hydroxyproline has been researched along with Brittle Bone Disease in 52 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Excerpt | Relevance | Reference |
---|---|---|
"Recessive mutations that prevent 3-hydroxyproline formation in type I collagen have been shown to cause forms of osteogenesis imperfecta." | 3.77 | Insights on the evolution of prolyl 3-hydroxylation sites from comparative analysis of chicken and Xenopus fibrillar collagens. ( Eyre, DR; Hudson, DM; Weis, M, 2011) |
" The patients were divided into two groups comparable in sex, age, height, and clinical severity of OI; seven patients (three boys) were treated for 12 months with hGH at a dosage of 0." | 1.29 | Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type I collagen synthesis. ( Antoniazzi, F; Bertoldo, F; Mottes, M; Sirpresi, S; Tató, L; Valentini, R; Valli, M; Zamboni, G, 1996) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 38 (73.08) | 18.7374 |
1990's | 6 (11.54) | 18.2507 |
2000's | 5 (9.62) | 29.6817 |
2010's | 3 (5.77) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Yao, X | 1 |
Carleton, SM | 1 |
Kettle, AD | 1 |
Melander, J | 1 |
Phillips, CL | 1 |
Wang, Y | 1 |
Gjaltema, RA | 1 |
Bank, RA | 2 |
Hasegawa, K | 1 |
Kataoka, K | 1 |
Inoue, M | 1 |
Seino, Y | 2 |
Morishima, T | 1 |
Tanaka, H | 1 |
Hudson, DM | 1 |
Weis, M | 1 |
Eyre, DR | 1 |
GOIDANICH, IF | 1 |
LENZI, L | 1 |
SILVA, E | 1 |
Radmer, RJ | 1 |
Klein, TE | 1 |
Ha-Vinh, R | 1 |
Alanay, Y | 1 |
Campos-Xavier, AB | 1 |
Zankl, A | 1 |
Superti-Furga, A | 1 |
Bonafé, L | 1 |
Guillot, PV | 1 |
Abass, O | 1 |
Bassett, JH | 1 |
Shefelbine, SJ | 1 |
Bou-Gharios, G | 1 |
Chan, J | 1 |
Kurata, H | 1 |
Williams, GR | 1 |
Polak, J | 1 |
Fisk, NM | 1 |
Krane, SM | 1 |
Fraser, J | 1 |
Lancaster, GA | 1 |
Scriver, CR | 2 |
Sbyrakis, S | 1 |
Mengreli, C | 1 |
Côté, GB | 1 |
Morakis, A | 1 |
Hata, R | 1 |
Sunada, H | 1 |
Nagai, Y | 1 |
Duterque, M | 1 |
Crouzet, J | 1 |
Kouri, N | 1 |
Nishi, Y | 1 |
Hyodo, S | 1 |
Yoshimitsu, K | 1 |
Sawano, K | 1 |
Yamaoka, K | 1 |
Usui, T | 1 |
Herbage, D | 1 |
Borsali, F | 1 |
Buffevant, C | 1 |
Flandin, F | 1 |
Aguercif, M | 1 |
Smith, R | 3 |
Mainardi, CL | 1 |
Kang, AH | 1 |
Lehmann, HW | 1 |
Rimek, D | 1 |
Bodo, M | 1 |
Brenner, RE | 1 |
Vetter, U | 1 |
Wörsdörfer, O | 1 |
Karbowski, A | 1 |
Müller, PK | 1 |
Minisola, S | 1 |
Piccioni, AL | 1 |
Rosso, R | 1 |
Romagnoli, E | 1 |
Pacitti, MT | 1 |
Scarnecchia, L | 1 |
Mazzuoli, G | 1 |
Antoniazzi, F | 1 |
Bertoldo, F | 1 |
Mottes, M | 1 |
Valli, M | 2 |
Sirpresi, S | 1 |
Zamboni, G | 1 |
Valentini, R | 1 |
Tató, L | 1 |
Scott, JE | 1 |
Dyne, KM | 1 |
