hydroxyproline has been researched along with Cirrhosis in 248 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epigallocatechin-3-gallate (EGCG) possesses anti-fibrotic potential in diverse tissues; however, the molecular mechanisms underlying the impacts of EGCG on diabetes-induced myocardial fibrosis remain unclear." | 8.12 | Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy. ( Jia, Q; Li, Y; Mehmood, S; Yang, R, 2022) |
| " The extent of fibrosis was also determined using various assays, such as immunohistochemistry, quantitative real-time PCR (qPCR), and hydroxyproline assays." | 8.12 | Obeticholic acid aggravates liver injury by up-regulating the liver expression of osteopontin in obstructive cholestasis. ( Huang, X; Jiang, Z; Miao, Y; Tang, Q; Wang, J; Wu, Q; Xu, Y; Yu, Q; Yuan, Z; Zhang, H; Zhang, L; Zhang, Z, 2022) |
| " Also, the effects of Pirfenidone on macrophage polarization and pulmonary fibrosis were evaluated in silicosis with early intervention and late treatment by histological examination, Enzyme-linked immunosorbent assay, Hydroxyproline assay, Western blot and Quantitative reverse transcription polymerase chain reaction." | 8.12 | Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways. ( Bo, C; Jia, Q; Li, M; Tang, Q; Xing, C; Zhang, Z, 2022) |
| "Empagliflozin administered early after myocardial infarction reduce myocardial fibrosis and inhibit the TGF-β1/Smad3 fibrotic pathway, probably prior to exerting any hemodynamic or physiological effect." | 8.02 | The impact of empagliflozin on cardiac physiology and fibrosis early after myocardial infarction in non-diabetic rats. ( Atar, S; Bandel, N; Daud, E; Ertracht, O; Moady, G; Reuveni, T; Shehadeh, M, 2021) |
| "Paraquat (PQ) induces pulmonary fibrosis, a progressive lung disorder resulting in severe respiratory failure and death." | 7.91 | Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice. ( Khodayar, MJ; Mansouri, E; Mirzaee, S; Shirani, M; Zeinvand-Lorestani, M, 2019) |
| "In this study we investigated the protective effects and possible mechanisms of pirfenidone (PF) in paraquat (PQ)-induced lung injury and fibrosis in mice." | 7.88 | Pirfenidone protects against paraquat-induced lung injury and fibrosis in mice by modulation of inflammation, oxidative stress, and gene expression. ( Ghazi-Khansari, M; Heidari, MR; Iranpour, M; Mandegary, A; Pourgholamhossein, F; Pourgholi, L; Pournamdari, M; Poursalehi, HR; Rasooli, R; Samareh-Fekri, M, 2018) |
| " Higher levels of plasma and lung heme have been recorded in acute lung injury associated with several insults." | 7.88 | Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema. ( Aggarwal, S; Ahmad, I; Athar, M; Carlisle, MA; Dransfield, MT; Lam, A; Li, C; Matalon, S; Raju, SV; Rowe, SM; Wells, JM, 2018) |
| " The present study investigated the effects of hydrogen-rich saline, a selective hydroxyl radical scavenger, on lipopolysaccharide (LPS)-induced pulmonary fibrosis." | 7.85 | Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis. ( Dong, WW; Jiang, L; Liu, YJ; Mao, YF; Sun, XJ; Zhang, YQ; Zhu, XY, 2017) |
| " Although hyperleptinemia is usually a characteristic of obese subjects, the relationship with atrial fibrosis and AF is unknown." | 7.85 | Hyperleptinemia Exacerbates High-Fat Diet-Mediated Atrial Fibrosis and Fibrillation. ( Aoki, K; Fukui, A; Fukunaga, N; Ikebe-Ebata, Y; Kondo, H; Masaki, T; Saito, S; Shinohara, T; Takahashi, N; Teshima, Y, 2017) |
| "The aim of this experimental study was to investigate the effectiveness of intramuscular pentoxifylline in the prevention of postoperative fibrosis." | 7.83 | Pentoxifylline Inhibits Epidural Fibrosis in Post-Laminectomy Rats. ( Antar, V; Erdogan, H; Karaoglan, A; Kelten, B; Kutnu, M; Orki, T; Sanel, S; Tuncdemir, M, 2016) |
| "In order to explore the effects of hydrogen sulfide (H2S) on myocardial fibrosis in diabetic rats and its underlying mechanisms, intraperitoneal injections of streptozotocin were used to establish the diabetes models and sodium hydrosulfide (NaHS) was used as an exogenous donor of H2S." | 7.81 | Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2015) |
| "To investigate the effect of ursolic acid (UA) on the alloxan-induced myocardial fibrosis in mice and discuss the possible mechanism." | 7.79 | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. ( Gong, Y; Qi, MY; Shi, J; Yang, JJ, 2013) |
| "We evaluated the antifibrotic effects of pomalidomide in preventive as well as therapeutic treatment regimes using bleomycin-induced dermal fibrosis as a model of early, inflammatory stages of fibrosis and the tight-skin mouse model as a model of later stages of fibrosis with endogenous activation of fibroblasts." | 7.78 | Pomalidomide is effective for prevention and treatment of experimental skin fibrosis. ( Beyer, C; Cedzik, D; Dees, C; Distler, A; Distler, JH; Distler, O; Palumbo-Zerr, K; Schafer, PH; Schett, G; Shankar, SL; Tomcik, M; Weingärtner, S; Zerr, P, 2012) |
| "We investigated whether melatonin was able to prevent left ventricular hypertrophy (LVH) and fibrosis associated with N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced hypertension." | 7.75 | Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. ( Adamcova, M; Barta, A; Krajcirovicova, K; Paulis, L; Pechanova, O; Pelouch, V; Simko, F; Zicha, J, 2009) |
| "To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI)." | 7.74 | [Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. ( Chen, H; Guo, CY; Li, HW; Li, ZZ; Shen, LH; Sun, T; Tang, CS, 2008) |
| "To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO)." | 7.74 | Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. ( Bu, DF; Li, YG; Liu, BG; Pang, YZ; Tan, XR; Tang, CS; Wang, DM; Wei, RH; Zhang, YG, 2007) |
| "We recently demonstrated that both lisinopril and candesartan, an angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor blocker, respectively, attenuate pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori (WBN/Kob) rats." | 7.73 | Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. ( Ando, T; Itoh, M; Joh, T; Kuno, A; Masuda, K; Nakamura, S; Nomura, T; Ogawa, K; Ohara, H; Okamoto, T; Shirai, T; Tang, M; Yamada, T, 2005) |
| "Trimetazidine reduces the degree of fibrosis and ameliorates histopathologic damage in experimental model of corrosive esophagitis in rats." | 7.73 | Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus. ( Karaoglu, AO; Ozutemiz, O; Tuncyurek, M; Yenisey, C; Yukselen, V, 2005) |
| "It is concluded that Ebselen has a preventive effect in the development of fibrosis and decrease the lipid peroxidation, and increase the antioxidant defense system activity in an experimental model of corrosive esophagitis in rats." | 7.73 | Beneficial effects of Ebselen on corrosive esophageal burns of rats. ( Coskun, O; Gurel, A; Hosnuter, M; Kanter, M; Ocakci, A; Tumkaya, L; Uzun, L, 2006) |
| "Although thalidomide had no effect on cardiac function, our results suggest that intervention with thalidomide may have beneficial effects in post-MI HF by attenuating collagen accumulation and development of myocardial fibrosis." | 7.73 | Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats. ( Attramadal, H; Aukrust, P; Bjørnerheim, R; Frøland, SS; Oie, E; Ueland, T; Vinge, LE; Wang, JE; Yndestad, A, 2006) |
| "A murine model of allergen-induced airway inflammation was used to examine the effects of exposure to ozone on airway inflammation and remodeling." | 7.72 | Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ozone. ( Kenyon, NJ; Last, JA; Temple, L; Ward, R, 2004) |
| "We studied the preventive effects of dimethyl sulfoxide (DMSO) on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats." | 7.71 | Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. ( Enjoji, M; Kato, M; Kotoh, K; Nakamuta, M; Nakashima, Y; Nawata, H; Ohta, S; Sugimoto, R; Tada, S; Tsuruta, S, 2001) |
| "To investigate whether tranilast reduces cardiac fibrosis in rats with two-kidney, one-clip (2K1C) renovascular hypertension." | 7.71 | Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension. ( Bauer, C; Eschenhagen, T; Godes, M; Hocher, B; Neumayer, HH; Olivier, J; Paul, M; Pinto, YM; Slowinski, T; Weil, J, 2002) |
| "Chronic administration of either angiotensin II (Ang II) or aldosterone (ALDO) leads to myocardial fibrosis." | 7.70 | Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade. ( Ramires, FJ; Sun, Y; Weber, KT, 1998) |
| "Liver fibrosis was induced in rats both with carbon tetrachloride and dimethylnitrosamine." | 7.68 | Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal prop ( Ala-Kokko, L; Günzler, V; Hoek, JB; Prockop, DJ; Rubin, E, 1992) |
| "A rabbit model of renal glomerulosclerosis induced by anti-glomerular basement membrane antibody was used to determine whether colchicine would protect renal function and reduce fibrosis." | 7.68 | Moderate protection of renal function and reduction of fibrosis by colchicine in a model of anti-GBM disease in the rabbit. ( Hsu, CH; Kshirsagar, AM; McClurkin, C; Patel, SR; Phan, SH; Spicker, JK; Wiggins, RC; Yuan, WY, 1990) |
| "Fibrosis/contracture is associated with the abnormal persistence of myofibroblasts, which over-produce and contract collagen matrices." | 5.56 | Sulfasalazine Resolves Joint Stiffness in a Rabbit Model of Arthrofibrosis. ( Atluri, K; Brouillette, MJ; Fowler, TP; Fredericks, D; Khorsand, B; Martin, JA; Petersen, E; Salem, AK; Sander, E; Seol, D; Smith, S, 2020) |
| "Renal fibrosis is a complication of kidney injury and associated with increased risk of morbidity and mortality." | 5.48 | Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats. ( Begum, J; Kumar, D; Kumar, P; Lingaraju, MC; Mathesh, K; Sharma, A; Singh, TU; Thakur, R, 2018) |
| " Collectively, exercise restored bioavailability of hydrogen sulfide in the heart of aged rats, which partly explained the benefits of exercise against myocardial fibrosis of aged population." | 5.48 | Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide. ( Liu, HM; Liu, JD; Ma, N; Wang, XZ; Xia, T, 2018) |
| "Myocardial fibrosis is the predominant pathological characteristic of diabetic myocardial damage." | 5.43 | Effects of hydrogen sulfide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2016) |
| "Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties." | 5.40 | Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats. ( Chen, F; Gong, H; Ji, A; Tao, H; Wang, K; Ye, F; Zhang, C; Zuo, Z, 2014) |
| "Hexarelin treatment significantly reduced cardiac fibrosis in SHRs by decreasing interstitial and perivascular myocardial collagen deposition and myocardial hydroxyproline content and reducing mRNA and protein expression of collagen I and III in SHR hearts." | 5.38 | Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat. ( Cao, JM; Chen, C; Ding, F; Gao, X; Hao, W; Pang, J; Xu, RK; Xu, X, 2012) |
| "Chronic pancreatitis was induced by continuous pancreatic ductal hypertension (PDH) for 14 days according to our previous study." | 5.37 | Treatment with pravastatin attenuates progression of chronic pancreatitis in rat. ( Harada, M; Otsuki, M; Wei, L; Yamamoto, M, 2011) |
| "Aldosterone promotes renal fibrosis via the mineralocorticoid receptor (MR), thus contributing to hypertension-induced nephropathy." | 5.35 | Hypertension-induced renal fibrosis and spironolactone response vary by rat strain and mineralocorticoid receptor gene expression. ( Camp, JR; Cavallari, LH; Fashingbauer, LA; Geenen, DL; King, ST, 2008) |
| "Fibrosis is a common pathological feature observed in muscle from patients with Duchenne muscular dystrophy and in mdx diaphragm." | 5.33 | Pentoxifylline fails to attenuate fibrosis in dystrophic (mdx) diaphragm muscle. ( Gosselin, LE; Williams, JE, 2006) |
| "Lung inflammation was measured by quantitative differential evaluation of lung lavage cells." | 5.32 | Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ultrafine particles. ( Kenyon, NJ; Last, JA; Pinkerton, KE; Temple, L; Ward, R, 2004) |
| "Colchicine treatment was associated with increased interstitium in WKY with increased passive myocardial stiffness." | 5.30 | Effect of chronic colchicine administration on the myocardium of the aging spontaneously hypertensive rat. ( Bing, OH; Brooks, WW; Cicogna, AC; Conrad, CH; Hayes, JA; Robinson, KG; Sen, S, 1997) |
| "Pirfenidone (PFD) is a novel anti-fibrotic agent that can prevent and even reverse extracellular matrix accumulation in several organs, as shown by experimental and clinical studies." | 5.30 | Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. ( Fukagawa, M; Hata, S; Kuroda, T; Kurokawa, K; Margolin, SB; Shimizu, T, 1998) |
| " Meanwhile, hydroxyproline (HYP) content was measured to evaluate the degree of retinal fibrosis." | 4.31 | Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway. ( Bao, B; Bi, H; Guo, D; Li, T; Liu, J; Wang, G; Xin, J; Yang, Z, 2023) |
| "Epigallocatechin-3-gallate (EGCG) possesses anti-fibrotic potential in diverse tissues; however, the molecular mechanisms underlying the impacts of EGCG on diabetes-induced myocardial fibrosis remain unclear." | 4.12 | Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy. ( Jia, Q; Li, Y; Mehmood, S; Yang, R, 2022) |
| " The extent of fibrosis was also determined using various assays, such as immunohistochemistry, quantitative real-time PCR (qPCR), and hydroxyproline assays." | 4.12 | Obeticholic acid aggravates liver injury by up-regulating the liver expression of osteopontin in obstructive cholestasis. ( Huang, X; Jiang, Z; Miao, Y; Tang, Q; Wang, J; Wu, Q; Xu, Y; Yu, Q; Yuan, Z; Zhang, H; Zhang, L; Zhang, Z, 2022) |
| " Additionally, FcεRI-deficient mice showed a significantly lower score of pulmonary fibrosis than wild-type mice following exposure to silica, with significantly lower hydroxyproline content and expression of fibrotic genes Col1a1 and Fn1." | 4.12 | FcεRI deficiency alleviates silica-induced pulmonary inflammation and fibrosis. ( Chen, Y; Hou, L; Hu, H; Jiang, X; Li, Z; Pang, J; Song, M; Wang, C; Wang, J; Yang, J; Yang, P; Zhang, H; Zhang, T; Zhang, Z; Zou, X, 2022) |
| " Also, the effects of Pirfenidone on macrophage polarization and pulmonary fibrosis were evaluated in silicosis with early intervention and late treatment by histological examination, Enzyme-linked immunosorbent assay, Hydroxyproline assay, Western blot and Quantitative reverse transcription polymerase chain reaction." | 4.12 | Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways. ( Bo, C; Jia, Q; Li, M; Tang, Q; Xing, C; Zhang, Z, 2022) |
