Potts, JT	1
Geho, WB	2
Nagode, LA	1
Fournié, A	1
Valverde, C	1
Tap, G	1
Bazerque, JJ	1
Ayrolles, C	1
Laitinen, O	2
Reunanen, MI	1
Sotaniemi, EA	1
Hakkarainen, HK	1
Rotstein, S	1
Glas, U	1
Eriksson, M	1
Pfeiffer, P	1
Hansen, J	1
Söderqvist, J	1
Bandmann, U	1
Strid, S	1
van de Braak, AE	2
van't Klooster, AT	1
Malestein, A	2
Meunier, PJ	1
Salson, C	1
Mathieu, L	1
Chapuy, MC	1
Delmas, P	1
Alexandre, C	1
Charhon, S	1
van 't Klooster, AT	1
Rojanasathit, S	1
Rosenberg, E	1
Haddad, JG	1
Nurmio, P	1
Rajakoski, E	1
Ryan, WG	1
Schwartz, TB	1
Northrop, G	1
Mautalen, CA	1
Dymling, JF	1
Horwith, M	1
Goldsmith, RS	1
Arnaud, CD	1
Muir, LA	1
Hibbs, JW	1
Smith, KL	1
Kalu, DN	1
Hillyard, C	1
Foster, GV	1
Cochran, M	1
Bulusu, L	1
Horsman, A	1
Stasiak, L	1
Nordin, BE	1
Caniggia, A	1
Gennari, C	1
Araszkiewicz, A	1
Miravet, L	1
Cohen-Solal, L	1
Hioco, D	1
Bell, NH	1
Avery, S	1
Johnston, CC	1
Kleeman, CR	1
Massry, SG	1
Coburn, JW	1
Milhaud, G	1
Tsien-Ming, L	1
Moukhtar, MS	1
Vaisrub, S	1
Harries, JT	1
Piesowicz, AT	1
Seakins, JW	1
Francis, DE	1
Wolff, OH	1
Wezeman, FH	1
Reynolds, WA	1
Eddy, RL	1
Herting, W	1
Liebegott, G	1
Fischer, JA	2
Binswanger, U	2
Schenk, R	2
Merz, W	2
Kistler, HJ	2
MacManus, J	1
Heaton, FW	1

Article	Year
The use of biochemical tests in the diagnosis of disorders of calcium metabolism. Annals of clinical biochemistry, 1980, Volume: 17, Issue:4 Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Calcitonin; Calcium; Calcium Metabolism Disorders; Ch	1980
The clinical physiology of calcium homeostasis, parathyroid hormone, and calcitonin. II. California medicine, 1971, Volume: 114, Issue:4 Topics: Adenoma; Alkaline Phosphatase; Calcitonin; Calcium; Dihydrotachysterol; Diuretics; Ergocalciferols;	1971

Article	Year
Controlled trial of 1apha-hydroxycholecalciferol in chronic renal failure. Lancet (London, England), 1976, May-15, Volume: 1, Issue:7968 Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Brain Injuries; Calcium; Clinical Trials as Topic	1976
Intravenous clodronate for the treatment of hypercalcaemia in breast cancer patients with bone metastases--a prospective randomised placebo-controlled multicentre study. European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:4-5 Topics: Adult; Aged; Aged, 80 and over; Blood Proteins; Bone Neoplasms; Breast Neoplasms; Calcium; Clodronic	1992
Effects of calcitonin in Paget's disease and polyostotic fibrous dysplasia. The Journal of clinical endocrinology and metabolism, 1970, Volume: 31, Issue:3 Topics: Adolescent; Aged; Alkaline Phosphatase; Calcitonin; Calcium; Clinical Trials as Topic; Collagen; Cre	1970