Thomlinson, AM | 1 |
Ritchie, M | 1 |
Bateman, J | 1 |
Cetta, G | 1 |
Prockop, DJ | 1 |
Cepollaro, C | 1 |
Gonnelli, S | 1 |
Pondrelli, C | 1 |
Montagnani, A | 1 |
Martini, S | 1 |
Bruni, D | 1 |
Gennari, C | 2 |
Uitto, J | 1 |
Lichtenstein, JR | 1 |
Rico Lenza, H | 2 |
del Río Vázquez, A | 2 |
Serrano Garijo, P | 1 |
Espinós Pérez, D | 2 |
Rosenberg, E | 1 |
Lang, R | 1 |
Boisseau, V | 1 |
Rojanasathit, S | 1 |
Avioli, LV | 1 |
August, GP | 1 |
Shapiro, J | 1 |
Hung, W | 1 |
Lancaster, G | 1 |
Goldman, H | 1 |
Gold, RJ | 1 |
Wong, I | 1 |
Francis, MJ | 2 |
Bauze, RJ | 1 |
Kruse, HP | 2 |
Kuhlencordt, F | 2 |
Gage, JP | 1 |
Whitaker, GE | 1 |
Bonaventure, J | 1 |
Cohen-Solal, L | 1 |
Lasselin, C | 1 |
Allain, JC | 1 |
Maroteaux, P | 1 |
Oxlund, H | 1 |
Pedersen, U | 1 |
Danielsen, CC | 1 |
Oxlund, I | 1 |
Elbrøond, O | 1 |
Castells, S | 2 |
Lu, C | 1 |
Baker, RK | 2 |
Wallach, S | 2 |
Hirthe, D | 2 |
Mühlbach, R | 3 |
Langness, U | 3 |
Behnke, H | 3 |
Kaiser, G | 1 |
Kyselka, R | 2 |
Beck, O | 2 |
Schramm, G | 2 |
Lindenhayn, K | 1 |
Bleckmann, H | 1 |
Kresse, H | 1 |
Wollensak, J | 1 |
Buddecke, E | 1 |
Lozano-Tonkin, C | 1 |
Schneider, C | 1 |
Sommer, E | 1 |
Goldfield, EB | 1 |
Braiker, BM | 1 |
Prendergast, JJ | 1 |
Kolb, FO | 1 |
Eastoe, JE | 1 |
Martens, P | 1 |
Thomas, NR | 1 |
Riley, FC | 1 |
Jowsey, J | 1 |
Brown, DM | 1 |
Inamdar, S | 1 |
Kocher, P | 1 |
Segrest, JP | 1 |
Cunningham, LW | 1 |
Czitober, H | 1 |
Raab, W | 1 |
Rubegni, M | 1 |
Forconi, S | 1 |
Romano, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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The Impact of Topical Prostaglandin Analogs on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma[NCT02388360] | Phase 4 | 35 participants (Actual) | Interventional | 2013-05-06 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
5 reviews available for hydroxyproline and Brittle Bone Disease
Article | Year |
---|---|
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease.
Topics: Animals; Arthrogryposis; Connective Tissue Diseases; Ehlers-Danlos Syndrome; Fibrillar Collagens; Gl | 2017 |
The importance of proline residues in the structure, stability and susceptibility to proteolytic degradation of collagens.
Topics: Amino Acid Sequence; Animals; Collagen; Glycine; Humans; Hydroxyproline; Mice; Models, Biological; M | 2008 |
Collagen and disorders of bone.
Topics: Adolescent; Bone Diseases; Bone Matrix; Collagen; Humans; Hydroxylysine; Hydroxyproline; Osteogenesi | 1980 |
Hopkins Memorial Medal lecture. Pleasant surprises en route from the biochemistry of collagen to attempts at gene therapy.
