hydroxyproline has been researched along with Bone Loss, Osteoclastic in 488 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In 21 patients with breast cancer and TIO, we determined the biochemical effects of a single infusion of pamidronate given at 30 mg (n = 5), 60 mg (n = 5), 90 mg (n = 5), or 120 mg (n = 6)." | 9.08 | Intravenous pamidronate in patients with tumor-induced osteolysis: a biochemical dose-response study. ( Body, JJ; Dumon, JC; Ford, J; Piccart, M, 1995) |
| "The superiority of pamidronate in controlling hypercalcemia is mirrored by the changes observed in these markers." | 9.08 | Evaluation of new bone resorption markers in a randomized comparison of pamidronate or clodronate for hypercalcemia of malignancy. ( Coleman, RE; Eastell, R; Guo, CY; Purohit, OP; Vinholes, J, 1997) |
| "To assess the effects of 3-amino-1-hydroxypropylidine-1,1-bisphosphonate (pamidronate) in rheumatoid arthritis (RA)." | 9.07 | Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. ( Breedveld, FC; Dijkmans, BA; Eggelmeijer, F; Papapoulos, SE; van Paassen, HC, 1994) |
| "Hydroxyproline excretion was increased by hyperthyroid patients." | 9.05 | [Effects of propranolol and indomethacin upon urinary hydroxyproline in hyperthyroid patients (author's transl)]. ( Benzoni, D; Beylot, M; Bodson, A; Mornex, R; Riou, JP; Vincent, M, 1982) |
| "To investigate whether experimental hyperhomocysteinemia (HHCY) can induce adverse changes in bone metabolism." | 7.74 | Experimental hyperhomocysteinemia disturbs bone metabolism in rats. ( Donmez, L; Herrmann, M; Ozdem, S; Sadan, G; Samanci, S; Tasatargil, A; Yildiz, A, 2007) |
| " pamidronate in patients with osteoporosis." | 7.71 | A pharmacokinetic and pharmacodynamic model for intravenous bisphosphonate (pamidronate) in osteoporosis. ( Cremers, S; den, HJ; Hamdy, N; Papapoulos, S; Sparidans, R; Vermeij, P, 2002) |
| "Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics." | 7.70 | Evaluation of the effect of low-dose oral theophylline therapy on some bone turnover markers and serum prolidase I activity in mild asthmatics. ( Büyüköztürk, S; Gürdöl, F; Kolanci, C; Oner, P; Oner-Iyidon, Y, 1999) |
| "Galactosylhydroxylysine appears to be a sensitive index of bone resorption, useful in the clinical assessment of bone involvement and in the management of patients with mild primary hyperparathyroidism." | 7.69 | Effect of bisphosphonate therapy and parathyroidectomy on the urinary excretion of galactosylhydroxylysine in primary hyperparathyroidism. ( Bertoldo, F; Bettica, P; Braga, V; LoCascio, V; Moro, L; Pasini, AF; Stefani, L, 1994) |
| ") infusion of 5 mg alendronate was studied in ten patients with Paget's disease, six patients with primary hyperparathyroidism and ten osteopenic postmenopausal women." | 7.69 | Duration of the effects of intravenous alendronate in postmenopausal women and in patients with primary hyperparathyroidism and Paget's disease of bone. ( Adami, S; Bertoldo, F; Braga, B; Dorizzi, R; Gatti, D; Locascio, V; Mian, M; Rossini, M; Zamberlan, N, 1994) |
| "Fasting urinary hydroxyproline: creatinine ratio (OHPr:Cr) and bone mineral content of the forearm (BMC) were measured in 125 normals, 67 females and 58 males, aged 20-79 years, and in 15 patients with primary hyperparathyroidism." | 7.67 | Bone mass as referent for urinary hydroxyproline excretion: age and sex-related changes in 125 normals and in primary hyperparathyroidism. ( Hyldstrup, L; Jensen, GF; McNair, P; Nielsen, HR; Transbøl, I, 1984) |
| "We administered high doses of calcitriol (up to 32 micrograms per day) to an infant with malignant osteopetrosis, in an attempt to stimulate bone resorption." | 7.67 | Treatment of congenital osteopetrosis with high-dose calcitriol. ( Arceci, R; Bar-Shavit, Z; Carnes, D; Cole, S; Gundberg, C; Holtrop, M; Kahn, A; Key, L; Shapiro, F; Steinberg, J, 1984) |
| "In 37 female patients with primary osteoporosis, urinary hydroxyproline excretion, determined in 18 24-h consecutive complete urine collections was compared with two radioisotopic measurements of bone resorption rate measured simultaneously using 85Sr." | 7.67 | Estimation of whole body bone resorption rate: a comparison of urinary total hydroxyproline excretion with two radioisotopic tracer methods in osteoporosis. ( Deacon, AC; Green, JR; Hesp, R; Hulme, P; Reeve, J; Tellez, M, 1987) |
| "The simple postabsorptive urine hydroxyproline (Spot-HYPRO) with dialyzable and non-dialyzable (ND) fractions was measured in 28 patients with multiple myeloma." | 7.66 | The postabsorptive urinary hydroxyproline (spot-HYPRO) in patients with multiple myeloma. ( Neely, CL; Niell, HB; Palmieri, GM, 1981) |
| "The effect of antithyroid treatment on the disturbed calcium-phosphorus metabolism in hyperthyroidism was studied in 16 patients." | 7.66 | Effect of antithyroid treatment on calcium-phosphorus metabolism in hyperthyroidism. I: Chemical quantities in serum and urine. ( Christensen, MS; Melsen, F; Mosekilde, L; Sørensen, NS, 1978) |
| "Hydroxyproline excretion was increased in both types of diabetes: Type 1: 21 (10-36) (median (IQR) mumol mmol creatinine-1; Type 2: 25 (13-43) mumol mmol creatinine-1; control: 10 (6-22) mumol mmol creatinine-1 (p < 0." | 5.29 | Hydroxyproline excretion is increased in diabetes mellitus and related to the presence of microalbuminuria. ( Marshall, SM; Selby, PL; Shearing, PA, 1995) |
| "daily for 4 weeks." | 5.28 | Buserelin-mediated osteoporosis: effects of restoring estrogen on bone resorption and whole body calcium content in the rat. ( Gold, E; Goulding, A, 1990) |
| "Treatment with ethinyl estradiol or norethindrone reduces the bone-turnover rate and plasma calcium levels in normal postmenopausal women, without affecting the secretion of calcium-regulating hormones." | 5.27 | Ethinyl estradiol and norethindrone in the treatment of primary hyperparathyroidism in postmenopausal women. ( Peacock, M; Selby, PL, 1986) |
| " In 21 patients with breast cancer and TIO, we determined the biochemical effects of a single infusion of pamidronate given at 30 mg (n = 5), 60 mg (n = 5), 90 mg (n = 5), or 120 mg (n = 6)." | 5.08 | Intravenous pamidronate in patients with tumor-induced osteolysis: a biochemical dose-response study. ( Body, JJ; Dumon, JC; Ford, J; Piccart, M, 1995) |
| "The superiority of pamidronate in controlling hypercalcemia is mirrored by the changes observed in these markers." | 5.08 | Evaluation of new bone resorption markers in a randomized comparison of pamidronate or clodronate for hypercalcemia of malignancy. ( Coleman, RE; Eastell, R; Guo, CY; Purohit, OP; Vinholes, J, 1997) |
| "To assess the effects of 3-amino-1-hydroxypropylidine-1,1-bisphosphonate (pamidronate) in rheumatoid arthritis (RA)." | 5.07 | Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. ( Breedveld, FC; Dijkmans, BA; Eggelmeijer, F; Papapoulos, SE; van Paassen, HC, 1994) |
| " Eight of these patients had either hypercalcemia or hypercalciuria, and all 10 had elevated urinary hydroxyproline levels as evidence of active skeletal disease." | 5.05 | Effects of dichloromethylene diphosphonate in women with breast carcinoma metastatic to the skeleton. ( Canfield, RE; Hyman, GA; Siris, ES, 1983) |
| "Hydroxyproline excretion was increased by hyperthyroid patients." | 5.05 | [Effects of propranolol and indomethacin upon urinary hydroxyproline in hyperthyroid patients (author's transl)]. ( Benzoni, D; Beylot, M; Bodson, A; Mornex, R; Riou, JP; Vincent, M, 1982) |
| "To investigate whether experimental hyperhomocysteinemia (HHCY) can induce adverse changes in bone metabolism." | 3.74 | Experimental hyperhomocysteinemia disturbs bone metabolism in rats. ( Donmez, L; Herrmann, M; Ozdem, S; Sadan, G; Samanci, S; Tasatargil, A; Yildiz, A, 2007) |
| " pamidronate in patients with osteoporosis." | 3.71 | A pharmacokinetic and pharmacodynamic model for intravenous bisphosphonate (pamidronate) in osteoporosis. ( Cremers, S; den, HJ; Hamdy, N; Papapoulos, S; Sparidans, R; Vermeij, P, 2002) |
| "This study investigated whether hydroxyproline, deoxypyridinoline, or the carboxyterminal telopeptide of type I collagen could be used as markers to provide evidence of bone resorption during hypocalcemia of dairy cows." | 3.70 | Comparison of bone resorption markers during hypocalcemia in dairy cows. ( Eicher, R; Liesegang, A; Riond, JL; Risteli, J; Sassi, ML; Wanner, M, 1998) |
| "Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics." | 3.70 | Evaluation of the effect of low-dose oral theophylline therapy on some bone turnover markers and serum prolidase I activity in mild asthmatics. ( Büyüköztürk, S; Gürdöl, F; Kolanci, C; Oner, P; Oner-Iyidon, Y, 1999) |
| "Galactosylhydroxylysine appears to be a sensitive index of bone resorption, useful in the clinical assessment of bone involvement and in the management of patients with mild primary hyperparathyroidism." | 3.69 | Effect of bisphosphonate therapy and parathyroidectomy on the urinary excretion of galactosylhydroxylysine in primary hyperparathyroidism. ( Bertoldo, F; Bettica, P; Braga, V; LoCascio, V; Moro, L; Pasini, AF; Stefani, L, 1994) |
| ") infusion of 5 mg alendronate was studied in ten patients with Paget's disease, six patients with primary hyperparathyroidism and ten osteopenic postmenopausal women." | 3.69 | Duration of the effects of intravenous alendronate in postmenopausal women and in patients with primary hyperparathyroidism and Paget's disease of bone. ( Adami, S; Bertoldo, F; Braga, B; Dorizzi, R; Gatti, D; Locascio, V; Mian, M; Rossini, M; Zamberlan, N, 1994) |
| " We compared several new markers of bone turnover in normocalcaemic patients with breast cancer-induced osteolysis before and after a single infusion of the bisphosphonate pamidronate." | 3.69 | Comparative evaluation of markers of bone resorption in patients with breast cancer-induced osteolysis before and after bisphosphonate therapy. ( Body, JJ; Delmas, PD; Dumon, JC; Gineyts, E, 1997) |
| " An evaluation was made of deoxypyridinoline as well as other bone markets, such as alkaline phosphatase, tartrate resistant acid phosphatase, and hydroxyproline in patients with the diagnosis of osteoporosis." | 3.69 | [Deoxypyridinoline and other biochemical markers of bone resorption in distinct pathologies]. ( García Merlo, S; Grijalba Uche, A; Martínez Rodríguez, JL; Palacios Sarrasqueta, M; Rivero Marcotegui, A; Sorbet Zubiría, MJ, 1997) |
| " Alpha, body weight, and serum albumin were all significantly lower in the osteoporotic than in the normal women, and plasma alkaline phosphatase, fasting urinary calcium, sodium, and hydroxyproline were all significantly higher in the osteoporotic than in the normal group." | 3.68 | Calcium absorption in normal and osteoporotic postmenopausal women. ( Horowitz, M; Morris, HA; Need, AG; Nordin, BE; O'Loughlin, PD, 1991) |
| " In young women estrogen-deficiency bone loss is a clinical problem associated with the use of luteinizing hormone releasing hormone (LHRH) agonists, such as buserelin, to treat endometriosis." | 3.68 | Preventive effects of clomiphene citrate on estrogen-deficiency osteopenia elicited by LHRH agonist administration in the rat. ( Fisher, L; Goulding, A, 1991) |
| "Plasma osteocalcin, or plasma bone GLA protein (BGP), total plasma alkaline phosphatase activity and urinary hydroxyproline excretion of twenty-four pregnant dairy cows (thirteen in their first or second pregnancy, i." | 3.68 | Assessment of bone turnover in the dry period of dairy cows by measurement of plasma bone GLA protein, total plasma alkaline phosphatase activity and urinary hydroxyproline. ( Corlett, SC; van Mosel, M, 1990) |
| "Fasting urinary hydroxyproline: creatinine ratio (OHPr:Cr) and bone mineral content of the forearm (BMC) were measured in 125 normals, 67 females and 58 males, aged 20-79 years, and in 15 patients with primary hyperparathyroidism." | 3.67 | Bone mass as referent for urinary hydroxyproline excretion: age and sex-related changes in 125 normals and in primary hyperparathyroidism. ( Hyldstrup, L; Jensen, GF; McNair, P; Nielsen, HR; Transbøl, I, 1984) |
| "We administered high doses of calcitriol (up to 32 micrograms per day) to an infant with malignant osteopetrosis, in an attempt to stimulate bone resorption." | 3.67 | Treatment of congenital osteopetrosis with high-dose calcitriol. ( Arceci, R; Bar-Shavit, Z; Carnes, D; Cole, S; Gundberg, C; Holtrop, M; Kahn, A; Key, L; Shapiro, F; Steinberg, J, 1984) |
| " Accordingly, we have studied the bone resorptive activity of highly enriched populations of isolated chicken osteoclasts, using as substrate devitalized rat bone which had been labeled in vivo with L-[5-3H]proline or 45Ca, and bone-like matrix produced and mineralized in vitro by osteoblast-like rat osteosarcoma cells." | 3.67 | Isolated osteoclasts resorb the organic and inorganic components of bone. ( Blair, HC; Crouch, EC; Jeffrey, JJ; Kahn, AJ; Teitelbaum, SL, 1986) |
| "In 37 female patients with primary osteoporosis, urinary hydroxyproline excretion, determined in 18 24-h consecutive complete urine collections was compared with two radioisotopic measurements of bone resorption rate measured simultaneously using 85Sr." | 3.67 | Estimation of whole body bone resorption rate: a comparison of urinary total hydroxyproline excretion with two radioisotopic tracer methods in osteoporosis. ( Deacon, AC; Green, JR; Hesp, R; Hulme, P; Reeve, J; Tellez, M, 1987) |
| " The additional Ca appearing in the urine during acidosis ultimately reflected augmented net bone resorption since daily urinary hydroxyproline excretion was increased from 0." | 3.67 | The importance of renal net acid excretion as a determinant of fasting urinary calcium excretion. ( Cheung, HS; Gray, RW; Lemann, J; Maierhofer, WJ, 1986) |
| "We have studied some effects of small doses of 1,25-dihydroxycalciferol (calcitriol) and calcium, either combined or separately, in 45 patients with osteoporosis and malabsorption of calcium." | 3.67 | 1,25-Dihydroxycalciferol and calcium therapy in osteoporosis with calcium malabsorption. Dose response relationship of calcium absorption and indices of bone turnover. ( Horowitz, M; Need, AG; Nordin, BE; Philcox, JC, 1985) |
| "The simple postabsorptive urine hydroxyproline (Spot-HYPRO) with dialyzable and non-dialyzable (ND) fractions was measured in 28 patients with multiple myeloma." | 3.66 | The postabsorptive urinary hydroxyproline (spot-HYPRO) in patients with multiple myeloma. ( Neely, CL; Niell, HB; Palmieri, GM, 1981) |
| "The effect of antithyroid treatment on the disturbed calcium-phosphorus metabolism in hyperthyroidism was studied in 16 patients." | 3.66 | Effect of antithyroid treatment on calcium-phosphorus metabolism in hyperthyroidism. I: Chemical quantities in serum and urine. ( Christensen, MS; Melsen, F; Mosekilde, L; Sørensen, NS, 1978) |
| "Cows fed a balanced diet with the required amounts of calcium and phosphorus developed acute hypocalcemia and hypophosphatemia shortly after parturition, even in the presence of the a responsive parathyroid gland, when bone resorption was selectively inhibited by the prepartal administration of disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP)." | 3.65 | Experimental parturient hypocalcemia in cows following prepartal chemical inhibition of bone resportion. ( Black, HE; Capen, CC; Geho, WB; Potts, JT; Re, R; Yarrington, JT, 1976) |
| "Dietary intakes, 24-h urinary calcium, bone resorption (urinary hydroxyproline) and formation (serum osteocalcin) biomarkers were examined at the gestational age of 20 and 34 weeks, and 6 weeks PP." | 2.76 | Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail. ( Chen, YM; Liu, Z; Qiu, L; Su, YX, 2011) |
| "With regard to bone resorption markers, at day 7, both N 25 mg and 50 mg compared to placebo significantly decreased NTx (p<0." | 2.70 | Single infusion of neridronate (6-amino-1-hydroxyhexylidene-1,1-bisphosphonate) in patients with active rheumatoid arthritis: effects on disease activity and bone resorption markers. ( Bulleri, M; Di Munno, O; Giordani, R; Mazzantini, M; Metelli, MR, 2002) |
| "A rapid and significant suppression of bone resorption was observed in all patients after intravenous treatment." | 2.69 | Effects of the bisphosphonate olpadronate in patients with carcinoma of the prostate metastatic to the skeleton. ( Hamdy, NA; Lycklama à Nijeholt, AA; Papapoulos, SE; Pelger, RC; Zwinderman, AH, 1998) |
| " The modes of prevention might be found in the use of modern pharmacotherapy of osteoporosis and from correctly dosage physical training." | 2.69 | Bone mineral status after pediatric spinal cord injury. ( Alaranta, H; Kannisto, M; Kärkkäinen, J; Kröger, H; Merikanto, J, 1998) |
| "The laboratory methods for urinary bone resorption markers were enzyme immunoassays (EIA) for urinary pyridoline (PYD) and deoxypyridoline crosslinks (DPD), and for cross-linked N-telopeptides of Type I Collagen (NTx), and an HPLC assay for urinary hydroxyproline (HOP)." | 2.69 | Urinary bone resorption markers in monitoring treatment of symptomatic osteoporosis. ( Alhava, E; Arnala, I; Jääskeläinen, K; Kröger, H; Parviainen, MT, 1999) |
| "Gallium nitrate is a potent antiresorptive drug that has been extensively tested in patients with accelerated bone turnover." | 2.68 | A multicenter trial of low dose gallium nitrate in patients with advanced Paget's disease of bone. ( Bitton, R; Bockman, RS; Bosco, BJ; Chausmer, A; Eyre, DR; Kotler, J; Levenson, D; Singer, F; Siris, E; Wilhelm, F, 1995) |
| "Calcitriol treatment had no effect on biochemical markers of bone resorption [serum C-terminal telopeptide of type I collagen (ICTP) and fasting urinary excretion of hydroxyproline/creatinine (OHP)]." | 2.68 | Dose-response effect of short-term calcitriol treatment on bone and mineral metabolism in normal males. ( Bollerslev, J; Gram, J; Junker, P; Nielsen, HK, 1996) |
| "Triiodothyronine (T3) was administered to the two groups as 20 micrograms doses three times daily for 7 days." | 2.68 | Skeletal responsiveness to thyroid hormone is not altered at menopause. ( Charles, P; Eriksen, EF; Langdahl, BL; Loft, AG; Mosekilde, L; Møller, N; Weeke, J, 1996) |
| "SAP and two markers of bone resorption, 24-hour urinary hydroxyproline/creatinine excretion (OHP) and 24-hour urinary calcium/creatinine excretion, were measured at baseline, 24 hours postinfusion (day 1) and on postinfusion days 3, 7, 10, and 14." | 2.68 | Antiresorptive effect of a single infusion of microgram quantities of zoledronate in Paget's disease of bone. ( Arden-Cordone, M; Knieriem, A; Lyles, KW; Newton, RA; Schaffer, V; Siris, ES; Zelenakas, K, 1997) |
| "Internally, bone resorption was significantly reduced at both measurement points: -64 and -60 mg/day at 4 weeks, and -82 and -162 mg/day at 31 weeks for raloxifene and estrogen, respectively." | 2.68 | Raloxifene and estrogen: comparative bone-remodeling kinetics. ( Draper, MW; Heaney, RP, 1997) |