Article	Year
The effects of salmon calcitonin-induced hypocalcemia on bone metabolism in ovariectomized rats. Journal of bone and mineral metabolism, 2005, Volume: 23, Issue:5 Topics: Animals; Body Weight; Bone and Bones; Calcitonin; Calcium; Estrogens; Female; Homeostasis; Hydroxypr	2005
Effect of mithramycin on calcium and hydroxyproline metabolism in patients with malignant disease. British medical journal, 1967, Feb-25, Volume: 1, Issue:5538 Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Female; Humans; Hydroxyproline; Hypocalce	1967
Mode of action of pharmacological doses of cholecalciferol during parturient hypocalcemia in dairy cows. The Journal of nutrition, 1980, Volume: 110, Issue:8 Topics: Animals; Calcium; Cattle; Cholecalciferol; Dihydroxycholecalciferols; Female; Hydroxyproline; Hypoca	1980
Hypercalcemia of malignancy: treatment with intravenous dichloromethylene diphosphonate. Annals of internal medicine, 1981, Volume: 94, Issue:3 Topics: Adult; Aged; Bone Neoplasms; Bone Resorption; Calcium; Clodronic Acid; Diarrhea; Diphosphonates; Dru	1981
Studies on the effect of the amount of calcium in the prepartum diet on blood levels of calcium, magnesium, inorganic phosphorus, parathyroid hormone and hydroxyproline in milk fever prone cows. Zentralblatt fur Veterinarmedizin. Reihe A, 1980, Volume: 27, Issue:3 Topics: Animals; Calcium; Calcium, Dietary; Cattle; Cattle Diseases; Female; Hydroxyproline; Hypocalcemia; M	1980
Vitamin D metabolites in plasma of cows fed a prepartum low-calcium diet for prevention of parturient hypocalcemia. Journal of dairy science, 1981, Volume: 64, Issue:2 Topics: Animals; Bone Diseases; Calcium; Calcium, Dietary; Cattle; Cattle Diseases; Dihydroxycholecalciferol	1981
Altered calcium-binding ability of plasma proteins as the cause of hypocalcemia in lepromatous leprosy. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1993, Volume: 61, Issue:4 Topics: Absorption; Acid Phosphatase; Alkaline Phosphatase; Blood Proteins; Calcifediol; Calcium; Calcium, D	1993
Comparison of bone resorption markers during hypocalcemia in dairy cows. Journal of dairy science, 1998, Volume: 81, Issue:10 Topics: Amino Acids; Animals; Biomarkers; Bone Resorption; Cattle; Cattle Diseases; Collagen; Collagen Type	1998
The course of selected bone resorption marker concentrations in response to short-term hypocalcemia experimentally induced with disodium EDTA infusions in dairy cows. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2000, Volume: 47, Issue:8 Topics: Amino Acids; Animals; Biomarkers; Bone Resorption; Calcium; Cattle; Cattle Diseases; Chelating Agent	2000
1,25-dihydroxycholecalciferol in hypoparathyroidism. Lancet (London, England), 1977, Jan-08, Volume: 1, Issue:8002 Topics: Administration, Oral; Adult; Calcium; Dihydroxycholecalciferols; Female; Humans; Hydroxycholecalcife	1977
Experimental parturient hypocalcemia in cows following prepartal chemical inhibition of bone resportion. The American journal of pathology, 1976, Volume: 83, Issue:3 Topics: Animals; Antigens; Bone Resorption; Calcium; Calcium, Dietary; Cattle; Cattle Diseases; Cyclic AMP;	1976
Effect of dichloromethane diphosphonate on calcium homeostatic mechanisms in pregnant cows. The American journal of pathology, 1977, Volume: 87, Issue:3 Topics: Animals; Calcium; Cattle; Clodronic Acid; Cyclic AMP; Diphosphonates; Duodenum; Edetic Acid; Female;	1977
[A test for acute hypocalcemia using swine and salmon calcitonin]. Revue du rhumatisme et des maladies osteo-articulaires, 1977, Volume: 44, Issue:2 Topics: Acute Disease; Alkaline Phosphatase; Animals; Calcitonin; Calcium; Hydroxyproline; Hypocalcemia; Ost	1977