Topics: Amino Acid Sequence; Animals; Awards and Prizes; Biochemistry; Collagen; Computer Simulation; Geneti | 1999 |
Defects in the biochemistry of collagen in diseases of connective tissue.
Topics: Aortic Diseases; Bone and Bones; Brain Diseases; Collagen; Connective Tissue; Cutis Laxa; Ehlers-Dan | 1976 |
1 trial available for hydroxyproline and Brittle Bone Disease
Article | Year |
---|---|
Effects of synthetic salmon calcitonin in osteogenesis imperfecta.
Topics: Adolescent; Animals; Bone Resorption; Calcitonin; Calcium; Calcium Radioisotopes; Child; Child, Pres | 1974 |
46 other studies available for hydroxyproline and Brittle Bone Disease
Article | Year |
---|---|
Gender-dependence of bone structure and properties in adult osteogenesis imperfecta murine model.
Topics: Animals; Biomechanical Phenomena; Carbonates; Disease Models, Animal; Elastic Modulus; Female; Hydro | 2013 |
Impaired pyridinoline cross-link formation in patients with osteogenesis imperfecta.
Topics: Amino Acids; Case-Control Studies; Child; Child, Preschool; Collagen Type I; Cross-Linking Reagents; | 2008 |
Insights on the evolution of prolyl 3-hydroxylation sites from comparative analysis of chicken and Xenopus fibrillar collagens.
Topics: Amino Acid Motifs; Animals; Binding Sites; Chickens; Collagen; Collagen Type III; Cross-Linking Reag | 2011 |
URINARY HYDROXYPROLINE EXCRETION IN NORMAL SUBJECTS AND IN PATIENTS AFFECTED WITH PRIMARY DISEASES OF BONE.
Topics: Adolescent; Amino Acids; Body Fluids; Bone Diseases; Child; Fibrous Dysplasia of Bone; Fluids and Se | 1965 |
Severity of osteogenesis imperfecta and structure of a collagen-like peptide modeling a lethal mutation site.
Topics: Amino Acid Sequence; Amino Acid Substitution; Collagen; Collagen Type I; Computer Simulation; Genes, | 2004 |
Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2.
Topics: Abnormalities, Multiple; Amino Acid Sequence; Child, Preschool; Collagen; Consanguinity; Contracture | 2004 |
Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.
Topics: Animals; Female; Fetal Stem Cells; Fractures, Bone; Gene Expression Regulation; Humans; Hydroxyproli | 2008 |
Secreted collagen ratios in normal human and osteogenesis imperfecta skin fibroblasts.
Topics: Adolescent; Adult; Age Factors; Cells, Cultured; Child; Child, Preschool; Chromatography, DEAE-Cellu | 1983 |
Vitamin D and related research in osteogenesis imperfecta.
Topics: Alkaline Phosphatase; Calcium; Child; Child, Preschool; Dihydroxycholecalciferols; Diphosphates; Fem | 1982 |
Sodium ion modulates collagen types in human fibroblastic cells in culture.
Topics: Adult; Cells, Cultured; Collagen; Fibroblasts; Humans; Hydroxyproline; Microbial Collagenase; Muscle | 1983 |
[Sclerodermiform lesions in Lobstein's disease].
Topics: Adult; Collagen; Diagnosis, Differential; Female; Humans; Hydroxyproline; Male; Middle Aged; Osteoge | 1984 |
Vitamin D metabolism in osteogenesis imperfecta during calcitonin therapy.
Topics: Adolescent; Alkaline Phosphatase; Calcitonin; Calcitriol; Calcium; Child, Preschool; Female; Humans; | 1984 |
Composition, cross-linking and thermal stability of bone and skin collagens in patients with osteogenesis imperfecta.
Topics: Adolescent; Bone and Bones; Calorimetry, Differential Scanning; Child; Child, Preschool; Collagen; D | 1982 |
Collagen disease: a new perspective.