| "We observed that BMD in IDDM patients before 40 years old was significantly lower than in healthy subject." | 2.68 | [Bone mineralization in insulin-dependent diabetes mellitus]. ( Goliat, E; Lipińska, A; Marusza, W; Ostrowski, K, 1997) |
| "Markers of bone resorption-fasting urinary hydroxyproline/creatinine and calcium/creatinine ratios - and of bone formation-serum alkaline phosphatase and osteocalcin-were determined initially, before the start of treatment and thereafter twice weekly (a total of 17 assessments for each women) during the 8-week treatment period." | 2.67 | Effect of two different progestins (cyproterone acetate and norgestrel), administered in a cyclical estradiol valerate regimen, on markers of bone turnover. ( Balint-Perić, L; Beljić, T; Elliesen, J; Petrović, J; Prelević, GM, 1994) |
| "The results suggest that bone resorption is reduced, although bone density in the distal radius is not significantly increased in young women using an oral contraceptive containing only 20 mcg ethinylestradiol for one year." | 2.67 | Bone metabolism in young women taking a monophasic pill containing 20 mcg ethinylestradiol: a prospective study. ( Ajossa, S; Fruzzetti, F; Guerriero, S; Mais, V; Melis, GB; Paoletti, AM, 1993) |
| "This weight reduction was obtained by a nutritionally adequate very-low-calorie diet." | 2.67 | Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction. ( Andersen, T; Breum, L; Hyldstrup, L; McNair, P; Transbøl, I, 1993) |
| "Significant increases in bone resorption markers were only seen at the end of the 28 d of injections, but were < 100% over baseline values, (P < 0." | 2.67 | An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. ( Adachi, JD; Fraher, LJ; Hodsman, AB; Ostbye, T; Steer, BM, 1993) |
| "Biochemical parameters reflecting bone resorption [urinary calcium/creatinine (Ca/Cr) and hydroxyproline/creatinine (OH/Cr)] were related to serum estrogens [estrone (E1) and estradiol (E2)] in 262 healthy women including 158 patients receiving estrogen replacement therapy (ERT) for at least 6 months, 49 eugonadal women, and 55 untreated postmenopausal women." | 2.67 | Minimal levels of serum estradiol prevent postmenopausal bone loss. ( Albert, A; Deroisy, R; Franchimont, P; Gaspard, U; Reginster, JY; Sarlet, N, 1992) |
| " The knowledge derived from this study could be adapted to the dosage schedule in long-term trials in osteoporosis." | 2.67 | Synthetic human calcitonin in postmenopausal osteoporosis: a placebo-controlled, double-blind study. ( Gärdsell, P; Johnell, O; Larsson, K; Lindh, E; Ljunghall, S; Obrant, K; Sernbo, I, 1991) |
| "Osteoclastic bone resorption, evaluated by urinary hydroxyproline excretion, was not stimulated in either group." | 2.67 | Short-term course of 1,25(OH)2D3 stimulates osteoblasts but not osteoclasts in osteoporosis and osteoarthritis. ( Bouillon, R; Dequeker, J; Devos, P; Geusens, P; Vanderschueren, D; Verstraeten, A, 1991) |
| "Treatment with gallium nitrate (100 mg/m2 daily for 5 days, intravenously in 5% glucose) significantly reduced serum calcium, serum phosphate, urinary calcium, and the ratio of maximum tubular reabsorption of phosphate to glomerular filtration rate in each patient." | 2.67 | Use of gallium to treat Paget's disease of bone: a pilot study. ( Apseloff, G; Gerber, N; Matkovic, V; Shepard, DR, 1990) |
| "Women with increased bone resorption induced by bilateral oophorectomy 1-5 years previously (of a total of 48 women in the study, 20 were controls, and 28 were the treatment group) were studied during a 3 year follow-up." | 2.66 | Prospective trial of ossein-hydroxyapatite compound in surgically induced postmenopausal women. ( Pacovský, V; Pospíchal, J; Presl, J; Stĕpán, JJ, 1989) |
| " At the dosage used (2." | 2.65 | Prospective double-blind trial of synthetic steroid (Org OD 14) for preventing postmenopausal osteoporosis. ( Hart, DM; Kraszewski, A; Lindsay, R, 1980) |
| "Biochemical markers of bone resorption that reflect osteoclast activity and/or collagen degradation provide a new and potentially important clinical tool for the assessment and monitoring of bone metabolism." | 2.42 | Urine products of bone breakdown as markers of bone resorption and clinical usefulness of urinary hydroxyproline: an overview. ( Karaca, I; Karacaer, O; Simsek, B, 2004) |
| "Biochemical markers of bone resorption and bone formation are abnormally raised in the blood and urine of patients with metastatic bone disease." | 2.41 | Biochemical markers and skeletal metastases. ( Costa, L; Demers, LM; Lipton, A, 2000) |
| "Markers of bone resorption are sensitive to changes in bone turnover induced by treatment." | 2.41 | Markers of bone turnover in bone metastases. ( Delmas, PD; Fontana, A, 2000) |
| "With respect to bone resorption, the measurement of urinary pyridinoline cross-links seems to be the most reliable assay." | 2.39 | Biochemical markers of bone turnover: an update. ( Birkenhäger, JC; Pols, HA; van Daele, PL, 1994) |
| "Assessment of bone resorption can be achieved with measurement of urinary hydroxyproline, urinary excretion of the pyridinium crosslinks (Pyr and D-Pyr), and by measurement of plasma TRAP activity." | 2.38 | What do we know about biochemical bone markers? ( Delmas, PD, 1991) |
| "Amongst the bone resorption markers studied are: 1) Calcium/creatinine urinary quotient; 2) Tartrate resistant acid phosphatase; 3) Urinary hydroxyproline; 4) Other substance derived from collagen disruption such as hydroxylysine glycoside, piridinolinic intermolecular bridges and the enzymatic activity of proline iminopeptidase." | 2.38 | [Usefulness of bone remodelling biochemical markers in the diagnosis and follow-up of Paget's bone disease, primary hyperparathyroidism, tumor hypercalcemia, and postmenopausal osteoporosis. II. Bone resorption markers]. ( de la Piedra Gordo, C; Torres Jiménez, R, 1990) |
| "The menopause is associated with a rise in obligatory urinary calcium loss resulting from an increase in the filtered load of calcium which may be due to the complexed fraction." | 2.37 | Calcium and osteoporosis. ( Horowitz, H; Morris, HA; Need, AG; Nordin, BE; Polley, KJ, 1988) |
| "In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum." | 1.42 | Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows. ( Devkota, B; Osawa, T; Sasaki, K; Sato, S; Takahashi, M; Ueki, A; Yamagishi, N, 2015) |
| "Curcumin is a potent inhibitor of the transcription factor activator protein-1 which plays an essential role in osteoclastogenesis." | 1.35 | Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. ( Hie, M; Tsukamoto, I; Yamazaki, M, 2009) |
| "Tibolone is successful in decreasing of bone resorption markers (urinary Hyp and calcium), but has no effect on reversing the impact of menopause on plasma TNFalpha, as well as IL-4, IL-10, IL-12." | 1.33 | Effects of menopause and postmenopausal tibolone treatment on plasma TNFalpha, IL-4, IL-10, IL-12 cytokine pattern and some bone turnover markers. ( Akgul, C; Canbaz, M; Vural, P, 2006) |
| "These changes are due to bone resorption based on bedridden patients' atrophy." | 1.31 | Free 4-hydroxyproline content in serum of bedridden aged people is elevated due to fracture. ( Koike, K; Li, Y; Sakurada, I; Seo, M; Tezuka, K; Uchikawa, K; Uchikura, K, 2000) |
| "m." | 1.31 | Effects of dose and timing of calcium supplementation on bone resorption in early menopausal women. ( Horowitz, M; Morris, HA; Need, AG; Nordin, BE; Scopacasa, F; Wishart, JM, 2002) |
| "Seventy patients with calcium nephrolithiasis and idiopathic hypercalciuria, 19 to 64 years old, were assessed for spine and femur mineral metabolism and bone density using a Dexa evaluation system." | 1.31 | Bone alterations in patients with idiopathic hypercalciuria and calcium nephrolithiasis. ( Bernardi, C; Cacciola, A; Ferrarese, P; Giannini, S; Ioverno, E; Nobile, M; Tasca, A; Visonà, E, 2002) |
| "Osteoporosis is a common disease among patients undergoing transplantation." | 1.30 | Reduction of bone mass in women after bone marrow transplantation. ( Arranz, R; Carmona, L; Carvajal, I; Castañeda, S; Díaz, A; García-Vadillo, A, 1997) |
| "These values indicated increased bone resorption." | 1.30 | [Interrelations of the calcium concentration in breast milk with maternal intake of cow's milk and milk products, bone resorption and bone mineral density during lactation]. ( Ikeda, J; Nagata, H; Yoneyama, K, 1997) |
| "Among the bone resorption markers, serum ICTP and urinary PYR, DPYR, HYP, NTX, and CTX levels were significantly higher in patients than in controls." | 1.30 | Collagen-related markers of bone turnover reflect the severity of liver fibrosis in patients with primary biliary cirrhosis. ( Alvarez, L; Ballesta, AM; Guañabens, N; Martínez de Osaba, MJ; Monegal, A; Parés, A; Peris, P; Rodés, J, 1998) |
| "Diurnal variations in the excretion of bone resorption markers were assessed in order to identify the type of urine collection which provides the most information on bone resorption rate and its relation to measuring bone dynamics in a postmenopausal population." | 1.30 | A proposal for standardizing urine collections for bone resorption markers measurement. ( Bernardi, D; Bonato, P; Plebani, M; Ujka, F; Zaninotto, M, 1998) |
| "6." | 1.30 | Alterations of bone turnover and bone mass at different skeletal sites due to pure glucocorticoid excess: study in eumenorrheic patients with Cushing's syndrome. ( Cammisa, M; Carnevale, V; Chiodini, I; Di Giorgio, A; Fusilli, S; Guglielmi, G; Liuzzi, A; Minisola, S; Modoni, S; Pileri, M; Scillitani, A; Torlontano, M; Trischitta, V, 1998) |
| "The urinary excretion of bone resorption markers was tested using different assays." | 1.30 | Comparison of urinary bone resorption markers in women of 40-70 years; day-to-day and long-term variation in individual subjects. ( Gerrits, MI; Oldenhave, A; Thijssen, JH; Vecht-Hart, IM, 1998) |
| "The renal bone disease which develops in chronic renal failure (CRF) is not an uniform disorder." | 1.30 | Investigations of bone turnover in renal osteopathy. ( Hein, G; Lehmann, G; Müller, A; Stein, G, 1999) |
| "The long-term effects of high bone resorption on blood ionized calcium and calciotropic hormone levels following oophorectomy in 6-month-old Sprague-Dawley female rats were investigated." | 1.30 | Ionized calcium and bone turnover in the estrogen-deficient rat. ( Morris, HA; Schulz, SR, 1999) |
| "Among bone resorption markers in postmenopausal women, urinary beta-CTX, alpha-CTX, NTX, and serum CTX showed the highest proportion of increased values (100%, 67%, 58%, 58%, respectively) as well as the greatest mean percent increase." | 1.30 | Biochemical markers of bone turnover after surgical menopause and hormone replacement therapy. ( Alvarez, L; Ballesta, AM; Durán, M; Echevarría, M; Guañabens, N; Martínez de Osaba, MJ; Monegal, A; Muñoz-Gómez, J; Peris, P; Pons, F, 1999) |
| "These results suggest that increase in bone resorption could occur during relatively short stay in microgravity." | 1.30 | Changes in urinary excretion of pyridinium cross-links during Spacelab-J. ( Itoh, T; Kambe, F; Matsui, N; Mohri, M; Murata, Y; Ohmori, S; Sekiguchi, C; Seo, H, 1997) |
| "The present open study included 16 prostate cancer patients who had painful bone metastases and who had failed hormonal therapy." | 1.29 | The effect of combined intravenous and oral clodronate treatment on bone pain in patients with metastatic prostate cancer. ( Kylmälä, T; Lindholm, TS; Seppänen, J; Tammela, TL, 1994) |
| "There was a transient further rise in bone resorption for the 10 years following menopause." | 1.29 | The effects of menopause and age on calcitropic hormones: a cross-sectional study of 655 healthy women aged 35 to 90. ( Criddle, A; Devine, A; Dick, I; Garcia-Webb, P; Gutteridge, DH; Kerr, D; Price, RI; Prince, RL; St John, A, 1995) |
| "Hydroxyproline excretion was determined in urine samples from 76 women more than 5 years post-menopause." | 1.29 | A simple and automated HPLC method for determination of total hydroxyproline in urine. Comparison with excretion of pyridinolines. ( Brazier, M; Castelain, S; Desmet, G; Kamel, S; Picard, C; Sebert, JL, 1995) |
| "All the urinary markers of bone resorption showed a prompt decline after bisphosphonates, with maximum reductions after 7-14 days: Pyr decreased by 43% +/- 9% and 42% +/- 22% (mean +/- SD), respectively in osteoporotic and pagetic subjects, OHP by 51% +/- 14% and 51% +/- 20%, and NTx by 55% +/- 15% and 65% +/- 26%." | 1.29 | Acute effects of bisphosphonates on new and traditional markers of bone resorption. ( Alfano, FS; Basini, G; Campanini, C; Fantuzzi, M; Gatti, C; Girasole, G; Passeri, M; Pedrazzoni, M, 1995) |
| "Pb-stimulated bone resorption was inhibited by indomethacin and flurbiprofen." | 1.29 | Stimulative effects of lead on bone resorption in organ culture. ( Hayashi, T; Ito, Y; Komiyama, H; Kozuka, H; Miyahara, T; Miyanishi, A; Nagai, M; Odake, H; Takata, M; Yamamoto, M, 1995) |
| "Hydroxyproline excretion was increased in both types of diabetes: Type 1: 21 (10-36) (median (IQR) mumol mmol creatinine-1; Type 2: 25 (13-43) mumol mmol creatinine-1; control: 10 (6-22) mumol mmol creatinine-1 (p < 0." | 1.29 | Hydroxyproline excretion is increased in diabetes mellitus and related to the presence of microalbuminuria. ( Marshall, SM; Selby, PL; Shearing, PA, 1995) |
| " Accordingly, definite dose-response studies can now be done in a reasonable time." | 1.29 | Biochemical markers of bone turnover for the clinical assessment of bone metabolism. ( Baylink, DJ; Libanati, C; Lueken, SA; Taylor, AK, 1994) |
| "Calcium supplementation decreases bone resorption and retards bone loss in women." | 1.29 | Oral calcium suppresses biochemical markers of bone resorption in normal men. ( Goh, D; Horowitz, M; Morris, HA; Need, AG; Nordin, BE; Wishart, JM, 1994) |
| "Markers of bone resorption were total urinary hydroxyproline, total and free pyridinoline and deoxypyridinoline cross-links, type I collagen cross-linked N-telopeptides, and serum C-terminal cross-linked telopeptide." | 1.29 | The short-term effects of conjugated estrogen on bone turnover in older women. ( Burleson, JA; Deftos, LJ; Delmas, PD; Pilbeam, CC; Prestwood, KM; Raisz, LG; Woodiel, FN, 1994) |
| "Omeprazole is an inhibitor of gastric H+,K(+)-ATPase." | 1.29 | Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans. ( Abe, K; Furukawa, Y; Katano, K; Mizunashi, K, 1993) |
| " Therapeutic regimens are largely based on pharmacodynamic information because of difficulties in obtaining and interpreting pharmacokinetic data." | 1.29 | Use of a rat model for the simultaneous assessment of pharmacokinetic and pharmacodynamic aspects of bisphosphonate treatment: application to the study of intravenous 14C-labeled 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate. ( Koopmans, SJ; Löwik, CW; Papapoulos, SE; van der Wee-Pals, L, 1994) |
| "The rate and degree of suppression of bone resorption were monitored in 6 of the patients similarly treated with intravenous dimethyl-APD at a dose of 4 mg/day for 10 days, by daily measurements of the 24 h urinary excretion of Pyr, Dpyr and OHP." | 1.29 | Urinary collagen crosslink excretion: a better index of bone resorption than hydroxyproline in Paget's disease of bone? ( Colwell, A; Eastell, R; Hamdy, NA; Papapoulos, SE; Russell, RG, 1993) |
| "Hydroxyproline (HYP) is an amino acid which is highly specific for bone collagen." | 1.29 | Reevaluation of the usefulness of serum free hydroxyproline as a parameter for assessing renal osteodystrophy. ( Uehara, H, 1993) |
| "Hydroxyproline was also measured." | 1.29 | Biochemical markers for detecting bone metastases in patients with breast cancer. ( Crivellari, D; de Bernard, B; Galligioni, E; Gazzarrini, C; Moro, L; Talamini, R, 1993) |
| "In these patients with active RA, bone resorption was increased, while bone formation was within normal limits." | 1.29 | Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis. ( Bijlsma, JW; Gerrits, MI; Jacobs, JW; Lems, WF; van Rijn, HJ; van Vugt, RM, 1996) |
| "In summary, increased bone resorption occurs after OLT with persistent decreased bone formation, leading to vertebral fracture in 25% of patients." | 1.29 | Bone loss after liver transplantation is not prevented by cyclical etidronate, calcium and alphacalcidol. The Liver Transplant Group, Groningen. ( Drent, G; Groen, EW; Haagsma, EB; Meerman, L; Oostdijk, A; Piers, DA; Riemens, SC; Slooff, MJ; Thijn, CJ; van Doormaal, JJ, 1996) |
| "The diagnostic criterion for postmenopausal osteoporosis was a bone mineral density (BMD) (Hologic QDR-1000) in lumbar spine and/or femoral neck more than 2 SD below the mean value corresponding to an age- and sex-matched healthy control group." | 1.29 | New biochemical markers of bone resorption derived from collagen breakdown in the study of postmenopausal osteoporosis. ( de la Piedra, C; Diaz Diego, EM; Diaz Martin, MA; Disla, T; Guerrero, R; Rapado, A, 1996) |
| "The changes, however, in bone resorption and formation after bisphosphonate therapy are predictable, and their correct interpretation may allow a rational therapeutic approach applicable to the individual patient." | 1.29 | Prediction of the outcome of treatment of Paget's disease of bone with bisphosphonates from short-term changes in the rate of bone resorption. ( Frölich, M; Papapoulos, SE, 1996) |
| "Hydroxyproline was measured in an early morning urine sample, after one day of diet without meat or gelatin." | 1.29 | [Effects of hormone replacement therapy in bone resorption, in post-menopausal women]. ( Arteaga, E; Campusano, C; López, JM; Nazar, G; O'Brien, A; Rojas, A; Villaseca, P, 1996) |
| "Transient increased bone resorption followed by bone formation during the course of TH can not be ruled out, but this has no negative impact on BMD." | 1.29 | Bone and mineral metabolism in transient hyperphosphatasaemia. ( Bayer, M; Kutílek, S; Stĕpán, JJ, 1994) |
| "4." | 1.28 | Whole-body and site-specific bone remodelling in patients with previous femoral fractures: relationships between reduced physical activity, reduced bone mass and increased bone resorption. ( Bradbeer, JN; Green, JR; Hesp, R; Reeve, J; Smith, T; Wand, JS, 1992) |
| "The major mechanism of bone loss in myelomatosis is increased osteoclastic resorption but decreased bone formation contributes to bone loss with heavy plasma cell burdens." | 1.28 | Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. ( Beneton, MN; Greaves, M; Kanis, JA; McCloskey, EV; Rogers, S; Taube, T, 1992) |
| "Short courses of prednisolone increased bone resorption and inhibited bone formation after two and four weeks." | 1.28 | Bone turnover during short course prednisolone treatment in patients with chronic obstructive airways disease. ( Ali, NJ; Capewell, S; Morrison, D; Routledge, PA, 1992) |