Bone, calcium, and hydroxyproline metabolism in hyperparathyroidism and after removal of parathyroid adenoma. Acta medica Scandinavica, 1977, Volume: 202, Issue:1-2 Topics: Adenoma; Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Female; Humans; Hydro	1977
Relation to osteoporosis of age- and hormone-induced changes in the metabolism of collagen and bone. Israel journal of medical sciences, 1976, Volume: 12, Issue:7 Topics: Aging; Animals; Bone and Bones; Bone Matrix; Calcium; Collagen; Female; Hormones; Humans; Hydroxypro	1976
Serum calcium balance during early phase of diphenylhydantoin therapy. International journal of clinical pharmacology and biopharmacy, 1976, Volume: 14, Issue:1 Topics: Adolescent; Adult; Alkaline Phosphatase; Epilepsy; Female; Humans; Hydroxyproline; Hypocalcemia; Mal	1976
Influence of a deficient supply of magnesium during the dry period on the rate of calcium mobilisation by dairy cows at parturition. Research in veterinary science, 1987, Volume: 42, Issue:1 Topics: Animal Feed; Animals; Calcium; Cattle; Cattle Diseases; Colostrum; Creatinine; Diet; Edetic Acid; Fe	1987
Skeletal distribution and biochemical parameters of Paget's disease. Clinical orthopaedics and related research, 1987, Issue:217 Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antibodies; Bone and Bones; Etidronic Acid; Fe	1987
Influence of prepartum calcium intake on calcium mobilization rate around parturition in dairy cows fed at a high prepartum feeding level. The veterinary quarterly, 1986, Volume: 8, Issue:1 Topics: Animal Nutritional Physiological Phenomena; Animals; Calcium; Calcium, Dietary; Cattle; Cattle Disea	1986
Paget's bone disease: response to human calcitonin in patients resistant to salmon calcitonin. Lancet (London, England), 1974, Dec-14, Volume: 2, Issue:7894 Topics: Aged; Alkaline Phosphatase; Animals; Antibodies; Antibody Formation; Calcitonin; Calcium; Female; Hu	1974
Hydroxyproline excretion in bovine puerperal paresis with special reference to bone resorption. Zentralblatt fur Veterinarmedizin. Reihe A, 1973, Volume: 20, Issue:8 Topics: Animals; Bone Resorption; Calcium; Cattle; Cattle Diseases; Creatinine; Female; Hydroxyproline; Hypo	1973
Treatment of Paget's disease with mithramycin: further experiences. Seminars in drug treatment, 1972,Summer, Volume: 2, Issue:1 Topics: Alkaline Phosphatase; Antibiotics, Antineoplastic; Gluconates; Humans; Hydroxyproline; Hypocalcemia;	1972
Pseudohypoparathyroidism 1942-1966. A negative progress report. The American journal of medicine, 1967, Volume: 42, Issue:6 Topics: Adult; Bone and Bones; Calcium; Calcium Isotopes; Cholecalciferol; Creatine; Dihydrotachysterol; Hum	1967
Laboratory aids in the diagnosis of metabolic bone disease. The Orthopedic clinics of North America, 1972, Volume: 3, Issue:3 Topics: Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Diseases; Calcium; Calcium, Dietary; Cyclic AMP;	1972
Ultrastructure of parathyroid glands and plasma immunoreactive parathyroid hormone in pregnant cows fed normal and high calcium diets. Laboratory investigation; a journal of technical methods and pathology, 1973, Volume: 29, Issue:2 Topics: Animals; Bone Resorption; Calcium; Calcium, Dietary; Cattle; Cyclic AMP; Edetic Acid; Female; Hydrox	1973
Effect of estrogen and progesterone on feed intake and hydroxyproline excretion following induced hypocalcemia in dairy cows. Journal of dairy science, 1972, Volume: 55, Issue:11 Topics: Animal Feed; Animals; Bone Resorption; Calcium; Calcium, Dietary; Cattle; Cattle Diseases; Edetic Ac	1972
