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hydroxyproline and Hypertension, Pulmonary

hydroxyproline has been researched along with Hypertension, Pulmonary in 22 studies

Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.

Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Research Excerpts

ExcerptRelevanceReference
" Pulmonary hydroxyproline content (HPC), pulmonary connective tissue growth factor (CTGF) transcription and lung compliance (LC) were analysed to characterize pulmonary fibrosis."7.79Effects of simvastatin on pulmonary fibrosis, pulmonary hypertension and exercise capacity in bleomycin-treated rats. ( Arzt, M; Blumberg, FC; Lange, TJ; Lehmann, H; Nowrotek, A; Pfeifer, M; Schroll, S; Sebah, D; Wensel, R, 2013)
"A polymeric prodrug of the proline analogue cis-4-hydroxy-l-proline (CHOP), poly(ethylene glycol)-lysine-CHOP or CHOP-PEG, prevents hypoxic pulmonary hypertension in rats by inhibiting collagen accumulation."7.73Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats. ( Belinka, B; Lu, SE; Pachence, J; Poiani, GJ; Riley, DJ; Simon, PM; Tozzi, CA, 2006)
"To determine whether all-trans retinoic acid (atRA) exerts an inhibitory effect on rats with pulmonary hypertension induced by monocrotaline."7.71All-trans retinoic acid in pulmonary vascular structural remodeling in rats with pulmonary hypertension induced by monocrotaline. ( Ben, X; Li, F; Liang, Y; Qin, Y; Shen, J; Zhou, A, 2001)
" Pulmonary hydroxyproline content (HPC), pulmonary connective tissue growth factor (CTGF) transcription and lung compliance (LC) were analysed to characterize pulmonary fibrosis."3.79Effects of simvastatin on pulmonary fibrosis, pulmonary hypertension and exercise capacity in bleomycin-treated rats. ( Arzt, M; Blumberg, FC; Lange, TJ; Lehmann, H; Nowrotek, A; Pfeifer, M; Schroll, S; Sebah, D; Wensel, R, 2013)
"A polymeric prodrug of the proline analogue cis-4-hydroxy-l-proline (CHOP), poly(ethylene glycol)-lysine-CHOP or CHOP-PEG, prevents hypoxic pulmonary hypertension in rats by inhibiting collagen accumulation."3.73Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats. ( Belinka, B; Lu, SE; Pachence, J; Poiani, GJ; Riley, DJ; Simon, PM; Tozzi, CA, 2006)
"To determine whether all-trans retinoic acid (atRA) exerts an inhibitory effect on rats with pulmonary hypertension induced by monocrotaline."3.71All-trans retinoic acid in pulmonary vascular structural remodeling in rats with pulmonary hypertension induced by monocrotaline. ( Ben, X; Li, F; Liang, Y; Qin, Y; Shen, J; Zhou, A, 2001)
" We determined whether there was a correlation between hydroxyproline content of rat pulmonary artery segments and elastance (EPA) of the pulmonary artery bed during development of hypoxic pulmonary hypertension (10% O2, 10 d) and normoxic recovery."3.69Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility. ( Christiansen, DL; Poiani, GJ; Riley, DJ; Tozzi, CA, 1994)
"Both 764-3 and ligustrazine significantly inhibited the increase of pulmonary arterial pressure and elevation of hydroxyproline content in extrapulmonary arterial wall during chronic hypoxia."3.69[Effect of 764-3 and ligustrazine on collagen content of extrapulmonary arteries during chronic hypoxia]. ( Chen, X; Sun, R; Yan, Y, 1996)
"We recently reported that platelet-activating factor (PAF) levels increased in lung tissue after 1 subcutaneous injection of monocrotaline (MCT) (which causes lung injury), and, further, that treatment with PAF antagonists reduced pulmonary hypertension in this chronic lung injury rat model [15]."3.68PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model. ( Ono, S; Voelkel, NF, 1992)
"Triamcinolone treatment (12 mg/kg intraperitoneally, once daily for 3 days) reduced mean right ventricular pressure (11 +/- 1 versus 14 +/- 1 mm Hg) and protein content of pulmonary arteries (1."1.29Effect of glucocorticoids on collagen accumulation in pulmonary vascular remodeling in the rat. ( Choe, JK; Poiani, GJ; Riley, DJ; Thakker-Varia, S; Tozzi, CA, 1994)
" Dose-response curves to prostaglandin F2 alpha, (PGF2 alpha), angiotensin II (ANG II), and norepinephrine (NE) and responses to a depolarizing concentration of KCl were obtained on rings of pulmonary artery from normal rats, chronically hypoxic (10% O2 for 10 days) rats, and chronically hypoxic rats treated with cis-4-hydroxy-L-proline (cHyp), an agent that blocks collagen accumulation."1.28Vascular collagen affects reactivity of hypertensive pulmonary arteries of the rat. ( Edelman, NH; Poiani, GJ; Riley, DJ; Tozzi, CA, 1989)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19904 (18.18)18.7374
1990's12 (54.55)18.2507
2000's3 (13.64)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schroll, S1
Lange, TJ1
Arzt, M1
Sebah, D1
Nowrotek, A1
Lehmann, H1
Wensel, R1
Pfeifer, M1
Blumberg, FC1
Tian, L1
Wang, Z2
Liu, Y1
Eickhoff, JC2
Eliceiri, KW1
Chesler, NC3
Estrada, KD1
Ooi, CY1
Tabima, DM1
Simon, PM1
Pachence, J1
Belinka, B1
Poiani, GJ6
Lu, SE1
Tozzi, CA7
Riley, DJ8
McKenzie, JC1
Klein, RM1
Kerr, JS2
Frank, MM1
Trelstad, RL1
Frankel, HM2
Sun, R2
Yan, Y2
Chen, X2
Si, Q1
Li, H1
Skalski, J1
Kortys-Puchalska, E1
Komarski, K1
Zmuda, A1
Wites, M1
Bochenek, A1
Rokicki, W1
Thakker-Varia, S1
Choe, JK2
Christiansen, DL1
Kemnitzer, JE1
Fox, JD1
Kohn, J1
Pelouch, V1
Kolár, F1
Ost'ádal, B1
Milerová, M1
Cihák, R1
Widimský, J1
Berg, JT1
Breen, EC1
Fu, Z1
Mathieu-Costello, O1
West, JB1
Liu, Z1
Cheng, X1
Cai, R1
Sun, B1
Zhu, Y1
Qin, Y1
Zhou, A1
Ben, X1
Shen, J1
Liang, Y1
Li, F1
Ono, S1
Voelkel, NF1
Bishop, JE1
Guerreiro, D1
Laurent, GJ1
Yohn, SE1
Edelman, NH1
Ruppert, CL1
Neubauer, JA1
Yu, SY1