| "Empagliflozin administered early after myocardial infarction reduce myocardial fibrosis and inhibit the TGF-β1/Smad3 fibrotic pathway, probably prior to exerting any hemodynamic or physiological effect." | 4.02 | The impact of empagliflozin on cardiac physiology and fibrosis early after myocardial infarction in non-diabetic rats. ( Atar, S; Bandel, N; Daud, E; Ertracht, O; Moady, G; Reuveni, T; Shehadeh, M, 2021) |
| "To evaluate the immune regulatory and anti-fibrosis function of thalidomide (Thal) in systemic sclerosis (SSc), we investigated the effects of Thal on: (a) Th17 and Treg cell production; (b) related factors expression; and (c) transforming growth factor (TGF)-β1/Smad3 pathway, using a mouse model of SSc." | 3.96 | Effects of thalidomide on Th17, Treg cells and TGF-β1/Smad3 pathway in a mouse model of systemic sclerosis. ( Lei, L; Li, X; Lu, Y; Tao, Z; Wen, J; Zhao, C; Zheng, L, 2020) |
| " In this study, we established a rat model of chronic doxorubicin-induced cardiotoxicity, in which the severity of cardiac fibrosis and hydroxyproline levels increased in a time-dependent manner." | 3.96 | NF-κB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity. ( Chen, F; Chen, Y; Deng, F; Gao, N; Kong, Y; Li, S; Li, Z; Liao, Q; Liu, H; Pan, L; Rao, Z; Sheng, X; Wei, D; Xie, L; Xu, A; Xu, G; Xue, L; Yao, C; Zeng, X; Zhou, X; Zhu, X, 2020) |
| "Paraquat (PQ) induces pulmonary fibrosis, a progressive lung disorder resulting in severe respiratory failure and death." | 3.91 | Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice. ( Khodayar, MJ; Mansouri, E; Mirzaee, S; Shirani, M; Zeinvand-Lorestani, M, 2019) |
| "In this study we investigated the protective effects and possible mechanisms of pirfenidone (PF) in paraquat (PQ)-induced lung injury and fibrosis in mice." | 3.88 | Pirfenidone protects against paraquat-induced lung injury and fibrosis in mice by modulation of inflammation, oxidative stress, and gene expression. ( Ghazi-Khansari, M; Heidari, MR; Iranpour, M; Mandegary, A; Pourgholamhossein, F; Pourgholi, L; Pournamdari, M; Poursalehi, HR; Rasooli, R; Samareh-Fekri, M, 2018) |
| " Higher levels of plasma and lung heme have been recorded in acute lung injury associated with several insults." | 3.88 | Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema. ( Aggarwal, S; Ahmad, I; Athar, M; Carlisle, MA; Dransfield, MT; Lam, A; Li, C; Matalon, S; Raju, SV; Rowe, SM; Wells, JM, 2018) |
| " The present study investigated the effects of hydrogen-rich saline, a selective hydroxyl radical scavenger, on lipopolysaccharide (LPS)-induced pulmonary fibrosis." | 3.85 | Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis. ( Dong, WW; Jiang, L; Liu, YJ; Mao, YF; Sun, XJ; Zhang, YQ; Zhu, XY, 2017) |
| " Although hyperleptinemia is usually a characteristic of obese subjects, the relationship with atrial fibrosis and AF is unknown." | 3.85 | Hyperleptinemia Exacerbates High-Fat Diet-Mediated Atrial Fibrosis and Fibrillation. ( Aoki, K; Fukui, A; Fukunaga, N; Ikebe-Ebata, Y; Kondo, H; Masaki, T; Saito, S; Shinohara, T; Takahashi, N; Teshima, Y, 2017) |
| "The aim of this experimental study was to investigate the effectiveness of intramuscular pentoxifylline in the prevention of postoperative fibrosis." | 3.83 | Pentoxifylline Inhibits Epidural Fibrosis in Post-Laminectomy Rats. ( Antar, V; Erdogan, H; Karaoglan, A; Kelten, B; Kutnu, M; Orki, T; Sanel, S; Tuncdemir, M, 2016) |
| " Macroscopic assessment, analysis of hydroxyproline content, and histological analysis were used to determine the therapeutic effect of the local application of RAPA on the inhibition of fibroblast proliferation and the reduction of epidural fibrosis after laminectomy." | 3.83 | Local application of rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis. ( Chen, H; Dai, J; He, J; Li, X; Sun, Y; Wang, D; Wang, J; Yan, L; Zhao, S, 2016) |
| "Zofenopril partially prevented the increase in systolic blood pressure and cardiac hypertrophy induced by angiotensin II and avoided the increase in collagen deposition." | 3.83 | Zofenopril exerts a cardiovascular protective effect on rats infused with angiotensin II beyond angiotensin-converting enzyme inhibition. ( Carrón, R; Gómez-Roso, M; Montero, MJ; Sevilla, MA, 2016) |
| "In order to explore the effects of hydrogen sulfide (H2S) on myocardial fibrosis in diabetic rats and its underlying mechanisms, intraperitoneal injections of streptozotocin were used to establish the diabetes models and sodium hydrosulfide (NaHS) was used as an exogenous donor of H2S." | 3.81 | Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2015) |
| "To investigate the effect of verapamil on the prevention of epidural fibrosis in laminectomy rats." | 3.80 | Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats. ( Liu, W; Wang, Y; Wang, Z; Xie, P; Zhang, S, 2014) |
| " The severity of fibrosis was determined by measuring hydroxyproline in pancreatic tissues and histological grading." | 3.79 | Antifibrotic role of chemokine CXCL9 in experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats. ( Chen, C; Gao, J; Han, W; Hu, G; Lu, H; Qian, L; Shen, J; Wan, R; Wang, X; Wu, M; Yu, Y; Zhu, S, 2013) |
| "To investigate the effect of ursolic acid (UA) on the alloxan-induced myocardial fibrosis in mice and discuss the possible mechanism." | 3.79 | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. ( Gong, Y; Qi, MY; Shi, J; Yang, JJ, 2013) |
| "Cohorts of animals were culled at 3, 7, 14 and 28 days to semi-quantitatively score the lung for fibrosis, and quantitate levels of hydroxyproline in the lung." | 3.78 | Assessment of respiratory physiology of C57BL/6 mice following bleomycin administration using barometric plethysmography. ( Dickinson, H; Jenkin, G; Lim, R; Milton, PL, 2012) |
| "We evaluated the antifibrotic effects of pomalidomide in preventive as well as therapeutic treatment regimes using bleomycin-induced dermal fibrosis as a model of early, inflammatory stages of fibrosis and the tight-skin mouse model as a model of later stages of fibrosis with endogenous activation of fibroblasts." | 3.78 | Pomalidomide is effective for prevention and treatment of experimental skin fibrosis. ( Beyer, C; Cedzik, D; Dees, C; Distler, A; Distler, JH; Distler, O; Palumbo-Zerr, K; Schafer, PH; Schett, G; Shankar, SL; Tomcik, M; Weingärtner, S; Zerr, P, 2012) |
| " Histological examination, Sirius red staining, and measurement of the contents of hydroxyproline and malondialdehyde of the pancreas were performed to evaluate pancreatic damage and fibrosis." | 3.77 | Comparison of antioxidative and antifibrotic effects of α-tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis. ( Du, YQ; Gao, J; Gong, YF; Gu, JJ; Hu, LH; Jiang, F; Li, ZS; Liao, Z; Man, XH, 2011) |
| "The present study was designed to determine whether atorvastatin reduced hypertension-induced cardiac remodeling and whether these effects involved Protein Kinase D (PKD) and Myocyte Enhancer Factor 2D (MEF2D), factors known to be implicated in cardiac hypertrophy and fibrosis." | 3.76 | Atorvastatin reverses cardiac remodeling possibly through regulation of protein kinase D/myocyte enhancer factor 2D activation in spontaneously hypertensive rats. ( Geng, J; Kang, W; Wang, W; Zhang, Y; Zhao, Z; Zhiming, GE, 2010) |
| "This study was carried out in order to investigate the effects of epigallocatechin gallate (EGCG) on myocardial fibrosis and cell proliferation in cardiac hypertrophy." | 3.75 | EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy. ( Gu, ZL; Guo, CY; Sheng, R; Xie, ML; Zhou, WX, 2009) |
| " LVH was characterized by increases in the ratios of heart and left ventricular weights to body weight, increased myocyte cross-sectional areas, myocardial and perivascular fibrosis, and elevated cardiac hydroxyproline." | 3.75 | K(ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function. ( Gao, S; Long, CL; Wang, H; Wang, RH, 2009) |
| " Thereafter, the anastomosed segment was resected to measure the tissue hydroxyproline level and the grade of anastomotic fibrosis." | 3.75 | Does the type of resuscitative fluid affect healing of colonic anastomosis in experimentally induced hemorrhagic shock in rats? ( Can, MF; Ersoz, N; Harlak, A; Kurt, B; Mentes, O; Tufan, T; Turker, T; Yagci, G, 2009) |
| "We investigated whether melatonin was able to prevent left ventricular hypertrophy (LVH) and fibrosis associated with N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced hypertension." | 3.75 | Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. ( Adamcova, M; Barta, A; Krajcirovicova, K; Paulis, L; Pechanova, O; Pelouch, V; Simko, F; Zicha, J, 2009) |
| "Rat models of experimental hepatic fibrosis were established by injection with CCl(4); the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time." | 3.75 | Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. ( Dong, MX; Geng, YT; Jia, Y; Li, CC; Li, XY; Liu, JC; Niu, YC; Zhang, YB; Zhou, L, 2009) |
| "To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI)." | 3.74 | [Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. ( Chen, H; Guo, CY; Li, HW; Li, ZZ; Shen, LH; Sun, T; Tang, CS, 2008) |
| "To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO)." | 3.74 | Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. ( Bu, DF; Li, YG; Liu, BG; Pang, YZ; Tan, XR; Tang, CS; Wang, DM; Wei, RH; Zhang, YG, 2007) |
| "MR elastography of the liver was performed in 10 rats with hepatic fibrosis induced by intraperitoneal carbon tetrachloride (CCl(4)) injections and five normal rats." | 3.74 | Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat. ( Abarca-Quinones, J; Annet, L; Leclercq, I; Peeters, F; Salameh, N; Sinkus, R; Ter Beek, LC; Van Beers, BE, 2007) |
| "We recently demonstrated that both lisinopril and candesartan, an angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor blocker, respectively, attenuate pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori (WBN/Kob) rats." | 3.73 | Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. ( Ando, T; Itoh, M; Joh, T; Kuno, A; Masuda, K; Nakamura, S; Nomura, T; Ogawa, K; Ohara, H; Okamoto, T; Shirai, T; Tang, M; Yamada, T, 2005) |
| "Trimetazidine reduces the degree of fibrosis and ameliorates histopathologic damage in experimental model of corrosive esophagitis in rats." | 3.73 | Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus. ( Karaoglu, AO; Ozutemiz, O; Tuncyurek, M; Yenisey, C; Yukselen, V, 2005) |
| "It is concluded that Ebselen has a preventive effect in the development of fibrosis and decrease the lipid peroxidation, and increase the antioxidant defense system activity in an experimental model of corrosive esophagitis in rats." | 3.73 | Beneficial effects of Ebselen on corrosive esophageal burns of rats. ( Coskun, O; Gurel, A; Hosnuter, M; Kanter, M; Ocakci, A; Tumkaya, L; Uzun, L, 2006) |
| "The mutant MCP-1 treated group inhibited early pancreatic inflammation and later pancreatic fibrosis histologically, and showed a decrease in serum MCP-1 concentration, intrapancreatic hydroxyproline, alpha-smooth muscle actin, and an increase in intrapancreatic amylase and protein content compared with the empty plasmid treated group." | 3.73 | Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats. ( Arita, Y; Egashira, K; Gibo, J; Ito, T; Kaku, T; Kawabe, K; Nawata, H; Oono, T; Usui, M; Zhao, HF; Zhao, QW, 2005) |
| "An experimental study was performed to investigate the efficacy of colchicine in the prevention of fibrosis in the alkaline burn of the esophagus in rats." | 3.73 | Colchicine in experimental alkaline burns of the rat esophagus: an old drug, a new indication? ( Karaoglu, AO; Ozutemiz, O; Vardar, E; Yenisey, C; Yukselen, O; Yukselen, V, 2006) |
| "Although thalidomide had no effect on cardiac function, our results suggest that intervention with thalidomide may have beneficial effects in post-MI HF by attenuating collagen accumulation and development of myocardial fibrosis." | 3.73 | Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats. ( Attramadal, H; Aukrust, P; Bjørnerheim, R; Frøland, SS; Oie, E; Ueland, T; Vinge, LE; Wang, JE; Yndestad, A, 2006) |
| "Lisinopril in drinking water (20, 50, or 200 mg/L) was administered to 10-week-old male Wistar Bonn/Kobori (WBN/Kob) rats for 10 weeks and then the inflammatory parameters, fibrosis, serum and pancreatic ACE activity, and expression of transforming growth factor-beta1 (TGF-beta1) messenger RNA (mRNA) as well as positive immunostaining for alpha-smooth muscle actin (alpha-SMA) were assessed." | 3.72 | Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats. ( Itoh, M; Joh, T; Kuno, A; Masuda, K; Nakamura, S; Nakazawa, T; Nomura, T; Ogawa, K; Ohara, H; Shirai, T; Sogawa, M; Yamada, T, 2003) |
| "There were significant fibrosis and inflammatory infiltration in the myocardium and blood vessels, represented by higher hydroxyproline and collagen volume fraction, and a large amount of inflammatory cells in the tissues of SAD rats." | 3.72 | Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. ( Chen, H; Shu, H; Su, DF; Xie, HH; Yuan, WJ; Zhang, C, 2003) |
| "A murine model of allergen-induced airway inflammation was used to examine the effects of exposure to ozone on airway inflammation and remodeling." | 3.72 | Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ozone. ( Kenyon, NJ; Last, JA; Temple, L; Ward, R, 2004) |
| " The fourth group, which received 4 weeks of HBO therapy, had a significantly reduced mortality rate, weight loss, and collagen score and hydroxyproline level if compared with the third group (P =." | 3.72 | Effects of hyperbaric oxygen therapy on caustic esophageal injury in rats. ( Aktas, S; Dagli, TE; Isbilen, E; Kiyan, G; Kotiloglu, E; Ozel, K, 2004) |
| " The effects of 900 MHz of radiation on fibrosis, lipid peroxidation, and anti-oxidant enzymes and the ameliorating effects of melatonin (Mel) were evaluated in rat skin." | 3.72 | Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin. ( Akturk, O; Altuntas, I; Ayata, A; Mollaoglu, H; Ozguner, F; Yilmaz, HR, 2004) |
| "To assess, in myocardium specimens obtained from necropsies, the correlation between the concentration of hydroxyproline, measured with the photocolorimetric method, and the intensity of fibrosis, determined with the morphometric method." | 3.71 | Correlations between the collagen content of the human left ventricular myocardium, measured by biochemical and morphometric methods. ( Gomes, RA; Hial, V; Lopes, IC; Lopes, JD; Reis, MA; Teixeira, Vde P, 2002) |
| "We studied the preventive effects of dimethyl sulfoxide (DMSO) on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats." | 3.71 | Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. ( Enjoji, M; Kato, M; Kotoh, K; Nakamuta, M; Nakashima, Y; Nawata, H; Ohta, S; Sugimoto, R; Tada, S; Tsuruta, S, 2001) |