| "Tamoxifen citrate is an estrogen agonist/antagonist which protects the skeleton from osteopenia when ovarian hormones are depleted." | 1.28 | Tamoxifen in the rat prevents estrogen-deficiency bone loss elicited with the LHRH agonist buserelin. ( Feng, W; Gold, E; Goulding, A, 1992) |
| "The hydroxyproline data were consistent with the suggestion arising from the bone formation data that remodelling declines progressively after menopause in the controls but not in the vertebral fracture patients." | 1.28 | Bone remodelling does not decline after menopause in vertebral fracture osteoporosis. ( Bradbeer, JN; Green, JR; Hampton, L; Hesp, R; Reeve, J; Sambrook, PN; Smith, T; Wand, JS; Zanelli, JM, 1992) |
| "In conclusion, the further increase in bone resorption by thyroid hormone is predisposed by menopausal changes in bone turnover." | 1.28 | Biochemical assessment of bone loss in patients on long-term thyroid hormone treatment. ( Límanová, Z; Stĕpán, JJ, 1992) |
| "The influence of chlorthalidone on bone resorption in immobilized patients treated with mechanical ventilation was studied." | 1.28 | Effects of chlorthalidone and mechanical ventilation on hydroxyprolinuria during immobilization by means of muscle relaxants. ( Duursma, SA; Sangster, B; van Heijst, AN; van Kesteren, RG, 1991) |
| "Significant osteopenia was present only in group 3 (P less than 0." | 1.28 | 17 beta-estradiol protects rats from osteopenia associated with administration of the luteinising hormone releasing hormone (LHRH) agonist, buserelin. ( Fisher, L; Goulding, A, 1991) |
| "Parameters of bone resorption (urinary hydroxyproline/creatinine ratio, serum acid phosphatase) and the levels of vitamin D metabolites remained unchanged." | 1.28 | The course of biochemical parameters of bone turnover during treatment with corticosteroids. ( Lips, P; Prummel, MF; Sanders, GT; Sauerwein, HP; Wiersinga, WM, 1991) |
| "Parameters reflecting bone resorption in od/od rats were reduced in the distal femoral metaphysis, but were similar to those of controls in the tail vertebrae." | 1.28 | Bone histomorphometric analysis for the cause of osteopenia in vitamin C-deficient rat (ODS rat). ( Fujita, T; Fukase, M; Tsunenari, T, 1991) |
| "daily for 4 weeks." | 1.28 | Buserelin-mediated osteoporosis: effects of restoring estrogen on bone resorption and whole body calcium content in the rat. ( Gold, E; Goulding, A, 1990) |
| "Static and dynamic parameters of bone resorption and formation were determined." | 1.28 | Trabecular bone remodeling and bone mineral density in the adult cat during chronic dietary acidification with ammonium chloride. ( Ching, SV; Fettman, MJ; LeCouteur, RA; Norrdin, RW, 1990) |
| "Treated rats had decreased bone resorption: urinary hydroxyproline, plasma acid phosphatase, and the number of osteoclasts in caudal vertebrae were significantly reduced." | 1.28 | Cyclosporin A induces in vivo inhibition of resorption and stimulation of formation in rat bone. ( Bielakoff, J; de Vernejoul, MC; Miravet, L; Modrowski, D; Orcel, P, 1989) |
| "Therefore the pathogenesis of osteopenia in type 1 DM remains unclear, and requires further investigation." | 1.28 | Study of bone loss in diabetes mellitus type 1. ( Hawkins, F; Larrodera, L; Leon, M; Lledo, G, 1989) |
| "The biochemical indices of bone resorption (urinary hydroxyproline excretion and plasma tartrate-resistant acid phosphatase activity), as well as osteoblastic function (serum osteocalcin and bone alkaline phosphatase isoenzyme), were significantly increased in untreated and insufficiently treated patients compared with treated patients." | 1.28 | Bone demineralization, biochemical indices of bone remodeling, and estrogen replacement therapy in adults with Turner's syndrome. ( Musilová, J; Pacovský, V; Stĕpán, JJ, 1989) |
| "Biochemical evaluation showed that bone resorption from metastatic disease was generally not enough to account for hypercalcaemia." | 1.27 | Relative contribution of humoral and metastatic factors to the pathogenesis of hypercalcaemia in malignancy. ( Boyle, IT; Fogelman, I; Gardiner, MD; Ralston, SH, 1984) |
| "Ours results indicate an increase of bone resorption as a cause of postmenopausal osteoporosis." | 1.27 | Lack of hormonal changes in postmenopausal women of equal weight with and without osteoporosis, including relation to time of menopause. ( Bordiu, E; Charro, A; Depablos, I; Espinos, D; Hernandez, ER; Rico, H, 1984) |
| "This was associated with a decrease in bone resorption as judged by decreases in urinary excretion of hydroxyproline and calcium." | 1.27 | Treatment of the hypercalcaemia of malignancy with intravenous clodronate. ( Gray, RE; Greaves, M; Hamdy, NA; Kanis, JA; McCloskey, EV; Neil, FE; Preston, FE; Urwin, GH; Yates, AJ, 1987) |
| "Bone resorption was monitored by measuring urinary hydroxyproline excretion." | 1.27 | Effects of NaCl on calcium balance, parathyroid function and hydroxyproline excretion in prednisolone-treated rats consuming low calcium diet. ( Goulding, A; McIntosh, J, 1986) |
| "Sodium chloride loads induce osteopenia in the rat." | 1.27 | Effects of dietary NaCl supplementation on bone synthesis of hydroxyproline, urinary hydroxyproline excretion and bone 45Ca uptake in the rat. ( Gold, E; Goulding, A, 1988) |
| "However, ovariectomy increased bone resorption and induced osteopenia whereas prednisolone decreased bone resorption and formation and caused osteopenia." | 1.27 | Effects of chronic prednisolone treatment on bone resorption and bone composition in intact and ovariectomized rats and in ovariectomized rats receiving beta-estradiol. ( Gold, E; Goulding, A, 1988) |
| "Bone resorption was stimulated by 0." | 1.27 | Effects of hypervitaminosis A on the bone and mineral metabolism of the rat. ( Avioli, LV; Bergfeld, MA; Gelderblom, D; Hough, S; Jenkins, G; Kurasi, H; Muir, H; Slatopolsky, E; Teitelbaum, SL, 1988) |
| "The prevalence of bone resorption relative to bone formation was evident even 12 years after oophorectomy, indicating continuous imbalance of bone remodeling in the patients." | 1.27 | Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women. ( Pacovský, V; Pospíchal, J; Presl, J; Stĕpán, JJ, 1987) |
| "Finally, biochemical indices of bone resorption were high in osteoporotic patients and poorly correlated with histological bone resorption." | 1.27 | Bone turnover in spinal osteoporosis. ( Christiansen, C; Johansen, JS; Leth, A; Pødenphant, J; Riis, BJ; Thomsen, K, 1987) |
| "Studies of a 63-year-old woman with osteopenia due to systemic mastocytosis are reported." | 1.27 | Osteopenia in systemic mastocytosis: natural history and responses to treatment with inhibitors of bone resorption. ( Beneton, MN; Cundy, T; Darby, AJ; Kanis, JA; Marshall, WJ, 1987) |
| "Treatment with ethinyl estradiol or norethindrone reduces the bone-turnover rate and plasma calcium levels in normal postmenopausal women, without affecting the secretion of calcium-regulating hormones." | 1.27 | Ethinyl estradiol and norethindrone in the treatment of primary hyperparathyroidism in postmenopausal women. ( Peacock, M; Selby, PL, 1986) |
| " Renal function was most severely affected in cows treated with 24,24-F2-dihydroxycholecalciferol and was evident even at the 100-micrograms dosage level." | 1.27 | Bone resorption, renal function and mineral status in cows treated with 1,25-dihydroxycholecalciferol and its 24-fluoro analogues. ( Boris, A; Goff, JP; Horst, RL; Littledike, ET; Uskokovic, MR, 1986) |
| "Adjuvant arthritis was induced in female Lewis rats by the injection of Mycobacterium butyricum in mineral oil in a hindpaw." | 1.27 | Bone changes in rats with adjuvant arthritis: treatment with 1 alpha-hydroxycholecalciferol. ( Binderup, L, 1986) |
| "Treatment with gallium nitrate for five to seven days caused a median reduction in 24-hour urinary calcium excretion of 66% relative to baseline measurements (P less than ." | 1.27 | Gallium nitrate inhibits accelerated bone turnover in patients with bone metastases. ( Alcock, NW; Bockman, RS; Warrell, RP, 1987) |
| "When bone resorption was stimulated by prostaglandin E2, DPH (50 micrograms/ml) also reduced the mobilization of bone mineral and the release of beta-glucuronidase without influencing the release of lactate dehydrogenase." | 1.26 | Influence of diphenylhydantoin on lysosomal enzyme release during bone resorption in vitro. ( Hänström, L; Lerner, U, 1980) |
| "The copper sulfate effect was twice that of sodium aurothiomalate, and sodium sulfate was not significantly inhibitory." | 1.26 | Inhibition of active bone resorption by copper. ( Gray, DH; Katz, JM; Wilson, T, 1981) |
| "Thyroxine increased bone resorption and formation rates, trabecular bone volume and balance, number of osteoclast nuclei, and life span of bone forming sites." | 1.26 | The effects of 1,25-dihydroxycholecalciferol, parathyroid hormone, and thyroxine on trabecular bone remodeling in adult dogs. A histomorphometric study. ( Black, HE; Capen, CC; High, WB, 1981) |
| "2." | 1.26 | The relation between bone loss and calcium balance in women. ( Crilly, RG; Horsman, A; Marshall, DH; Nordin, BE; Simpson, M, 1980) |
| " The dosage of the antibiotic was adjusted to obtain plasma concentrations comparable with human therapeutic levels." | 1.26 | Effects of oxytetracycline on mineralization of bone in young rats. ( Engesaeter, LB; Langeland, N; Underdal, T, 1980) |
| "An active bone resorption was stimulated by a concentration of 1 microgram/ml of the chemotactic factor." | 1.26 | Effects of a chemotactic factor and Bacteroides fragilis lipopolysaccharide on bone resorption in tissue culture. ( Sveen, K, 1980) |
| "In most cases bone resorption became normal within a week of treatment, whereas the return to normal bone formation took 3-6 months; this difference produced a transient imbalance between resorption and formation." | 1.26 | Treatment of Paget's disease with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.). ( Bijvoet, OL; Frijlink, WB; Heynen, G; te Velde, J, 1979) |
| "The rate of bone resorption normalized." | 1.26 | Investigation of bone and mineral metabolism in hyperthyroidism before and after treatment using calcitonin, 47Ca and balance studies. ( Hendriks, JT; Smeenk, D, 1979) |
| "Rapid bone loss, high bone resorption and low calcium absorption are shown to be associated with poor oestrogen status, with crush fracture cases presenting an exaggerated view of the normal post-menopausal situation." | 1.26 | The relationship between oestrogen status and bone loss in post-menopausal women. ( Brook, R; Horsman, A; Nordin, BE; Williams, DA, 1976) |
| "Glucagon given by intravenous infusion at a dosage of 0." | 1.25 | Glucagon in the treatment of Paget's disease of bone. ( Condon, JR, 1971) |
| "Before treatment, bone resorption was greater than normal in all but one patient and bone formation was normal." | 1.25 | Effect of sex hormones on bone in primary osteoporosis. ( Jones, JD; Jowsey, J; Kelly, PJ; Maher, FT; Riggs, BL, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 274 (56.15) | 18.7374 |
| 1990's | 177 (36.27) | 18.2507 |
| 2000's | 31 (6.35) | 29.6817 |
| 2010's | 6 (1.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Czernick, D | 1 |
| Lin, SC | 1 |
| Alasmari, A | 1 |
| Serge, D | 1 |
| Salih, E | 1 |
| Devkota, B | 2 |
| Takahashi, M | 5 |
| Sato, S | 1 |
| Sasaki, K | 2 |
| Ueki, A | 1 |
| Osawa, T | 2 |
| Yamagishi, N | 2 |
| Magomedov, AM | 1 |
| Gertsen, GI | 1 |
| Fey, S | 1 |
| Kuzub, TA | 1 |
| Krinitskaya, OF | 1 |
| Husek, P | 1 |
| Svagera, Z | 1 |
| Vsianský, F | 1 |
| Franeková, J | 1 |
| Simek, P | 1 |
| Das, AS | 2 |
| Mukherjee, M | 2 |
| Das, D | 2 |
| Mitra, C | 2 |
| Hie, M | 1 |
| Yamazaki, M | 1 |
| Tsukamoto, I | 2 |
| Liu, Z | 1 |
| Qiu, L | 1 |
| Chen, YM | 1 |
| Su, YX | 1 |
| Potu, BK | 1 |
| Nampurath, GK | 1 |
| Rao, MS | 1 |
| Bhat, KM | 1 |
| Itagaki, K | 1 |
| Kim, D | 1 |
| Furuhama, K | 1 |
| Parker, CR | 1 |
| Blackwell, PJ | 1 |
| Freemont, AJ | 1 |
| Hosking, DJ | 2 |
| Sato, J | 1 |
| Okada, K | 1 |
| Fukuda, S | 1 |
| Sato, R | 1 |
| Yasuda, J | 1 |
| Naito, Y | 1 |
| Ohta, H | 1 |
| Makita, K | 1 |
| Komukai, S | 1 |
| Nozawa, S | 1 |
| Mazzantini, M | 1 |
| Di Munno, O | 1 |
| Metelli, MR | 1 |
| Bulleri, M | 1 |
| Giordani, R | 1 |
| SMITH, DA | 3 |
| NORDIN, BE | 27 |
| JASANI, C | 2 |
| SWANSON, I | 1 |
| LAGIER, R | 1 |
| RUTISHAUSER, E | 1 |
| AVIOLI, LV | 7 |
| MCDONALD, JE | 1 |
| SINGER, RA | 1 |
| STERN, BD | 1 |
| GLIMCHER, MJ | 5 |
| MECHANIC, GL | 2 |
| GOLDHABER, P | 8 |
| Shapses, SA | 2 |
| Cifuentes, M | 1 |
| Spevak, L | 1 |
| Chowdhury, H | 2 |
| Brittingham, J | 1 |
| Boskey, AL | 1 |
| Denhardt, DT | 1 |
| Goto, A | 1 |
| Simsek, B | 1 |
| Karacaer, O | 1 |
| Karaca, I | 1 |
| Lello, S | 1 |
| Paoletti, AM | 2 |
| Migliaccio, S | 1 |
| Melis, GB | 2 |
| Mukherjee, S | 1 |
| Vural, P | 1 |
| Canbaz, M | 1 |
| Akgul, C | 1 |
| Pagani, F | 1 |
| Francucci, CM | 1 |
| Moro, L | 6 |
| Asplin, JR | 1 |
| Donahue, S | 1 |
| Kinder, J | 1 |
| Coe, FL | 1 |
| Ozdem, S | 1 |
| Samanci, S | 1 |
| Tasatargil, A | 1 |
| Yildiz, A | 1 |
| Sadan, G | 1 |
| Donmez, L | 1 |
| Herrmann, M | 1 |
| Laitinen, O | 2 |
| Robinson, CJ | 2 |
| Martin, TJ | 3 |
| Matthews, EW | 1 |
| MacIntyre, I | 4 |
| Pechet, MM | 2 |
| Bobadilla, E | 1 |
| Carroll, EL | 1 |
| Hesse, RH | 1 |
| Birkenhäger, JC | 2 |
| van der Heul, RO | 1 |
| Smeenk, D | 2 |
| van der Sluys Veer, J | 2 |
| van Seters, AP | 1 |
| Douglas, DL | 2 |
| Duckworth, T | 1 |
| Russell, RG | 9 |
| Kanis, JA | 11 |
| Preston, CJ | 2 |
| Preston, FE | 2 |
| Prenton, MA | 1 |
| Woodhead, JS | 1 |
| Brown, JP | 1 |
| Delmas, PD | 12 |
| Malaval, L | 1 |
| Edouard, C | 6 |
| Chapuy, MC | 3 |
| Meunier, PJ | 5 |
| Nuti, R | 1 |
| Righi, G | 1 |
| Turchetti, V | 1 |
| Vattimo, A | 2 |
| Charhon, S | 2 |
| Vignon, E | 2 |
| Briancon, D | 2 |
| Siris, ES | 5 |
| Hyman, GA | 1 |
| Canfield, RE | 4 |
| Beard, DJ | 1 |
| Cameron, EC | 1 |
| Forrest, AR | 1 |
| Guilland-Cumming, D | 1 |
| Paterson, AD | 1 |
| Poser, J | 1 |
| Milford-Ward, A | 1 |
| Woodhead, S | 1 |
| Rico Lenza, H | 3 |
| Huertas García-Alejo, R | 2 |
| Kruse, K | 4 |
| Kracht, U | 2 |
| Göpfert, G | 1 |
| Stenner, D | 1 |
| Wahner, HW | 1 |
| Mann, KG | 1 |
| Riggs, BL | 5 |
| Delaissé, JM | 2 |
| Eeckhout, Y | 2 |
| Vaes, G | 4 |
| Ralston, SH | 1 |
| Fogelman, I | 2 |
| Gardiner, MD | 1 |
| Boyle, IT | 1 |
| Hyldstrup, L | 4 |
| McNair, P | 3 |
| Jensen, GF | 2 |
| Nielsen, HR | 1 |
| Transbøl, I | 3 |
| Sherman, WH | 1 |
| Baquiran, DC | 2 |
| Schlatterer, JP | 1 |
| Osserman, EF | 1 |
| Jacobs, TP | 2 |
| Bilezikian, JP | 1 |
| Shane, E | 1 |
| Minaire, P | 2 |
| Berard, E | 1 |
| Goedert, G | 1 |
| Pilonchery, G | 1 |
| Alexandre, C | 1 |
| Rico, H | 1 |
| Charro, A | 1 |
| Depablos, I | 1 |
| Bordiu, E | 1 |
| Hernandez, ER | 1 |
| Espinos, D | 1 |
| Key, L | 2 |
| Carnes, D | 1 |
| Cole, S | 1 |
| Holtrop, M | 1 |
| Bar-Shavit, Z | 1 |
| Shapiro, F | 1 |
| Arceci, R | 1 |
| Steinberg, J | 1 |
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| Gold, E | 5 |
| Feng, W | 1 |
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| van Kesteren, RG | 1 |
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| Schwartz, Z | 3 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Correlation Between Peri-implantitis and Assumptions of Medications: a Retrospective Study[NCT04783974] | 270 participants (Actual) | Observational | 2021-02-15 | Completed | |||
| Determining the Maximal Safe Dose of a Continuous Infusion of Parathyroid Hormone-related Protein(1-36): Effects on Bone Formation[NCT00580788] | Early Phase 1 | 14 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Determining the Maximal Safe Dose of a Continuous Infusion of Parathyroid Hormone(1-34): Effects on Bone Formation[NCT00377312] | Early Phase 1 | 11 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| Urine N-telopeptide, Serum Vit D, Parathormone and Calcium Levels in Hyperemesis Gravidarum[NCT02862496] | 60 participants (Anticipated) | Observational [Patient Registry] | 2016-06-30 | Recruiting | |||
| A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420] | Phase 1 | 4 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
mg/gm creatinine collected on day 7 of PTHrP infusion (NCT00580788)
Timeframe: 24 hours
| Intervention | mg/gm creatinine (Mean) |
|---|---|
| Group 1 | 121.64 |
| Group 2 | 283.43 |
| Group 3 | 320.23 |
DLT was defined as achieving one major criterion or two minor criteria rated at ≥ 2 on a scale of 0-5. The major criteria were defined as symptomatic orthostatic hypotension (systolic BP fall >30 mm/hg), tachycardia (pulse > 120), hypertension (systolic BP >160 mm/hg on 2 occasions), hypercalcemia (serum calcium ≥ 12 mg/dl), and hypophosphatemia (serum phosphorous < 1.5 mg/dl). Minor criteria included symptoms such as flushing, nausea, abdominal or muscle cramps, dizziness, lightheadedness, palpitations, etc. (NCT00580788)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days
| Intervention | participants (Number) |
|---|---|
| Group 1 | 0 |
| Group 2 | 0 |
| Group 3 | 2 |
| Group 4 | 2 |
pg/ml (NCT00580788)
Timeframe: Baseline and Daily through day 8 then at follow-up visit
| Intervention | pg/ml (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 34.13 | 38.40 | 30.13 | 32.23 | 32.27 | 42.77 | 40.53 | 32.37 | 40.10 |
| Group 2 | 45.08 | 45.88 | 36.58 | 40.38 | 46.40 | 34.90 | 37.12 | 33.43 | 45.78 |
| Group 3 | 39.0 | 39.77 | 36.73 | 35.17 | 32.07 | 35.37 | 31.17 | 30.63 | 36.33 |
% change from baseline (NCT00580788)
Timeframe: Baseline, Daily, and 1 week follow-up
| Intervention | % change (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0.00 | -1.05 | -6.83 | -12.16 | -5.63 | -8.42 | -12.59 | -16.03 | -7.12 |
| Group 2 | 0.00 | -17.49 | -30.44 | -25.66 | -21.27 | -31.71 | -30.98 | -36.60 | 0.60 |
| Group 3 | 0.00 | -23.88 | -37.77 | -39.44 | -45.04 | -39.55 | -39.88 | -38.53 | 46.67 |
% change from baseline (NCT00580788)
Timeframe: Baseline, Daily, and 1 week follow-up
| Intervention | % change (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0.00 | -12.53 | -6.35 | -5.82 | -0.33 | -8.16 | -11.91 | -7.80 | -1.25 |
| Group 2 | 0.00 | -1.17 | -1.44 | -3.79 | -9.64 | -10.88 | -16.78 | -14.01 | 6.16 |
| Group 3 | 0.00 | 24.54 | 34.77 | 19.49 | 13.61 | 9.02 | 9.86 | 15.27 | 18.23 |
% calculated from daily second morning void (NCT00580788)
Timeframe: daily
| Intervention | % of filtered load (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | |
| Group 1 | 1.93 | 1.31 | 1.07 | 1.57 | 3.05 | 3.37 | 2.72 |
| Group 2 | 2.57 | 2.26 | 2.85 | 2.79 | 2.05 | 2.75 | 3.94 |
| Group 3 | 2.38 | 4.11 | 3.27 | 2.14 | 3.12 | 5.42 | 4.13 |