Other Studies

22 other studies available for hydroxyproline and Hypertension, Pulmonary

ArticleYear
Effects of simvastatin on pulmonary fibrosis, pulmonary hypertension and exercise capacity in bleomycin-treated rats.
    Acta physiologica (Oxford, England), 2013, Volume: 208, Issue:2

    Topics: Animals; Bleomycin; Hydroxyproline; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung Co

2013
Validation of an arterial constitutive model accounting for collagen content and crosslinking.
    Acta biomaterialia, 2016, Volume: 31

    Topics: Aminopropionitrile; Animals; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Elasticity;

2016
Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia.
    Biomechanics and modeling in mechanobiology, 2009, Volume: 8, Issue:4

    Topics: Animals; Biomechanical Phenomena; Collagen; Extracellular Matrix; Gene Expression Profiling; Gene Ex

2009
The role of collagen in extralobar pulmonary artery stiffening in response to hypoxia-induced pulmonary hypertension.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:6

    Topics: Animals; Biomechanical Phenomena; Blood Pressure; Chronic Disease; Collagen Type I; Collagen Type I,

2010
Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats.
    Pulmonary pharmacology & therapeutics, 2006, Volume: 19, Issue:4

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Hydroxyproline; Hypertension, Pulmonary;

2006
Protein synthesis in the rat pulmonary trunk during the early development of hypoxia-induced pulmonary hypertension.
    Blood vessels, 1983, Volume: 20, Issue:6

    Topics: Animals; Cardiomegaly; Collagen; Glycine; Hematocrit; Hydroxyproline; Hypertension, Pulmonary; Hypox

1983
Reduction of chronic hypoxic pulmonary hypertension in the rat by beta-aminopropionitrile.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1984, Volume: 57, Issue:6