| "To investigate whether tranilast reduces cardiac fibrosis in rats with two-kidney, one-clip (2K1C) renovascular hypertension." | 3.71 | Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension. ( Bauer, C; Eschenhagen, T; Godes, M; Hocher, B; Neumayer, HH; Olivier, J; Paul, M; Pinto, YM; Slowinski, T; Weil, J, 2002) |
| "Chronic administration of either angiotensin II (Ang II) or aldosterone (ALDO) leads to myocardial fibrosis." | 3.70 | Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade. ( Ramires, FJ; Sun, Y; Weber, KT, 1998) |
| " Pathohistological changes in pancreas, bile duct and liver as well as pathobiochemical parameters of pancreatitis (amylase and lipase activity), liver lesions (alkaline phosphatase activity and bilirubin) and fibrosis (hydroxyproline and hyaluronic acid) were measured 1 day and 1 to 24 weeks after DBTC- and DBTC/ethanol administration." | 3.70 | The influence of ethanol on long-term effects of dibutyltin dichloride (DBTC) in pancreas and liver of rats. ( Hennighausen, G; Jonas, L; Merkord, J; Nizze, H; Weber, H, 1998) |
| " Pericardial fibrosis occurred postpericardiotomy as indicated by increased hydroxyproline content from normal value of 50 +/- 3 microg/mg to 75 +/- 4 microg/mg (P < 0." | 3.70 | Effects of angiotensin type-I receptor blockade on pericardial fibrosis. ( Baicu, SC; Crawford, FA; de Gasparo, M; Hendrick, JW; King, MK; Loging, JA; New, RB; Spinale, FG, 1999) |
| "Bleomycin was subcutaneously injected every day in WBB6F1-W/W(V) and their normal littermate WBB6F1-+/+ mice for 4 weeks, and mice were analyzed for histological sclerosis, mast cell number, plasma histamine level, and hydroxyproline content." | 3.70 | Animal model of sclerotic skin. II. Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1-W/W(V) mice. ( Katayama, I; Nishioka, K; Takagawa, S; Takahashi, Y; Yamamoto, T, 1999) |
| " This study aimed to analyze the effects of lisinopril on mortality rate, cardiac function, degree of cardiac hypertrophy and fibrosis in rats with different infarct sizes." | 3.70 | Effects of lisinopril on experimental ischemia in rats. Influence of infarct size. ( Matsubara, BB; Matsubara, LS; Paiva, SA; Spadaro, J; Tornero, MT; Zornoff, LA, 1999) |
| "Because progressive fibrosis is a histological hallmark of the aging kidney, we sought to characterize the course of some fibrosis-related genes [pro-alpha2(I)collagen (COL-I), pro-alpha1(III)collagen (COL-III), and transforming growth factors beta1 and beta3 (TGF-beta1 and TGF-beta3)] of interstitial collagen accumulation [COL-I and COL-III proteins, hydroxyproline (PRO-OH), histology] and its degradation (matrix metalloproteinase MMP-1 and -2) during maturation and early aging in rats." | 3.70 | Age-dependent expression of fibrosis-related genes and collagen deposition in rat kidney cortex. ( Annoni, G; Arosio, B; Balestrieri, MR; Gagliano, N; Masson, S; Padoani, G; Santambrogio, D; Tagliabue, J; Vergani, C, 2000) |
| " Treatment with PC-SOD at 10 mg/kg significantly reduced the hydroxyproline content and fibrosis score." | 3.69 | Effect of lecithinized-superoxide dismutase on the interstitial pneumonia model induced by bleomycin in mice. ( Hori, Y; Horie, K; Hoshino, J; Miyauchi, S; Mizuno, S; Sekiguchi, T; Yamazaki, C, 1997) |
| " The administration of antiinflammatory drugs resulted at some laser intensities in increased scores of maximum wound area, healing time, cumulated wound area, fibrosis, hydroxyproline, and hydroxylysine, being mostly pronounced for indomethacin at 0." | 3.68 | Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model. ( Haedersdal, M; Poulsen, T; Wulf, HC, 1993) |
| " Ultraviolet irradiation resulted at some of the used laser intensities in decreased scores of maximum wound area, wound healing time, cumulated wound area, and a decreased skin content of hydroxyproline, whereas the degree of the chronic fibrosis tended to increase." | 3.68 | Side effects of laser therapy, modified by ultraviolet irradiation and para-aminobenzoic acid in mice. ( Haedersdal, M; Poulsen, T; Wulf, HC, 1993) |
| "Liver fibrosis was induced in rats both with carbon tetrachloride and dimethylnitrosamine." | 3.68 | Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal prop ( Ala-Kokko, L; Günzler, V; Hoek, JB; Prockop, DJ; Rubin, E, 1992) |
| " Radiation induced fibrosis was evaluated by determining the ratio of hydroxyproline concentration of irradiated and non-irradiated lung in the same animal." | 3.68 | The hydroxyproline content in the lung tissue of young pigs after fractionated irradiation with photons or neutrons. ( Herrmann, T; Knorr, A; Voigtmann, L, 1991) |
| "A rabbit model of renal glomerulosclerosis induced by anti-glomerular basement membrane antibody was used to determine whether colchicine would protect renal function and reduce fibrosis." | 3.68 | Moderate protection of renal function and reduction of fibrosis by colchicine in a model of anti-GBM disease in the rabbit. ( Hsu, CH; Kshirsagar, AM; McClurkin, C; Patel, SR; Phan, SH; Spicker, JK; Wiggins, RC; Yuan, WY, 1990) |
| " Percent hydroxyproline of intima-media segments of the thoracic aorta remained normal during the 8-week period, indicating that increases in aortic dry weight did not represent disproportional fibrosis and thus are attributable to muscular hypertrophy." | 3.67 | Aortic hypertrophy and "waterlogging" in the development of coarctation hypertension. ( Magargal, WW; Overbeck, HW, 1989) |
| "Lung fibrosis was evaluated by histological examinations and hydroxyproline colorimetric assay." | 1.91 | Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis. ( Assarehzadegan, MA; Bayati, P; Mojtabavi, N; Poormoghim, H; Soleimani, M; Taherian, M, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD), a hepatic characteristic of metabolic syndrome, received significant attention in clinical settings." | 1.72 | Probiotics suppress nonalcoholic steatohepatitis and carcinogenesis progression in hepatocyte-specific PTEN knockout mice. ( Aizawa, K; Arai, N; Iwamoto, S; Maeda, H; Miura, K; Morimoto, N; Nagayama, M; Sakamoto, H; Sekiya, M; Yamamoto, H, 2022) |
| "Arthrofibrosis is a debilitating complication after total knee arthroplasty (TKA) which becomes a considerable burden for both patients and clinical practitioners." | 1.62 | Identification of novel biomarkers for arthrofibrosis after total knee arthroplasty in animal models and clinical patients. ( Chen, X; Chu, M; Deng, W; Huang, Y; Wang, Z; Zhou, Y, 2021) |
| "Fibrosis/contracture is associated with the abnormal persistence of myofibroblasts, which over-produce and contract collagen matrices." | 1.56 | Sulfasalazine Resolves Joint Stiffness in a Rabbit Model of Arthrofibrosis. ( Atluri, K; Brouillette, MJ; Fowler, TP; Fredericks, D; Khorsand, B; Martin, JA; Petersen, E; Salem, AK; Sander, E; Seol, D; Smith, S, 2020) |
| "Metformin (MET) has anti-inflammatory and anti-fibrotic effects, but its effect on the in vivo pathogenesis of scleroderma remains unknown." | 1.51 | Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation. ( Feng, M; Gao, C; Guo, H; Li, X; Liang, Z; Luo, J; Qin, K; Wang, Y; Zhang, S; Zhao, X, 2019) |
| "Renal fibrosis is a complication of kidney injury and associated with increased risk of morbidity and mortality." | 1.48 | Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats. ( Begum, J; Kumar, D; Kumar, P; Lingaraju, MC; Mathesh, K; Sharma, A; Singh, TU; Thakur, R, 2018) |
| " Collectively, exercise restored bioavailability of hydrogen sulfide in the heart of aged rats, which partly explained the benefits of exercise against myocardial fibrosis of aged population." | 1.48 | Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide. ( Liu, HM; Liu, JD; Ma, N; Wang, XZ; Xia, T, 2018) |
| "Intestinal fibrosis is a common complication of Crohn's disease (CD)." | 1.48 | IL-17A Promotes Initiation and Development of Intestinal Fibrosis Through EMT. ( Guan, L; Li, Y; Sun, MJ; Zhang, HJ; Zhang, YN; Zhou, H, 2018) |
| "Intestinal fibrosis is thought to be a consequence of excessive tissue repair, and constitutes a common problem in patients with Crohn's disease (CD)." | 1.48 | Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis. ( Fagagnini, S; Hausmann, M; Hünerwadel, A; Jaeger, SU; Lutz, C; Mamie, C; Rogler, G; Ruiz, PA; Weder, B, 2018) |
| "Hyperoxaluria induces crystalluria, interstitial fibrosis, and progressive renal failure." | 1.46 | Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: Contribution to oxalate kidney injury. ( Borges, FT; Convento, MB; Cruz, E; da Glória, MA; Pessoa, EA; Schor, N, 2017) |
| "Fibrosis was assessed by measuring the liver hydroxyproline content." | 1.46 | Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans. ( Arauz, J; Favari, L; Galicia-Moreno, M; Hernández-Aquino, E; Muriel, P; Segovia, J; Zarco, N, 2017) |
| "Renal fibrosis is a well‑known cause for the progression of chronic kidney disease." | 1.43 | Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice. ( Baba, I; Egi, Y; Suzuki, K, 2016) |
| "Myocardial fibrosis is the predominant pathological characteristic of diabetic myocardial damage." | 1.43 | Effects of hydrogen sulfide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2016) |
| "Pancreatic cancer is notorious for its poor prognosis." | 1.43 | Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2. ( Cabral, H; Iwata, C; Kano, MR; Miyazono, K; Morishita, Y; Sakai, S; Tanaka, HY, 2016) |
| "Triptolide (TPL) is a diterpene triepoxide with potent immunosuppressive and anti-inflammatory properties." | 1.42 | Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-β1/Smad3 and p38 MAPK signaling pathway. ( Chen, J; Huang, D; Huang, Y; Ke, J; Li, L; Liu, M; Wu, W, 2015) |
| "Cardiac inflammation is important in the pathogenesis of heart failure." | 1.42 | Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice. ( Ahmed, MS; Alfsnes, K; Aronsen, JM; Attramadal, H; Aukrust, P; Christensen, G; Dhondup, Y; Gullestad, L; Haugstad, SB; Holmen, SD; Ranheim, T; Sandanger, Ø; Scott, H; Sjaastad, I; Vinge, LE; Yndestad, A; Zhang, L, 2015) |
| "Hydroxyproline (HPro) was used as a marker of collagen production." | 1.40 | Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation. ( El Hajj, EC; El Hajj, MC; Gardner, JD; Gilpin, NW; Khoutorova, E; Molina, PE; Mouton, AJ; Voloshenyuk, TG, 2014) |
| "The tight skin 2 (Tsk2) mouse model of systemic sclerosis (SSc) has many features of the human disease including tight skin, fibrosis, extracellular matrix abnormalities, and reported antinuclear antibodies (ANA)." | 1.40 | Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis. ( Artlett, CM; Blankenhorn, EP; Long, KB, 2014) |
| "Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties." | 1.40 | Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats. ( Chen, F; Gong, H; Ji, A; Tao, H; Wang, K; Ye, F; Zhang, C; Zuo, Z, 2014) |
| "Coronary fibrosis was also increased in diabetic WT and AI(+/+)AII(-/-) mice (1." | 1.38 | Diabetes-induced vascular dysfunction involves arginase I. ( Ali, MI; Caldwell, RB; Caldwell, RW; Cederbaum, SD; Iddings, JA; Platt, DH; Romero, MJ; Stepp, DW, 2012) |
| "Chronic pancreatitis is a progressive inflammatory disease featuring irreversible irregular scarring of the exocrine parenchyma characterized by acinar destruction and fibrosis subsequent to inflammation in the pancreas." | 1.38 | Recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) attenuates caerulein-induced chronic pancreatitis in mice. ( Gao, J; Han, W; Qian, L; Shen, J; Wang, X; Wu, M; Xiang, D; Yang, L; Yu, Y; Zhang, J; Zhu, S, 2012) |
| "Kidney fibrosis is a common process that leads to the progression of various types of kidney disease." | 1.38 | A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. ( Chen, EY; Chen, N; Chuang, PY; D'Agati, V; Dai, Y; Fan, Y; He, JC; Jin, Y; Ma'ayan, A; Mazloom, AR; Ratnam, K; Ross, MJ; Xiong, H; Zhong, Y, 2012) |
| "Hexarelin treatment significantly reduced cardiac fibrosis in SHRs by decreasing interstitial and perivascular myocardial collagen deposition and myocardial hydroxyproline content and reducing mRNA and protein expression of collagen I and III in SHR hearts." | 1.38 | Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat. ( Cao, JM; Chen, C; Ding, F; Gao, X; Hao, W; Pang, J; Xu, RK; Xu, X, 2012) |
| " Clinical chemistry and histopathology indicated male rats were slightly more affected than female rats following dosing with the 120 and 180 ppm formulations; hydroxyproline excretion also supports this finding." | 1.38 | Metabolomics evaluation of hydroxyproline as a potential marker of melamine and cyanuric acid nephrotoxicity in male and female Fischer F344 rats. ( Beger, RD; Bhattacharyya, S; Gamboa da Costa, G; Pence, LM; Schnackenberg, LK; Sun, J, 2012) |
| "Chronic pancreatitis was induced by continuous pancreatic ductal hypertension (PDH) for 14 days according to our previous study." | 1.37 | Treatment with pravastatin attenuates progression of chronic pancreatitis in rat. ( Harada, M; Otsuki, M; Wei, L; Yamamoto, M, 2011) |
| "Silicosis is a kind of pneumoconiosis caused by inhalation of silica dust, which is characterized by lung fibrosis." | 1.36 | A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice. ( Chen, J; Chen, Y; Lv, L; Wang, X, 2010) |
| "Fibrosis is the final common pathway for various tissue lesions that lead to chronic progressive organ failure, and consequently effective antifibrotic drugs are strongly desired." | 1.36 | A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats. ( Kato, M; Mizuno, M; Sada, T; Terashima, H; Tsuchida, H; Yasumo, H, 2010) |
| "Aldosterone promotes renal fibrosis via the mineralocorticoid receptor (MR), thus contributing to hypertension-induced nephropathy." | 1.35 | Hypertension-induced renal fibrosis and spironolactone response vary by rat strain and mineralocorticoid receptor gene expression. ( Camp, JR; Cavallari, LH; Fashingbauer, LA; Geenen, DL; King, ST, 2008) |
| "Obstruction-induced fibrosis is a leading cause of end-stage renal failure in children." | 1.34 | AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction. ( Eskild-Jensen, A; Frøkiaer, J; Nyengaard, JR; Olesen, P; Paulsen, LF; Pedersen, L; Wogensen, L, 2007) |
| " Although a daily dosage of isoflavone was not sufficient to prevent tissue fibrosis under marked oxidative stress in the early stage of diabetes, isoflavones might promise significant clinical benefits by reducing oxidative stress in the heart during aging." | 1.34 | Inhibitory effects of soy isoflavones on cardiovascular collagen accumulation in rats. ( Ebihara, K; Kishida, T; Miyatake, A; Mizushige, K; Mizushige, T, 2007) |