mg/dl (NCT00580788)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days, Follow-up 1 week after infusion complete
| Intervention | mg/dl (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline | 11P DAY 1 | 7A DAY 2 | 3P DAY 2 | 11P DAY 2 | 7A DAY 3 | 3P DAY 3 | 11P DAY 3 | 7A DAY 4 | 3P DAY 4 | 11P DAY 4 | 7A DAY 5 | 3P DAY 5 | 11P DAY 5 | 7A DAY 6 | 3P DAY 6 | 11P DAY 6 | 7A DAY 7 | 3P DAY 7 | 11P DAY 7 | 7A DAY 8 | FOLLOW-UP | |
| Group 1 | 4.79 | 4.51 | 4.77 | 4.52 | 4.48 | 4.77 | 4.73 | 4.41 | 4.75 | 4.45 | 4.47 | 4.71 | 4.61 | 4.60 | 4.63 | 4.72 | 4.32 | 4.55 | 4.84 | 4.56 | 5.00 | 4.68 |
| Group 2 | 4.72 | 4.77 | 4.98 | 4.99 | 5.04 | 5.31 | 4.99 | 4.58 | 4.90 | 4.68 | 4.46 | 4.82 | 4.67 | 4.58 | 4.77 | 4.83 | 4.72 | 5.01 | 5.04 | 4.87 | 5.43 | 4.83 |
| Group 3 | 4.55 | 4.75 | 5.07 | 5.07 | 4.84 | 5.25 | 4.91 | 4.83 | 5.11 | 4.72 | 4.69 | 4.97 | 4.87 | 4.79 | 5.25 | 5.35 | 5.19 | 5.55 | 5.25 | 5.24 | 5.69 | 4.80 |
pg/ml (NCT00580788)
Timeframe: Baseline and Daily
| Intervention | pg/ml (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 42.97 | 23.47 | 21.43 | 26.77 | 22.37 | 21.13 | 19.40 | 12.60 | 56.37 |
| Group 2 | 30.70 | 7.82 | 5.23 | 7.88 | 7.54 | 6.57 | 5.67 | 3.00 | 31.60 |
| Group 3 | 48.27 | 3.60 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 44.20 |
% change from baseline (NCT00580788)
Timeframe: Baseline, Daily, and 1 week follow-up
| Intervention | % change (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0.00 | 32.86 | 26.73 | 28.32 | 41.29 | 11.41 | 35.04 | 65.77 | -14.95 |
| Group 2 | 0.00 | 87.75 | 91.53 | 90.86 | 82.36 | 123.08 | 161.55 | 214.90 | -3.33 |
| Group 3 | 0.00 | 54.21 | 88.51 | 89.57 | 116.58 | 150.82 | 176.42 | 108.69 | -9.02 |
% change from baseline (NCT00580788)
Timeframe: Baseline, Daily, and 1 week follow-up
| Intervention | % change (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0.00 | 59.78 | 66.67 | 71.19 | 79.39 | 74.09 | 109.27 | 110.61 | -35.73 |
| Group 2 | 0.00 | 147.12 | 180.27 | 167.01 | 167.27 | 239.51 | 283.15 | 368.31 | -8.60 |
| Group 3 | 0.00 | 105.06 | 148.45 | 165.16 | 174.58 | 230.42 | 267.89 | 140.58 | -41.33 |
mg/dl (NCT00580788)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days, Follow-up 1 week after infusion complete
| Intervention | mg/dl (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline | 11P DAY 1 | 7A DAY 2 | 3P DAY 2 | 11P DAY 2 | 7A DAY 3 | 3P DAY 3 | 11P DAY 3 | 7A DAY 4 | 3P DAY 4 | 11P DAY 4 | 7A DAY 5 | 3P DAY 5 | 11P DAY 5 | 7A DAY 6 | 3P DAY 6 | 11P DAY 6 | 7A DAY 7 | 3P DAY 7 | 11P DAY 7 | 7A DAY 8 | FOLLOW-UP | |
| Group 1 | 3.55 | 3.87 | 4.07 | 3.63 | 4.13 | 3.90 | 3.53 | 4.03 | 4.07 | 3.90 | 3.67 | 3.87 | 3.57 | 3.93 | 4.00 | 3.67 | 3.93 | 4.30 | 4.07 | 4.20 | 4.43 | 3.57 |
| Group 2 | 3.63 | 3.90 | 4.20 | 3.50 | 3.52 | 3.77 | 3.53 | 3.58 | 3.90 | 3.37 | 3.48 | 4.02 | 3.35 | 3.45 | 4.00 | 3.80 | 3.90 | 4.28 | 3.62 | 3.62 | 4.10 | 3.48 |
| Group 3 | 3.55 | 4.03 | 3.63 | 3.70 | 3.63 | 3.43 | 3.60 | 3.70 | 3.30 | 3.33 | 3.63 | 3.20 | 3.10 | 3.87 | 3.63 | 3.73 | 3.93 | 3.73 | 3.50 | 3.60 | 3.40 | 3.87 |
mg/dl (NCT00580788)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days, Follow-up 1 week after infusion complete
| Intervention | mg/dl (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| baseline | 11P DAY 1 | 7A DAY 2 | 3P DAY 2 | 11P DAY 2 | 7A DAY 3 | 3P DAY 3 | 11P DAY 3 | 7A DAY 4 | 3P DAY 4 | 11P DAY 4 | 7A DAY 5 | 3P DAY 5 | 11P DAY 5 | 7A DAY 6 | 3P DAY 6 | 11P DAY 6 | 7A DAY 7 | 3P DAY 7 | 11P DAY 7 | 7A DAY 8 | FOLLOW-UP | |
| Group 1 | 9.37 | 9.67 | 9.4 | 9.57 | 9.67 | 9.6 | 9.73 | 9.40 | 9.47 | 9.40 | 9.37 | 9.30 | 9.50 | 9.43 | 9.57 | 9.43 | 9.43 | 9.40 | 9.70 | 9.60 | 9.83 | 9.33 |
| Group 2 | 9.58 | 9.80 | 10.05 | 10.28 | 10.32 | 10.40 | 10.42 | 9.73 | 10.00 | 9.92 | 9.48 | 9.62 | 9.83 | 9.45 | 9.83 | 10.08 | 9.67 | 10.13 | 10.22 | 10.27 | 10.67 | 9.80 |
| Group 3 | 9.2 | 9.67 | 10.17 | 10.47 | 10.23 | 10.73 | 10.67 | 9.93 | 10.3 | 10.33 | 10.00 | 10.53 | 10.27 | 9.80 | 10.53 | 10.83 | 10.43 | 10.90 | 10.70 | 10.73 | 11.17 | 9.17 |
mg/dl calculated from daily second morning void (NCT00580788)
Timeframe: daily
| Intervention | mg/dl (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | |
| Group 1 | 3.43 | 4.48 | 4.28 | 4.42 | 4.43 | 4.90 | 4.15 |
| Group 2 | 3.91 | 4.08 | 3.74 | 3.75 | 3.95 | 3.98 | 3.98 |
| Group 3 | 3.38 | 3.47 | 3.25 | 3.15 | 3.37 | 3.38 | 2.95 |
mg/gm creatinine (NCT00377312)
Timeframe: 24 hours period from Day 7 to Day 8
| Intervention | mg/gm creatinine (Mean) |
|---|---|
| Group 1 | 315.278845 |
| Group 2 | 210.24827 |
DLT was defined as achieving one major criterion or two minor criteria rated at ≥ 2 on a scale of 0-5. The major criteria were defined as symptomatic orthostatic hypotension (systolic BP fall >30 mm/hg), tachycardia (pulse > 120), hypertension (systolic BP >160 mm/hg on 2 occasions), hypercalcemia (serum calcium ≥ 12 mg/dl), and hypophosphatemia (serum phosphorous < 1.5 mg/dl). Minor criteria included symptoms such as flushing, nausea, abdominal or muscle cramps, dizziness, lightheadedness, palpitations, etc. (NCT00377312)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days
| Intervention | participants (Number) |
|---|---|
| Group 1 | 0 |
| Group 2 | 2 |
pg/ml (NCT00377312)
Timeframe: baseline, daily up to Day 8 and follow-up
| Intervention | pg/ml (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 37.78 | 40.90 | 35.68 | 27.70 | 36.16 | 38.00 | 32.18 | 34.78 | 37.06 |
| Group 2 | 39.18 | 42.72 | 41.74 | 34.72 | 31.53 | 35.68 | 28.48 | 33.13 | 40.16 |
% change from baseline (NCT00377312)
Timeframe: baseline, daily, one week follow-up
| Intervention | % change from baseline (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0 | -18.536953 | -31.14427 | -32.942391 | -31.506308 | -36.35864 | -40.709396 | -39.046467 | 31.4333667 |
| Group 2 | 0 | -16.118573 | -35.577655 | -35.018736 | -35.309609 | -35.064188 | -30.58629 | -35.619862 | 26.3367446 |
% change from baseline (NCT00377312)
Timeframe: baseline, daily, one week follow-up
| Intervention | % change from baseline (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0 | 7.35 | -5.61 | 4.34 | -8.75 | -3.42 | -1.35 | 2.09 | 14.08 |
| Group 2 | 0 | 7.91 | 9.05 | 0.77 | -2.19 | -8.89 | -13.72 | -9.91 | 5.51 |
% = (S Creatinine X U Calcium)/(S Calcium X U Creatinine) (NCT00377312)
Timeframe: baseline and daily
| Intervention | % of excretion (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 8 | |
| Group 1 | 3.38 | 2.83 | 4.28 | 2.82 | 3.90 | 4.44 | 5.54 |
| Group 2 | 1.80 | 2.87 | 3.76 | 3.87 | 2.54 | 3.49 | 4.58 |
mg/dl (NCT00377312)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days, Follow-up 1 week after infusion complete
| Intervention | mg/dl (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 11P Day 1 | 7 A Day 2 | 3P Day 2 | 11P Day 2 | 7A Day 3 | 3P Day 3 | 11P Day 3 | 7A Day 4 | 3P Day 4 | 11P Day 4 | 7A Day 5 | 3P Day 5 | 11P Day 5 | 7A Day 6 | 3P Day 6 | 11P Day 6 | 7A Day 7 | 3P Day 7 | 11P Day 7 | 7A Day 8 | FOLLOW-UP | |
| Group 1 | 4.72 | 4.93 | 5.17 | 5.08 | 5.01 | 5.21 | 5.08 | 4.80 | 5.10 | 4.86 | 4.93 | 5.18 | 5.03 | 4.90 | 5.29 | 5.17 | 5.02 | 5.20 | 4.89 | 5.15 | 5.34 | 4.79 |
| Group 2 | 4.52 | 4.54 | 5.04 | 5.01 | 4.97 | 5.22 | 5.11 | 4.82 | 4.90 | 4.77 | 4.70 | 4.84 | 4.91 | 4.68 | 4.95 | 4.89 | 4.82 | 4.99 | 4.88 | 4.86 | 5.28 | 4.70 |
pg/ml (NCT00377312)
Timeframe: baseline, daily up to Day 8 and follow-up
| Intervention | pg/ml (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 20.90 | 3.86 | 3.00 | 4.12 | 4.64 | 3.50 | 3.58 | 3.09 | 23.60 |
| Group 2 | 52.44 | 5.30 | 3.38 | 5.00 | 11.68 | 6.34 | 6.68 | 3.00 | 35.20 |
% change from baseline (NCT00377312)
Timeframe: baseline, daily, one week follow-up
| Intervention | % change from baseline (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0 | 61.8428952 | 85.7699521 | 96.3668762 | 107.517148 | 150.594712 | 141.193285 | 153.72039 | 4.06445076 |
| Group 2 | 0 | 77.4709521 | 85.9288044 | 59.9595445 | 83.3701575 | 120.268081 | 109.660098 | 148.451289 | 1.05486408 |
% change from baseline (NCT00377312)
Timeframe: baseline, daily, one week follow-up
| Intervention | % change from baseline (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | Day 8 | follow-up | |
| Group 1 | 0 | 113.70 | 136.76 | 142.66 | 165.97 | 205.39 | 206.06 | 225.04 | -6.78 |
| Group 2 | 0 | 104.07 | 112.11 | 70.74 | 92.13 | 141.66 | 168.77 | 244.50 | -11.82 |
mg/dl (NCT00377312)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days, Follow-up 1 week after infusion complete
| Intervention | mg/dl (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 11P Day 1 | 7 A Day 2 | 3P Day 2 | 11P Day 2 | 7A Day 3 | 3P Day 3 | 11P Day 3 | 7A Day 4 | 3P Day 4 | 11P Day 4 | 7A Day 5 | 3P Day 5 | 11P Day 5 | 7A Day 6 | 3P Day 6 | 11P Day 6 | 7A Day 7 | 3P Day 7 | 11P Day 7 | 7A Day 8 | FOLLOW-UP | |
| Group 1 | 3.51 | 4.16 | 3.78 | 3.82 | 3.86 | 3.68 | 3.68 | 3.86 | 3.58 | 3.38 | 3.76 | 3.56 | 3.70 | 3.56 | 3.86 | 3.78 | 3.70 | 3.70 | 3.12 | 3.48 | 3.82 | 4.12 |
| Group 2 | 3.45 | 3.78 | 3.68 | 3.44 | 3.78 | 3.58 | 3.28 | 3.60 | 3.64 | 3.22 | 3.52 | 3.72 | 3.22 | 3.64 | 3.60 | 3.03 | 3.63 | 3.90 | 3.18 | 3.55 | 3.80 | 3.64 |
mg/dl (NCT00377312)
Timeframe: 12 hours after the infusion was started then q 8 hours for 7 days, Follow-up 1 week after infusion complete
| Intervention | mg/dl (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 11P Day 1 | 7 A Day 2 | 3P Day 2 | 11P Day 2 | 7A Day 3 | 3P Day 3 | 11P Day 3 | 7A Day 4 | 3P Day 4 | 11P Day 4 | 7A Day 5 | 3P Day 5 | 11P Day 5 | 7A Day 6 | 3P Day 6 | 11P Day 6 | 7A Day 7 | 3P Day 7 | 11P Day 7 | 7A Day 8 | FOLLOW-UP | |
| Group 1 | 9.33 | 9.56 | 9.74 | 10.14 | 9.84 | 10.10 | 10.32 | 9.72 | 10.04 | 9.94 | 9.54 | 10.16 | 10.26 | 9.82 | 10.18 | 10.28 | 9.56 | 10.18 | 10.02 | 9.82 | 10.38 | 9.50 |
| Group 2 | 9.11 | 9.78 | 10.06 | 10.30 | 10.38 | 10.52 | 10.66 | 9.94 | 9.88 | 9.94 | 9.56 | 9.64 | 9.72 | 9.46 | 9.92 | 10.28 | 9.60 | 9.90 | 9.98 | 10.03 | 10.50 | 9.50 |
mg/dl (NCT00377312)
Timeframe: baseline and daily
| Intervention | mg/dl (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| baseline | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 8 | |
| Group 1 | 3.80 | 3.28 | 3.37 | 3.25 | 3.19 | 3.45 | 3.52 |
| Group 2 | 3.50 | 3.30 | 3.11 | 3.66 | 3.31 | 3.25 | 3.43 |
22 reviews available for hydroxyproline and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Urine products of bone breakdown as markers of bone resorption and clinical usefulness of urinary hydroxyproline: an overview.
Topics: Biomarkers; Bone Diseases, Metabolic; Bone Resorption; Collagen; Humans; Hydroxylysine; Hydroxyproli | 2004 |
Bone markers: biochemical and clinical significance.
Topics: Alkaline Phosphatase; Amino Acids; Biomarkers; Bone and Bones; Bone Remodeling; Bone Resorption; Hum | 2004 |
Markers of bone turnover: biochemical and clinical perspectives.
Topics: Acid Phosphatase; Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Remodeling; Bone Resorption | 2005 |
[Calcitonin: a hormone with multisystemic effects].
Topics: Age Factors; Amino Acid Sequence; Amino Acids; Animals; Bone Resorption; Calcitonin; Calcium; Cyclic | 1981 |
Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease.
Topics: Animals; Bone Neoplasms; Bone Resorption; Calcinosis; Clinical Trials as Topic; Clodronic Acid; Dose | 1994 |
Biochemical markers of bone turnover: an update.
Topics: Acid Phosphatase; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone and Bones; Bone Remodeling; Bo | 1994 |
Biochemical markers of bone turnover. I: Theoretical considerations and clinical use in osteoporosis.
Topics: Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Density; Bone Resorption; Calcium; Female; Hip F | 1993 |
Biochemical markers and skeletal metastases.
Topics: Alkaline Phosphatase; Biomarkers; Bone Development; Bone Neoplasms; Bone Resorption; Humans; Hydroxy | 2000 |
Markers of bone turnover in bone metastases.
Topics: Alkaline Phosphatase; Biomarkers; Bone Development; Bone Neoplasms; Bone Resorption; Collagen; Human | 2000 |
Diagnostic procedures in disorders of calcium metabolism.
Topics: Absorptiometry, Photon; Bone and Bones; Bone Resorption; Calcium; Calcium Metabolism Disorders; Crea | 1978 |
Biochemical markers of bone turnover: methodology and clinical use in osteoporosis.
Topics: Aging; Alkaline Phosphatase; Biomarkers; Bone Resorption; Collagen; Female; Humans; Hydroxyproline; | 1991 |
What do we know about biochemical bone markers?
Topics: Adult; Aged; Alkaline Phosphatase; Biomarkers; Bone Matrix; Bone Remodeling; Bone Resorption; Female | 1991 |
[Usefulness of bone remodelling biochemical markers in the diagnosis and follow-up of Paget's bone disease, primary hyperparathyroidism, tumor hypercalcemia, and postmenopausal osteoporosis. II. Bone resorption markers].
Topics: Acid Phosphatase; Adult; Biomarkers; Bone Resorption; Child; Female; Follow-Up Studies; Humans; Hydr | 1990 |
Calcium and osteoporosis.
Topics: Bone Resorption; Calcium; Calcium, Dietary; Female; Humans; Hydroxyproline; Menopause; Nutritional R | 1988 |
Degradation processes in bone and cartilage.
Topics: Alkaline Phosphatase; Animals; Birds; Bone and Bones; Bone Diseases; Bone Resorption; Calcium Metabo | 1970 |
Parathyroid hormone and thyrocalcitonin: their mode of action and regulation.
Topics: Adenoma; Adenylyl Cyclases; Adult; Animals; Biological Transport; Bone and Bones; Bone Resorption; C | 1971 |
Paget's disease of bone: problems and management.
Topics: Adrenocorticotropic Hormone; Alkaline Phosphatase; Aspirin; Bone Regeneration; Bone Resorption; Calc | 1972 |
Bone resorption in tissue culture and its relevance to periodontal disease.
Topics: Alveolar Process; Bone Development; Bone Resorption; Culture Techniques; Gingiva; Heparin; Humans; H | 1973 |
[Urine hydroxyproline a review].
Topics: Acromegaly; Bone Resorption; Carbon Isotopes; Collagen; Humans; Hydroxyproline; Hyperthyroidism; Hyp | 1968 |
[Bone changes in hyperparathyroidism].
Topics: Adult; Bone and Bones; Bone Resorption; Calcium; Diagnosis, Differential; Female; Humans; Hydroxypro | 1969 |
Some basic aspects of bone metabolism in relation to osteoporosis.
Topics: Age Factors; Aged; Ascorbic Acid; Black People; Bone and Bones; Bone Regeneration; Bone Resorption; | 1970 |
Some aspects of metabolic bone disease related to rheumatology.
Topics: Absorptiometry, Photon; Adult; Aged; Aging; Bone Diseases; Bone Resorption; Calcium; Child; Estrogen | 1971 |
75 trials available for hydroxyproline and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail.
Topics: Absorptiometry, Photon; Adult; Animals; Body Mass Index; Bone Density; Bone Resorption; Calcium; Cre | 2011 |
Single infusion of neridronate (6-amino-1-hydroxyhexylidene-1,1-bisphosphonate) in patients with active rheumatoid arthritis: effects on disease activity and bone resorption markers.
Topics: Aged; Amino Acids; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; Bone Resorption; C-Reacti | 2002 |
Long-term effects of dichloromethylene diphosphonate (CI2MDP) on skeletal lesions in multiple myeloma.
Topics: Biopsy; Bone and Bones; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Humans; Hydroxypro | 1982 |
Effects of dichloromethylene diphosphonate in women with breast carcinoma metastatic to the skeleton.
Topics: Administration, Oral; Adult; Aged; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Clini | 1983 |
Effects of dichloromethylene diphosphonate on skeletal mobilization of calcium in multiple myeloma.
Topics: Adult; Aged; Bone and Bones; Bone Resorption; Calcium; Clinical Trials as Topic; Clodronic Acid; Dip | 1980 |
Effects of disodium dichloromethylene diphosphonate on bone loss in paraplegic patients.
Topics: Adolescent; Adult; Alkaline Phosphatase; Bone Resorption; Calcium; Clodronic Acid; Female; Humans; H | 1981 |
Effect of 1,25-dihydroxyvitamin D3 on biochemical indices of bone turnover in postmenopausal women.
Topics: Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Female; Humans; Hy | 1984 |
Dietary calcium and serum 1,25-(OH)2-vitamin D concentrations as determinants of calcium balance in healthy men.
Topics: Adult; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Calcium, Dietary; Dihydroxycholecalcife | 1984 |
Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men.
Topics: Bone Resorption; Calcitriol; Calcium; Calcium, Dietary; Humans; Hydroxyproline; Intestinal Absorptio | 1983 |
Prospective double-blind trial of synthetic steroid (Org OD 14) for preventing postmenopausal osteoporosis.
Topics: Bone Resorption; Calcium; Climacteric; Clinical Trials as Topic; Double-Blind Method; Female; Hormon | 1980 |
[Effects of propranolol and indomethacin upon urinary hydroxyproline in hyperthyroid patients (author's transl)].
Topics: Adult; Aged; Bone Resorption; Calcium; Female; Humans; Hydroxyproline; Hyperthyroidism; Indomethacin | 1982 |
Short-term changes in calcium but not protein intake alter the rate of bone resorption in healthy subjects as assessed by urinary pyridinium cross-link excretion.
Topics: Adult; Amino Acids; Bone Resorption; Calcium; Calcium, Dietary; Collagen; Creatinine; Dietary Protei | 1995 |
Galactosyl hydroxylysine in assessment of Paget's bone disease.
Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Resorption; C | 1995 |
Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease.
Topics: Acid Phosphatase; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Amino Acids; Biomarkers; Bon | 1995 |
Effect of two different progestins (cyproterone acetate and norgestrel), administered in a cyclical estradiol valerate regimen, on markers of bone turnover.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Creatinine; Cyproterone Acetate; Dou | 1994 |
A multicenter trial of low dose gallium nitrate in patients with advanced Paget's disease of bone.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Resorption; Creatinine; Dose-Response Relationship, Drug; Fe | 1995 |
Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study.
Topics: Adult; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Calcium; Diphosphonates; Double-Blind | 1994 |
Effects of infusion of parathyroid hormone and primary hyperparathyroidism on formation and breakdown of type I collagen.
Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Bone Resorption; Calcium; Collagen; Female; Hu | 1994 |
Extended duration of vertical position might impair bone metabolism.
Topics: Adolescent; Biomarkers; Bone and Bones; Bone Density; Bone Resorption; Calcium; Fasting; Humans; Hyd | 1994 |
Doxycycline may inhibit postmenopausal bone damage. Preliminary observations.
Topics: Alkaline Phosphatase; Biomarkers; Bone Resorption; Doxycycline; Estradiol; Estrone; Female; Fibronec | 1994 |
Specificity of urinary excretion of cross-linked N-telopeptides of type I collagen as a marker of bone turnover.