Topics: Collagen; Collagen Diseases; Ehlers-Danlos Syndrome; Extracellular Space; Genes; Humans; Hydroxylysi | 1981 |
Hydroxylation of collagen type I: evidence that both lysyl and prolyl residues are overhydroxylated in osteogenesis imperfecta.
Topics: Adolescent; Adult; Body Height; Cells, Cultured; Child; Child, Preschool; Collagen; Female; Fibrobla | 1995 |
Reduced serum levels of carboxy-terminal propeptide of human type I procollagen in a family with type I-A osteogenesis imperfecta.
Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Bone Density; Bone Reso | 1994 |
Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type I collagen synthesis.
Topics: Alkaline Phosphatase; Bone Density; Calcium; Child; Child, Preschool; Collagen; Female; Growth; Grow | 1996 |
Human cells unable to express decoron produced disorganized extracellular matrix lacking "shape modules" (interfibrillar proteoglycan bridges).
Topics: Adult; Cells, Cultured; Child, Preschool; Collagen; Decorin; Extracellular Matrix; Extracellular Mat | 1998 |
Osteogenesis imperfecta: bone turnover, bone density, and ultrasound parameters.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Amino Acids; Bone and Bones; Bone Density; Bone | 1999 |
[Osteogenesis imperfecta tarda: the value of the determination of the urinary excretion of hydroxyprolyne (author's transl)].
Topics: Adolescent; Arm; Child; Female; Foot; Hand; Humans; Hydroxyproline; Leg; Male; Osteogenesis Imperfec | 1979 |
Effect of long-term calcitonin therapy on the clinical course of osteogenesis imperfecta.
Topics: Acid Phosphatase; Age Factors; Alkaline Phosphatase; Animals; Calcitonin; Calcium; Child; Child, Pre | 1977 |
Calcitonin therapy of children with osteogenesis imperfecta.
Topics: Adolescent; Animals; Calcitonin; Child, Preschool; Female; Humans; Hydroxyproline; Hypokalemia; Hypo | 1977 |
[Hydroxyprolinuria, index of severity in osteogenesis imperfecta tarda].
Topics: Adolescent; Child; Female; Humans; Hydroxyproline; Male; Osteogenesis Imperfecta; Prognosis | 1978 |
Dominantly inherited osteogenesis imperfecta in man: an examination of collagen biosynthesis.
Topics: Adolescent; Adult; Carbon Radioisotopes; Child; Child, Preschool; Chromatography, Gel; Chromatograph | 1975 |
Osteogenesis imperfecta. A clinical and biochemical study of a generalized connective tissue disorder.
Topics: Adolescent; Adult; Age Factors; Aged; Alkaline Phosphatase; Biopsy; Bone Diseases; Bony Callus; Calc | 1975 |
On an attempt to treat primary and secondary osteoporosis with human growth hormone.
Topics: Adult; Alkaline Phosphatase; Calcium; Follow-Up Studies; Growth Hormone; Humans; Hydroxyproline; Mal | 1975 |
Dentine is biochemically abnormal in osteogenesis imperfecta.
Topics: Amino Acids; Dentin; Glycine; Humans; Hydroxyproline; Lysine; Osteogenesis Imperfecta | 1986 |
Abnormal procollagen synthesis in fibroblasts from three patients of the same family with a severe form of osteogenesis imperfecta (type III).
Topics: Adolescent; Adult; Child; Child, Preschool; Collagen; Electrophoresis, Polyacrylamide Gel; Female; F | 1986 |
Reduced strength of skin in osteogenesis imperfecta.
Topics: Adult; Collagen; Female; Humans; Hydroxyproline; Male; Osteogenesis Imperfecta; Skin; Tensile Streng | 1985 |
[Differential diagnosis of congenital systemic diseases of the skeleton based on biochemical changes in the body fluids].