| "Fibrosis is a hallmark of progressive organ disease." | 1.34 | Blockade of IP-10/CXCR3 promotes progressive renal fibrosis. ( Furuichi, K; Gerard, C; Haino, M; Ishida, Y; Kaneko, S; Kawachi, H; Kitagawa, K; Kondo, T; Matsushima, K; Nakaya, I; Narumi, S; Sakai, N; Shimizu, F; Sugaya, T; Wada, T; Yokoyama, H, 2007) |
| "Fibrosis is a common pathological feature observed in muscle from patients with Duchenne muscular dystrophy and in mdx diaphragm." | 1.33 | Pentoxifylline fails to attenuate fibrosis in dystrophic (mdx) diaphragm muscle. ( Gosselin, LE; Williams, JE, 2006) |
| "Hepatic fibrosis was induced in BALB/c mice by repetitive intraperitoneal CCl4 injection." | 1.33 | Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. ( Berres, ML; Gressner, AM; Grötzinger, J; Henkel, C; Matern, S; Roderfeld, M; Roeb, E; Wagner, S; Weiskirchen, R, 2006) |
| "Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by activation of fibroblasts and overproduction of extracellular matrix (ECM)." | 1.33 | Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. ( Choi, AM; Feghali-Bostwick, CA; Ifedigbo, E; Kaminski, N; Kim, HP; Liu, F; Oury, TD; Wang, XM; Xu, X; Zhang, Y; Zhou, Z, 2006) |
| "Fibrosis was assessed histologically and by measurement of hydroxyproline." | 1.32 | Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta. ( Fujita, M; Gauldie, J; Hara, N; Mason, RJ; Morikawa, O; Shannon, JM, 2003) |
| "Pressure-overload left ventricular hypertrophy (LVH) is characterized by an increase in myocyte size and fibrosis." | 1.32 | Reduction of cardiac fibrosis decreases systolic performance without affecting diastolic function in hypertensive rats. ( Carretero, OA; Cingolani, OH; Liu, YH; Rhaleb, NE; Villanueva, M; Yang, XP, 2004) |
| "Hydroxyproline content was quantified." | 1.32 | The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis. ( Autschbach, R; Dronskowski, R; Hanrath, P; Hoffmann, R; Huster, J; Langebartels, G; Mevissen, V; Ortlepp, JR; Schmitz, F; Weber, C; Weiss, S; Zerres, K, 2004) |
| "Lung inflammation was measured by quantitative differential evaluation of lung lavage cells." | 1.32 | Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ultrafine particles. ( Kenyon, NJ; Last, JA; Pinkerton, KE; Temple, L; Ward, R, 2004) |
| "Reduced fibrosis is due to deregulated fibroblast function, as the inflammatory response induced by bleomycin was similar in wild-type and Smad3(-/-) mice." | 1.32 | Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. ( Chen, SJ; DiPietro, LA; Ferreira, AM; Han, G; Lakos, G; Masuda, K; Takagawa, S; Varga, J; Wang, XJ, 2004) |
| "Spinal deformity in the form of kyphosis or kyphoscoliosis occurs in most patients with Duchenne muscular dystrophy (DMD), a fatal X-linked disorder caused by an absence of the subsarcolemmal protein dystrophin." | 1.32 | Progression of kyphosis in mdx mice. ( Hoey, A; Laws, N, 2004) |
| "This inflammation is accompanied by lower levels of CTGF and tissue inhibitor of metalloproteinase-1 gene expression compared with fibrosis-prone C57BL/6 mice." | 1.32 | Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs. ( Ask, K; Bonniaud, P; Gauldie, J; Kolb, M; Margetts, PJ; Martin, G; Robertson, J, 2004) |
| "Cardioprotective effects of HGF for idiopathic dilated cardiomyopathy were examined in hamsters with electroporation of plasmid DNA into skeletal muscle." | 1.32 | Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle. ( Kangawa, K; Kitakaze, M; Kitamura, S; Komamura, K; Matsumoto, K; Miyatake, K; Miyazaki, J; Nakamura, T; Nakatani, T; Shimizu, Y; Tatsumi, R; Tomoike, H; Yamato, E, 2004) |
| "Liver cirrhosis was induced by CCl(4) inhalation and phenobarbital in Wistar rats." | 1.31 | Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats. ( Castilla-Cortázar, I; García, M; Muguerza, B; Prieto, J; Quiroga, J; Santidrián, S, 2001) |
| "Scarring is markedly reduced in MRL mice compared with C57BL/6 mice, consistent with both the reduced hydroxyproline levels seen after injury and an elevated cardiomyocyte mitotic index of 10-20% for the MRL compared with 1-3% for the C57BL/6." | 1.31 | Heart regeneration in adult MRL mice. ( Bedelbaeva, K; Heber-Katz, E; Lankford, EB; Leferovich, JM; Samulewicz, S; Zhang, XM; Zwas, D, 2001) |
| "The hydroxyproline/proline ratio was increased by 64% in MI-control and reduced to the sham value in MI-FG041 rats." | 1.31 | Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. ( Bean, M; Brenner, MC; Buttrick, PM; Geenen, D; Huang, X; Nwogu, JI, 2001) |
| "Colchicine treatment was associated with increased interstitium in WKY with increased passive myocardial stiffness." | 1.30 | Effect of chronic colchicine administration on the myocardium of the aging spontaneously hypertensive rat. ( Bing, OH; Brooks, WW; Cicogna, AC; Conrad, CH; Hayes, JA; Robinson, KG; Sen, S, 1997) |
| "Based on the doses that killed 50% of the animals (LD50s), the various components were found to be 10 to 1250 times more toxic when given intratracheally than when given orally (according to reported oral LD50s in rats)." | 1.30 | Pulmonary toxicity of components of textile paint linked to the Ardystil syndrome: intratracheal administration in hamsters. ( Clottens, FL; Demedts, M; Nemery, B; Verbeken, EK, 1997) |
| "Pirfenidone (PFD) is a new compound that prevents and even reverses the extracellular matrix accumulation in several organs as shown by experimental and clinical studies." | 1.30 | Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy. ( Fukagawa, M; Hata, S; Iwasaki, Y; Kuroda, T; Kurokawa, K; Margolin, SB; Nemoto, M; Shimizu, F; Shimizu, T; Shirai, K; Yamauchi, S, 1997) |
| "Laser-induced wounds, scars, and hyperpigmentation were evaluated by macroscopic, histologic, and biochemical examinations." | 1.30 | Ultraviolet exposure influences laser-induced wounds, scars, and hyperpigmentation: a murine study. ( Bech-Thomsen, N; Haedersdal, M; Poulsen, T; Wulf, HC, 1998) |
| "Pirfenidone (PFD) is a novel anti-fibrotic agent that can prevent and even reverse extracellular matrix accumulation in several organs, as shown by experimental and clinical studies." | 1.30 | Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. ( Fukagawa, M; Hata, S; Kuroda, T; Kurokawa, K; Margolin, SB; Shimizu, T, 1998) |
| "The aim of this study was to assess the effect of the early and chronic administration of octreotide in the prevention of hepatic fibrosis and portal hypertension (PHT)." | 1.30 | Antifibrotic and hemodynamic effects of the early and chronic administration of octreotide in two models of liver fibrosis in rats. ( Calès, P; Douay, O; Fort, J; Gallois, Y; Oberti, F; Pilette, C; Rosenbaum, J; Rousselet, MC; Veal, N, 1998) |
| "For verification and quantification of scar formation (postoperative fibrosis) light microscopic examinations and determination of hydroxyproline were done, using Bergman's spectrophotometric method." | 1.29 | Effect of CO2 laser on spinal epidural fibrosis. ( Açikgöz, B; Aydin, NE; Bavbek, M; Colak, A; Renda, N, 1996) |
| "The hydroxyproline concentration was significantly increased (P less than 0." | 1.28 | Hydroxyproline in the oesophageal mucosa of patients with progressive systemic sclerosis during omeprazole-induced healing of reflux oesophagitis. ( Hendel, L, 1991) |
| "Obstructive lymphedema is a pathologic condition resulting in the accumulation and stagnation of serum proteins in the lymphatics and interstitial spaces." | 1.27 | Protein metabolism and fibrosis in experimental canine obstructive lymphedema. ( Barton, RM; Chen, HC; Coe, SA; Collopy, PA; Knight, KR; McCann, JJ; O'Brien, BM; Vanderkolk, CA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (3.63) | 18.7374 |
| 1990's | 35 (14.11) | 18.2507 |
| 2000's | 91 (36.69) | 29.6817 |
| 2010's | 93 (37.50) | 24.3611 |
| 2020's | 20 (8.06) | 2.80 |
| Authors | Studies |
|---|---|
| Han, L | 2 |
| Zou, Y | 1 |
| Yu, C | 1 |
| Jia, Q | 2 |
| Yang, R | 1 |
| Mehmood, S | 1 |
| Li, Y | 4 |
| Wang, J | 5 |
| Yuan, Z | 1 |
| Zhang, H | 2 |
| Wu, Q | 2 |
| Miao, Y | 1 |
| Xu, Y | 2 |
| Yu, Q | 2 |
| Huang, X | 3 |
| Zhang, Z | 3 |
| Tang, Q | 2 |
| Zhang, L | 2 |
| Jiang, Z | 1 |
| Chen, Y | 4 |
| Song, M | 1 |
| Li, Z | 2 |
| Hou, L | 1 |
| Hu, H | 1 |
| Jiang, X | 2 |
| Yang, J | 4 |
| Zou, X | 1 |
| Pang, J | 2 |
| Zhang, T | 1 |
| Yang, P | 1 |
| Wang, C | 1 |
| Xing, C | 1 |
| Li, M | 1 |
| Bo, C | 1 |
| Arai, N | 1 |
| Miura, K | 1 |
| Aizawa, K | 1 |
| Sekiya, M | 1 |
| Nagayama, M | 1 |
| Sakamoto, H | 1 |
| Maeda, H | 1 |
| Morimoto, N | 1 |
| Iwamoto, S | 1 |
| Yamamoto, H | 1 |
| Suzuka, T | 1 |
| Kotani, T | 1 |
| Saito, T | 1 |
| Matsuda, S | 1 |
| Sato, T | 1 |
| Takeuchi, T | 1 |
| Serdjebi, C | 1 |
| Bertotti, K | 1 |
| Huang, P | 1 |
| Wei, G | 1 |
| Skelton-Badlani, D | 1 |
| Leclercq, IA | 1 |
| Barbes, D | 1 |
| Lepoivre, B | 1 |
| Popov, YV | 1 |
| Julé, Y | 1 |
| Asker, ME | 1 |
| Abdelmeged, AA | 1 |
| Shaheen, MA | 1 |
| Eissa, RG | 1 |
| Bao, B | 1 |
| Liu, J | 2 |
| Li, T | 1 |
| Yang, Z | 1 |
| Wang, G | 2 |
| Xin, J | 1 |
| Bi, H | 1 |
| Guo, D | 1 |
| Taherian, M | 1 |
| Bayati, P | 1 |
| Assarehzadegan, MA | 1 |
| Soleimani, M | 1 |
| Poormoghim, H | 1 |
| Mojtabavi, N | 1 |
| Atluri, K | 1 |
| Brouillette, MJ | 1 |
| Seol, D | 1 |
| Khorsand, B | 1 |
| Sander, E | 1 |
| Salem, AK | 1 |
| Fredericks, D | 1 |
| Petersen, E | 1 |
| Smith, S | 1 |
| Fowler, TP | 1 |
| Martin, JA | 1 |
| Mirzaee, S | 1 |
| Mansouri, E | 1 |
| Shirani, M | 1 |
| Zeinvand-Lorestani, M | 1 |
| Khodayar, MJ | 1 |
| Lu, Y | 3 |
| Zhao, C | 3 |
| Lei, L | 3 |
| Tao, Z | 1 |
| Zheng, L | 2 |
| Wen, J | 1 |
| Li, X | 4 |
| Li, L | 3 |
| Zhang, S | 4 |
| Wei, L | 2 |
| Wang, Z | 3 |
| Ma, W | 1 |
| Liu, F | 2 |
| Shen, Y | 1 |
| Zhang, X | 1 |
| Hang, Y | 1 |
| Qian, Y | 1 |
| Corden, B | 1 |
| Lim, WW | 1 |
| Song, W | 1 |
| Chen, X | 2 |
| Ko, NSJ | 1 |
| Su, L | 1 |
| Tee, NGZ | 1 |
| Adami, E | 1 |
| Schafer, S | 1 |
| Cook, SA | 1 |
| Xu, A | 1 |
| Deng, F | 1 |
| Kong, Y | 1 |
| Pan, L | 1 |
| Liao, Q | 1 |
| Rao, Z | 1 |
| Xie, L | 1 |
| Yao, C | 1 |
| Li, S | 1 |
| Zeng, X | 1 |
| Zhu, X | 1 |
| Liu, H | 1 |
| Gao, N | 1 |
| Xue, L | 1 |
| Chen, F | 2 |
| Xu, G | 1 |
| Wei, D | 1 |
| Zhou, X | 1 |
| Sheng, X | 1 |
| Honda, Y | 1 |
| Tanaka, N | 1 |
| Kajiwara, Y | 1 |
| Kondo, Y | 1 |
| Kataoka, H | 1 |
| Sakamoto, J | 1 |
| Akimoto, R | 1 |
| Nawata, A | 1 |
| Okita, M | 1 |
| Stegemann, A | 1 |
| Raker, V | 1 |
| Del Rey, A | 1 |
| Steinbrink, K | 1 |
| Böhm, M | 1 |
| Daud, E | 1 |
| Ertracht, O | 1 |
| Bandel, N | 1 |
| Moady, G | 1 |
| Shehadeh, M | 1 |
| Reuveni, T | 1 |
| Atar, S | 1 |
| Huang, Y | 3 |
| Deng, W | 1 |
| Zhou, Y | 1 |
| Chu, M | 1 |
| Wermuth, PJ | 2 |
| Carney, KR | 1 |
| Mendoza, FA | 2 |
| Piera-Velazquez, S | 1 |
| Jimenez, SA | 2 |
| Convento, MB | 1 |
| Pessoa, EA | 1 |
| Cruz, E | 1 |
| da Glória, MA | 1 |
| Schor, N | 1 |
| Borges, FT | 1 |
| Li, J | 1 |
| Ren, G | 1 |
| Zhang, W | 1 |
| Arauz, J | 1 |
| Zarco, N | 1 |
| Hernández-Aquino, E | 1 |
| Galicia-Moreno, M | 1 |
| Favari, L | 1 |
| Segovia, J | 1 |
| Muriel, P | 1 |
| Dong, WW | 1 |
| Zhang, YQ | 1 |
| Zhu, XY | 1 |
| Mao, YF | 1 |
| Sun, XJ | 3 |
| Liu, YJ | 1 |
| Jiang, L | 1 |
| Zhao, SM | 1 |
| Wu, HM | 1 |
| Cao, ML | 1 |
| Han, D | 1 |
| Pourgholamhossein, F | 1 |
| Rasooli, R | 1 |
| Pournamdari, M | 1 |
| Pourgholi, L | 1 |
| Samareh-Fekri, M | 1 |
| Ghazi-Khansari, M | 1 |
| Iranpour, M | 1 |
| Poursalehi, HR | 1 |
| Heidari, MR | 1 |
| Mandegary, A | 1 |
| Thakur, R | 1 |
| Sharma, A | 1 |
| Lingaraju, MC | 1 |
| Begum, J | 1 |
| Kumar, D | 2 |
| Mathesh, K | 1 |
| Kumar, P | 1 |
| Singh, TU | 1 |
| Alba, DL | 1 |
| Farooq, JA | 1 |
| Lin, MYC | 1 |
| Schafer, AL | 1 |
| Shepherd, J | 1 |
| Koliwad, SK | 1 |
| Ma, N | 1 |
| Liu, HM | 1 |
| Xia, T | 2 |
| Liu, JD | 1 |
| Wang, XZ | 1 |
| Zhang, HJ | 1 |
| Zhang, YN | 1 |
| Zhou, H | 1 |
| Guan, L | 1 |
| Sun, MJ | 1 |
| Hünerwadel, A | 1 |
| Fagagnini, S | 1 |
| Rogler, G | 1 |
| Lutz, C | 1 |
| Jaeger, SU | 1 |
| Mamie, C | 1 |
| Weder, B | 1 |
| Ruiz, PA | 1 |
| Hausmann, M | 1 |
| Aggarwal, S | 1 |
| Ahmad, I | 1 |
| Lam, A | 1 |
| Carlisle, MA | 1 |
| Li, C | 2 |
| Wells, JM | 1 |
| Raju, SV | 1 |
| Athar, M | 1 |
| Rowe, SM | 1 |
| Dransfield, MT | 1 |
| Matalon, S | 1 |
| Li, PF | 1 |
| He, RH | 1 |
| Shi, SB | 1 |
| Li, R | 1 |
| Wang, QT | 1 |
| Rao, GT | 1 |
| Yang, B | 1 |
| Yadav, S | 1 |
| Yuan, CC | 1 |
| Kazmierczak, K | 1 |
| Liang, J | 1 |
| Huang, W | 1 |
| Takeuchi, LM | 1 |
| Kanashiro-Takeuchi, RM | 1 |
| Szczesna-Cordary, D | 1 |
| Ren, J | 1 |
| Zhang, J | 3 |
| Rudemiller, NP | 1 |
| Griffiths, R | 1 |
| Wen, Y | 1 |
| Lu, X | 2 |
| Privratsky, JR | 1 |
| Gunn, MD | 1 |
| Crowley, SD | 1 |
| Wang, Y | 3 |
| Liang, Z | 2 |
| Feng, M | 1 |
| Zhao, X | 1 |
| Qin, K | 1 |
| Gao, C | 1 |
| Guo, H | 1 |
| Luo, J | 3 |
| Shkurupiy, VA | 1 |
| Kim, LB | 2 |
| Nikonova, IK | 1 |
| Potapova, OV | 1 |
| Cherdantseva, LA | 1 |
| Sharkova, TV | 1 |
| Shen, J | 4 |
| Gao, J | 3 |
| Chen, C | 3 |
| Lu, H | 1 |
| Hu, G | 1 |
| Zhu, S | 2 |
| Wu, M | 2 |
| Wang, X | 6 |
| Qian, L | 2 |
| Yu, Y | 2 |
| Han, W | 2 |
| Wan, R | 1 |
| Yao, L | 2 |
| Liu, CJ | 1 |
| Luo, Q | 1 |
| Gong, M | 1 |
| Chen, J | 3 |
| Wang, LJ | 1 |
| Xu, F | 1 |
| Li, TY | 1 |
| Shu, C | 1 |
| Du, CQ | 1 |
| Yang, L | 2 |
| Han, J | 1 |
| Hu, XS | 1 |
| Wu, T | 1 |
| Hu, SJ | 1 |
| Lieber, GB | 1 |
| Fernandez, X | 1 |
| Mingo, GG | 1 |
| Jia, Y | 2 |
| Caniga, M | 1 |
| Gil, MA | 1 |
| Keshwani, S | 1 |
| Woodhouse, JD | 1 |
| Cicmil, M | 1 |
| Moy, LY | 1 |
| Kelly, N | 1 |
| Jimenez, J | 1 |
| Crawley, Y | 1 |
| Anthes, JC | 1 |
| Klappenbach, J | 1 |
| Ma, YL | 1 |
| McLeod, RL | 1 |
| El Hajj, EC | 1 |
| El Hajj, MC | 1 |
| Voloshenyuk, TG | 1 |
| Mouton, AJ | 1 |
| Khoutorova, E | 1 |
| Molina, PE | 1 |
| Gilpin, NW | 1 |
| Gardner, JD | 1 |
| Yang, JJ | 1 |
| Gong, Y | 1 |
| Shi, J | 1 |
| Qi, MY | 1 |
| Xie, P | 1 |
| Liu, W | 1 |
| Zhang, C | 4 |
| Kong, X | 1 |
| Liu, C | 2 |
| Zhao, H | 1 |
| Tong, W | 1 |
| Ning, G | 1 |
| Shen, W | 1 |
| Feng, S | 1 |
| Kach, J | 1 |
| Sandbo, N | 1 |
| La, J | 1 |
| Denner, D | 1 |
| Reed, EB | 1 |
| Akimova, O | 1 |
| Koltsova, S | 1 |
| Orlov, SN | 1 |
| Dulin, NO | 1 |
| Smith, LR | 1 |
| Barton, ER | 1 |
| Usategui, A | 1 |
| Criado, G | 1 |
| Del Rey, MJ | 1 |
| Faré, R | 1 |
| Pablos, JL | 1 |
| Liu, JJ | 1 |
| Bi, XY | 1 |
| Yu, XJ | 1 |
| Kong, SS | 1 |
| Qin, FF | 1 |
| Zhou, J | 1 |
| Zang, WJ | 1 |
| Long, KB | 1 |
| Artlett, CM | 1 |
| Blankenhorn, EP | 1 |
| Chen, Q | 1 |
| Pang, L | 1 |
| Huang, S | 1 |
| Lei, W | 1 |
| Huang, D | 2 |