Topics: Adolescent; Adult; Amino Acids; Analysis of Variance; Biomarkers; Bone Resorption; Calcium; Collagen | 1994 |
Bone turnover in asthmatic children treated with oral prednisolone or inhaled budesonide.
Topics: 25-Hydroxyvitamin D 2; Administration, Inhalation; Administration, Oral; Adolescent; Alkaline Phosph | 1993 |
Monitoring bone resorption in early postmenopausal women by an immunoassay for cross-linked collagen peptides in urine.
Topics: Alendronate; Amino Acids; Biomarkers; Bone Density; Bone Resorption; Calcium; Diphosphonates; Enzyme | 1994 |
Preventive treatment of cortical bone loss with salmon nasal calcitonin in early postmenopausal women.
Topics: Absorptiometry, Photon; Administration, Intranasal; Administration, Oral; Alkaline Phosphatase; Biom | 1993 |
Acute effects of nasal salmon calcitonin on calcium and bone metabolism.
Topics: Administration, Intranasal; Adult; Alkaline Phosphatase; Amino Acids; Animals; Biomarkers; Bone and | 1993 |
Bone metabolism in young women taking a monophasic pill containing 20 mcg ethinylestradiol: a prospective study.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Bone and Bones; Bone Density; Bone Resorption; | 1993 |
Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Bone Density; Bone Resorption; Calcification, Physiolog | 1993 |
Intranasal calcitonin suppresses increased bone resorption during short-term immobilization: a double-blind study of the effects of intranasal calcitonin on biochemical parameters of bone turnover.
Topics: Administration, Intranasal; Adult; Bed Rest; Bone and Bones; Bone Resorption; Calcitonin; Calcium; C | 1993 |
Therapy with parenteral pamidronate prevents thyroid hormone-induced bone turnover in humans.
Topics: Adolescent; Adult; Amino Acids; Bone Resorption; Calcitriol; Calcium; Creatinine; Diphosphonates; Hu | 1993 |
Comparative effects of clodronate and calcitonin on bone in metastatic breast cancer: a histomorphometric study.
Topics: Adult; Aged; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcitonin; Calcium; | 1993 |
An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis.
Topics: Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Development; Bone Resorption; Calcitonin; | 1993 |
An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis.
Topics: Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Development; Bone Resorption; Calcitonin; | 1993 |
An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis.
Topics: Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Development; Bone Resorption; Calcitonin; | 1993 |
An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis.
Topics: Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Development; Bone Resorption; Calcitonin; | 1993 |
The effect of chlorothiazide on bone-related biochemical variables in normal post-menopausal women.
Topics: Acid-Base Equilibrium; Aged; Biomarkers; Body Weight; Bone Resorption; Calcium; Chlorothiazide; Crea | 1993 |
Intravenous pamidronate in patients with tumor-induced osteolysis: a biochemical dose-response study.
Topics: Adult; Aged; Analysis of Variance; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcitriol; Ca | 1995 |
Dose-response effect of short-term calcitriol treatment on bone and mineral metabolism in normal males.
Topics: Administration, Oral; Adult; Analysis of Variance; Biomarkers; Bone Density; Bone Development; Bone | 1996 |
Skeletal responsiveness to thyroid hormone is not altered at menopause.
Topics: Alkaline Phosphatase; Amino Acids; Blood Chemical Analysis; Blood Gas Analysis; Bone Density; Bone R | 1996 |
Evaluation of new bone resorption markers in a randomized comparison of pamidronate or clodronate for hypercalcemia of malignancy.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers; Bone Neoplasms; Bone Resorption; Calcium; C | 1997 |
Antiresorptive effect of a single infusion of microgram quantities of zoledronate in Paget's disease of bone.
Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Bone Resorption; Calcium; Creatini | 1997 |
Biochemical markers of bone resorption compared with estimates of bone resorption from radiotracer kinetic studies in osteoporosis.
Topics: Aged; Biomarkers; Bone Resorption; Calcium; Chromatography, High Pressure Liquid; Cross-Linking Reag | 1997 |
Raloxifene and estrogen: comparative bone-remodeling kinetics.
Topics: Bone Remodeling; Bone Resorption; Calcium; Creatinine; Estrogen Antagonists; Estrogens; Female; Huma | 1997 |
Assessment of different markers of bone resorption in postmenopausal osteoporotic women treated with pamidronate.
Topics: Aged; Amino Acids; Biomarkers; Bone Resorption; Chromatography, High Pressure Liquid; Diphosphonates | 1997 |
Calcium supplementation suppresses bone resorption in early postmenopausal women.
Topics: Amino Acids; Biomarkers; Bone Resorption; Calcium; Creatinine; Dietary Supplements; Drug Administrat | 1998 |
[Bone mineralization in insulin-dependent diabetes mellitus].
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcification, | 1997 |
Effects of the bisphosphonate olpadronate in patients with carcinoma of the prostate metastatic to the skeleton.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alkaline Phosphatase; Antineoplastic Agents; Bone Neo | 1998 |
Bone mineral status after pediatric spinal cord injury.
Topics: Absorptiometry, Photon; Adolescent; Adult; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone and B | 1998 |
Urinary bone resorption markers in monitoring treatment of symptomatic osteoporosis.
Topics: Aged; Anabolic Agents; Biomarkers; Bone Resorption; Calcium; Collagen; Collagen Type I; Double-Blind | 1999 |
Single infusion of zoledronate in Paget's disease of bone: a placebo-controlled, dose-ranging study.
Topics: Aged; Alkaline Phosphatase; Biomarkers; Bone Resorption; Creatinine; Diphosphonates; Dose-Response R | 1999 |
[Clinical biochemical observations on treatment for postmenopausal osteoporosis with gusong-II].
Topics: Bone Resorption; Calcium; Drugs, Chinese Herbal; Estradiol; Female; Follow-Up Studies; Humans; Hydro | 1997 |
The effect of modifying dietary calcium intake pattern on the circadian rhythm of bone resorption.
Topics: Aged; Aged, 80 and over; Amino Acids; Bone Resorption; Calcium; Calcium, Dietary; Circadian Rhythm; | 1999 |
Inhibition of bone resorption by divided-dose calcium supplementation in early postmenopausal women.
Topics: Amino Acids; Biomarkers; Bone Resorption; Calcium; Dietary Supplements; Drug Administration Schedule | 2000 |
Long-term prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Brain Injuries; Calcium; Castration; C | 1976 |
Effect of correction of metabolic acidosis on bone mineralisation rates in patients with renal osteomalacia.
Topics: Acidosis; Acidosis, Renal Tubular; Adolescent; Adult; Alkaline Phosphatase; Blood; Bone and Bones; B | 1975 |
[Treatment of Paget's disease with salmon calcitonin].
Topics: Aged; Alkaline Phosphatase; Bone Resorption; Calcitonin; Calcium; Clinical Trials as Topic; Female; | 1977 |
The effect of 1alpha-hydroxycholecalciferol and hormone therapy on the calcium balance of post-menopausal osteoporosis.
Topics: Bone and Bones; Bone Regeneration; Bone Resorption; Calcium; Clinical Trials as Topic; Ethinyl Estra | 1977 |
Comparative effects of oestrogen and a progestogen on bone loss in postmenopausal women.
Topics: Adult; Bone and Bones; Bone Regeneration; Bone Resorption; Clinical Trials as Topic; Creatinine; Dou | 1978 |
A new diphosphonate: dissociation between effects on cells and mineral in rats and a preliminary trial in Paget's disease.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Clinical Trials as Topic; Diphosphonates; Humans; | 1978 |
Comparison of a rapid (2-h) versus a slow (24-h) infusion of alendronate in the treatment of hypercalcemia of malignancy.
Topics: Aged; Aged, 80 and over; Alendronate; Bone Neoplasms; Bone Resorption; Calcium; Diphosphonates; Doub | 1992 |
Minimal levels of serum estradiol prevent postmenopausal bone loss.
Topics: Analysis of Variance; Bone Resorption; Calcium; Creatinine; Estradiol; Estrogen Replacement Therapy; | 1992 |
Disodium pamidronate identifies differential osteoclastic bone resorption in metastatic prostate cancer.
Topics: Alkaline Phosphatase; Bone Neoplasms; Bone Resorption; Calcium; Creatinine; Diphosphonates; Humans; | 1992 |
Synthetic human calcitonin in postmenopausal osteoporosis: a placebo-controlled, double-blind study.
Topics: Aged; Aged, 80 and over; Analgesia; Bone Density; Bone Resorption; Calcitonin; Calcium; Double-Blind | 1991 |
Short-term course of 1,25(OH)2D3 stimulates osteoblasts but not osteoclasts in osteoporosis and osteoarthritis.
Topics: Aged; Bone Development; Bone Resorption; Calcitriol; Calcium; Female; Humans; Hydroxyproline; Middle | 1991 |
Use of gallium to treat Paget's disease of bone: a pilot study.
Topics: Aged; Alkaline Phosphatase; Antineoplastic Agents; Bone Regeneration; Bone Resorption; Clinical Tria | 1990 |
Dietary salt affects biochemical markers of resorption and formation of bone in elderly women.
Topics: Aged; Bone and Bones; Bone Development; Bone Resorption; Female; Humans; Hydroxyproline; Osteocalcin | 1989 |
Prospective trial of ossein-hydroxyapatite compound in surgically induced postmenopausal women.
Topics: Alkaline Phosphatase; Bone Resorption; Clinical Trials as Topic; Collagen; Creatinine; Female; Human | 1989 |
[Disorders of calcium and bone metabolism in glucocorticoid treatment].
Topics: Adolescent; Adrenocorticotropic Hormone; Bone Resorption; Calcium; Child; Child, Preschool; Dexameth | 1988 |
Dichloromethylene diphosphonate action in hematologic and other malignancies.
Topics: Administration, Oral; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clinical Tr | 1987 |
Bone turnover in postmenopausal women after withdrawal of estrogen/gestagen replacement therapy.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium-Binding Proteins; Clinical Trials as | 1987 |
Hydrochlorothiazide inhibits bone resorption in men despite experimentally elevated serum 1,25-dihydroxyvitamin D concentrations.
Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Body Weight; Bone Resorption; Calcitriol; Calcium; Creat | 1985 |
Gallium nitrate in prostatic cancer: evaluation of antitumor activity and effects on bone turnover.
Topics: Adenocarcinoma; Aged; Bone and Bones; Bone Neoplasms; Bone Resorption; Calcium; Clinical Trials as T | 1987 |
Hydroxyproline/creatinine ratios as estimates of bone resorption in early postmenopausal women. Fasting and 24-h urine samples compared.
Topics: Bone Resorption; Clinical Trials as Topic; Creatinine; Double-Blind Method; Drug Combinations; Estra | 1986 |
Diphosphonates in Paget's disease.
Topics: Administration, Oral; Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Resorption; Calcium; Clinic | 1974 |
Effects of synthetic salmon calcitonin in osteogenesis imperfecta.
Topics: Adolescent; Animals; Bone Resorption; Calcitonin; Calcium; Calcium Radioisotopes; Child; Child, Pres | 1974 |
Estrogenic antagonism of metabolic effects of administered growth hormone.
Topics: Adult; Bone Resorption; Calcium; Clinical Trials as Topic; Estrogens, Conjugated (USP); Ethinyl Estr | 1969 |
Total urinary hydroxyproline excretion after administration of Vitamin D to patients with hypoparathyroidism.
Topics: Adult; Bone Diseases; Bone Resorption; Calcium; Clinical Trials as Topic; Ergocalciferols; Female; H | 1970 |
The clinical and metabolic effects of porcine calcitonin on Paget's disease of bone.
Topics: Aged; Alkaline Phosphatase; Animals; Audiometry; Bone and Bones; Bone Resorption; Calcitonin; Calciu | 1971 |
Effects of prolonged administration of porcine calcitonin in postmenopausal osteoporosis.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Calcium Isotope | 1971 |
391 other studies available for hydroxyproline and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Novel bioactivity of phosvitin in connective tissue and bone organogenesis revealed by live calvarial bone organ culture models.
Topics: Acid Phosphatase; Animals; Antioxidants; Ascorbic Acid; Bone and Bones; Bone Remodeling; Bone Resorp | 2013 |
Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows.
Topics: Acid Phosphatase; Animals; Biomarkers; Bone Resorption; Calcium; Cattle; Collagen Type I; Estradiol; | 2015 |
[IMPACT OF RADIAL SHOCK-WAVE THERAPY OF A LOW FREQUENCY ON METABOLIC PROCESSES IN THE BONE TISSUE IN TRAUMATIC TIBIAL DEFECTS IN EXPERIMENT].
Topics: Animals; Biomarkers; Bone Resorption; Collagen; Fracture Healing; Glycosaminoglycans; Hydroxyproline | 2016 |
Prolyl-hydroxyproline dipeptide in non-hydrolyzed morning urine and its value in postmenopausal osteoporosis.
Topics: Adult; Aged; Aged, 80 and over; Alendronate; Biomarkers; Bone and Bones; Bone Resorption; Dipeptides | 2008 |
Protective action of aqueous black tea (Camellia sinensis) extract (BTE) against ovariectomy-induced oxidative stress of mononuclear cells and its associated progression of bone loss.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Resorption; Camellia sinensis; Catalase; Cells, Cult | 2009 |
Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes.
Topics: Acid Phosphatase; Amino Acids; Animals; Blood Glucose; Body Weight; Bone Marrow Cells; Bone Resorpti | 2009 |
Effect of Cissus quadrangularis Linn on the development of osteopenia induced by ovariectomy in rats.
Topics: Acid Phosphatase; Alkaline Phosphatase; Alkanes; Animals; Biomarkers; Bone Diseases, Metabolic; Bone | 2011 |
Relationship between sex hormone fluctuations and biomarkers of bone resorption in bovine plasma during the oestrous cycle.
Topics: Acid Phosphatase; Animals; Biomarkers; Bone Resorption; Calcium; Cattle; Estradiol; Estrous Cycle; F | 2012 |
Biochemical measurements in the prediction of histologic subtype of renal transplant bone disease in women.
Topics: Adult; Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Density; Bone Resorption; Chronic K | 2002 |
Serum activities of tartrate-resistant acid phosphatase and bone specific alkaline phosphatase as indices of bone metabolism in the cow.
Topics: Acid Phosphatase; Aging; Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Cattle; Cat | 2002 |
Bone resorption versus estrogen loss following oophorectomy and menopause.
Topics: Amino Acids; Biomarkers; Bone Density; Bone Resorption; Calcium; Collagen Type I; Creatinine; Estrad | 2002 |
THE RELATION BETWEEN CALCIUM BALANCE AND HYDROXYPROLINE EXCRETION IN OSTEOPOROSIS.
Topics: Amino Acids; Body Fluids; Bone Resorption; Calcium; Calcium, Dietary; Humans; Hydroxyproline; Osteom | 1964 |
SPINAL OSTEOPOROSIS AND THE MENOPAUSE.
Topics: Blood; Bone Resorption; Calcium; Ethinyl Estradiol; Female; Fluids and Secretions; Glycerophosphates | 1965 |
OSTEOARTICULAR CHANGES IN A CASE OF ESSENTIAL OSTEOLYSIS; AN ANATOMICAL AND RADIOLOGICAL STUDY.
Topics: Adolescent; Blood; Bone Diseases; Bone Resorption; Cartilage Diseases; Elbow; Foot; Hand; Humans; Hy | 1965 |
EXCRETION OF PYROPHOSPHATE IN DISORDERS OF BONE METABOLISM.
Topics: Bone Neoplasms; Bone Resorption; Chromatography; Diphosphates; Fluids and Secretions; Humans; Hydrox | 1965 |
STUDIES OF COLLAGEN DEGRADATION DURING BONE RESORPTION IN TISSUE CULTURE.
Topics: Animals; Bone Resorption; Collagen; Endopeptidases; Gelatin; Hydroxyproline; Mice; Papain; Parathyro | 1965 |
Osteopontin facilitates bone resorption, decreasing bone mineral crystallinity and content during calcium deficiency.
Topics: Amino Acids; Animals; Biomarkers; Bone Density; Bone Resorption; Calcium; Calcium, Dietary; Crystall | 2003 |
Increase in tartrate-resistant acid phosphatase of bone at the early stage of ascorbic acid deficiency in the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Ascorbic Acid Deficiency; Body Weight; Bone Resorpt | 2003 |
Phytoestrogenic effects of black tea extract (Camellia sinensis) in an oophorectomized rat (Rattus norvegicus) model of osteoporosis.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Density; Bone Resorption; Calcium; Collagen; Dietary | 2005 |
Effects of menopause and postmenopausal tibolone treatment on plasma TNFalpha, IL-4, IL-10, IL-12 cytokine pattern and some bone turnover markers.
Topics: Adult; Biomarkers; Bone Resorption; Calcium; Cytokines; Female; Humans; Hydroxyproline; Middle Aged; | 2006 |
Urine calcium excretion predicts bone loss in idiopathic hypercalciuria.
Topics: Absorptiometry, Photon; Adult; Aged; Alkaline Phosphatase; Bone and Bones; Bone Density; Bone Resorp | 2006 |
Experimental hyperhomocysteinemia disturbs bone metabolism in rats.
Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Collagen Type I; Creatine; Fema | 2007 |
Parathyroid-induced changes in collagen and calcium metabolism in vivo.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Calcium Isotopes; Collagen; Hydroxyproline; Parat | 1967 |
Mode of action of thyrocalcitonin.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Calcium Isotopes; Hydroxyproline; Kidney; Nephrectomy | 1967 |
Regulation of bone resorption and formation. Influences of thyrocalcitonin, parathyroid hormone, neutral phosphate and vitamin D3.
Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Calcitonin; Calcium; Chromatography, Gel | 1967 |
Bone changes associated with glucocorticoid excess.
Topics: Adolescent; Adult; Biopsy; Bone and Bones; Bone Resorption; Collagen; Cushing Syndrome; Glucocortico | 1967 |
Effect of dichloromethylene diphosphonate in Paget's disease of bone and in hypercalcaemia due to primary hyperparathyroidism or malignant disease.
Topics: Alkaline Phosphatase; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Humans; Hydroxyproli | 1980 |
Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis.
Topics: Aged; Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Resorption; Calcium-Binding Proteins; Femal | 1984 |
[Sodium etidronate (EHDP) and osteoporosis].
Topics: Adult; Aged; Bone Resorption; Calcium; Cyclic AMP; Etidronic Acid; Female; Humans; Hydroxyproline; M | 1981 |
Biochemical markers of bone turnover in Paget's disease.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Diphosphonates; Humans; | 1981 |
Response of kidney and bone to parathyroid hormone in children receiving anticonvulsant drugs.
Topics: Adolescent; Anticonvulsants; Bone Resorption; Calcium; Child; Cyclic AMP; Epilepsy; Female; Humans; | 1982 |
Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss.
Topics: 1-Carboxyglutamic Acid; Adult; Aged; Aging; Alkaline Phosphatase; Bone and Bones; Bone Development; | 1983 |
In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Cells, Cultured; Cysteine Endopeptidases; Embryo, | 1984 |
Relative contribution of humoral and metastatic factors to the pathogenesis of hypercalcaemia in malignancy.
Topics: Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Carcinoma, Bronchogenic; | 1984 |
Bone mass as referent for urinary hydroxyproline excretion: age and sex-related changes in 125 normals and in primary hyperparathyroidism.
Topics: Adult; Age Factors; Aged; Bone and Bones; Bone Resorption; Creatinine; Female; Humans; Hydroxyprolin | 1984 |
Hypercalcemia of malignancy: treatment with intravenous dichloromethylene diphosphonate.
Topics: Adult; Aged; Bone Neoplasms; Bone Resorption; Calcium; Clodronic Acid; Diarrhea; Diphosphonates; Dru | 1981 |
Long term effects of dichloromethylene diphosphonate in Paget's disease of bone.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Huma | 1982 |
Lack of hormonal changes in postmenopausal women of equal weight with and without osteoporosis, including relation to time of menopause.
Topics: Age Factors; Aged; Body Weight; Bone Resorption; Creatinine; Estrogens; Female; Hormones; Humans; Hy | 1984 |
Treatment of congenital osteopetrosis with high-dose calcitriol.
Topics: 1-Carboxyglutamic Acid; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Calcium, Dietary; Dihy | 1984 |
The in vitro effect of indomethacin on basal bone resorption, on prostaglandin production and on the response to added prostaglandins.
Topics: Animals; Bone Resorption; Calcium; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Hydrox | 1983 |
[Biochemical monitoring of bone involvement in multiple myeloma].
Topics: Alkaline Phosphatase; Bone Resorption; Humans; Hydroxyproline; Multiple Myeloma; Osteolysis | 1983 |
Plasma hydroxyproline in uremia: relationships with histologic and biological indices of bone turnover.
Topics: Adolescent; Adult; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Chronic Kidney Disease-Min | 1983 |
Continuous infusion of 1,25-dihydroxyvitamin D3 stimulates bone turnover in the normal young mouse.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcitri | 1983 |
Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcium; | 1980 |
Influence of diphenylhydantoin on lysosomal enzyme release during bone resorption in vitro.
Topics: Animals; beta-Galactosidase; Bone and Bones; Bone Resorption; Calcium; Galactosidases; Glucuronidase | 1980 |
Inhibition of active bone resorption by copper.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Copper; Copper Sulfate; Culture Techniques; DNA; | 1981 |
Apposition and resorption of bone during oral treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD).
Topics: Administration, Oral; Animals; Anthropometry; Bone and Bones; Bone Development; Bone Resorption; Cal | 1983 |
The effects of 1,25-dihydroxycholecalciferol, parathyroid hormone, and thyroxine on trabecular bone remodeling in adult dogs. A histomorphometric study.