    Topics: Aminopropionitrile; Animals; Body Weight; Chronic Disease; Heart Ventricles; Hematocrit; Hemodynamic

1984
Role of collagen metabolism changes in the pathogenesis of pulmonary hypertension in rats and its reversibility.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 1994, Volume: 9, Issue:3

    Topics: Animals; Blood Pressure; Collagen; Drugs, Chinese Herbal; Hydroxyproline; Hypertension, Pulmonary; H

1994
[Hydroxyproline in serum and urine in children with pulmonary hypertension in the course of congenital heart defects].
    Przeglad lekarski, 1994, Volume: 51, Issue:10

    Topics: Child; Child, Preschool; Collagen; Heart Defects, Congenital; Humans; Hydroxyproline; Hypertension,

1994
Effect of glucocorticoids on collagen accumulation in pulmonary vascular remodeling in the rat.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:4 Pt 1

    Topics: Analysis of Variance; Animals; Collagen; Dose-Response Relationship, Drug; Hemodynamics; Hydroxyprol

1994
Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:5

    Topics: Animals; Collagen; Elasticity; Hydroxyproline; Hypertension, Pulmonary; In Vitro Techniques; Male; P

1994
Polymeric carrier of proline analogue with antifibrotic effect in pulmonary vascular remodeling.
    American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:4

    Topics: Amylopectin; Animals; Cells, Cultured; Collagen; Drug Carriers; Endothelium, Vascular; Hydroxyprolin

1997
Regression of chronic hypoxia-induced pulmonary hypertension, right ventricular hypertrophy, and fibrosis: effect of enalapril.
    Cardiovascular drugs and therapy, 1997, Volume: 11, Issue:2

    Topics: Altitude Sickness; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Chronic Disease;

1997
[Effect of 764-3 and ligustrazine on collagen content of extrapulmonary arteries during chronic hypoxia].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1996, Volume: 19, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Drugs, Chinese Herbal; Hydroxyproline; H

1996
Alveolar hypoxia increases gene expression of extracellular matrix proteins and platelet-derived growth factor-B in lung parenchyma.
    American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:6

    Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Capillaries; Collagen; Endothelial Growt

1998
[Effects of 764-3 on collagen deposition in hypertensive pulmonary arteries in hypoxic rats].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1998, Volume: 20, Issue:3

    Topics: Aminopropionitrile; Animals; Collagen; Drugs, Chinese Herbal; Hydroxyproline; Hypertension, Pulmonar

1998
All-trans retinoic acid in pulmonary vascular structural remodeling in rats with pulmonary hypertension induced by monocrotaline.
    Chinese medical journal, 2001, Volume: 114, Issue:5

    Topics: Animals; Blood Pressure; Hydroxyproline; Hypertension, Pulmonary; Lung; Male; Matrix Metalloproteina

2001
PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model.
    Lung, 1992, Volume: 170, Issue:1

    Topics: Animals; Azepines; Blood Pressure; Hydroxyproline; Hypertension, Pulmonary; Lung; Male; Monocrotalin

1992
Changes in the composition and metabolism of arterial collagens during the development of pulmonary hypertension in rabbits.
    The American review of respiratory disease, 1990, Volume: 141, Issue:2

    Topics: Animals; Aorta; Bleomycin; Collagen; Electrophoresis, Polyacrylamide Gel; Hydroxyproline; Hypertensi

1990
An antifibrotic agent reduces blood pressure in established pulmonary hypertension in the rat.
    Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 68, Issue:4

    Topics: Animals; Arterioles; Blood Viscosity; Collagen; Hematocrit; Hemodynamics; Hydroxyproline; Hypertensi

1990
Vascular collagen affects reactivity of hypertensive pulmonary arteries of the rat.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 66, Issue:4

    Topics: Angiotensin II; Animals; Collagen; Dinoprost; Hydroxyproline; Hypertension, Pulmonary; Hypoxia; Male

1989
Reduction of chronic hypoxic pulmonary hypertension in the rat by an inhibitor of collagen production.
    The American review of respiratory disease, 1987, Volume: 135, Issue:2

    Topics: Animals; Arterioles; Cardiac Output; Chronic Disease; Collagen; Heart Ventricles; Hematocrit; Hydrox

1987