| Lv, P | 2 |
| Zhao, J | 3 |
| Su, W | 2 |
| Liang, X | 1 |
| Zhang, K | 2 |
| Lu, R | 1 |
| Oak, NR | 1 |
| Gumucio, JP | 1 |
| Flood, MD | 1 |
| Saripalli, AL | 1 |
| Davis, ME | 1 |
| Harning, JA | 1 |
| Lynch, EB | 1 |
| Roche, SM | 1 |
| Bedi, A | 1 |
| Mendias, CL | 1 |
| Wong, L | 1 |
| Hutson, PR | 1 |
| Bushman, W | 1 |
| Zuo, Z | 2 |
| Wang, K | 1 |
| Gong, H | 1 |
| Ye, F | 1 |
| Ji, A | 1 |
| Tao, H | 1 |
| Cui, K | 1 |
| Kou, JQ | 1 |
| Gu, JH | 1 |
| Han, R | 2 |
| Zhen, X | 1 |
| Qin, ZH | 1 |
| Zhong, XN | 2 |
| He, ZY | 2 |
| Luo, L | 1 |
| Wei, Q | 1 |
| Zhao, LM | 1 |
| Wang, LP | 1 |
| Wang, HF | 1 |
| Ma, XZ | 1 |
| Zhou, DX | 1 |
| Deng, XL | 1 |
| Lunghi, B | 1 |
| De Cunto, G | 1 |
| Cavarra, E | 1 |
| Fineschi, S | 2 |
| Bartalesi, B | 1 |
| Lungarella, G | 2 |
| Lucattelli, M | 1 |
| Ohashi, T | 1 |
| Yamamoto, T | 2 |
| Liu, M | 1 |
| Ke, J | 1 |
| Wu, W | 1 |
| Xiao, T | 2 |
| Zeng, O | 2 |
| Wu, Z | 2 |
| Li, F | 3 |
| Dhondup, Y | 1 |
| Sjaastad, I | 1 |
| Scott, H | 1 |
| Sandanger, Ø | 1 |
| Haugstad, SB | 1 |
| Aronsen, JM | 1 |
| Ranheim, T | 1 |
| Holmen, SD | 1 |
| Alfsnes, K | 1 |
| Ahmed, MS | 1 |
| Attramadal, H | 2 |
| Gullestad, L | 1 |
| Aukrust, P | 2 |
| Christensen, G | 1 |
| Yndestad, A | 2 |
| Vinge, LE | 2 |
| Abdul, N | 1 |
| Dixon, D | 1 |
| Walker, A | 1 |
| Horabin, J | 1 |
| Smith, N | 1 |
| Weir, DJ | 1 |
| Brewster, NT | 1 |
| Deehan, DJ | 1 |
| Mann, DA | 1 |
| Borthwick, LA | 1 |
| Baba, I | 1 |
| Egi, Y | 1 |
| Suzuki, K | 2 |
| Choe, S | 1 |
| Veliceasa, D | 1 |
| Bond, CW | 1 |
| Harrington, DA | 1 |
| Stupp, SI | 1 |
| McVary, KT | 1 |
| Podlasek, CA | 1 |
| Kelten, B | 1 |
| Erdogan, H | 1 |
| Antar, V | 1 |
| Sanel, S | 1 |
| Tuncdemir, M | 1 |
| Kutnu, M | 1 |
| Karaoglan, A | 1 |
| Orki, T | 1 |
| Sakai, S | 1 |
| Iwata, C | 1 |
| Tanaka, HY | 1 |
| Cabral, H | 1 |
| Morishita, Y | 1 |
| Miyazono, K | 1 |
| Kano, MR | 1 |
| Wu, X | 1 |
| Qi, X | 1 |
| Lin, C | 1 |
| Yuan, Y | 1 |
| Zhu, Q | 1 |
| Yin, Q | 1 |
| Li, W | 1 |
| Bian, H | 1 |
| Sun, Y | 3 |
| Zhao, S | 1 |
| Yan, L | 1 |
| Wang, D | 1 |
| Chen, H | 3 |
| Dai, J | 2 |
| He, J | 2 |
| Fang, J | 1 |
| Wang, W | 2 |
| Sun, S | 1 |
| Li, Q | 1 |
| Qiu, M | 1 |
| Zhang, Y | 5 |
| Zheng, J | 1 |
| Yu, F | 1 |
| Dong, P | 1 |
| Wu, L | 1 |
| Hu, Y | 1 |
| Gómez-Roso, M | 1 |
| Montero, MJ | 1 |
| Carrón, R | 1 |
| Sevilla, MA | 1 |
| Dinulovic, I | 1 |
| Furrer, R | 1 |
| Di Fulvio, S | 1 |
| Ferry, A | 1 |
| Beer, M | 1 |
| Handschin, C | 1 |
| Kang, L | 1 |
| Gao, Y | 1 |
| Tian, J | 1 |
| Fukui, A | 1 |
| Ikebe-Ebata, Y | 1 |
| Kondo, H | 1 |
| Saito, S | 2 |
| Aoki, K | 1 |
| Fukunaga, N | 1 |
| Shinohara, T | 1 |
| Masaki, T | 1 |
| Teshima, Y | 1 |
| Takahashi, N | 1 |
| Du, Q | 1 |
| Chen, Z | 1 |
| Zhou, LF | 1 |
| Zhang, Q | 1 |
| Huang, M | 1 |
| Yin, KS | 1 |
| Cavallari, LH | 1 |
| Fashingbauer, LA | 1 |
| Camp, JR | 1 |
| King, ST | 1 |
| Geenen, DL | 1 |
| Jodynis-Liebert, J | 1 |
| Adamska, T | 1 |
| Ewertowska, M | 1 |
| Bylka, W | 1 |
| Matławska, I | 1 |
| Sheng, R | 1 |
| Gu, ZL | 1 |
| Xie, ML | 1 |
| Zhou, WX | 1 |
| Guo, CY | 2 |
| Kuramoto, E | 1 |
| Nishiuma, T | 2 |
| Kobayashi, K | 2 |
| Yamamoto, M | 2 |
| Kono, Y | 1 |
| Funada, Y | 1 |
| Kotani, Y | 1 |
| Sisson, TH | 2 |
| Simon, RH | 2 |
| Nishimura, Y | 2 |
| Sun, T | 1 |
| Shen, LH | 1 |
| Li, HW | 1 |
| Li, ZZ | 1 |
| Tang, CS | 2 |
| Prakobwong, S | 1 |
| Pinlaor, S | 1 |
| Yongvanit, P | 1 |
| Sithithaworn, P | 1 |
| Pairojkul, C | 1 |
| Hiraku, Y | 1 |
| Weng, D | 1 |
| Gao, S | 1 |
| Long, CL | 1 |
| Wang, RH | 1 |
| Wang, H | 1 |
| Vazquez, R | 1 |
| Khojeini, EV | 1 |
| Patel, C | 1 |
| Venkataramani, R | 1 |
| Larson, DF | 1 |
| Harlak, A | 1 |
| Can, MF | 1 |
| Mentes, O | 1 |
| Ersoz, N | 1 |
| Kurt, B | 1 |
| Turker, T | 1 |
| Yagci, G | 1 |
| Tufan, T | 1 |
| Freitas, TP | 1 |
| Gomes, M | 1 |
| Fraga, DB | 1 |
| Freitas, LS | 1 |
| Rezin, GT | 1 |
| Santos, PM | 1 |
| Silveira, PC | 1 |
| Paula, MM | 1 |
| Pinho, RA | 1 |
| Streck, EL | 1 |
| Paulis, L | 1 |
| Pechanova, O | 1 |
| Zicha, J | 1 |
| Krajcirovicova, K | 1 |
| Barta, A | 1 |
| Pelouch, V | 1 |
| Adamcova, M | 2 |
| Simko, F | 1 |
| Geng, J | 1 |
| Zhao, Z | 1 |
| Kang, W | 1 |
| Zhiming, GE | 1 |
| French, CJ | 1 |
| Zaman, AK | 1 |
| Sobel, BE | 1 |
| Dong, MX | 1 |
| Zhang, YB | 1 |
| Li, CC | 1 |
| Geng, YT | 1 |
| Zhou, L | 1 |
| Li, XY | 1 |
| Liu, JC | 1 |
| Niu, YC | 1 |
| Wang, QL | 1 |
| Yuan, JL | 2 |
| Tao, YY | 1 |
| Liu, P | 2 |
| Liu, CH | 2 |
| Lv, L | 1 |
| Wu, SJ | 1 |
| Tam, KW | 1 |
| Tsai, YH | 1 |
| Chang, CC | 1 |
| Chao, JC | 1 |
| Potáčová, A | 1 |
| Popelová, O | 1 |
| Štěrba, M | 1 |
| Mazurová, Y | 1 |
| Aupperle, H | 1 |
| Geršl, V | 1 |
| Terashima, H | 1 |
| Kato, M | 2 |
| Yasumo, H | 1 |
| Tsuchida, H | 1 |
| Mizuno, M | 1 |
| Sada, T | 1 |
| Nakanishi, T | 1 |
| Morokata, T | 1 |
| Noto, T | 1 |
| Kubo, K | 1 |
| Umeno, H | 1 |
| Kinugasa, F | 1 |
| Eikyu, Y | 1 |
| Kozuki, Y | 1 |
| Seki, N | 1 |
| Bostick, B | 1 |
| Yue, Y | 1 |
| Duan, D | 3 |
| Harada, M | 1 |
| Otsuki, M | 2 |
| Hakim, CH | 2 |
| Grange, RW | 1 |
| Song, L | 1 |
| Xu, J | 1 |
| Qu, J | 1 |
| Sai, Y | 1 |
| Yu, L | 1 |
| Li, D | 1 |
| Guo, X | 1 |
| Putiatina, AN | 1 |
| Jiang, F | 1 |
| Liao, Z | 1 |
| Hu, LH | 1 |
| Du, YQ | 1 |
| Man, XH | 1 |
| Gu, JJ | 1 |
| Gong, YF | 1 |
| Li, ZS | 1 |
| Milton, PL | 1 |
| Dickinson, H | 1 |
| Jenkin, G | 1 |
| Lim, R | 1 |
| Yuan, XP | 1 |
| Liu, LS | 1 |
| Fu, Q | 1 |
| Wang, CX | 1 |
| Duman, L | 1 |
| Büyükyavuz, BI | 1 |
| Altuntas, I | 2 |
| Gökcimen, A | 1 |
| Ceyhan, L | 1 |
| Darici, H | 1 |
| Aylak, F | 1 |
| Tomruk, O | 1 |
| Romero, MJ | 1 |
| Iddings, JA | 1 |
| Platt, DH | 1 |
| Ali, MI | 1 |
| Cederbaum, SD | 1 |
| Stepp, DW | 1 |
| Caldwell, RB | 1 |
| Caldwell, RW | 1 |
| Chen, R | 1 |
| Xue, J | 1 |
| Xie, M | 1 |
| Xiang, D | 1 |
| Krivoruchko, IA | 1 |
| Boĭko, VV | 1 |
| Zhukov, VI | 1 |
| Goncharova, NN | 1 |
| Andreeshchev, SA | 1 |
| Moiseenko, AS | 1 |
| Jin, Y | 1 |
| Ratnam, K | 1 |
| Chuang, PY | 1 |
| Fan, Y | 1 |
| Zhong, Y | 1 |
| Dai, Y | 1 |
| Mazloom, AR | 1 |
| Chen, EY | 1 |
| D'Agati, V | 1 |
| Xiong, H | 1 |
| Ross, MJ | 1 |
| Chen, N | 1 |
| Ma'ayan, A | 1 |
| He, JC | 1 |
| Friman, T | 1 |
| Gustafsson, R | 1 |
| Stuhr, LB | 1 |
| Chidiac, J | 1 |
| Heldin, NE | 1 |
| Reed, RK | 1 |
| Oldberg, A | 1 |
| Rubin, K | 1 |
| Maulik, SK | 1 |
| Prabhakar, P | 1 |
| Dinda, AK | 1 |
| Seth, S | 1 |
| Xu, X | 2 |
| Ding, F | 1 |
| Gao, X | 2 |
| Xu, RK | 1 |
| Hao, W | 1 |
| Cao, JM | 1 |
| Qiu, X | 1 |
| Ji, S | 1 |
| Li, H | 1 |
| Pan, B | 1 |
| Xiao, S | 1 |
| Xia, Z | 1 |
| Schnackenberg, LK | 1 |
| Sun, J | 1 |
| Pence, LM | 1 |
| Bhattacharyya, S | 1 |
| Gamboa da Costa, G | 1 |
| Beger, RD | 1 |
| Weingärtner, S | 1 |
| Zerr, P | 1 |
| Tomcik, M | 1 |
| Palumbo-Zerr, K | 1 |
| Distler, A | 1 |
| Dees, C | 1 |
| Beyer, C | 1 |
| Shankar, SL | 1 |
| Cedzik, D | 1 |
| Schafer, PH | 1 |
| Distler, O | 1 |
| Schett, G | 1 |
| Distler, JH | 1 |
| Zeren, S | 1 |
| Kesici, S | 1 |
| Kesici, U | 1 |
| Isbilir, S | 1 |
| Turkmen, UA | 1 |
| Ulusoy, H | 1 |
| Karpuz, V | 1 |
| Ozcan, O | 1 |
| Polat, E | 1 |
| Ipcioglu, OM | 1 |
| Sari, MK | 1 |
| Lopes, JD | 1 |
| Gomes, RA | 1 |
| Hial, V | 1 |
| Lopes, IC | 1 |
| Reis, MA | 1 |
| Teixeira, Vde P | 1 |
| Fleck, M | 1 |
| Appenroth, D | 2 |
| Malich, A | 1 |
| Stein, G | 2 |
| Fleck, C | 2 |
| Vujaskovic, Z | 1 |
| Batinic-Haberle, I | 1 |
| Rabbani, ZN | 1 |
| Feng, QF | 1 |
| Kang, SK | 1 |
| Spasojevic, I | 1 |
| Samulski, TV | 1 |
| Fridovich, I | 1 |
| Dewhirst, MW | 1 |
| Anscher, MS | 1 |
| Belperio, JA | 1 |
| Dy, M | 1 |
| Burdick, MD | 1 |
| Xue, YY | 1 |
| Li, K | 1 |
| Elias, JA | 1 |
| Keane, MP | 1 |
| Araki, Y | 1 |
| Andoh, A | 1 |
| Fujiyama, Y | 1 |
| Bamba, T | 1 |
| Inoue, M | 1 |
| Ino, Y | 1 |
| Gibo, J | 2 |
| Ito, T | 2 |
| Hisano, T | 1 |
| Arita, Y | 2 |
| Nawata, H | 3 |
| Tsuburai, T | 1 |
| Suzuki, M | 2 |
| Nagashima, Y | 1 |
| Suzuki, S | 1 |
| Inoue, S | 1 |
| Hasiba, T | 1 |
| Ueda, A | 1 |
| Ikehara, K | 1 |
| Matsuse, T | 1 |
| Ishigatsubo, Y | 1 |
| Desaki, M | 1 |
| Sugawara, I | 1 |
| Iwakura, Y | 1 |
| Yamamoto, K | 2 |
| Takizawa, H | 1 |
| Xie, C | 1 |
| Vincent, R | 1 |
| Churg, A | 1 |
| Kuno, A | 3 |
| Yamada, T | 3 |
| Masuda, K | 4 |
| Ogawa, K | 3 |
| Sogawa, M | 2 |
| Nakamura, S | 3 |
| Nakazawa, T | 2 |
| Ohara, H | 3 |
| Nomura, T | 3 |
| Joh, T | 3 |
| Shirai, T | 2 |
| Itoh, M | 3 |
| Ortiz, LA | 2 |
| Gambelli, F | 1 |
| McBride, C | 1 |
| Gaupp, D | 1 |
| Baddoo, M | 1 |
| Kaminski, N | 2 |
| Phinney, DG | 1 |
| Fujita, M | 1 |
| Shannon, JM | 1 |
| Morikawa, O | 1 |
| Gauldie, J | 2 |
| Hara, N | 1 |
| Mason, RJ | 1 |
| Chuang-Tsai, S | 1 |
| Hattori, N | 1 |
| Tsai, CG | 1 |
| Subbotina, NM | 1 |
| Hanson, KE | 1 |
| Tian, B | 1 |
| Kleidon, J | 1 |
| Henke, C | 1 |
| Kenyon, NJ | 3 |
| Gohil, K | 1 |
| Last, JA | 3 |
| Ando, T | 2 |
| Sano, H | 1 |
| CHVAPIL, M | 2 |
| Xie, HH | 1 |
| Shu, H | 1 |
| Yuan, WJ | 1 |
| Su, DF | 1 |
| Ward, R | 2 |
| Temple, L | 2 |
| Nagashio, Y | 1 |
| Asaumi, H | 1 |
| Watanabe, S | 1 |
| Nomiyama, Y | 1 |
| Taguchi, M | 1 |
| Tashiro, M | 1 |
| Sugaya, T | 2 |
| Cingolani, OH | 1 |
| Yang, XP | 1 |
| Liu, YH | 1 |
| Villanueva, M | 1 |
| Rhaleb, NE | 1 |
| Carretero, OA | 1 |
| Ortlepp, JR | 1 |
| Schmitz, F | 1 |
| Mevissen, V | 1 |
| Weiss, S | 1 |
| Huster, J | 1 |
| Dronskowski, R | 1 |
| Langebartels, G | 1 |
| Autschbach, R | 1 |
| Zerres, K | 1 |
| Weber, C | 1 |
| Hanrath, P | 1 |
| Hoffmann, R | 1 |
| Ahn, J | 1 |
| Varagic, J | 1 |
| Slama, M | 1 |
| Susic, D | 2 |
| Frohlich, ED | 2 |
| Pinkerton, KE | 1 |
| Lakos, G | 1 |
| Takagawa, S | 2 |
| Chen, SJ | 1 |
| Ferreira, AM | 1 |
| Han, G | 1 |
| Wang, XJ | 1 |
| DiPietro, LA | 1 |
| Varga, J | 1 |
| Laws, N | 1 |
| Hoey, A | 1 |
| Bonniaud, P | 1 |
| Martin, G | 1 |
| Margetts, PJ | 1 |
| Ask, K | 1 |
| Robertson, J | 1 |
| Kolb, M | 1 |
| Komamura, K | 1 |
| Tatsumi, R | 1 |
| Miyazaki, J | 1 |
| Matsumoto, K | 1 |
| Yamato, E | 1 |
| Nakamura, T | 1 |
| Shimizu, Y | 1 |
| Nakatani, T | 1 |
| Kitamura, S | 1 |
| Tomoike, H | 1 |
| Kitakaze, M | 1 |
| Kangawa, K | 1 |
| Miyatake, K | 1 |
| Kiyan, G | 1 |
| Aktas, S | 1 |
| Ozel, K | 1 |
| Isbilen, E | 1 |
| Kotiloglu, E | 1 |
| Dagli, TE | 1 |
| Jayasankar, V | 1 |
| Woo, YJ | 1 |
| Bish, LT | 1 |
| Pirolli, TJ | 1 |
| Berry, MF | 1 |
| Burdick, J | 1 |
| Bhalla, RC | 1 |
| Sharma, RV | 1 |
| Gardner, TJ | 1 |
| Sweeney, HL | 1 |
| Jiang, ZH | 1 |
| Cui, HY | 1 |
| Xu, LM | 1 |
| Hu, YY | 1 |
| Li, FH | 1 |
| Turcani, M | 1 |
| Thormaehlen, D | 1 |
| Rupp, H | 1 |
| Tang, M | 1 |
| Okamoto, T | 1 |
| Maruyama, K | 1 |
| Vellaichamy, E | 1 |
| Khurana, ML | 1 |
| Fink, J | 1 |
| Pandey, KN | 1 |
| Ayata, A | 1 |
| Mollaoglu, H | 1 |
| Yilmaz, HR | 1 |
| Akturk, O | 1 |
| Ozguner, F | 1 |
| Yukselen, V | 2 |
| Karaoglu, AO | 2 |
| Yenisey, C | 2 |
| Tuncyurek, M | 1 |
| Ozutemiz, O | 2 |
| Morrison, J | 2 |
| Palmer, DB | 1 |
| Cobbold, S | 1 |
| Partridge, T | 2 |
| Bou-Gharios, G | 2 |
| Ocakci, A | 1 |
| Coskun, O | 1 |
| Tumkaya, L | 1 |
| Kanter, M | 1 |
| Gurel, A | 1 |
| Hosnuter, M | 1 |
| Uzun, L | 1 |
| McAnulty, RJ | 1 |
| Zhao, HF | 1 |
| Kawabe, K | 1 |
| Oono, T | 1 |
| Kaku, T | 1 |
| Zhao, QW | 1 |
| Usui, M | 1 |
| Egashira, K | 1 |
| Kinov, P | 1 |
| Leithner, A | 1 |
| Radl, R | 1 |
| Bodo, K | 1 |
| Khoschsorur, GA | 1 |
| Schauenstein, K | 1 |
| Windhager, R | 1 |
| Vardar, E | 1 |
| Yukselen, O | 1 |
| Gosselin, LE | 1 |
| Williams, JE | 1 |
| Roderfeld, M | 1 |
| Weiskirchen, R | 1 |
| Wagner, S | 1 |
| Berres, ML | 1 |
| Henkel, C | 1 |
| Grötzinger, J | 1 |
| Gressner, AM | 1 |
| Matern, S | 1 |
| Roeb, E | 1 |
| Bjørnerheim, R | 1 |
| Ueland, T | 1 |
| Wang, JE | 1 |
| Frøland, SS | 1 |
| Oie, E | 1 |
| Berlin, AA | 1 |
| Hogaboam, CM | 1 |
| Lukacs, NW | 1 |
| Dong, Z | 1 |
| Shen, H | 1 |
| Ma, H | 1 |
| Jia, JD | 1 |
| Parsons, SA | 1 |
| Millay, DP | 1 |
| Sargent, MA | 1 |
| McNally, EM | 1 |
| Molkentin, JD | 1 |
| Chan, ES | 1 |
| Fernandez, P | 1 |
| Merchant, AA | 1 |
| Montesinos, MC | 1 |
| Trzaska, S | 1 |
| Desai, A | 1 |
| Tung, CF | 1 |
| Khoa, DN | 1 |
| Pillinger, MH | 1 |
| Reiss, AB | 1 |
| Tomic-Canic, M | 1 |
| Chen, JF | 1 |
| Schwarzschild, MA | 1 |
| Cronstein, BN | 1 |
| Yoshimura, S | 1 |
| Yamashita, T | 1 |
| Yokoyama, M | 1 |
| Wang, XM | 1 |
| Kim, HP | 1 |
| Zhou, Z | 1 |
| Feghali-Bostwick, CA | 1 |
| Ifedigbo, E | 1 |
| Oury, TD | 1 |
| Choi, AM | 1 |
| Zhang, YG | 1 |
| Li, YG | 1 |
| Liu, BG | 1 |
| Wei, RH | 1 |
| Wang, DM | 1 |
| Tan, XR | 1 |
| Bu, DF | 1 |
| Pang, YZ | 1 |
| Eskild-Jensen, A | 1 |
| Paulsen, LF | 1 |
| Wogensen, L | 1 |
| Olesen, P | 1 |
| Pedersen, L | 1 |
| Frøkiaer, J | 1 |
| Nyengaard, JR | 1 |
| Park, DH | 1 |
| Baik, SK | 1 |
| Choi, YH | 1 |
| Kim, MY | 1 |
| Rhim, DW | 1 |
| Kim, JW | 1 |
| Kwon, SO | 1 |
| Cho, MY | 1 |
| Kim, CH | 1 |
| Ahn, SC | 1 |
| Mizushige, T | 1 |
| Mizushige, K | 1 |
| Miyatake, A | 1 |
| Kishida, T | 1 |
| Ebihara, K | 1 |
| Attallah, AM | 1 |
| Toson, EA | 1 |
| Shiha, GE | 1 |
| Omran, MM | 1 |
| Abdel-Aziz, MM | 1 |
| El-Dosoky, I | 1 |
| Nakaya, I | 1 |
| Wada, T | 1 |
| Furuichi, K | 1 |
| Sakai, N | 1 |
| Kitagawa, K | 1 |
| Yokoyama, H | 1 |
| Ishida, Y | 1 |
| Kondo, T | 1 |
| Kawachi, H | 1 |
| Shimizu, F | 2 |
| Narumi, S | 1 |
| Haino, M | 1 |
| Gerard, C | 1 |
| Matsushima, K | 1 |
| Kaneko, S | 1 |
| Salameh, N | 1 |
| Peeters, F | 1 |
| Sinkus, R | 1 |
| Abarca-Quinones, J | 1 |
| Annet, L | 1 |
| Ter Beek, LC | 1 |
| Leclercq, I | 1 |
| Van Beers, BE | 1 |
| Bruno, NE | 1 |
| Yano, Y | 1 |
| Takei, Y | 1 |
| Gabazza, EC | 1 |
| Qin, L | 1 |
| Nagashima, M | 1 |
| Morser, J | 1 |
| D'Alessandro-Gabazza, CN | 1 |
| Taguchi, O | 1 |
| Sumida, Y | 1 |
| Zhai, Y | 1 |
| Peng, L | 1 |
| Lin, J | 1 |
| Bongiovanni, M | 1 |
| Donati, Y | 1 |
| Djaafar, S | 1 |
| Naso, F | 1 |
| Goffin, L | 1 |
| Argiroffo, CB | 1 |
| Pache, JC | 1 |
| Dayer, JM | 1 |
| Ferrari-Lacraz, S | 1 |
| Chizzolini, C | 1 |
| Followill, DS | 1 |
| Travis, EL | 1 |
| Saperstein, LA | 1 |
| Jirtle, RL | 1 |
| Farouk, M | 1 |
| Thompson, HJ | 1 |
| Chung, KS | 1 |
| Meyers, WC | 1 |
| Unemori, EN | 1 |
| Beck, LS | 1 |
| Lee, WP | 1 |
| Siegel, M | 1 |
| Keller, G | 1 |
| Liggitt, HD | 1 |
| Bauer, EA | 1 |
| Amento, EP | 1 |
| Brilla, CG | 1 |
| Matsubara, LS | 3 |
| Weber, KT | 3 |
| Haedersdal, M | 3 |
| Poulsen, T | 3 |
| Wulf, HC | 3 |
| Colak, A | 1 |
| Bavbek, M | 1 |
| Aydin, NE | 1 |
| Renda, N | 1 |
| Açikgöz, B | 1 |
| Brown, KE | 1 |
| Poulos, JE | 1 |
| Soweid, AM | 1 |
| Ramm, GA | 1 |
| O'Neill, R | 1 |