Topics: Animals; Bone and Bones; Bone Regeneration; Bone Resorption; Calcitriol; Dogs; Female; Hydroxyprolin | 1981 |
Fasting urinary sodium/creatinine in relation to calcium/creatinine and hydroxyproline/creatinine in a general population of women.
Topics: Adolescent; Adult; Aged; Bone Resorption; Calcium; Creatinine; Diet; Fasting; Female; Humans; Hydrox | 1981 |
Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Cartilage; Chick Embryo; Hydroxyproline; Kinetics | 1981 |
[The effects of fluorides on bone metabolism (author's transl)].
Topics: Animals; Bone and Bones; Bone Resorption; Fluorides; Hydroxyproline; Rats | 1981 |
Smoking, the menopause and biochemical parameters of bone loss and bone turnover.
Topics: Age Factors; Bone and Bones; Bone Resorption; Calcium; Creatinine; Female; Humans; Hydroxyproline; M | 1982 |
[Laboratory tests and bone biopsy in the diagnosis and treatment of osteoporosis].
Topics: Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Female; Humans; Hydroxyproline; Male; Middle A | 1982 |
[Diminished bone turnover in patients treated with anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Bone Regeneration; Bone Resorption; Epilepsy; Female; Humans; Hy | 1982 |
Indomethacin inhibits bone resorption in vitro without affecting bone collagen synthesis.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Collagen; Hydroxyproline; Indomethacin; Mice; Org | 1982 |
Effects of thyroxine on cortical bone remodeling in adult dogs: a histomorphometric study.
Topics: Animals; Body Temperature; Body Weight; Bone and Bones; Bone Resorption; Dogs; Electrolytes; Female; | 1981 |
The postabsorptive urinary hydroxyproline (spot-HYPRO) in patients with multiple myeloma.
Topics: Bone Resorption; Creatinine; Dialysis; Follow-Up Studies; Humans; Hydroxyproline; Kidney Diseases; M | 1981 |
Effect of lactation and calcium deficiency, and of fluoride intake, on bone turnover in rats: isotopic measurements of bone resorption and formation.
Topics: Animals; Bone Resorption; Calcium; Female; Fluorides; Humerus; Hydroxyproline; Lactation; Osteogenes | 1981 |
Mineral metabolism in spinal cord injury.
Topics: Adult; Bone and Bones; Bone Resorption; Calcium; Humans; Hydroxyproline; Magnesium; Male; Minerals; | 1980 |
The relation between bone loss and calcium balance in women.
Topics: Aged; Alkaline Phosphatase; Bone and Bones; Bone Regeneration; Bone Resorption; Calcium; Female; Fem | 1980 |
Pharmacology of disodium (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate.
Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Calcium; Diphosphonates; Homeostasis; Hy | 1980 |
Effects of oxytetracycline on mineralization of bone in young rats.
Topics: Age Factors; Animals; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcium; Carbon R | 1980 |
Effects of a chemotactic factor and Bacteroides fragilis lipopolysaccharide on bone resorption in tissue culture.
Topics: Animals; Bacteroides fragilis; Bone Resorption; Calcium; Chemotactic Factors; Culture Techniques; Fe | 1980 |
The effect of combined intravenous and oral clodronate treatment on bone pain in patients with metastatic prostate cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Bone Neoplasms; Bone Resorption; Clodronic Acid; Dose | 1994 |
The effects of menopause and age on calcitropic hormones: a cross-sectional study of 655 healthy women aged 35 to 90.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alkaline Phosphatase; Bone Development; Bone Resorption; Calc | 1995 |
Collagen metabolism in two types of autosomal dominant osteopetrosis during stimulation with thyroid hormones.
Topics: Adult; Alkaline Phosphatase; Biomarkers; Bone Development; Bone Resorption; Collagen; Female; Fibrob | 1995 |
Urinary biochemical markers for bone resorption during the menstrual cycle.
Topics: Adult; Amino Acids; Biomarkers; Bone Resorption; Female; Follicular Phase; Humans; Hydroxyproline; L | 1995 |
Different responses of biochemical markers of bone resorption to bisphosphonate therapy in Paget disease.
Topics: Acid Phosphatase; Aged; Aged, 80 and over; Amino Acids; Biomarkers; Bone Resorption; Chromatography, | 1995 |
Increased bone resorption and decreased bone formation in Chinese patients with hip fracture.
Topics: Acid Phosphatase; Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Bone Development; Bone | 1995 |
Heterogeneous decrease of bone mineral density in the vertebral column of ovariectomized rats.
Topics: Absorptiometry, Photon; Alkaline Phosphatase; Analysis of Variance; Animals; Body Weight; Bone Densi | 1995 |
Supplemented gamma-linolenic acid and eicosapentaenoic acid influence bone status in young male rats: effects on free urinary collagen crosslinks, total urinary hydroxyproline, and bone calcium content.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Calcium; Eating; Eic | 1995 |
A simple and automated HPLC method for determination of total hydroxyproline in urine. Comparison with excretion of pyridinolines.
Topics: Aged; Amino Acids; Bone Resorption; Chromatography, High Pressure Liquid; Colorimetry; Female; Fluor | 1995 |
The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate--is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system?
Topics: Alkaline Phosphatase; Amino Acids; Analysis of Variance; Animals; Biomechanical Phenomena; Bone Dens | 1995 |
Acute effects of bisphosphonates on new and traditional markers of bone resorption.
Topics: Acid Phosphatase; Aged; Aged, 80 and over; Alendronate; Amino Acids; Biomarkers; Bone and Bones; Bon | 1995 |
Effect of age on bone density and bone turnover in men.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Androgens; Bone Density; Bone Development; Bone Resorpt | 1995 |
Urinary excretion of galactosyl-hydroxylysine is a marker of growth in children.
Topics: Adolescent; Adult; Aging; Amino Acids; Biomarkers; Bone Resorption; Child; Child Development; Child, | 1995 |
Stimulative effects of lead on bone resorption in organ culture.
Topics: Animals; Anti-Bacterial Agents; Bone Resorption; Calcitonin; Calcium; Dinoprostone; Hydroxyproline; | 1995 |
Increased urinary excretion of collagen crosslinks in girls with Ullrich-Turner syndrome.
Topics: Adolescent; Amino Acids; Bone Resorption; Child; Child, Preschool; Collagen; Female; Humans; Hydroxy | 1995 |
Urinary citrate, bone resorption and intestinal alkali absorption in stone formers with fasting hypercalciuria.
Topics: Adult; Alkalies; Bone Resorption; Calcitonin; Calcitriol; Calcium; Calcium Metabolism Disorders; Cit | 1994 |
Hydroxyproline excretion is increased in diabetes mellitus and related to the presence of microalbuminuria.
Topics: Adult; Aged; Albuminuria; Biomarkers; Bone Resorption; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1995 |
Mechanisms of rapid bone loss following cardiac transplantation.
Topics: Absorptiometry, Photon; Adult; Bone and Bones; Bone Resorption; Calcium; Creatine; Female; Heart Tra | 1994 |
Reduced serum levels of carboxy-terminal propeptide of human type I procollagen in a family with type I-A osteogenesis imperfecta.
Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Bone Density; Bone Reso | 1994 |
Comparison of serum osteocalcin with total and bone specific alkaline phosphatase and urinary hydroxyproline:creatinine ratio in patients with Paget's disease of bone.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Bone and Bones; Bone Development; Bone Resorption; Cr | 1994 |
Biochemical markers of bone turnover for the clinical assessment of bone metabolism.
Topics: Acid Phosphatase; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Development; Bone Resorption; | 1994 |
Oral calcium suppresses biochemical markers of bone resorption in normal men.
Topics: Absorption; Adult; Amino Acids; Biomarkers; Bone Resorption; Calcium; Calcium Radioisotopes; Creatin | 1994 |
Biochemical measurements in Paget's disease of bone.
Topics: Alkaline Phosphatase; Biomarkers; Bone Resorption; Humans; Hydroxyproline; Osteitis Deformans | 1994 |
The short-term effects of conjugated estrogen on bone turnover in older women.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Amino Acids; Bone and Bones; Bone Density; Bone Resor | 1994 |
Effect of bisphosphonate therapy and parathyroidectomy on the urinary excretion of galactosylhydroxylysine in primary hyperparathyroidism.
Topics: Aged; Alendronate; Biomarkers; Bone Resorption; Diphosphonates; Female; Humans; Hydroxylysine; Hydro | 1994 |
Duration of the effects of intravenous alendronate in postmenopausal women and in patients with primary hyperparathyroidism and Paget's disease of bone.
Topics: Aged; Alendronate; Alkaline Phosphatase; Bone Diseases, Metabolic; Bone Resorption; Calcium; Diphosp | 1994 |
Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Body Weight; Bone Resorption; Calcium; Ch | 1993 |
Loss of bone in the proximal part of the femur following unstable fractures of the leg.
Topics: Absorptiometry, Photon; Aged; Bone Density; Bone Resorption; Calcium; Creatinine; Female; Femur; Hum | 1994 |
Biochemical markers of bone turnover.
Topics: Alkaline Phosphatase; Biomarkers; Bone Development; Bone Resorption; Calcium; Collagen; Humans; Hydr | 1993 |
Use of a rat model for the simultaneous assessment of pharmacokinetic and pharmacodynamic aspects of bisphosphonate treatment: application to the study of intravenous 14C-labeled 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate.
Topics: Animals; Bone Resorption; Creatinine; Diphosphonates; Disease Models, Animal; Dose-Response Relation | 1994 |
Biochemical effects of a calcium supplement in postmenopausal women with primary hyperparathyroidism.
Topics: Absorption; Aged; Aged, 80 and over; Bone Resorption; Calcium; Creatinine; Female; Humans; Hydroxypr | 1994 |
Usefulness of biochemical markers of bone turnover in rats after clodronate administration.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Biomarkers; Bone Development; Bone Resorption; Clod | 1993 |
Urinary collagen crosslink excretion: a better index of bone resorption than hydroxyproline in Paget's disease of bone?
Topics: Amino Acids; Biomarkers; Bone Resorption; Calcitonin; Chromatography, High Pressure Liquid; Diphosph | 1993 |
Effects of short-term low-dose heparin administration on biochemical parameters of bone turnover.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bone and Bones; Bone | 1993 |
Importance of bone resorption in the determination of bone density in women more than 10 years past the menopause.
Topics: Aged; Ankle; Body Mass Index; Bone Density; Bone Resorption; Calcitriol; Creatinine; Female; Hip; Hu | 1993 |
Possible variation in bone resorption during the normal menstrual cycle.
Topics: Adult; Alkaline Phosphatase; Amino Acids; Bone Resorption; Collagen; Collagen Type I; Creatine; Estr | 1993 |
Changes in markers of bone formation and resorption in a bed rest model of weightlessness.
Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Amino Acids; Bed Rest; Biomarkers; Bone and Bones; Bo | 1993 |
Changes of bone metabolic markers in patients with bone metastases: clinical significance in assessing bone response to chemotherapy.
Topics: Adult; Aged; Alkaline Phosphatase; Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Biom | 1993 |
Reevaluation of the usefulness of serum free hydroxyproline as a parameter for assessing renal osteodystrophy.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Resorption; Chronic Kidney Disease-Mineral and Bone Disorder | 1993 |
Urinary hydroxypyridinium crosslinks of collagen as markers of bone resorption and estrogen efficacy in postmenopausal osteoporosis.
Topics: Acid Phosphatase; Adult; Aged; Amino Acids; Biomarkers; Bone Density; Bone Resorption; Collagen; Cro | 1993 |
The nature and significance of the relationship between urinary sodium and urinary calcium in women.
Topics: Adult; Age Factors; Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Calcium, Dietary; Creatini | 1993 |
Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption.
Topics: Aged; Amino Acids; Biomarkers; Bone Development; Bone Resorption; Female; Humans; Hydroxyproline; Mi | 1993 |
Acute changes in calcium homeostasis during treatment of primary hyperparathyroidism with risedronate.
Topics: Administration, Oral; Aged; Alkaline Phosphatase; Analysis of Variance; Bone Resorption; Calcium; Et | 1993 |
Biochemical markers for detecting bone metastases in patients with breast cancer.
Topics: Alkaline Phosphatase; Biomarkers, Tumor; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neo | 1993 |
Menatetrenone inhibits bone resorption partly through inhibition of PGE2 synthesis in vitro.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Dinoprostone; Hydroxyproline; Indomet | 1993 |
Immunoassay for urinary pyridinoline: the new marker of bone resorption.
Topics: Adult; Amino Acids; Biomarkers; Bone Resorption; Chromatography; Chromatography, High Pressure Liqui | 1993 |
Serum osteocalcin in metabolic bone diseases: what is its real significance?
Topics: Adult; Alkaline Phosphatase; Bone Diseases; Bone Resorption; Calcitonin; Female; Humans; Hydroxyprol | 1993 |
Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasty.
Topics: Adult; Aged; Bone Resorption; Cell Division; Cell Membrane; Cytokines; DNA; Female; Hip Prosthesis; | 1995 |
Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis.
Topics: Acute Disease; Adult; Aged; Alkaline Phosphatase; Amino Acids; Anti-Inflammatory Agents; Arthritis, | 1996 |
Variable efficacy of bone remodeling biochemical markers in the management of patients with Paget's disease of bone treated with tiludronate.
Topics: Administration, Oral; Aged; Alkaline Phosphatase; Biomarkers; Bone Remodeling; Bone Resorption; Coll | 1996 |
Urine hydroxyproline increase in patients with diabetes mellitus.
Topics: Acid Phosphatase; Albuminuria; Alkaline Phosphatase; Biomarkers; Bone Resorption; Diabetes Mellitus, | 1996 |
New marker of bone resorption: hydroxyproline-containing peptide. High-performance liquid chromatographic assay without hydrolysis as an alternative to hydroxyproline determination: a preliminary report.
Topics: Adult; Amino Acids; Biomarkers; Bone Resorption; Chromatography, High Pressure Liquid; Female; Fluor | 1996 |
Bone loss after liver transplantation is not prevented by cyclical etidronate, calcium and alphacalcidol. The Liver Transplant Group, Groningen.
Topics: Absorptiometry, Photon; Adult; Biomarkers; Bone Density; Bone Resorption; Calcium; Creatinine; Etidr | 1996 |
New biochemical markers of bone resorption derived from collagen breakdown in the study of postmenopausal osteoporosis.
Topics: Adult; Aged; Amino Acids; Biomarkers; Bone Diseases, Metabolic; Bone Resorption; Calcium; Collagen; | 1996 |
Estradiol treatment transiently increases trabecular bone volume in ovariectomized rats.
Topics: Alkaline Phosphatase; Analysis of Variance; Animals; Bone Density; Bone Resorption; Cell Division; D | 1996 |
Prediction of the outcome of treatment of Paget's disease of bone with bisphosphonates from short-term changes in the rate of bone resorption.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Bone Resorption; Collagen; Collagen Type I; Diphosphona | 1996 |
Measurements of deoxypyridinoline and hydroxyproline in 24-h, first morning, and second morning urine samples.
Topics: Amino Acids; Bone Resorption; Chromatography, High Pressure Liquid; Collagen; Female; Humans; Hydrox | 1996 |
[Bone metabolism and diseases].
Topics: Adult; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Calcium; Female; Gon | 1996 |
Comparative evaluation of markers of bone resorption in patients with breast cancer-induced osteolysis before and after bisphosphonate therapy.
Topics: Adult; Aged; Amino Acids; Analysis of Variance; Biomarkers; Bone Neoplasms; Bone Resorption; Breast | 1997 |
Bilateral tibial marrow ablation in rats induces a rapid hypercalcemia arising from extratibial bone resorption inhibitable by methylprednisolone or deflazacort.
Topics: alpha-Macroglobulins; Animals; Bone Marrow; Bone Resorption; Calcium; Disease Models, Animal; Fractu | 1997 |
Reduction of bone mass in women after bone marrow transplantation.
Topics: Adolescent; Adult; Biomarkers; Bone Density; Bone Diseases, Metabolic; Bone Marrow Transplantation; | 1997 |
[Interrelations of the calcium concentration in breast milk with maternal intake of cow's milk and milk products, bone resorption and bone mineral density during lactation].
Topics: Adult; Animals; Bone Density; Bone Resorption; Calcium; Creatinine; Dairy Products; Diet; Female; Hu | 1997 |
Prophylactic effects of 1,24,25-trihydroxyvitamin D3 on ovariectomy-induced cancellous bone loss in the rat.
Topics: Alkaline Phosphatase; Animals; Biomarkers; Body Weight; Bone and Bones; Bone Density; Bone Resorptio | 1997 |
The value of biochemical markers of bone turnover in osteoporosis.
Topics: Alkaline Phosphatase; Biomarkers; Bone Density; Bone Resorption; Collagen; Female; Humans; Hydroxypr | 1997 |
Is skeletal responsiveness to thyroid hormone altered in primary osteoporosis or following estrogen replacement therapy?
Topics: Absorptiometry, Photon; Administration, Oral; Aged; Alkaline Phosphatase; Amino Acids; Bone Density; | 1997 |
[Deoxypyridinoline and other biochemical markers of bone resorption in distinct pathologies].
Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Resorption; Female; Hum | 1997 |
The effect of olpadronate in ovariectomized thyroxine-treated rats.
Topics: Alkaline Phosphatase; Animals; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Creatinin | 1997 |
Quantification of biochemical markers of bone turnover by kinetic measures of bone formation and resorption in young healthy females.
Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Biomarkers; Bone Density; Bone Developmen | 1997 |
[Effects of hormone replacement therapy in bone resorption, in post-menopausal women].
Topics: Adult; Aged; Analysis of Variance; Bone Resorption; Estrogen Replacement Therapy; Female; Humans; Hy | 1996 |
Bone and mineral metabolism in transient hyperphosphatasaemia.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Density; Bone Resorption; Child, Preschool; Female; Human | 1994 |
The measurement of urinary amino-terminal telopeptides of type I collagen to monitor bone resorption in patients with primary hyperparathyroidism.
Topics: Absorptiometry, Photon; Acid Phosphatase; Adenoma; Adult; Aged; Alkaline Phosphatase; Bone Density; | 1997 |
Effects of tibolone (Org OD14) treatment for 3 months on ovariectomy-induced osteopenia in 8-month-old rats on a low-calcium diet: preventive testing for 3 months.
Topics: Administration, Oral; Amino Acids; Anabolic Agents; Animals; Antineoplastic Agents, Hormonal; Biomar | 1998 |
[Role of bones in the physiopathology of idiopathic hypercalciuria: effect of amino-bisphosphonate alendronate].
Topics: Alendronate; Bone and Bones; Bone Density; Bone Resorption; Calcium; Cytokines; Humans; Hydroxyproli | 1997 |
Collagen-related markers of bone turnover reflect the severity of liver fibrosis in patients with primary biliary cirrhosis.
Topics: Acid Phosphatase; Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers; Bone and Bones; Bone Dens | 1998 |
A proposal for standardizing urine collections for bone resorption markers measurement.
Topics: Adult; Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Density; Bone Resorption; Collagen; | 1998 |
Alterations of bone turnover and bone mass at different skeletal sites due to pure glucocorticoid excess: study in eumenorrheic patients with Cushing's syndrome.
Topics: Absorptiometry, Photon; Adolescent; Adult; Amino Acids; Bone Density; Bone Remodeling; Bone Resorpti | 1998 |
Urinary collagen crosslinks reflect further bone loss of femoral neck in osteoporotic patients undergoing vitamin D therapy.
Topics: Alkaline Phosphatase; Amino Acids; Analysis of Variance; Biomarkers; Bone Density; Bone Resorption; | 1998 |
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism.
Topics: Amino Acids; Animals; Biomarkers; Bone Density; Bone Resorption; Estradiol; Estrogens, Non-Steroidal | 1998 |
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.
Topics: Aldehydes; Animals; Bone and Bones; Bone Resorption; Calcium; Cathepsin L; Cathepsins; Cysteine Endo | 1998 |
Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause.
Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Body Heigh | 1998 |
Comparison of bone resorption markers during hypocalcemia in dairy cows.
Topics: Amino Acids; Animals; Biomarkers; Bone Resorption; Cattle; Cattle Diseases; Collagen; Collagen Type | 1998 |
Comparison of urinary bone resorption markers in women of 40-70 years; day-to-day and long-term variation in individual subjects.
Topics: Adult; Age Factors; Aged; Amino Acids; Biomarkers; Bone Resorption; Collagen; Collagen Type I; Enzym | 1998 |
Investigations of bone turnover in renal osteopathy.
Topics: Adult; Aged; Amino Acids; Biomarkers; Bone Remodeling; Bone Resorption; Calcium; Chromatography, Hig | 1999 |
The effect of toremifene on bone and uterine histology and on bone resorption in ovariectomised rats.
Topics: Amino Acids; Animals; Biomarkers; Bone and Bones; Bone Resorption; Calcium; Drug Interactions; Estra | 1999 |
[Effect of KW-8232 on bone turnover in ovariectomized rats].
Topics: Alkaline Phosphatase; Amino Acids; Animals; Bone Density; Bone Resorption; Calcium; Disease Models, | 1998 |
Big future in store for biochemical bone markers.
Topics: Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Resorption; Humans; Hydroxyproline; Osteoporosis | 1996 |
Ionized calcium and bone turnover in the estrogen-deficient rat.
Topics: Alkaline Phosphatase; Amino Acids; Animals; Bone Resorption; Calcium; Creatinine; Estradiol; Estroge | 1999 |
Osteogenesis imperfecta: bone turnover, bone density, and ultrasound parameters.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Amino Acids; Bone and Bones; Bone Density; Bone | 1999 |
Evaluation of the effect of low-dose oral theophylline therapy on some bone turnover markers and serum prolidase I activity in mild asthmatics.
