hydroxyproline has been researched along with Cystic Fibrosis in 9 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The urinary excretion of collagen metabolites (hydroxylysine, hydroxyproline and proline) was significantly increased in 10 patients with cystic fibrosis and chronic broncho-pulmonary Pseudomonas aeruginosa infection as compared with 14 age matched controls." | 3.67 | Excretion of urinary collagen metabolites correlates to severity of pulmonary disease in cystic fibrosis. ( Ammitzbøll, T; Espersen, F; Pedersen, SS; Schiøler, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Engelen, MP | 1 |
| Com, G | 1 |
| Deutz, NE | 1 |
| Gavina, JM | 1 |
| White, CE | 1 |
| Finan, TM | 1 |
| Britz-McKibbin, P | 1 |
| THEIL, GB | 1 |
| BENOIT, FL | 1 |
| WATTEN, RH | 1 |
| Ammitzbøll, T | 1 |
| Pedersen, SS | 1 |
| Espersen, F | 1 |
| Schiøler, H | 1 |
| Langgård, H | 1 |
| Haase, H | 1 |
| Flensborg, EW | 1 |
| Hirthe, D | 1 |
| Mühlbach, R | 1 |
| Wilson, RG | 1 |
| Lindy, S | 1 |
| Kahanpää, K | 1 |
| Karhunen, P | 1 |
| Halme, J | 1 |
| Uitto, J | 1 |
| Segrest, JP | 1 |
| Cunningham, LW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Leucine-enriched Essential Amino Acid Intake to Optimize Protein Anabolism in Children With Cystic Fibrosis[NCT01172301] | 14 participants (Actual) | Interventional | 2008-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for hydroxyproline and Cystic Fibrosis
| Article | Year |
|---|---|
Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis.
Topics: Absorptiometry, Photon; Adolescent; Adult; Anthropometry; Body Composition; Bone Density; Bone Disea | 2014 |
Determination of 4-hydroxyproline-2-epimerase activity by capillary electrophoresis: A stereoselective platform for inhibitor screening of amino acid isomerases.
Topics: Amino Acid Isomerases; Bacterial Proteins; Cystic Fibrosis; Electrophoresis, Capillary; Enzyme Inhib | 2010 |
AN ORAL GELATIN-XYLOSE TEST FOR ESTIMATING PANCREATIC PROTEOLYTIC ACTIVITY.
Topics: Celiac Disease; Child; Colitis; Colitis, Ulcerative; Creatine; Creatinine; Cystic Fibrosis; Gelatin; | 1963 |
Excretion of urinary collagen metabolites correlates to severity of pulmonary disease in cystic fibrosis.
Topics: Adolescent; Adult; Bronchitis; Cystic Fibrosis; Female; Forced Expiratory Volume; Humans; Hydroxylys | 1988 |
Composition of the skin in mucoviscidosis.
Topics: Child; Child, Preschool; Cystic Fibrosis; Glycosaminoglycans; Hexosamines; Humans; Hydroxyproline; I | 1968 |
[Differential diagnosis of congenital systemic diseases of the skeleton based on biochemical changes in the body fluids].
Topics: Bone Diseases; Calcium; Cystic Fibrosis; Diagnosis, Differential; Glycosaminoglycans; Humans; Hydrox | 1968 |
Glycosaminoglycans in the skin of patients with cystic fibrosis of the pancreas.
Topics: Child; Child, Preschool; Cystic Fibrosis; Glycosaminoglycans; Hexosamines; Humans; Hydroxyproline; S | 1972 |
Lactate dehydrogenase isoenzymes during the development of experimental fibrosis.
Topics: Animals; Buffers; Centrifugation; Collagen; Cystic Fibrosis; Electrophoresis; Hydroxyproline; Isoenz | 1970 |
Variations in human urinary O-hydroxylysyl glycoside levels and their relationship to collagen metabolism.
Topics: Achondroplasia; Adolescent; Adult; Aged; Amino Acids; Arthritis, Rheumatoid; Bone and Bones; Bronchi | 1970 |