Effect of glucagon on bone collagen metabolism in the rat. The Journal of endocrinology, 1972, Volume: 55, Issue:2 Topics: Animals; Blood Glucose; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Collagen; Femur; Gluca	1972
Hypocalcaemia and bone disease in renal failure. Nephron, 1973, Volume: 10, Issue:2 Topics: Absorptiometry, Photon; Acidosis; Adolescent; Adult; Aged; Alkaline Phosphatase; Bicarbonates; Biops	1973
[Metabolic effects of calcitonin in man]. Minerva medica, 1973, Volume: 64, Issue:43 Topics: Adult; Aged; Calcitonin; Calcium; Calcium Isotopes; Female; Humans; Hydroxyproline; Hypocalcemia; Ma	1973
[Effects of rifampicin and ethambutol on calcium metabolism in the rat]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1973, Volume: 167, Issue:6 Topics: Animals; Calcium; Calcium Metabolism Disorders; Calcium Radioisotopes; Ethambutol; Feces; Hydroxypro	1973
[Synergism and antagonism of thyroxine, parathormone and thyrocalcitonin on calcemia and phosphatemia]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1967, Feb-06, Volume: 264, Issue:6 Topics: Animals; Calcitonin; Calcium; Drug Antagonism; Drug Synergism; Hydroxyproline; Hypocalcemia; Male; P	1967
New therapies in Paget's disease of bone. JAMA, 1971, Sep-06, Volume: 217, Issue:10 Topics: Administration, Oral; Anti-Bacterial Agents; Bone Resorption; Calcitonin; Calcium; Humans; Hydroxypr	1971
Urinary and plasma hydroxyproline during pregnancy, parturition and lactation in cows with parturient hypocalcemia. Metabolism: clinical and experimental, 1971, Volume: 20, Issue:4 Topics: Animals; Bone and Bones; Calcium; Cattle; Cattle Diseases; Female; Hydroxyproline; Hypocalcemia; Lac	1971
Low proline diet in type I hyperprolinaemia. Archives of disease in childhood, 1971, Volume: 46, Issue:245 Topics: Amino Acid Metabolism, Inborn Errors; Bone Diseases; Diet Therapy; Electroencephalography; Glycine;	1971
Stability of fetal calcium levels and bone metabolism after maternal administration of thyrocalcitonin. Endocrinology, 1971, Volume: 89, Issue:2 Topics: Amniotic Fluid; Animals; Bone and Bones; Calcitonin; Calcium; Calcium Isotopes; Female; Fetus; Hydro	1971
Metabolic bone disease after gastrectomy. The American journal of medicine, 1971, Volume: 50, Issue:4 Topics: Adult; Aged; Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Diseases; Calcium; Calcium Metabolis	1971
[Congenital familial osteopetrosis (marble bone disease Albers-Schönberg). A contribution to the pathogenesis]. Beitrage zur Pathologie, 1971, Volume: 143, Issue:2 Topics: Albuminuria; Amino Acids; Anemia; Autopsy; Bone and Bones; Female; Goiter; Humans; Hydroxyproline; H	1971
[Normocalcemic hyperparathyroidism in malabsorption]. Schweizerische medizinische Wochenschrift, 1968, May-11, Volume: 98, Issue:19 Topics: Calcium; Humans; Hydroxyproline; Hyperparathyroidism; Hypocalcemia; Intestinal Absorption; Malabsorp	1968
The effect of magnesium deficiency on calcium homeostasis in the rat. Clinical science, 1969, Volume: 36, Issue:2 Topics: Animals; Bone and Bones; Calcium; Calcium, Dietary; Diet; Homeostasis; Hydroxyproline; Hypercalcemia	1969
Normocalcemic secondary hyperparathyroidism and malabsorption. Helvetica medica acta, 1969, Volume: 35, Issue:1 Topics: Adult; Bone and Bones; Calcium; Celiac Disease; Glomerular Filtration Rate; Humans; Hydroxyproline;	1969

hydroxyproline and Hypocalcemia

Research Excerpts

Research

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