Topics: Administration, Oral; Adolescent; Adult; Aged; Alkaline Phosphatase; Amino Acids; Asthma; Biomarkers | 1999 |
Bone metabolism in type 2 diabetes mellitus.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Biomarkers; Bone Density; Bone Resorption; Calcium; | 1999 |
Biochemical markers of bone turnover after surgical menopause and hormone replacement therapy.
Topics: Acid Phosphatase; Administration, Cutaneous; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Dev | 1999 |
Free 4-hydroxyproline content in serum of bedridden aged people is elevated due to fracture.
Topics: Adult; Aged; Aged, 80 and over; Aging; Bed Rest; Bone Density; Bone Resorption; Calibration; Female; | 2000 |
Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene.
Topics: Adult; Aged; Animals; Biomarkers; Bone Density; Bone Remodeling; Bone Resorption; Case-Control Studi | 2000 |
Regulation of collagenolytic protease secretion through c-Src in osteoclasts.
Topics: Actins; Androstadienes; Animals; Base Sequence; Bone Resorption; Calcitriol; Cathepsin B; Cathepsin | 2000 |
The course of selected bone resorption marker concentrations in response to short-term hypocalcemia experimentally induced with disodium EDTA infusions in dairy cows.
Topics: Amino Acids; Animals; Biomarkers; Bone Resorption; Calcium; Cattle; Cattle Diseases; Chelating Agent | 2000 |
Calcaneal ultrasonometry in patients with Charcot osteoarthropathy and its relationship with densitometry in the lumbar spine and femoral neck and with markers of bone turnover.
Topics: Absorptiometry, Photon; Adult; Arthropathy, Neurogenic; Biomarkers; Bone Density; Bone Resorption; C | 2001 |
[Laboratory diagnosis of osteoporosis].
Topics: Adult; Aged; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone and Bones; Bone Resorption; Child; | 2001 |
Changes in urinary excretion of pyridinium cross-links during Spacelab-J.
Topics: Aerospace Medicine; Bone and Bones; Bone Demineralization, Pathologic; Bone Resorption; Calcium; Hum | 1997 |
Biochemical markers of bone turnover.
Topics: Alkaline Phosphatase; Biomarkers; Bone Resorption; Humans; Hydroxylysine; Hydroxyproline; Osteocalci | 2001 |
[Bone complication in diabetes subjects with good metabolic control and without longterm complications: certain problems. Part II. Basal parameters of bone turnover].
Topics: Alkaline Phosphatase; Bone Resorption; Creatine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 2001 |
Effects of dose and timing of calcium supplementation on bone resorption in early menopausal women.
Topics: Amino Acids; Bone Resorption; Calcium; Creatinine; Dietary Supplements; Drug Administration Schedule | 2002 |
A pharmacokinetic and pharmacodynamic model for intravenous bisphosphonate (pamidronate) in osteoporosis.
Topics: Adult; Aged; Bone Resorption; Diphosphonates; Female; Humans; Hydroxyproline; Male; Middle Aged; Mod | 2002 |
A cysteine protease inhibitor prevents suspension-induced declines in bone weight and strength in rats.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Cathepsin K; Cathepsins; Collagenases; Cysteine P | 2002 |
Bone alterations in patients with idiopathic hypercalciuria and calcium nephrolithiasis.
Topics: Adult; Alkaline Phosphatase; Bone Density; Bone Resorption; Calcium; Calcium Metabolism Disorders; F | 2002 |
Treatment of Paget's disease with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.).
Topics: Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Diphosphonates; Female; Follow | 1979 |
Inhibition of osteolytic bone lesions by (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.).
Topics: Bone Resorption; Breast Neoplasms; Calcium; Creatinine; Diphosphonates; Female; Humans; Hydroxyproli | 1979 |
[Biological exploration of Paget's disease].
Topics: Acid Phosphatase; Alkaline Phosphatase; Bone Resorption; Calcitonin; Calcium; Follow-Up Studies; Hum | 1976 |
Bone and ageing.
Topics: Absorptiometry, Photon; Adolescent; Adult; Age Determination by Skeleton; Age Factors; Aged; Aging; | 1975 |
Effect of the diphosphonate EHDP on bone mineral metabolism during prolonged bed rest.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Depression, Chemical; Diphosp | 1975 |
[Malignant hypercalcemia during Basedow's disease].
Topics: Adenoma; Adult; Bipolar Disorder; Bone Resorption; Calcitonin; Calcium; Carbimazole; Graves Disease; | 1975 |
Experimental parturient hypocalcemia in cows following prepartal chemical inhibition of bone resportion.
Topics: Animals; Antigens; Bone Resorption; Calcium; Calcium, Dietary; Cattle; Cattle Diseases; Cyclic AMP; | 1976 |
Changes in plasma 25-hydroxycholecalciferol and selected blood parameters after injection of massive doses of cholecalciferol or 25-hydroxycholecalciferol in non-lactating dairy cows.
Topics: Animals; Bone Resorption; Calcium; Cattle; Cholecalciferol; Female; Half-Life; Hydroxycholecalcifero | 1977 |
The effect of long term estrogen administration on bone metabolism in the female rat.
Topics: Animals; Body Weight; Bone and Bones; Bone Resorption; Calcium; Castration; Collagen; Estradiol; Fem | 1979 |
Collagenase activity and morphological and chemical bone resorption induced by prostaglandin E2 in tissue culture.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Culture Techniques; Hydroxyproline; Mice; Microbi | 1979 |
Investigation of bone and mineral metabolism in hyperthyroidism before and after treatment using calcitonin, 47Ca and balance studies.
Topics: Adult; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Calcium Radioisotopes; Female; Humans; | 1979 |
Collagen synthesis and degradation in embryonic chick-bone explants.
Topics: Animals; Bone Resorption; Chick Embryo; Collagen; Culture Media; Culture Techniques; Hydroxyproline; | 1979 |
Sitting, muscular exercises, and collagen metabolism in tetraplegia.
Topics: Adolescent; Adult; Bone Resorption; Calcium; Collagen; Humans; Hydroxyproline; Male; Osteoporosis; P | 1979 |
Effect of antithyroid treatment on calcium-phosphorus metabolism in hyperthyroidism. I: Chemical quantities in serum and urine.
Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Carbimazole; Female; Hu | 1978 |
Effect of rigid plate fixation on structure and mineral content of cortical bone.
Topics: Animals; Bone and Bones; Bone Development; Bone Plates; Bone Resorption; Calcium; Collagen; Epiphyse | 1978 |
Metabolic balance studies in patients with Paget's disease receiving salmon calcitonin over long periods.
Topics: Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Female; Humans; Hy | 1977 |
Parathormone-stimulated resorption of devitalised bone by cultured osteoclast-type bone cells.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Cells, Cultured; Hydroxyproline; Mice; Osteoblasts; O | 1977 |
Aspects of calcium metabolism in obstructive nephropathy: a metabolic and bone biopsy investigation.
Topics: Adult; Bone Resorption; Calcium; Chronic Kidney Disease-Mineral and Bone Disorder; Creatinine; Femal | 1977 |
Bone, calcium, and hydroxyproline metabolism in hyperparathyroidism and after removal of parathyroid adenoma.
Topics: Adenoma; Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Female; Humans; Hydro | 1977 |
Endogenous oestrogen and bone loss following oophorectomy.
Topics: Bone and Bones; Bone Resorption; Creatinine; Estradiol; Female; Humans; Hydroxyproline; Hysterectomy | 1977 |
Histological measurements in Paget's disease of bone.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Humans; Hydroxycholecalciferols; Hyd | 1977 |
The in vitro effect of oestradiol on collagen metabolism in metaphyseal rat bone.
Topics: Animals; Bone and Bones; Bone Regeneration; Bone Resorption; Collagen; Estradiol; Female; Hydroxypro | 1977 |
Effect of parathyroid hormone on bone resorption in uremic patients.
Topics: Adolescent; Adult; Alkaline Phosphatase; Bone Resorption; Female; Fibrous Dysplasia of Bone; Humans; | 1976 |
Phosphorus deficiency, parathyroid hormone and bone resorption in the growing rat.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Cell Count; Hydroxyproline; Magnesium; Male; Oste | 1976 |
Effects of phosphorus supplementation on serum parathyroid hormone and bone morphology in osteoporosis.
Topics: Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Calcium, Dietary; Female; Huma | 1976 |
The relationship between oestrogen status and bone loss in post-menopausal women.
Topics: Aging; Bone Resorption; Calcium; Creatinine; Estrogens; Female; Fractures, Bone; Humans; Hydroxyprol | 1976 |
25-hydroxycholecalciferol-enhanced bone maturation in the parathyroprivic state.
Topics: Animals; Bone and Bones; Bone Development; Bone Matrix; Bone Resorption; Calcium; Collagen; Dihydrox | 1975 |
The hydroxyproline content of plasma of patients with impaired renal function.
Topics: Alkaline Phosphatase; Blood Proteins; Bone Resorption; Calcium; Creatinine; Humans; Hydroxyproline; | 1975 |
Bone resorbing activity of vitamin D metabolites and congeners in vitro: influence of hydroxyl substituents in the A ring.
Topics: Animals; Bone and Bones; Bone Resorption; Collagen; Culture Media; Culture Techniques; Hydroxycholec | 1975 |
Post-menopausal osteopenia and osteoporosis.
Topics: Adult; Bone and Bones; Bone Resorption; Calcium; Creatinine; Female; Humans; Hydroxyproline; Male; M | 1975 |
Effect of adrenal steroids on bone resorption in rats.
Topics: Animals; Body Weight; Bone Resorption; Calcitonin; Calcium; Calcium, Dietary; Desoxycorticosterone; | 1976 |
Collagen studies in acro-osteolysis.
Topics: Adult; Biopsy; Bone Resorption; Collagen; Fingers; Humans; Hydroxyproline; Male; Osteolysis; Proline | 1976 |
Recombinant human interferon gamma therapy for osteopetrosis.
Topics: Bone and Bones; Bone Marrow; Bone Resorption; Calcium; Calcium, Dietary; Child; Child, Preschool; He | 1992 |
Whole-body and site-specific bone remodelling in patients with previous femoral fractures: relationships between reduced physical activity, reduced bone mass and increased bone resorption.
Topics: Aged; Bone and Bones; Bone Density; Bone Remodeling; Bone Resorption; Creatinine; Female; Femoral Ne | 1992 |
Effects on cultured neonatal mouse calvaria of 1 alpha,25-dihydroxyvitamin D3, 26,26,26,27,27,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 26,26,26,27,27,27-hexafluoro-1 alpha,23S,25-trihydroxyvitamin D3.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Cells, Cultured; Di | 1992 |
Bone-resorption markers galactosyl hydroxylysine, pyridinium crosslinks, and hydroxyproline compared.
Topics: Adult; Aged; Amino Acids; Biomarkers; Bone Resorption; Child; Chromatography, High Pressure Liquid; | 1992 |
Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption.
Topics: Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Density; Bone Development; Bone Remodeling; Bone | 1992 |
A specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urine.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Amino Acids; Antibodies, Monoclonal; Bone Diseases, Me | 1992 |
Quantitative analyses of urinary pyridinoline and deoxypyridinoline excretion in patients with hyperthyroidism.
Topics: Adult; Alkaline Phosphatase; Amino Acids; Biomarkers; Bone Resorption; Female; Humans; Hydroxyprolin | 1992 |
Bone turnover during short course prednisolone treatment in patients with chronic obstructive airways disease.
Topics: Aged; Bone and Bones; Bone Resorption; Creatinine; Humans; Hydroxyproline; Lung Diseases, Obstructiv | 1992 |
Tamoxifen in the rat prevents estrogen-deficiency bone loss elicited with the LHRH agonist buserelin.
Topics: Animals; Body Weight; Bone Diseases, Metabolic; Bone Resorption; Buserelin; Calcium; Disease Models, | 1992 |
A new mathematical model to study bone turnover in growing rats.
Topics: Absorptiometry, Photon; Aging; Animals; Biomarkers; Bone and Bones; Bone Density; Bone Development; | 1992 |
Regulation of bone turnover and prevention of bone atrophy in ovariectomized beagle dogs by the administration of 24R,25(OH)2D3.
Topics: 24,25-Dihydroxyvitamin D 3; Animals; Bone and Bones; Bone Resorption; Disease Models, Animal; Dogs; | 1992 |
Bone remodelling does not decline after menopause in vertebral fracture osteoporosis.
Topics: Age Factors; Aged; Alkaline Phosphatase; Bone Remodeling; Bone Resorption; Creatinine; Female; Fract | 1992 |
Biochemical assessment of bone loss in patients on long-term thyroid hormone treatment.
Topics: Acid Phosphatase; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Analysis of Variance; Bone D | 1992 |
Acute effects of an oral calcium load in pregnancy and lactation: findings on renal calcium conservation and biochemical indices of bone turnover.
Topics: Absorption; Adult; Bone and Bones; Bone Resorption; Calcium; Cyclic AMP; Female; Humans; Hydroxyprol | 1991 |
Calcium absorption in normal and osteoporotic postmenopausal women.
Topics: Absorption; Adult; Aged; Aged, 80 and over; Aging; Alkaline Phosphatase; Body Weight; Bone Resorptio | 1991 |
Preventive effects of clomiphene citrate on estrogen-deficiency osteopenia elicited by LHRH agonist administration in the rat.
Topics: Animals; Bone Diseases, Metabolic; Bone Resorption; Buserelin; Calcium; Clomiphene; Endometriosis; E | 1991 |
Effects of chlorthalidone and mechanical ventilation on hydroxyprolinuria during immobilization by means of muscle relaxants.
Topics: Adolescent; Adult; Aged; Bone Resorption; Calcium; Chlorthalidone; Female; Humans; Hydrogen-Ion Conc | 1991 |
Direct and sex-specific enhancement of bone formation and calcification by sex steroids in fetal mice long bone in vitro (biochemical and morphometric study.
Topics: Animals; Bone Resorption; Calcification, Physiologic; Calcium; Estradiol; Female; Fetus; Hydroxyprol | 1991 |
Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis.
Topics: Aged; Amino Acids; Biomarkers; Bone and Bones; Bone Regeneration; Bone Resorption; Female; Humans; H | 1991 |
Clinical usefulness of serum tartrate-resistant acid phosphatase in Paget's disease of bone: correlation with other biochemical markers of bone remodelling.
Topics: Acid Phosphatase; Aged; Alkaline Phosphatase; Biomarkers; Bone Resorption; Creatinine; Female; Human | 1991 |
17 beta-estradiol protects rats from osteopenia associated with administration of the luteinising hormone releasing hormone (LHRH) agonist, buserelin.
Topics: Animals; Bone Diseases, Metabolic; Bone Resorption; Buserelin; Calcium; Calcium Radioisotopes; Estra | 1991 |
Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases.
Topics: Aged; Aged, 80 and over; Amino Acids; Biomarkers; Bone Diseases, Metabolic; Bone Resorption; Collage | 1991 |
Effect of a single infusion of aminohydroxypropylidene on calcium and bone metabolism in healthy volunteers monitored during 2 months.
Topics: 24,25-Dihydroxyvitamin D 3; Adult; Alkaline Phosphatase; Bone and Bones; Bone Development; Bone Reso | 1991 |
The course of biochemical parameters of bone turnover during treatment with corticosteroids.
Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Bone Development; Bone Resorption; Creatinine; Female | 1991 |
Bone histomorphometric analysis for the cause of osteopenia in vitamin C-deficient rat (ODS rat).
Topics: Alkaline Phosphatase; Animals; Ascorbic Acid Deficiency; Body Weight; Bone and Bones; Bone Diseases, | 1991 |
Effect of salt restriction on urine hydroxyproline excretion in postmenopausal women.
Topics: Aged; Bone Resorption; Calcium; Diet, Sodium-Restricted; Female; Humans; Hydroxyproline; Menopause; | 1991 |
Bone turnover during high dose inhaled corticosteroid treatment.
Topics: Administration, Inhalation; Adult; Alkaline Phosphatase; Beclomethasone; Bone and Bones; Bone Resorp | 1991 |
Effects of amino-butylidene diphosphonate in hypercalcemia due to malignancy.
Topics: Adult; Aged; Bone Resorption; Calcium; Diphosphonates; Female; Humans; Hydroxyproline; Hypercalcemia | 1991 |
Effects of retinoic acid on bone formation and resorption in cultured mouse calvaria.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Development; Bone Resorption; Calcium; Female; H | 1991 |
Biochemical parameters of bone turnover during ten days of bed rest and subsequent mobilization.
Topics: Adult; Alkaline Phosphatase; Bed Rest; Bone and Bones; Bone Resorption; Calcifediol; Calcitriol; Cal | 1991 |
Buserelin-mediated osteoporosis: effects of restoring estrogen on bone resorption and whole body calcium content in the rat.
Topics: Animals; Body Weight; Bone and Bones; Bone Resorption; Buserelin; Calcium; Estradiol; Female; Femur; | 1990 |
Assessment of bone turnover in the dry period of dairy cows by measurement of plasma bone GLA protein, total plasma alkaline phosphatase activity and urinary hydroxyproline.
Topics: Alkaline Phosphatase; Animals; Bone Resorption; Calcium; Cattle; Diet; Female; Hydroxyproline; Labor | 1990 |
Urinary total hydroxyproline measured by HPLC: comparison of spot and timed urine collections.
Topics: Autoanalysis; Bone Resorption; Chromatography, High Pressure Liquid; Humans; Hydroxyproline; Specime | 1990 |
Effects of clomiphene and tamoxifen in vivo on the bone-resorbing effects of parathyroid hormone and of high oral doses of calcitriol (1,25(OH)2D3) in rats with intact ovarian function consuming low calcium diet.
Topics: Animals; Bone Resorption; Calcitriol; Calcium; Calcium Radioisotopes; Clomiphene; Diet; Dose-Respons | 1990 |
Lower mobility and markers of bone resorption in the elderly.
Topics: Aged; Aged, 80 and over; Bone Resorption; Calcitriol; Calcium; Creatinine; Homes for the Aged; Human | 1990 |
Trabecular bone remodeling and bone mineral density in the adult cat during chronic dietary acidification with ammonium chloride.
Topics: Acidosis; Ammonium Chloride; Animal Feed; Animals; Biopsy; Bone Density; Bone Development; Bone Reso | 1990 |
Accelerated bone resorption in senescence-accelerated mouse (SAM-P/6).
Topics: Aging; Alkaline Phosphatase; Animals; Body Weight; Bone Resorption; Calcium; Cyclic AMP; Femur; Glom | 1989 |
Procollagenase associated with the noncalcified matrix of bone and its regulation by parathyroid hormone.
Topics: Animals; Bone Matrix; Bone Resorption; Collagenases; Enzyme Precursors; Hydroxyproline; Mice; Mice, | 1989 |
[Psoriatic osteopathy].
Topics: Alkaline Phosphatase; Arthritis, Psoriatic; Bone and Bones; Bone Density; Bone Resorption; Calcium; | 1989 |
[A single infusion of Pamidronate (APD) in Paget's disease of bone].
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Bone Resorption; Diphosphonates; Female; Humans; Hydr | 1989 |
Cyclosporin A induces in vivo inhibition of resorption and stimulation of formation in rat bone.
Topics: Acid Phosphatase; Animals; Bone Development; Bone Resorption; Cell Count; Cyclosporins; Female; Hydr | 1989 |
Study of bone loss in diabetes mellitus type 1.
Topics: Alkaline Phosphatase; Blood Glucose; Blood Proteins; Bone and Bones; Bone Diseases, Metabolic; Bone | 1989 |
Bone demineralization, biochemical indices of bone remodeling, and estrogen replacement therapy in adults with Turner's syndrome.
Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Bone and Bones; Bone Regeneration; Bone Resorption; C | 1989 |
Application of an in vitro model and a clinical protocol in the assessment of the potency of a new bisphosphonate.
Topics: Administration, Oral; Aged; Animals; Bone and Bones; Bone Resorption; Clinical Protocols; Diphosphon | 1989 |
Comparative effects of intravenous diphosphonates on calcium and skeletal metabolism in man.
Topics: Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Resorption; Clodronic Acid; Diphosphonates; Etidr | 1987 |
Calcium metabolism, serum thyroid-stimulating hormone, prolactin, and growth hormone in spontaneously hypercholesterolemic rats.
Topics: Animals; Body Weight; Bone Resorption; Calcium; Growth Hormone; Hydroxyproline; Hypercholesterolemia | 1989 |
Treatment of the hypercalcaemia of malignancy with intravenous clodronate.
Topics: Adult; Aged; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Female; Humans; Hydroxyprolin | 1987 |
Clodronate in the medical management of hyperparathyroidism.
Topics: Administration, Oral; Bone Resorption; Clodronic Acid; Diphosphonates; Humans; Hydroxyproline; Hyper | 1987 |
A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Culture Techniques; Embryo, Mammalian; Hydroxypro | 1985 |
Bone resorption and hypercalciuria in calcium stoneformers.
Topics: Adult; Bone Resorption; Calcium; Circadian Rhythm; Creatinine; Cyclic AMP; Fasting; Humans; Hydroxyp | 1986 |
Effects of NaCl on calcium balance, parathyroid function and hydroxyproline excretion in prednisolone-treated rats consuming low calcium diet.
Topics: Absorption; Animals; Bone Resorption; Calcium; Cyclic AMP; Diet; Feces; Glucocorticoids; Hydroxyprol | 1986 |
The effects of hydrocortisone, parathyroid hormone and the bisphosphonate, APD, on bone resorption in neonatal mouse calvaria.