| Britton, RS | 1 |
| Bacon, BR | 1 |
| Cicogna, AC | 2 |
| Brooks, WW | 1 |
| Hayes, JA | 1 |
| Robinson, KG | 1 |
| Sen, S | 1 |
| Conrad, CH | 1 |
| Bing, OH | 1 |
| Karim, MA | 1 |
| Frizzell, S | 1 |
| Inman, L | 1 |
| Shinn, M | 1 |
| Miller, DD | 1 |
| Chung, HT | 1 |
| Choi, BM | 1 |
| Jun, CD | 1 |
| Park, SD | 1 |
| Rim, JS | 1 |
| Clottens, FL | 1 |
| Verbeken, EK | 1 |
| Demedts, M | 1 |
| Nemery, B | 1 |
| Yamazaki, C | 1 |
| Hoshino, J | 1 |
| Hori, Y | 1 |
| Sekiguchi, T | 1 |
| Miyauchi, S | 1 |
| Mizuno, S | 1 |
| Horie, K | 1 |
| Shimizu, T | 2 |
| Fukagawa, M | 2 |
| Kuroda, T | 2 |
| Hata, S | 2 |
| Iwasaki, Y | 1 |
| Nemoto, M | 1 |
| Shirai, K | 1 |
| Yamauchi, S | 1 |
| Margolin, SB | 2 |
| Kurokawa, K | 2 |
| Ramires, FJ | 2 |
| Bech-Thomsen, N | 1 |
| Matsubara, BB | 2 |
| Okoshi, MP | 1 |
| Franco, M | 1 |
| Nunez, E | 1 |
| Hosoya, K | 1 |
| Merkord, J | 1 |
| Weber, H | 1 |
| Jonas, L | 1 |
| Nizze, H | 1 |
| Hennighausen, G | 1 |
| Venkatesan, N | 1 |
| Punithavathi, D | 1 |
| Chandrakasan, G | 2 |
| Fort, J | 1 |
| Oberti, F | 1 |
| Pilette, C | 1 |
| Veal, N | 1 |
| Gallois, Y | 1 |
| Douay, O | 1 |
| Rousselet, MC | 1 |
| Rosenbaum, J | 1 |
| Calès, P | 1 |
| Zhang, JQ | 1 |
| Vaquero, E | 1 |
| Molero, X | 1 |
| Tian, X | 1 |
| Salas, A | 1 |
| Malagelada, JR | 1 |
| Miller, GR | 1 |
| Smith, CA | 1 |
| Stauber, WT | 1 |
| Loging, JA | 1 |
| New, RB | 1 |
| Baicu, SC | 1 |
| King, MK | 1 |
| Hendrick, JW | 1 |
| Crawford, FA | 1 |
| de Gasparo, M | 1 |
| Spinale, FG | 1 |
| Lasky, JA | 1 |
| Safah, H | 1 |
| Reyes, M | 1 |
| Miller, A | 1 |
| Friedman, M | 1 |
| Takahashi, Y | 1 |
| Katayama, I | 1 |
| Nishioka, K | 1 |
| Takeuchi, M | 2 |
| Tredget, EE | 2 |
| Scott, PG | 2 |
| Kilani, RT | 2 |
| Ghahary, A | 2 |
| Zornoff, LA | 1 |
| Paiva, SA | 1 |
| Tornero, MT | 1 |
| Spadaro, J | 1 |
| Lu, QL | 1 |
| Pastoret, C | 1 |
| Shen, Q | 1 |
| Gagliano, N | 1 |
| Arosio, B | 1 |
| Santambrogio, D | 1 |
| Balestrieri, MR | 1 |
| Padoani, G | 1 |
| Tagliabue, J | 1 |
| Masson, S | 1 |
| Vergani, C | 1 |
| Annoni, G | 1 |
| Han, DS | 1 |
| Holt, L | 1 |
| Connolly, K | 1 |
| Hubert, M | 1 |
| Miceli, R | 1 |
| Okoye, Z | 1 |
| Santiago, G | 1 |
| Windle, K | 1 |
| Wong, E | 1 |
| Sartor, RB | 1 |
| George, J | 1 |
| Nishimura, H | 1 |
| Phelps, RG | 1 |
| Wolf, I | 1 |
| Honjo, T | 1 |
| Bona, C | 1 |
| Sköld, CM | 1 |
| Ohkuni, Y | 1 |
| Liu, XD | 1 |
| Numerof, R | 1 |
| Rennard, SI | 1 |
| Muguerza, B | 1 |
| Castilla-Cortázar, I | 1 |
| García, M | 1 |
| Quiroga, J | 1 |
| Santidrián, S | 1 |
| Prieto, J | 1 |
| Leferovich, JM | 1 |
| Bedelbaeva, K | 1 |
| Samulewicz, S | 1 |
| Zhang, XM | 1 |
| Zwas, D | 1 |
| Lankford, EB | 1 |
| Heber-Katz, E | 1 |
| Nakamuta, M | 1 |
| Ohta, S | 1 |
| Tada, S | 1 |
| Tsuruta, S | 1 |
| Sugimoto, R | 1 |
| Kotoh, K | 1 |
| Nakashima, Y | 1 |
| Enjoji, M | 1 |
| Hoffmann, KF | 1 |
| McCarty, TC | 1 |
| Segal, DH | 1 |
| Chiaramonte, M | 1 |
| Hesse, M | 1 |
| Davis, EM | 1 |
| Cheever, AW | 1 |
| Meltzer, PS | 1 |
| Morse, HC | 1 |
| Wynn, TA | 1 |
| Lupp, A | 1 |
| Kriegsmann, J | 1 |
| Sawall, S | 1 |
| Splinther, J | 1 |
| Sommer, M | 1 |
| Nwogu, JI | 1 |
| Geenen, D | 1 |
| Bean, M | 1 |
| Brenner, MC | 1 |
| Buttrick, PM | 1 |
| Hocher, B | 1 |
| Godes, M | 1 |
| Olivier, J | 1 |
| Weil, J | 1 |
| Eschenhagen, T | 1 |
| Slowinski, T | 1 |
| Neumayer, HH | 1 |
| Bauer, C | 1 |
| Paul, M | 1 |
| Pinto, YM | 1 |
| Saito, E | 1 |
| Fujimoto, M | 1 |
| Hasegawa, M | 1 |
| Komura, K | 1 |
| Hamaguchi, Y | 1 |
| Kaburagi, Y | 1 |
| Nagaoka, T | 1 |
| Takehara, K | 1 |
| Tedder, TF | 1 |
| Sato, S | 1 |
| Masuyama, T | 1 |
| Sakata, Y | 1 |
| Nishikawa, N | 1 |
| Mano, T | 1 |
| Yoshida, J | 1 |
| Miwa, T | 1 |
| Sugawara, M | 1 |
| Yamaguchi, Y | 1 |
| Ookawara, T | 1 |
| Hori, M | 1 |
| Poiani, GJ | 1 |
| Wilson, FJ | 1 |
| Fox, JD | 1 |
| Sumka, JM | 1 |
| Peng, BW | 1 |
| Liao, WC | 1 |
| Tozzi, CA | 1 |
| Riley, DJ | 1 |
| Ala-Kokko, L | 1 |
| Günzler, V | 1 |
| Hoek, JB | 1 |
| Rubin, E | 1 |
| Prockop, DJ | 1 |
| Hendel, L | 1 |
| Knorr, A | 1 |
| Herrmann, T | 1 |
| Voigtmann, L | 1 |
| McClurkin, C | 1 |
| Phan, SH | 1 |
| Hsu, CH | 1 |
| Patel, SR | 1 |
| Spicker, JK | 1 |
| Kshirsagar, AM | 1 |
| Yuan, WY | 1 |
| Wiggins, RC | 1 |
| Knight, KR | 1 |
| Collopy, PA | 1 |
| McCann, JJ | 1 |
| Vanderkolk, CA | 1 |
| Coe, SA | 1 |
| Barton, RM | 1 |
| Chen, HC | 1 |
| O'Brien, BM | 1 |
| Eghbali, M | 2 |
| Robinson, TF | 1 |
| Seifter, S | 1 |
| Blumenfeld, OO | 1 |
| Overbeck, HW | 1 |
| Magargal, WW | 1 |
| Barsky, SH | 1 |
| Gopalakrishna, R | 1 |
| Murray, JC | 1 |
| Parkins, CS | 1 |
| Kinami, Y | 1 |
| Sakata, N | 1 |
| Takata, M | 1 |
| Ozeki, T | 1 |
| Kan, M | 1 |
| Iwaki, K | 1 |
| Ohuchi, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study of Pirfenidone in the Treatment of Myocardial Fibrosis After Acute Myocardial Infarction: a Phase II Prospective, Randomized, Double-blind，Placebo Controlled Clinical Trial[NCT05531955] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-08-05 | Active, not recruiting | ||
| A Phase I, Trial to Evaluate the Safety, Tolerability, and Potential Efficacy of Allogeneic Human Mesenchymal Stem Cell (hMSC) Infusion in Patients With Non-Cystic Fibrosis Bronchiectasis[NCT02625246] | Phase 1 | 6 participants (Actual) | Interventional | 2016-02-04 | Completed | ||
| A Phase I, Trial to Evaluate the Safety, Tolerability, and Potential Efficacy of Allogeneic Human Mesenchymal Stem Cell Infusion in Patients With Mild Asthma[NCT03137199] | Phase 1 | 3 participants (Actual) | Interventional | 2017-06-22 | Terminated (stopped due to First cohort completed. Per sponsor decision.) | ||
| Mesenchymal Stem Cell Therapy for Liver Cirrhosis: A Phase I/II Study[NCT03626090] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2018-08-18 | Recruiting | ||
| Pirfenidone: A Novel Anti-Scarring Therapy for Diabetic Nephropathy[NCT00063583] | Phase 1/Phase 2 | 77 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Pirfenidone Effect on the Recovery of Renal Function in Patients With Septic Acute Kidney Injury[NCT02530359] | Phase 4 | 90 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyproline and Cirrhosis
| Article | Year |
|---|---|
[Hydroxyproline].
Topics: Biomarkers; Bone Diseases, Metabolic; Chromatography, High Pressure Liquid; Colorimetry; Fibrosis; H | 2004 |
247 other studies available for hydroxyproline and Cirrhosis
| Article | Year |
|---|---|
Targeting CC chemokine ligand (CCL) 20 by miR-143-5p alleviate lead poisoning-induced renal fibrosis by regulating interstitial fibroblasts excessive proliferation and dysfunction.
Topics: Animals; Cell Proliferation; Chemokines, CC; Female; Fibroblasts; Fibrosis; Humans; Hydroxyproline; | 2022 |
Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Autophagy; Beclin-1; Blood Glucose; Catechin; Col | 2022 |
Obeticholic acid aggravates liver injury by up-regulating the liver expression of osteopontin in obstructive cholestasis.
Topics: Alkaline Phosphatase; Animals; Chenodeoxycholic Acid; Cholestasis; Fibrosis; Hydroxyproline; Liver; | 2022 |
FcεRI deficiency alleviates silica-induced pulmonary inflammation and fibrosis.
Topics: Animals; beta-N-Acetylhexosaminidases; Fibrosis; Histamine; Hydroxyproline; Immunoglobulin E; Interl | 2022 |
Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways.
Topics: Animals; Fibrosis; Hydroxyproline; Interleukin-18; Janus Kinase 2; Macrophages; Pneumonia; Pulmonary | 2022 |
Probiotics suppress nonalcoholic steatohepatitis and carcinogenesis progression in hepatocyte-specific PTEN knockout mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytokines; Fibrosis; Glutathione; Hepatocytes; H | 2022 |
Therapeutic effects of adipose-derived mesenchymal stem/stromal cells with enhanced migration ability and hepatocyte growth factor secretion by low-molecular-weight heparin treatment in bleomycin-induced mouse models of systemic sclerosis.
Topics: Actins; Animals; Anti-Inflammatory Agents; Bleomycin; Collagen; Disease Models, Animal; Fibrosis; He | 2022 |
Automated whole slide image analysis for a translational quantification of liver fibrosis.
Topics: Animals; Collagen; Fibrosis; Hydroxyproline; Liver; Liver Cirrhosis; Mice | 2022 |
Sunitinib displays pulmonary fibrosis in experimental rats: Role of IL-17A dependent pathway.
Topics: Animals; Collagen; Fibrosis; Hydroxyproline; Interleukin-17; Interleukin-6; Pulmonary Fibrosis; Rats | 2023 |
Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway.
Topics: Animals; Collagen; Fibrosis; Guinea Pigs; Hydroxyproline; Matrix Metalloproteinase 2; Myopia; Phosph | 2023 |
Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis.
Topics: Animals; Carrier Proteins; Fibrosis; Hydroxyproline; Idiopathic Pulmonary Fibrosis; Mammals; Mechani | 2023 |
Sulfasalazine Resolves Joint Stiffness in a Rabbit Model of Arthrofibrosis.
Topics: Aminopropionitrile; Animals; Collagen; Contracture; Disease Models, Animal; Fibrosis; Hydroxyproline | 2020 |
Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice.
Topics: Animals; Antioxidants; Diosmin; Fibrosis; Glutathione; Hydroxyproline; Lung Injury; Male; Mice; Mice | 2019 |
Effects of thalidomide on Th17, Treg cells and TGF-β1/Smad3 pathway in a mouse model of systemic sclerosis.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Fibrosis; Hydroxyproline; Immunosuppressive Agen | 2020 |
Anti-fibrotic effect of melittin on TRIM47 expression in human embryonic lung fibroblast through regulating TRIM47 pathway.
Topics: Actins; Carrier Proteins; Cell Proliferation; Connective Tissue Growth Factor; Fibroblasts; Fibrosis | 2020 |
Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload-Induced Cardiac Fibrosis in Mice.
Topics: Angiotensin II; Animals; Antibodies, Neutralizing; Aorta; Arterial Pressure; Cardiomyopathies; Colla | 2021 |
NF-κB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Autophagy; Blood Vessels; Cardiotoxicity; Doxorubicin; Endothe | 2020 |
Effect of belt electrode-skeletal muscle electrical stimulation on immobilization-induced muscle fibrosis.
Topics: Actins; Animals; Ankle; Chemokine CCL2; Electric Stimulation; Electrodes; Fibrosis; Hydroxyproline; | 2021 |
Expression of the α7 Nicotinic Acetylcholine Receptor Is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bleomycin; Bridged Bicyclo Compounds, Heterocyclic | 2022 |
The impact of empagliflozin on cardiac physiology and fibrosis early after myocardial infarction in non-diabetic rats.
Topics: Animals; Benzhydryl Compounds; Collagen; Disease Models, Animal; Fibrosis; Glucosides; Hydroxyprolin | 2021 |
Identification of novel biomarkers for arthrofibrosis after total knee arthroplasty in animal models and clinical patients.
Topics: Adult; Aged; Animals; Arthroplasty, Replacement, Knee; Biomarkers; Female; Fibrosis; Humans; Hydroxy | 2021 |
Endothelial cell-specific activation of transforming growth factor-β signaling in mice induces cutaneous, visceral, and microvascular fibrosis.
Topics: Animals; Endothelial Cells; Female; Fibrosis; Hydroxyproline; Immunohistochemistry; Lung; Male; Mice | 2017 |
Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: Contribution to oxalate kidney injury.
Topics: Animals; Calcium Oxalate; Cell Movement; Epithelial-Mesenchymal Transition; Ethylene Glycol; Fibrosi | 2017 |
Reduction of Abdominal Adhesions with Elecrospun Fiber Membranes in Rat Models.
Topics: Animals; Cecum; Chitosan; Disease Models, Animal; Fibrosis; Humans; Hydroxybutyrates; Hydroxyproline | 2018 |
Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans.
Topics: Actins; Animals; Antioxidants; Bile Ducts; Caffeine; Coffee; Connective Tissue Growth Factor; Diseas | 2017 |
Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis.
Topics: Animals; Cadherins; Collagen; Collagen Type I; Epithelial Cells; Epithelial-Mesenchymal Transition; | 2017 |
5-aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hyperoxia-induced lung fibrosis via re-expression of P16 in neonatal rats.
Topics: Animals; Animals, Newborn; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Femal | 2018 |
Pirfenidone protects against paraquat-induced lung injury and fibrosis in mice by modulation of inflammation, oxidative stress, and gene expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Bronchoalveolar Lavage Fluid; Fibrosi | 2018 |
Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats.
Topics: Adenine; Animals; Blood Urea Nitrogen; Collagen Type I; Connective Tissue Growth Factor; Creatinine; | 2018 |
Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.
Topics: Adiposity; Adult; Aged; Anthropometry; Asian; Blood Glucose; Body Composition; Body Mass Index; Fema | 2018 |
Chronic aerobic exercise training alleviates myocardial fibrosis in aged rats through restoring bioavailability of hydrogen sulfide.
Topics: Aging; Animals; Chemokine CCL2; Endoplasmic Reticulum Stress; Fibrosis; Heart; Hydrogen Sulfide; Hyd | 2018 |
IL-17A Promotes Initiation and Development of Intestinal Fibrosis Through EMT.
Topics: Animals; Cell Line; Colon; Crohn Disease; Epithelial-Mesenchymal Transition; Female; Fibrosis; Human | 2018 |
Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis.
Topics: Animals; Colitis; Collagen; Colon; Crohn Disease; Disease Models, Animal; Fibrosis; Hydroxyproline; | 2018 |
Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema.
Topics: Acute Lung Injury; Aged; Animals; Emphysema; Endoplasmic Reticulum Stress; Female; Fibrosis; Heme; H | 2018 |
Abrogation of transforming growth factor-β-induced tissue fibrosis in mice with a global genetic deletion of Nox4.
Topics: Animals; DNA Damage; Fibrosis; Gene Knockout Techniques; Hydroxyproline; Lung; Mice; Mice, Inbred C5 | 2019 |
Modulation of miR-10a-mediated TGF-β1/Smads signaling affects atrial fibrillation-induced cardiac fibrosis and cardiac fibroblast proliferation.
Topics: 3' Untranslated Regions; Animals; Atrial Fibrillation; Cell Proliferation; Collagen; Disease Models, | 2019 |
Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM.
Topics: Animals; Cardiomyopathy, Hypertrophic, Familial; Dependovirus; Disease Models, Animal; Echocardiogra | 2019 |
Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis
Topics: Actins; Animals; Benzofurans; Collagen Type I; CX3C Chemokine Receptor 1; Disease Models, Animal; Ex | 2019 |
Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg/Teff cells and reducing spleen germinal center formation.
Topics: Animals; Bleomycin; Cell Differentiation; Collagen; Disease Models, Animal; Female; Fibrosis; Germin | 2019 |
Hydroxyproline content and fibrogenesis in mouse liver and lungs during the early stages of BCG granulomatosis.