Topics: Bone Diseases; Calcium; Cystic Fibrosis; Diagnosis, Differential; Glycosaminoglycans; Humans; Hydrox | 1968 |
[Biochemical studies on osteogenesis imperfecta].
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Collagen; Connective Tissue; Female; Femur | 1970 |
[The significance of the excretion of amino acids and acid mucopolysaccharides in the urine in orthopedic diseases].
Topics: Adolescent; Adult; Amino Acids; Bone Diseases; Chromatography, Paper; Collagen; Glycosaminoglycans; | 1969 |
[Glycosaminoglycan and collagen analyses in osteogenesis imperfecta].
Topics: Acetone; Aorta; Autoanalysis; Bone and Bones; Cartilage; Cartilage, Articular; Child, Preschool; Cho | 1971 |
[Does the determination of acid mucopolysaccharides and hydroxyproline contribute to the differential diagnosis of fibrous dysplasia (Jaffé-Lichtenstein) and osteogenesis imperfecta congenita?].
Topics: Diagnosis, Differential; Fibrous Dysplasia of Bone; Fractures, Spontaneous; Glycosaminoglycans; Huma | 1972 |
[Application of growth hormone in osteoporosis (author's transl)].
Topics: Adult; Alkaline Phosphatase; Calcium; Growth Hormone; Humans; Hydroxyproline; Injections, Intramuscu | 1974 |
Synthetic salmon calcitonin. Treatment of Paget's disease and osteogenesis imperfecta.
Topics: Aged; Alkaline Phosphatase; Bone Resorption; Calcitonin; Calcium; Female; Humans; Hydroxyproline; Ma | 1972 |
The amino-acid composition of human hard tissue collagens in osteogenesis imperfecta and dentinogenesis imperfecta.
Topics: Alanine; Amino Acids; Bone and Bones; Child; Collagen; Dentin; Dentinogenesis Imperfecta; Glycine; H | 1973 |
Osteogenesis imperfecta: morphologic and biochemical studies of connective tissue.
Topics: Adolescent; Adult; Biopsy; Bone Regeneration; Bone Resorption; Child; Child, Preschool; Collagen; Co | 1973 |
Effects of porcine calcitonin in osteogenesis imperfecta tarda.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Child, Preschool; Female; Humans; Hydroxyproline; Inj | 1972 |
[Study of urinary hydroxyproline in osteopathies].
Topics: Acromegaly; Adult; Aged; Bone Neoplasms; Female; Humans; Hydroxyproline; Hyperparathyroidism; Hypert | 1966 |
Variations in human urinary O-hydroxylysyl glycoside levels and their relationship to collagen metabolism.
Topics: Achondroplasia; Adolescent; Adult; Aged; Amino Acids; Arthritis, Rheumatoid; Bone and Bones; Bronchi | 1970 |
Collagen metabolites in plasma and urine in osteogenesis imperfecta.
Topics: Adolescent; Adult; Blood Proteins; Child; Collagen; Creatinine; Female; Humans; Hydroxyproline; Male | 1971 |
[Urinary hydroxyproline excretion in generalized bone diseases].
Topics: Adult; Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Bone Diseases; Bone Neoplasms; Female; Hum | 1967 |
[Correlation between hydroxyprolinuria, alkaline phosphatasemia and Ca45 dynamics].
Topics: Adult; Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Female; Humans; Hydroxyproline; Hyperpa | 1965 |
[Hydroxyproline excretion as an index for the evaluation of metabolic bone changes].
Topics: Adult; Animals; Bone Neoplasms; Breast Neoplasms; Child; Female; Humans; Hydroxyproline; Metabolic D | 1966 |
[Hydroxyproline elimination in urine in osteogenesis imperfecta].
Topics: Adolescent; Adult; Child; Child, Preschool; Collagen; Female; Humans; Hydroxyproline; Male; Middle A | 1966 |