Topics: Animals; Cell Proliferation; Fibroblasts; Fibrosis; Granuloma; Granuloma, Respiratory Tract; Hydroxy | 2013 |
Antifibrotic role of chemokine CXCL9 in experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Antibodies, Neutralizing; Cell Proliferation; Chemokine CXCL9; Collagen Type I; Fibrosis; H | 2013 |
Protection against hyperoxia-induced lung fibrosis by KGF-induced MSCs mobilization in neonatal rats.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cell Transplantation; Female; Fibroblast Growth F | 2013 |
Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine-induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Amyloid beta-Protein Precursor; Animals; Cell Proliferation; Cells, Cultured; Dimethylallyltranstran | 2014 |
Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models.
Topics: Animals; Bleomycin; Disease Models, Animal; Elasticity; Fibrosis; Hydroxyproline; Hypersensitivity; | 2013 |
Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation.
Topics: Actins; Alcoholism; Animals; Blotting, Western; Central Nervous System Depressants; Collagen; Ethano | 2014 |
[Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice].
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Fibrosis; Hydroxyproline; Male; M | 2013 |
Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats.
Topics: Animals; Calcium Channel Blockers; Cicatrix; Dura Mater; Epidural Space; Fibrosis; Hydroxyproline; I | 2014 |
ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats.
Topics: Animals; Collagen; Double-Blind Method; Epidural Space; Female; Fibrosis; Hydroxyproline; Inflammati | 2014 |
Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.
Topics: Animals; Antineoplastic Agents; Antitussive Agents; Bleomycin; Cell Line, Tumor; Cyclic AMP-Dependen | 2014 |
Collagen content does not alter the passive mechanical properties of fibrotic skeletal muscle in mdx mice.
Topics: Animals; Biomechanical Phenomena; Collagen; Diaphragm; Disease Models, Animal; Elasticity; Extracell | 2014 |
Topical vitamin D analogue calcipotriol reduces skin fibrosis in experimental scleroderma.
Topics: Administration, Topical; Animals; Bleomycin; Calcitriol; Collagen; Cytokines; Dermatologic Agents; D | 2014 |
Pyridostigmine ameliorates cardiac remodeling induced by myocardial infarction via inhibition of the transforming growth factor-β1/TGF-β1-activated kinase pathway.
Topics: Animals; Cholinesterase Inhibitors; Fibrosis; Hemodynamics; Hydroxyproline; Male; MAP Kinase Kinase | 2014 |
Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis.
Topics: Age Factors; Animals; Carrier Proteins; Collagen; Extracellular Matrix; Fibrosis; Fluorescent Antibo | 2014 |
Effects of emodin and irbesartan on ventricular fibrosis in Goldblatt hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blotting, West | 2014 |
An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1.
Topics: Animals; Cicatrix; Collagen; Down-Regulation; Epidural Space; Fibroblasts; Fibrosis; Gene Expression | 2015 |
Immunomodulatory effectiveness of licofelone in preventing epidural fibrosis in post-laminectomy rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Disease Models, Animal; Double-Blind Met | 2015 |
Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Apoptosis Regulatory Proteins; Autophagy-Related Protein 5; | 2014 |
Resolution of chronic bacterial-induced prostatic inflammation reverses established fibrosis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Chromatography, High Pressure Liquid; Collagen; Dise | 2015 |
Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Cell Proliferation; Cicatrix; Double-Blind Method; D | 2014 |
Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Bleomycin; Elapid Venoms; Elapidae; Female; Fibrosi | 2014 |
IL-21 induction of CD4+ T cell differentiation into Th17 cells contributes to bleomycin-induced fibrosis in mice.
Topics: Animals; Bleomycin; CD4-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Female | 2015 |
Elevated frequencies of CD4(+) IL-21(+) T, CD4(+) IL-21R(+) T and IL-21(+) Th17 cells, and increased levels of IL-21 in bleomycin-induced mice may be associated with dermal and pulmonary inflammation and fibrosis.
Topics: Animals; Bleomycin; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Disease Model | 2016 |
Effects of rapamycin on reduction of peridural fibrosis: an experimental study.
Topics: Analysis of Variance; Animals; Cell Proliferation; Cells, Cultured; Cytokines; DNA Primers; Drug Eva | 2015 |
The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Aorta, Abdominal; Blood Pressure; | 2015 |
Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.
Topics: Animals; Apoptosis; Arginase; Bronchiolitis; Chitinases; Desmosine; Fibrosis; Hydroxyproline; Interl | 2015 |
Antifibrotic effect of lysophosphatidic acid receptors LPA1 and LPA3 antagonist on experimental murine scleroderma induced by bleomycin.
Topics: Animals; Bleomycin; Cell Count; Chemokine CCL3; Collagen Type I; Connective Tissue Growth Factor; Di | 2015 |
Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-β1/Smad3 and p38 MAPK signaling pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiotonic Agents; Diterpenes; Ep | 2015 |
Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Heart; Hydrogen Sulfi | 2015 |
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.
Topics: Animals; Chromatography, High Pressure Liquid; Collagen Type I; Collagen Type III; Diastole; Fibrosi | 2015 |
Fibrosis is a common outcome following total knee arthroplasty.
Topics: Actins; Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Knee; Arthroscopes; Biopsy; Colla | 2015 |
Partial deletion of the ROCK2 protein fails to reduce renal fibrosis in a unilateral ureteral obstruction model in mice.
Topics: Animals; Collagen Type I; Disease Models, Animal; Fibrosis; Gene Deletion; Heterozygote; Hydroxyprol | 2016 |
Effects of hydrogen sulfide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats.
Topics: Animals; Autophagy; Biomarkers; Collagen Type I; Collagen Type II; Cystathionine gamma-Lyase; Diabet | 2016 |
Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction.
Topics: Animals; Collagen; Diabetes Mellitus; Disease Models, Animal; Drug Delivery Systems; Erectile Dysfun | 2016 |
Pentoxifylline Inhibits Epidural Fibrosis in Post-Laminectomy Rats.
Topics: Animals; Epidural Space; Fibroblasts; Fibrosis; Hydroxyproline; Laminectomy; Male; Pentoxifylline; P | 2016 |
Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.
Topics: Albumin-Bound Paclitaxel; Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, T | 2016 |
Liguzinediol protects against cardiac fibrosis in rats in vivo and in vitro.
Topics: Animals; Cardiotonic Agents; Cell Proliferation; Cell Shape; Collagen Type I; Collagen Type III; Dow | 2016 |
Local application of rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Cicatrix; Epidural Space; Fibroblasts; Fibr | 2016 |
Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Blood Urea Nitrogen; Creatinine; Discr | 2016 |
Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152.
Topics: Actins; Animals; Cell Movement; Collagen; Collagen Type I; CpG Islands; DNA Methylation; Epigenesis, | 2016 |
Zofenopril exerts a cardiovascular protective effect on rats infused with angiotensin II beyond angiotensin-converting enzyme inhibition.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, T | 2016 |
PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle.
Topics: Animals; Cobra Cardiotoxin Proteins; Fibrosis; Gene Expression; Hydroxyproline; Macrophages; Male; M | 2016 |
Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis.
Topics: Angiotensin II; Animals; Cardiomegaly; Collagen Type I; Collagen Type III; Feedback, Physiological; | 2017 |
Hyperleptinemia Exacerbates High-Fat Diet-Mediated Atrial Fibrosis and Fibrillation.
Topics: Actins; Animals; Atrial Fibrillation; Biomarkers; Cardiac Pacing, Artificial; Chemokine CCL2; Collag | 2017 |
Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.
Topics: Actins; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Ch | 2008 |
Hypertension-induced renal fibrosis and spironolactone response vary by rat strain and mineralocorticoid receptor gene expression.
Topics: Aldosterone; Animals; Blood Pressure; Body Weight; Collagen Type I; Fibrosis; Gene Expression Regula | 2008 |
Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats.
Topics: Animals; Aquilegia; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fibrosis; Glutathi | 2009 |
EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy.
Topics: Angiotensin II; Animals; Antioxidants; Atrial Natriuretic Factor; Camellia sinensis; Cardiomegaly; C | 2009 |
Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model.
Topics: Administration, Inhalation; Animals; Asthma; Base Sequence; Bronchoalveolar Lavage Fluid; Cells, Cul | 2009 |
[Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction].
Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Carvedilol; Collagen; Disease Models, Animal; Fibr | 2008 |
Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury.
Topics: Animals; Asia, Southeastern; Bile Duct Diseases; Collagen; Cricetinae; Cytokines; Electrophoresis; E | 2009 |
[Function of type I repetitive consequence peptide segment of thrombospondin-1 in inhibition of fibrosis of mice].
Topics: Animals; Disease Models, Animal; Female; Fibrosis; Hydroxyproline; Lung; Mice; Thrombospondin 1 | 2009 |
K(ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function.
Topics: Animals; Aorta, Abdominal; Atrial Natriuretic Factor; Blood Pressure; Cardiovascular Agents; Disease | 2009 |
IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice.
Topics: Animals; Blood Pressure; Blood Volume; Cell Separation; Collagen; Enzyme-Linked Immunosorbent Assay; | 2009 |
Does the type of resuscitative fluid affect healing of colonic anastomosis in experimentally induced hemorrhagic shock in rats?
Topics: Anastomosis, Surgical; Animals; Blood Transfusion, Autologous; Colon; Fibrosis; Fluid Therapy; Hydro | 2009 |
Effect of therapeutic pulsed ultrasound on lipoperoxidation and fibrogenesis in an animal model of wound healing.
Topics: Animals; Collagen; Fibrosis; Hydroxyproline; Lipid Peroxidation; Male; Rats; Rats, Wistar; Skin; Ski | 2010 |
Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats.
Topics: Animals; Blood Pressure; Fibrosis; Free Radical Scavengers; Heart Ventricles; Hemodynamics; Hydroxyp | 2009 |
Atorvastatin reverses cardiac remodeling possibly through regulation of protein kinase D/myocyte enhancer factor 2D activation in spontaneously hypertensive rats.
Topics: Animals; Atorvastatin; Blood Pressure; Disease Models, Animal; Enzyme Activation; Fibrosis; Heptanoi | 2010 |
Cardiac fibrosis and diastolic dysfunction after myocardial infarction in apolipoprotein E knockout mice.
Topics: Animals; Apolipoproteins E; Body Weight; Diastole; Disease Models, Animal; Echocardiography, Doppler | 2009 |
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2009 |
Fuzheng Huayu recipe and vitamin E reverse renal interstitial fibrosis through counteracting TGF-beta1-induced epithelial-to-mesenchymal transition.
Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Biological Transport; Cadherins; Collagen | 2010 |
A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice.
Topics: Animals; CD36 Antigens; Collagen Type I; Collagen Type III; Disease Models, Animal; Female; Fibrosis | 2010 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2010 |
Cardiac remodeling and MMPs on the model of chronic daunorubicin-induced cardiomyopathy in rabbits.
Topics: Animals; Antibiotics, Antineoplastic; Cardiomyopathies; Cardiovascular Agents; Chronic Disease; Coll | 2010 |
A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzamides; Collagen; Collagen Type I; Collagen Ty | 2010 |
Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats.
Topics: Acridines; Animals; Chemokine CCL2; Chronic Disease; Collagen; Fibrosis; Hydroxyproline; IMP Dehydro | 2010 |
Gender influences cardiac function in the mdx model of Duchenne cardiomyopathy.
Topics: Animals; Blood Pressure; Blood Volume; Cardiomyopathy, Dilated; Electrocardiography; Female; Fibrosi | 2010 |
Treatment with pravastatin attenuates progression of chronic pancreatitis in rat.
Topics: Analysis of Variance; Animals; Fibrosis; Hydroxyproline; Immunohistochemistry; Interleukin-10; Male; | 2011 |
The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2- to 20-mo-old mdx mice.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Biomechanical Phenomena; Body Weight; Disease Mod | 2011 |
A therapeutic role for mesenchymal stem cells in acute lung injury independent of hypoxia-induced mitogenic factor.
Topics: Actins; Acute Lung Injury; Animals; Bone Marrow Cells; Cytokines; Fibrosis; Hydroxyproline; Intercel | 2012 |
[Dynamics of biochemical markers of reparative fibrosis in uncomplicated course of myocardial infarction].
Topics: Adult; Aged; Biomarkers; Disease Progression; Echocardiography; Electrocardiography; Female; Fibrone | 2010 |
Comparison of antioxidative and antifibrotic effects of α-tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis.
Topics: Actins; Administration, Oral; alpha-Tocopherol; Animals; Anti-Inflammatory Agents; Antioxidants; Apo | 2011 |
Assessment of respiratory physiology of C57BL/6 mice following bleomycin administration using barometric plethysmography.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Body Temperature; Body Weight; Disease Models, Anim | 2012 |
Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis.
Topics: Actins; Animals; Bone Morphogenetic Protein 7; Cell Line; Collagen; Connective Tissue Growth Factor; | 2012 |
The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn.
Topics: Animals; Burns, Chemical; Caustics; Cell Differentiation; Cell Division; Cicatrix; Drug Evaluation, | 2011 |
Diabetes-induced vascular dysfunction involves arginase I.
Topics: Animals; Aorta; Arginase; Arteries; Carotid Arteries; Compliance; Coronary Vessels; Diabetes Mellitu | 2012 |
Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression.
Topics: Animals; Biological Products; Cardiomyopathies; Cardiotonic Agents; Collagen; Disease Models, Animal | 2012 |
Recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) attenuates caerulein-induced chronic pancreatitis in mice.
Topics: Amylases; Animals; Ceruletide; Collagen; Disease Models, Animal; Fibrosis; Humans; Hydroxyproline; I | 2012 |
[Methabolism of connective tissue in patients with complicated chronic pancreatitis].
Topics: Adult; Collagen; Connective Tissue; Female; Fibrosis; Glycosaminoglycans; Humans; Hydroxyproline; Ma | 2011 |
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.
Topics: Analysis of Variance; Animals; Apoptosis; Carrier Proteins; Cell Differentiation; Cells, Cultured; C | 2012 |
Increased fibrosis and interstitial fluid pressure in two different types of syngeneic murine carcinoma grown in integrin β3-subunit deficient mice.
Topics: Animals; Carcinoma; Cell Line, Tumor; Collagen; Extracellular Fluid; Female; Fibrosis; Gene Expressi | 2012 |
Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Enzyme Inhibitors; Fibr | 2012 |
Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Cardiovascular Agents; Collagen Type I; Collagen Type III; Disease Models, | 2012 |
The therapeutic efficacy of Ulinastatin for rats with smoking inhalation injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Collagen Type I; | 2012 |
Metabolomics evaluation of hydroxyproline as a potential marker of melamine and cyanuric acid nephrotoxicity in male and female Fischer F344 rats.
Topics: Animals; Biomarkers; Female; Fibrosis; Hydroxyproline; Kidney Diseases; Male; Metabolomics; Rats; Ra | 2012 |
Pomalidomide is effective for prevention and treatment of experimental skin fibrosis.
Topics: Animals; Disease Models, Animal; Fibrosis; Hydroxyproline; Immunosuppressive Agents; Mice; Mice, Inb | 2012 |
Truncated dystrophins reduce muscle stiffness in the extensor digitorum longus muscle of mdx mice.
Topics: Age Factors; Animals; Biomechanical Phenomena; Body Weight; Disease Models, Animal; Dystrophin; Elas | 2013 |
Effects of levobupivacaine on wound healing.
Topics: Anesthetics, Local; Animals; Biopsy; Bupivacaine; Cell Proliferation; Female; Fibrosis; Hydroxyproli | 2013 |
Correlations between the collagen content of the human left ventricular myocardium, measured by biochemical and morphometric methods.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cadaver; Collagen; Colorimetry; Female; Fibrosis; Heart | 2002 |
Renal interstitial fibrosis (RIF): II. Ultrasound follow up study of single uranyl nitrate administration causing renal dysfunction in rats--comparison with histologic and functional renal parameters.
Topics: Acute Disease; Animals; Creatinine; Disease Models, Animal; Female; Fibrosis; Follow-Up Studies; Glu | 2002 |
A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.
Topics: Animals; Antioxidants; Collagen; Female; Fibrosis; Free Radicals; Hydroxyproline; Immunohistochemist | 2002 |
Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Blotting, Western; Chemokines; Chemokines, CC; Enzy | 2002 |
Do mast cells play any role in the pathogenesis of experimental pancreatic fibrosis in rats?
Topics: Animals; Cell Count; Ditiocarb; Enzyme Inhibitors; Fibrosis; Hydroxyproline; Mast Cells; Mastocytosi | 2002 |
The role of monocyte chemoattractant protein-1 in experimental chronic pancreatitis model induced by dibutyltin dichloride in rats.
Topics: Amylases; Animals; Chemokine CCL2; Chronic Disease; Fibrosis; Hydroxyproline; Injections, Intravenou | 2002 |
Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway.
Topics: Adenoviridae; Animals; Apoptosis; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; DNA; D | 2002 |
Role of interferon-gamma in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo.
Topics: Animals; Bronchi; Female; Fibrosis; Hydroxyproline; Immunity, Mucosal; Interferon-gamma; Interleukin | 2002 |
Air pollution particles produce airway wall remodeling in rat tracheal explants.
Topics: Air Pollution; alpha-Fetoproteins; Animals; Cells, Cultured; Chelating Agents; Collagen; Deferoxamin | 2003 |
Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats.
Topics: Actins; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Chronic Disease; Fibrosis; G | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
Topics: Animals; Bleomycin; Bone Marrow Transplantation; Collagen; Drug Resistance; Enzyme Induction; Female | 2003 |
Overexpression of tumor necrosis factor-alpha diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-beta.
Topics: Adenoviridae; Animals; Antibiotics, Antineoplastic; Bleomycin; Cytokines; Dinoprostone; Fibrosis; Ge | 2003 |
Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1.
Topics: Animals; Collagen; Extracellular Matrix; Fibrin; Fibrosis; Foreign Bodies; Hydroxyproline; Lung; Mic | 2003 |
An HSV-TK transgenic mouse model to evaluate elimination of fibroblasts for fibrosis therapy.
Topics: Animals; Antiviral Agents; Apoptosis; Cells, Cultured; Collagen Type I; Disease Models, Animal; Fibr | 2003 |
Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: mechanisms and consequences.
Topics: Aerosols; Animals; Cell Count; Collagen; Coloring Agents; Fibrosis; Gene Expression Regulation, Enzy | 2003 |
Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats.
Topics: Actins; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl | 2003 |
[Studies on fibroplasia. III. Hydroxyproline in scleroproteins in the lungs in ontogenesis in rats].
Topics: Aging; Animals; Fibrosis; Hydroxyproline; Lung; Proline; Proteins; Rats; Scleroproteins | 1956 |
A study of fibroplasia. III. Hydroxyproline content of scleroproteins in the lungs of rats during ontogeny.
Topics: Aging; Animals; Fibrosis; Hydroxyproline; Lung; Proline; Proteins; Rats; Scleroproteins | 1956 |
Inflammation is involved in the organ damage induced by sinoaortic denervation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aorta; Blood Vessels; Cardiomegaly; | 2003 |
Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ozone.
Topics: Aerosols; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Coloring Agents; Fibrosis; Hydroxyproli | 2004 |
Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice.
Topics: Animals; Ceruletide; Fibrosis; Hydroxyproline; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreas; P | 2004 |
Reduction of cardiac fibrosis decreases systolic performance without affecting diastolic function in hypertensive rats.
Topics: Animals; Capillaries; Cell Size; Collagen; Diastole; Fibrosis; Heart Ventricles; Hydroxyproline; Hyp | 2004 |
The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis.
Topics: Aged; Aortic Valve; Aortic Valve Stenosis; Calcinosis; Crystallization; Durapatite; Female; Fibrosis | 2004 |
Cardiac structural and functional responses to salt loading in SHR.
Topics: Aging; Animals; Blood Pressure; Cardiomegaly; Echocardiography; Fibrosis; Heart; Heart Failure; Hydr | 2004 |
Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ultrafine particles.
Topics: Air Pollutants; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, Animal; Dr | 2004 |
Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma.
Topics: Actins; Animals; Bleomycin; Blotting, Western; Cells, Cultured; Collagen; Connective Tissue Growth F | 2004 |
Progression of kyphosis in mdx mice.
Topics: Aging; Animals; Disease Progression; Fibrosis; Hydroxyproline; Kyphosis; Mice; Mice, Inbred mdx; Mus | 2004 |
Connective tissue growth factor is crucial to inducing a profibrotic environment in "fibrosis-resistant" BALB/c mouse lungs.
Topics: Adenoviridae; Animals; Bleomycin; Bronchoalveolar Lavage; Connective Tissue Growth Factor; DNA Prime | 2004 |
Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle.
Topics: Animals; Cardiomyopathy, Dilated; Cricetinae; Electroporation; Fibrosis; Genetic Therapy; Genetic Ve | 2004 |
Effects of hyperbaric oxygen therapy on caustic esophageal injury in rats.
Topics: Animals; Burns, Chemical; Collagen; Esophageal Spasm, Diffuse; Esophagitis; Esophagus; Fibrosis; Hyd | 2004 |
Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathy.
Topics: Adenoviridae; Animals; Defective Viruses; Drug Evaluation, Preclinical; Fibrosis; Genes, Synthetic; | 2004 |
[Effects of Fuzheng Huayu recipe on renal toxic interstitial fibrosis in rats].
Topics: Animals; Creatinine; Dimethylnitrosamine; Disease Models, Animal; Drugs, Chinese Herbal; Fibrosis; H | 2004 |
Tedisamil attenuates foetal transformation of myosin in the hypertrophied rat myocardium.
Topics: Animals; Blood Pressure; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Cardiomegaly; Cardiot | 2004 |
Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats.
Topics: Actins; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazol | 2005 |
Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blotting, Northern; Blotting, Western; Cell Nucleu | 2005 |
Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin.
Topics: Animals; Antioxidants; Catalase; Cell Phone; Disease Models, Animal; Fibrosis; Free Radical Scavenge | 2004 |
Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus.
Topics: Animals; Burns, Chemical; Caustics; Drug Evaluation, Preclinical; Esophageal Stenosis; Esophagus; Fi | 2005 |
Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse.
Topics: Animals; Connective Tissue; Fibrosis; Flow Cytometry; Hydroxyproline; Lymphocyte Depletion; Mice; Mi | 2005 |
Beneficial effects of Ebselen on corrosive esophageal burns of rats.
Topics: Analysis of Variance; Animals; Antioxidants; Azoles; Burns; Catalase; Esophagus; Fibrosis; Glutathio | 2006 |
Methods for measuring hydroxyproline and estimating in vivo rates of collagen synthesis and degradation.
Topics: Animals; Chemistry Techniques, Analytical; Chromatography; Chromatography, High Pressure Liquid; Col | 2005 |
Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats.
Topics: Actins; Animals; Blotting, Western; Chemokine CCL2; Chemokines; Cytokines; Disease Models, Animal; D | 2005 |
Role of free radicals in aseptic loosening of hip arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Female; Fibrosis; Free Radicals; Glu | 2006 |
Colchicine in experimental alkaline burns of the rat esophagus: an old drug, a new indication?
Topics: Analysis of Variance; Animals; Burns, Chemical; Caustics; Colchicine; Disease Models, Animal; Dose-R | 2006 |
Pentoxifylline fails to attenuate fibrosis in dystrophic (mdx) diaphragm muscle.
Topics: Animals; Collagen Type I; Collagen Type III; Diaphragm; Disease Models, Animal; Enzyme Inhibitors; F | 2006 |
Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice.
Topics: Adenoviridae; Amino Acid Substitution; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride Poisonin | 2006 |
Thalidomide attenuates the development of fibrosis during post-infarction myocardial remodelling in rats.
Topics: Animals; Blood Pressure; Cytokines; Disease Models, Animal; Fibrosis; Gene Expression; Hydroxyprolin | 2006 |
Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthma.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Benzamides; Bronchi; Bronchial Hyperreactivi | 2006 |
[Immune complex induced rat liver fibrosis model by intraperitoneal injection of human serum albumin].
Topics: Animals; Antigen-Antibody Complex; Disease Models, Animal; Fibrosis; Humans; Hyaluronic Acid; Hydrox | 2006 |
Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy.
Topics: Aging; Animals; Body Weight; Cobra Cardiotoxin Proteins; Disease Models, Animal; Fibrosis; Gene Dele | 2006 |
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.
Topics: Animals; Cells, Cultured; Collagen; Dermis; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; | 2006 |
Overexpression of nitric oxide synthase by the endothelium attenuates bleomycin-induced lung fibrosis and impairs MMP-9/TIMP-1 balance.
Topics: Animals; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Endothelium, Vascular; Fibrosis | 2006 |
Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.
Topics: Actins; Animals; Bleomycin; Caveolin 1; Collagen Type I; Epithelial Cells; Extracellular Matrix; Fib | 2006 |
Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Proliferation; Collagen; Fibroblasts; Fibrosis; Hydroxyp | 2007 |
AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Apoptosis; Benzi | 2007 |
[Inhibitory effect of angiotensin blockade on hepatic fibrosis in common bile duct-ligated rats].
Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Animals; Bile Ducts; Captopril; Fibrosis; Hydroxypr | 2007 |
Inhibitory effects of soy isoflavones on cardiovascular collagen accumulation in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Blood Glucose; Blood Pressure; Cardiovascular System | 2007 |
Evaluation of serum procollagen aminoterminal propeptide III, laminin, and hydroxyproline as predictors of severe fibrosis in patients with chronic hepatitis C.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Collagen Type III; Diagnosis, Differential; | 2007 |
Blockade of IP-10/CXCR3 promotes progressive renal fibrosis.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Chemokine CXCL10; Chemokines, CXC; Disease Progres | 2007 |
Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat.
Topics: Animals; Automation; Carbon Tetrachloride; Elasticity; Elasticity Imaging Techniques; Fibrosis; Hydr | 2007 |
Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis.
Topics: Animals; Carboxypeptidase B2; Cytokines; Fibrinolysin; Fibrosis; Hydroxyproline; Kidney Diseases; Ma | 2008 |
Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-beta(1)/Smad 7 expression in the spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Cardiomegaly; Cholesterol; Collagen; Dose-Response Relat | 2008 |
In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
Topics: Animals; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Collagen Type I; Fibrosis; Hydroxypr | 2008 |
Differential expression of collagen types I and III in consequential and primary fibrosis in irradiated mouse colon.
Topics: Animals; Cesium Radioisotopes; Collagen; Colon; Fibrosis; Gene Expression; Hydroxyproline; Immunohis | 1995 |
Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat.
Topics: Animals; Bile Duct Diseases; Bile Ducts, Intrahepatic; Common Bile Duct; DNA; Fibrosis; Hydroxyproli | 1994 |
Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis.
Topics: Animals; Collagen; Disease Models, Animal; Female; Fibrosis; Gelatin Sponge, Absorbable; Humans; Hyd | 1993 |
Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Heart; Hydroxyproline; Hyperaldosteronism; Hypert | 1993 |
Laser induced wounds and scarring modified by antiinflammatory drugs: a murine model.
Topics: Administration, Oral; Animals; Burns; Cicatrix; Dose-Response Relationship, Radiation; Female; Fibro | 1993 |
Side effects of laser therapy, modified by ultraviolet irradiation and para-aminobenzoic acid in mice.
Topics: 4-Aminobenzoic Acid; Animals; Cicatrix; Female; Fibrosis; Hydroxylysine; Hydroxyproline; Laser Thera | 1993 |
Effect of CO2 laser on spinal epidural fibrosis.
Topics: Animals; Cicatrix; Epidural Space; Fibrosis; Guinea Pigs; Hydroxyproline; Laminectomy; Laser Therapy | 1996 |
Effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload.
Topics: Alanine Transaminase; Animals; Body Weight; Diet; Fibrosis; Hydroxyproline; Immunohistochemistry; Ir | 1997 |
Effect of chronic colchicine administration on the myocardium of the aging spontaneously hypertensive rat.
Topics: Aging; Animals; Colchicine; Disease Models, Animal; Fibrosis; Heart; Hydroxyproline; Hypertension; M | 1997 |
In vivo role of glucocorticoids in barotrauma vascular repair and fibrosis.
Topics: Angioplasty; Animals; Barotrauma; Blood Vessels; Cross-Sectional Studies; Dexamethasone; DNA; Fibros | 1997 |
Antisense transforming growth factor-beta 1 in wound healing.
Topics: Animals; Blotting, Northern; Cicatrix; Drug Evaluation, Preclinical; Enzyme Induction; Fibrosis; Gen | 1997 |
Pulmonary toxicity of components of textile paint linked to the Ardystil syndrome: intratracheal administration in hamsters.
Topics: Acetylglucosaminidase; Administration, Inhalation; Alkaline Phosphatase; Animals; Body Weight; Bronc | 1997 |
Effect of lecithinized-superoxide dismutase on the interstitial pneumonia model induced by bleomycin in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Disease Models, Animal; Fibrosis; Hydroxyprolin | 1997 |
Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Body Weight; Collagen; Creatin | 1997 |
Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade.
Topics: Aldosterone; Angiotensin II; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Collagen; D | 1998 |
Ultraviolet exposure influences laser-induced wounds, scars, and hyperpigmentation: a murine study.
Topics: Animals; Cicatrix; Contracture; Copper; Dermatologic Surgical Procedures; Esthetics; Facial Dermatos | 1998 |
Myocardial fibrosis rather than hypertrophy induces diastolic dysfunction in renovascular hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Fibrosis; Heart; Hydroxyproline; Hypertension, Re | 1997 |
Coronary hemodynamics in aging spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: Aging; Animals; Aorta; Body Weight; Collagen; Coronary Circulation; Fibrosis; Hemodynamics; Hydroxyp | 1998 |
The influence of ethanol on long-term effects of dibutyltin dichloride (DBTC) in pancreas and liver of rats.
Topics: Administration, Oral; Amylases; Animals; Drug Synergism; Edema; Ethanol; Fibrosis; Hyaluronic Acid; | 1998 |
Pirfenidone improves renal function and fibrosis in the post-obstructed kidney.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Collagen; Disea | 1998 |
Glycoprotein composition in cyclophosphamide-induced lung fibrosis.
Topics: Animals; Cyclophosphamide; Disease Models, Animal; Endopeptidases; Fibrosis; Glycoproteins; Glycosyl | 1998 |
Antifibrotic and hemodynamic effects of the early and chronic administration of octreotide in two models of liver fibrosis in rats.
Topics: Animals; Body Weight; Fibronectins; Fibrosis; Hemodynamics; Hyaluronic Acid; Hydroxyproline; Liver; | 1998 |
Appearance and regression of rat pouch tissue.
Topics: Animals; Cheek; Collagen; Collagenases; Fibrosis; Hydroxyproline; Male; Matrix Metalloproteinase 1; | 1999 |
Myofibroblast proliferation, fibrosis, and defective pancreatic repair induced by cyclosporin in rats.
Topics: Actins; Acute Disease; Animals; Cell Division; Ceruletide; Collagenases; Cyclosporine; Fibrosis; Gas | 1999 |
Determination of fibrosis from cryostat sections using high performance liquid chromatography: skeletal muscle.
Topics: Amino Acids; Animals; Chromatography, High Pressure Liquid; Collagen; Female; Fibronectins; Fibrosis | 1999 |
Effects of angiotensin type-I receptor blockade on pericardial fibrosis.
Topics: Angiotensin Receptor Antagonists; Animals; Cardiac Surgical Procedures; Collagen; Fibrosis; Hydroxyp | 1999 |
Exacerbation of bleomycin-induced lung injury in mice by amifostine.
Topics: Amifostine; Animals; Antibiotics, Antineoplastic; Bleomycin; Collagen; Female; Fibrosis; Gene Expres | 1999 |
Animal model of sclerotic skin. II. Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1-W/W(V) mice.
Topics: Animals; Antibiotics, Antineoplastic; Biopsy; Bleomycin; Cell Count; Disease Models, Animal; Female; | 1999 |
The antifibrogenic effects of liposome-encapsulated IFN-alpha2b cream on skin wounds.
Topics: Animals; Cicatrix; Dosage Forms; Extracellular Matrix; Female; Fibrosis; Guinea Pigs; Hydroxyproline | 1999 |
Effects of lisinopril on experimental ischemia in rats. Influence of infarct size.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Fibrosis; Hydroxyproline; Lisinopri | 1999 |
T-cell-dependent fibrosis in the mdx dystrophic mouse.
Topics: Aging; Animals; Extracellular Matrix Proteins; Fibrosis; Hydroxyproline; Mice; Mice, Inbred C57BL; M | 2000 |
Liposome associated interferon-alpha-2b functions as an anti-fibrogenic factor in dermal wounds in the guinea pig.
Topics: Administration, Cutaneous; Animals; Blotting, Northern; Cells, Cultured; Collagen; Dermis; Drug Carr | 2000 |
Age-dependent expression of fibrosis-related genes and collagen deposition in rat kidney cortex.
Topics: Age Factors; Animals; Collagen; Fibrosis; Gene Expression; Hydroxyproline; Kidney Cortex; Male; Matr | 2000 |
Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Division; Chroni | 2000 |
Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine.
Topics: Animals; Blood Glucose; Cholesterol; Creatinine; Dimethylnitrosamine; Fibrosis; Hydroxyproline; Insu | 2000 |
Induction of skin fibrosis in mice expressing a mutated fibrillin-1 gene.
Topics: Animals; Fibrillin-1; Fibrillins; Fibrosis; Genotype; Hydroxyproline; Mice; Mice, Inbred C57BL; Mice | 2000 |
Co-cultured human mast cells stimulate fibroblast-mediated contraction of collagen gels.
Topics: Animals; Benzimidazoles; Cells, Cultured; Coculture Techniques; Collagen; Extracellular Matrix; Fibr | 2001 |
Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats.
Topics: Actins; Animals; Carbon Tetrachloride; Collagen; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Heart regeneration in adult MRL mice.
Topics: Animals; Biomarkers; Cicatrix; Cold Temperature; Collagen; Collagen Type I; Collagen Type I, alpha 1 | 2001 |
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Body Weight; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen T | 2001 |
Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions.
Topics: Animals; Apoptosis; Eosinophils; Fibrosis; Gene Expression Profiling; Genotype; Hydroxyproline; Infl | 2001 |
Temporary warm ischaemia, 5/6 nephrectomy and single uranyl nitrate administration--comparison of three models intended to cause renal fibrosis in rats.
Topics: Animals; Creatinine; Disease Models, Animal; Female; Fibrosis; Hydroxyproline; Kidney; Nephrectomy; | 2001 |
Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction.
Topics: Animals; Collagen; Dilatation, Pathologic; Disease Models, Animal; Echocardiography; Enzyme Inhibito | 2001 |
Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cell Division; Fibrosis; Heart Ve | 2002 |
CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, CD19; Antigens, Differe | 2002 |
Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart.
Topics: Analysis of Variance; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; | 2002 |
Liposome-entrapped antifibrotic agent prevents collagen accumulation in hypertensive pulmonary arteries of rats.
Topics: Animals; Collagen; Drug Carriers; Fibrosis; Hydroxyproline; Hypertension; Liposomes; Male; Microscop | 1992 |
Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal prop
Topics: Animals; Biomarkers; Carbon Tetrachloride Poisoning; Collagen; Dimethylnitrosamine; Female; Fibrosis | 1992 |
Hydroxyproline in the oesophageal mucosa of patients with progressive systemic sclerosis during omeprazole-induced healing of reflux oesophagitis.
Topics: Adult; Aged; Biopsy; Esophagitis, Peptic; Esophagus; Female; Fibrosis; Humans; Hydroxyproline; Male; | 1991 |
The hydroxyproline content in the lung tissue of young pigs after fractionated irradiation with photons or neutrons.
Topics: Animals; Fibrosis; Hydroxyproline; Lung; Neutrons; Radiation; Radiation Dosage; Radiation Injuries, | 1991 |
Moderate protection of renal function and reduction of fibrosis by colchicine in a model of anti-GBM disease in the rabbit.
Topics: Animals; Basement Membrane; Colchicine; Creatinine; Fibrosis; Glomerulonephritis; Guinea Pigs; Hydro | 1990 |
Protein metabolism and fibrosis in experimental canine obstructive lymphedema.
Topics: alpha-Macroglobulins; Animals; Collagen; Disease Models, Animal; Dogs; Extracellular Space; Fibrosis | 1987 |
Collagen accumulation in heart ventricles as a function of growth and aging.
Topics: Aging; Animals; Collagen; Fibrosis; Heart; Heart Ventricles; Hydroxyproline; Male; Muscle Proteins; | 1989 |
Aortic hypertrophy and "waterlogging" in the development of coarctation hypertension.
Topics: Amino Acids; Animals; Aorta; Aortic Coarctation; Blood Pressure; Body Water; Fibrosis; Hydroxyprolin | 1989 |
An experimental model for studying the desmoplastic response to tumor invasion.
Topics: Animals; Cell Line; Collagen; Female; Fibrosis; Hydroxyproline; Melanoma; Mice; Mice, Inbred C57BL; | 1987 |
Collagen metabolism in mouse lung after X irradiation.
Topics: Animals; Collagen; Fibrosis; Hydroxyproline; Lung; Mice; Protein Biosynthesis; Radiation Injuries, E | 1987 |
Effects of antifibrotic substances on pancreatic fibrosis following acute necrotizing pancreatitis.
Topics: Animals; Azetidinecarboxylic Acid; Azetines; Colchicine; Fibrosis; Hydroxyproline; Male; Pancreas; P | 1986 |
Orosomucoid as the accelerator of hepatic fibrosis.
Topics: Animals; Collagen; Fibrosis; Hydroxyproline; Liver; Liver Diseases; Male; Orosomucoid; Rats; Rats, I | 1986 |