Topics: Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Calcium; Diphosphonates; DNA; Drug Inter | 1986 |
Biochemical effects of calcium supplementation in postmenopausal osteoporosis.
Topics: Alkaline Phosphatase; Bone Resorption; Calcium; Creatinine; Female; Humans; Hydroxyproline; Menopaus | 1988 |
Effects of dietary NaCl supplementation on bone synthesis of hydroxyproline, urinary hydroxyproline excretion and bone 45Ca uptake in the rat.
Topics: Animals; Biological Transport, Active; Bone and Bones; Bone Diseases, Metabolic; Bone Resorption; Ca | 1988 |
Bone turnover in postmenopausal osteoporosis. Effect of calcitonin treatment.
Topics: Aging; Biomarkers; Bone Resorption; Calcitonin; Calcium-Binding Proteins; Female; Humans; Hydroxypro | 1988 |
Effects of chronic prednisolone treatment on bone resorption and bone composition in intact and ovariectomized rats and in ovariectomized rats receiving beta-estradiol.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Estradiol; Female; Hydroxyproline; Ovariectomy; P | 1988 |
Inhibition of bone resorption in vitro by serine-esterase inhibitors.
Topics: Acetylglucosaminidase; Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Bone and Bones; B | 1988 |
Calcium and magnesium dietary intakes and plasma and milk concentrations of Nepalese lactating women.
Topics: Bone Resorption; Calcium; Diet; Female; Humans; Hydroxyproline; India; Lactation; Magnesium; Milk, H | 1988 |
Effects of hypervitaminosis A on the bone and mineral metabolism of the rat.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcifediol; Calcitriol; Calcium; Co | 1988 |
The anti-bone-resorptive agent calcitonin also acts in vitro to directly increase bone formation and bone cell proliferation.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Bone and Bones; Bone Development; Bone Resorption; | 1988 |
Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome.
Topics: Aspirin; Bone Resorption; Child; Child, Preschool; Dinoprostone; Female; Humans; Hydroxyproline; Hyp | 1988 |
Isolated osteoclasts resorb the organic and inorganic components of bone.
Topics: Animals; Bone Matrix; Bone Resorption; Calcium; Calcium Radioisotopes; Cell Line; Chickens; Collagen | 1986 |
[Osteocalcin values in reflex sympathetic dystrophy].
Topics: Alkaline Phosphatase; Bone Resorption; Calcium-Binding Proteins; Female; Humans; Hydroxyproline; Mal | 1986 |
Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women.
Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Bone Resorption; Cross-Sectional Studies; Female; Hum | 1987 |
Bone turnover in spinal osteoporosis.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Development; Bone Resorption; Calcium; Calcium-Binding Prote | 1987 |
The development of fetal mice long bones in vitro: an assay of bone modeling.
Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Calcification, Physiologic; Calcium; Fem | 1986 |
Effect of age on calcium release from mouse calvaria in tissue culture.
Topics: Aging; Animals; Bone and Bones; Bone Resorption; Calcium; Culture Techniques; Dexamethasone; Dinopro | 1986 |
The effects of insulin and glucose on bone modelling in vitro.
Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Calcium; Culture Techniques; Glucose; Hy | 1986 |
Osteopenia in systemic mastocytosis: natural history and responses to treatment with inhibitors of bone resorption.
Topics: Biopsy; Bone and Bones; Bone Diseases, Metabolic; Bone Resorption; Female; Humans; Hydroxyproline; M | 1987 |
Estimation of whole body bone resorption rate: a comparison of urinary total hydroxyproline excretion with two radioisotopic tracer methods in osteoporosis.
Topics: Aged; Bone Resorption; Calcium; Creatinine; Female; Humans; Hydroxyproline; Kinetics; Middle Aged; O | 1987 |
The importance of renal net acid excretion as a determinant of fasting urinary calcium excretion.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Bone Resorption; Calcium; Creatinine; Diet; Fasting; Humans; | 1986 |
Relation between signs and symptoms in Paget's disease of bone.
Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Cell Count; Female; Hum | 1986 |
Ethinyl estradiol and norethindrone in the treatment of primary hyperparathyroidism in postmenopausal women.
Topics: Bone Resorption; Calcitriol; Calcium; Ethinyl Estradiol; Female; Humans; Hydroxyproline; Hyperparath | 1986 |
Bone resorption, renal function and mineral status in cows treated with 1,25-dihydroxycholecalciferol and its 24-fluoro analogues.
Topics: Animals; Bone Resorption; Calcitriol; Calcium; Cattle; Female; Glomerular Filtration Rate; Hydroxypr | 1986 |
Seasonal variations in indices of bone formation precede appropriate bone mineral changes in normal men.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Creatinine; Diphosphonates; Humans; Hy | 1986 |
The effects of metabolic acidosis on bone formation and bone resorption in the rat.
Topics: Acidosis; Animals; Bone and Bones; Bone Development; Bone Resorption; Hydroxyproline; Male; Minerals | 1986 |
Bone changes in rats with adjuvant arthritis: treatment with 1 alpha-hydroxycholecalciferol.
Topics: Alkaline Phosphatase; Animals; Arthritis; Arthritis, Experimental; Bone and Bones; Bone Development; | 1986 |
Gallium nitrate inhibits accelerated bone turnover in patients with bone metastases.
Topics: Adult; Aged; Antineoplastic Agents; Bone Development; Bone Neoplasms; Bone Resorption; Calcium; Fema | 1987 |
[Effect of administration of various cytostatics on selected indicators of calcium metabolism in healthy rats].
Topics: Animals; Antineoplastic Agents; Bone Resorption; Calcium; Drug Evaluation, Preclinical; Hydroxyproli | 1986 |
[Therapeutic choices in osteoporosis].
Topics: Aged; Aging; Bone and Bones; Bone Regeneration; Bone Resorption; Calcitonin; Calcium; Densitometry; | 1987 |
1,25-Dihydroxycalciferol and calcium therapy in osteoporosis with calcium malabsorption. Dose response relationship of calcium absorption and indices of bone turnover.
Topics: Alkaline Phosphatase; Bone Resorption; Calcitriol; Calcium; Creatinine; Dose-Response Relationship, | 1985 |
Normal bone turnover in isolated hyperphosphatasemia.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Bone Development; Bone Resorption; Calcium-Binding Prot | 1985 |
Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bone and Bones; Bone Development; Bone Resorption; Calcitonin; C | 1985 |
Bone isoenzyme of serum alkaline phosphatase and urinary hydroxyproline excretion in thyrotoxicosis.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Regeneration; Bone Resorption; Calcium; Female; Humans; Hydr | 1985 |
Estimation of bone turnover evaluated by 47Ca-kinetics. Efficiency of serum bone gamma-carboxyglutamic acid-containing protein, serum alkaline phosphatase, and urinary hydroxyproline excretion.
Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calc | 1985 |
Bone mass as referent for urinary hydroxyproline excretion.
Topics: Bone Resorption; Humans; Hydroxyproline; Hyperparathyroidism; Reference Values | 1985 |
The effect of calcium supplements on plasma alkaline phosphatase and urinary hydroxyproline in postmenopausal women.
Topics: Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Female; Humans; Hydroxyproline; Menopause; Mid | 1985 |
Age and sex dependency of the biochemical indices of bone remodelling.
Topics: Acid Phosphatase; Adolescent; Adult; Aging; Alkaline Phosphatase; Bone and Bones; Bone Development; | 1985 |
Diphosphonates and Page's disease of bone.
Topics: Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Humans; Hydroxyproline; Male; Middle Aged; Org | 1971 |
Treatment with with oestrogens of primary hyperparathyroidism in post-menopausal women.
Topics: Bone Resorption; Calcium; Ethinyl Estradiol; Female; Humans; Hydroxyproline; Hyperparathyroidism; Ki | 1972 |
Fine structural and enzymatic evaluation of bone in thyroparathyroidectomized rats receiving various levels of vitamin D.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Analysis of Variance; Animals; Bone Resorption; Cal | 1973 |
Action of 1alpha-hydroxy vitamin D3 on calcium absorption and bone resorption in man.
Topics: Administration, Oral; Adult; Aged; Aging; Bone and Bones; Bone Resorption; Calcium; Female; Fracture | 1974 |
Letter: Plasma-phosphate in Paget's disease.
Topics: Bone Resorption; Calcium; Humans; Hydroxyproline; Kidney Tubules; Osteitis Deformans; Phosphates | 1974 |
[Urinary hydroxyproline as an indicator of thyroid function activity].
Topics: Adult; Biomarkers; Bone Resorption; Female; Humans; Hydroxyproline; Hyperthyroidism; Hypothyroidism; | 1967 |
The mode of action of thyrocalcitonin.
Topics: Animals; Blood; Bone Resorption; Calcitonin; Calcium; Creatine; Hydroxyproline; Rats; Urine | 1966 |
Vitamin-D deficiency, bone turnover, and urinary hydroxyproline.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium Metabolism Disorders; Dogs; Humans; Hydroxyproline | 1968 |
[Osseous localizations of mastocytosis].
Topics: Adult; Age Factors; Anemia; Bone Diseases; Bone Resorption; Calcium; Fluorides; Glucocorticoids; Hep | 1969 |
Paget's disease of bone. Experience with a diphosphonate (disodium etidronate) in treatment.
Topics: Adult; Aged; Alkaline Phosphatase; Biopsy; Bone Resorption; Calcitonin; Calcium; Clinical Enzyme Tes | 1973 |
Hydroxyproline excretion in bovine puerperal paresis with special reference to bone resorption.
Topics: Animals; Bone Resorption; Calcium; Cattle; Cattle Diseases; Creatinine; Female; Hydroxyproline; Hypo | 1973 |
Effects of ethylenediaminetetraacetate (EDTA) on urinary excretion of hydroxyproline, calcium and phosphorus in the rat.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Chelating Agents; Collagen; Creatinine; Edetic Acid; | 1974 |
The development of osteoporosis. Experimental studies in the adult rat.
Topics: Analysis of Variance; Animals; Body Weight; Bone and Bones; Bone Resorption; Calcium; Calcium Isotop | 1969 |
Hypoparathyroidism and Paget's disease: the effect of parathyroid hormone administration.
Topics: Bone Resorption; Calcium; Humans; Hydroxyproline; Hypoparathyroidism; Male; Middle Aged; Osteitis De | 1972 |
Influence of parathyroid hormone on ultrastructural and enzymatic changes induced by vitamin D in bone of thyroparathyroidectomized rats.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcium; | 1974 |
Skeletal response to exogenous ascorbic acid by vitamins D3 deficient chicks.
Topics: Animals; Ascorbic Acid; Bone and Bones; Bone Resorption; Calcium; Cholecalciferol; Glucose; Hydroxyp | 1966 |
Effect of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism.
Topics: Adenine Nucleotides; Animals; Bone Resorption; Butyrates; Calcitonin; Calcium; Cyclic AMP; Hydroxypr | 1968 |
Skeletal renewal and metabolic bone disease.
Topics: Age Determination by Skeleton; Aging; Animals; Bone and Bones; Bone Development; Bone Diseases; Bone | 1969 |
Enzymatic and other biochemical events accompanying bone resorption in tissue culture.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcium Isotopes; Catalase; Citrates | 1970 |
Effect of chronic uremia on collagen metabolism in skin and bone.
Topics: Animals; Bone and Bones; Bone Diseases; Bone Resorption; Carbon Isotopes; Cholecalciferol; Collagen; | 1970 |
Bone formation and resorption in tissue culture. Effect of agents implicated in renal osteodystrophy.
Topics: Animals; Bone and Bones; Bone Development; Bone Diseases; Bone Resorption; Calcitonin; Calcium Isoto | 1970 |
Effect of estrogen on immobilization osteoporosis in rat.
Topics: Absorptiometry, Photon; Animals; Bone and Bones; Bone Resorption; Calcium; Casts, Surgical; Collagen | 1971 |
Effect of prolonged bed rest on bone mineral.
Topics: Adult; Body Weight; Bone and Bones; Bone Resorption; Calcaneus; Calcium; Creatinine; Diet; Diphospha | 1970 |
Comparative effects of 25-hydroxycholecalciferol and vitamin D 3 in thyro-parathyroidectomized rats.
Topics: Animals; Bone Resorption; Calcium; Cholecalciferol; Diet; Hydroxylation; Hydroxyproline; Male; Parat | 1971 |
[Osseous effects of hyperthyroidism].
Topics: Adolescent; Adult; Aged; Bone Diseases; Bone Resorption; Calcium; Calcium Metabolism Disorders; Fema | 1972 |
[Urinary hydroxyproline correlated with quantitative bone histological data. Attempted physiopathological interpretation].
Topics: Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Diseases; Bone Neoplasms; Bone Resorption; Humans | 1972 |
Bone as a target organ: toward a better definition of osteoporosis.
Topics: Bone and Bones; Bone Matrix; Bone Resorption; Calcitonin; Calcium; Collagen; Cyclic AMP; Endocrine S | 1973 |
Ultrastructure of parathyroid glands and plasma immunoreactive parathyroid hormone in pregnant cows fed normal and high calcium diets.
Topics: Animals; Bone Resorption; Calcium; Calcium, Dietary; Cattle; Cyclic AMP; Edetic Acid; Female; Hydrox | 1973 |
[Physiopathology of osteoporosis in the young adult].
Topics: Adult; Alkaline Phosphatase; Back Pain; Biopsy; Bone and Bones; Bone Resorption; Calcinosis; Calcium | 1974 |
Young adult osteoporosis.
Topics: Adult; Age Factors; Alkaline Phosphatase; Biological Transport; Bone and Bones; Bone Resorption; Cal | 1973 |
Response of adult patients with osteomalacia to treatment with crystalline 1alpha-hydroxy vitamin D3.
Topics: Aged; Biopsy; Bone and Bones; Bone Resorption; Calcium; Cell Count; Crystallization; Feces; Female; | 1974 |
The role of parathyroid hormone in the maintenance of plasma calcium levels in rats.
Topics: Age Factors; Animals; Bone Resorption; Calcium; Hydroxyproline; Kidney; Male; Parathyroid Glands; Pa | 1974 |
Quantitative histological data on disuse osteoporosis: comparison with biological data.
Topics: Adipose Tissue; Adult; Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Marrow; Bone Marrow Cells; | 1974 |
Metabolic effects of synthetic salmon calcitonin in Paget's disease of bone.
Topics: Aged; Alkaline Phosphatase; Animals; Bone Resorption; Calcitonin; Calcium; Calcium Radioisotopes; Fe | 1974 |
Influence of in vivo-incorporated fluoride on collagen metabolism by mouse calvaria in organ culture.
Topics: Animals; Bone and Bones; Bone Resorption; Carbon Isotopes; Collagen; Depression, Chemical; Female; F | 1973 |
Metabolic studies of bone in uremia before and after treatment.
Topics: Adult; Azathioprine; Bone and Bones; Bone Resorption; Carbon Isotopes; Chronic Kidney Disease-Minera | 1972 |
Effect of calcitonin on experimental osteolathyrism. (3). Selective inhibition of collagen resorption by calcitonin.
Topics: Animals; Bone and Bones; Bone Diseases; Bone Resorption; Calcitonin; Calcium; Collagen; Cysteine; De | 1972 |
Effect of estrogen and progesterone on feed intake and hydroxyproline excretion following induced hypocalcemia in dairy cows.
Topics: Animal Feed; Animals; Bone Resorption; Calcium; Calcium, Dietary; Cattle; Cattle Diseases; Edetic Ac | 1972 |
[Bone composition in phosphorus deficient rats. Influence of parathyroidectomy].
Topics: Animals; Bone and Bones; Bone Resorption; Deficiency Diseases; Hydroxyproline; Male; Parathyroid Gla | 1972 |
Effect of glucagon on bone collagen metabolism in the rat.
Topics: Animals; Blood Glucose; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Collagen; Femur; Gluca | 1972 |
Metabolic response to growth hormone administration, with particular reference to the occurrence of hypercalcuria.
Topics: Adolescent; Arginine; Basal Metabolism; Bone Resorption; Calcium; Child; Child, Preschool; Creatinin | 1972 |
Effects of long-term administration of bendroflumethiazide on bone metabolism in the rat.
Topics: Animals; Bendroflumethiazide; Bone and Bones; Bone Matrix; Bone Resorption; Calcium; Calcium Isotope | 1972 |
Synthetic salmon calcitonin. Treatment of Paget's disease and osteogenesis imperfecta.
Topics: Aged; Alkaline Phosphatase; Bone Resorption; Calcitonin; Calcium; Female; Humans; Hydroxyproline; Ma | 1972 |
Effect of growth hormone on fluoride balance.
Topics: Adolescent; Bone Resorption; Calcium; Child; Child, Preschool; Diet; Feces; Female; Fluorides; Growt | 1973 |
Hypocalcaemia and bone disease in renal failure.
Topics: Absorptiometry, Photon; Acidosis; Adolescent; Adult; Aged; Alkaline Phosphatase; Bicarbonates; Biops | 1973 |
Osteogenesis imperfecta: morphologic and biochemical studies of connective tissue.
Topics: Adolescent; Adult; Biopsy; Bone Regeneration; Bone Resorption; Child; Child, Preschool; Collagen; Co | 1973 |
The effect of ethinyloestradiol on calcium and phosphorus metabolism of post-menopausal women with primary hyperparathyroidism.
Topics: Aged; Alkaline Phosphatase; Blood Proteins; Bone Resorption; Calcium; Calcium Radioisotopes; Creatin | 1973 |
Effects of cortisone on bone metabolism in intact and thyroidectomized rabbits.
Topics: Animals; Body Weight; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Collagen; Cortisone; Hex | 1973 |
Radiological evidence of a dose-related response to long-term treatment of Paget's disease with human calcitonin.
Topics: Alkaline Phosphatase; Bone Resorption; Calcitonin; Dose-Response Relationship, Drug; Female; Hand; H | 1974 |
Diphosphonate treatment of Paget's disease of bone. A correlated metabolic, calcium kinetic and morphometric study.
Topics: Acid Phosphatase; Aged; Biopsy; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Eth | 1974 |
Bone remodeling in vitro: the effects of two diphosphonates on osteoid synthesis and bone resorption in mouse calvaria.
Topics: Animals; Bone Regeneration; Bone Resorption; Culture Techniques; Ethanol; Extracellular Space; Hydro | 1974 |
UCLA conference: Current concepts of bone metabolism.
Topics: Animals; Bone and Bones; Bone Development; Bone Resorption; Calcitonin; Calcium; Calcium, Dietary; C | 1974 |
Osteoporosis in ovarian dysgenesis.
Topics: Adolescent; Adult; Alkaline Phosphatase; Bone Resorption; Calcium; Child; Female; Femur; Humans; Hyd | 1974 |
Response of Paget's disease to porcine and salmon calcitonins: effects of long-term treatment.
Topics: Alkaline Phosphatase; Animals; Bone Resorption; Calcitonin; Fibula; Humans; Hydroxyproline; Injectio | 1974 |
Nondialyzable urinary hydroxyproline as an index of bone collagen formation.
Topics: Acromegaly; Adolescent; Adult; Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calciton | 1970 |
[Assay of various diets active on the utilization of calcium in opposition to bone resorption following ovariectomy].
Topics: Animals; Bone Resorption; Calcium; Castration; Citrates; Diet; Female; Hydroxyproline; Lactose; Orga | 1970 |
[Kinetics of the utilization of alkaline earth in the aged rat constantly vitamin D deficient].
Topics: Age Factors; Animals; Bone and Bones; Bone Resorption; Calcium; Feces; Hydroxyproline; Kinetics; Mal | 1971 |
[Bone resorption by phosphorus deprivation in rats].
Topics: Animals; Bone Resorption; Calcium; Calcium, Dietary; Deficiency Diseases; Hydroxyproline; Intestinal | 1971 |
Effects of thyrocalcitonin and phosphate ion on the parathyroid hormone stimulated resorption of bone.
Topics: Animals; Autoradiography; Bone and Bones; Bone Matrix; Bone Resorption; Calcitonin; Calcium; Calcium | 1972 |
The influence of two diphosphonates on calcium metabolism in the rat.
Topics: Animals; Biological Transport, Active; Bone and Bones; Bone Development; Bone Resorption; Calcium; C | 1972 |
Treatment of osteoporosis with calcium infusions.
Topics: Bone Resorption; Calcitonin; Calcium; Humans; Hydroxyproline; Infusions, Parenteral; Osteoporosis; P | 1972 |
Juvenile osteoporosis: bone findings in seven patients.
Topics: Adolescent; Alkaline Phosphatase; Bone Regeneration; Bone Resorption; Calcium; Female; Fractures, Sp | 1972 |
Osteoporosis in aging rats induced by high phosphorus diets.
Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Bone and Bones; Bone Resorp | 1972 |
Effects of porcine calcitonin in osteogenesis imperfecta tarda.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Child, Preschool; Female; Humans; Hydroxyproline; Inj | 1972 |
Treatment of Paget's disease with calcitonin.
Topics: Alkaline Phosphatase; Animals; Bone Resorption; Calcitonin; Humans; Hydroxyproline; Osteitis Deforma | 1972 |
Effect of calcitonin on (3H)proline incorporation into bone hydroxyproline in the rat.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium, Dietary; Hydroxyproline; Male; Parath | 1971 |
A decreased response to parathyroid hormone in magnesium deficiency.
Topics: Animals; Bone and Bones; Bone Resorption; Calcium; Femur; Hydroxyproline; In Vitro Techniques; Magne | 1971 |
New therapies in Paget's disease of bone.
Topics: Administration, Oral; Anti-Bacterial Agents; Bone Resorption; Calcitonin; Calcium; Humans; Hydroxypr | 1971 |
Hydroxyproline, calcium, and magnesium contents of bones in rats after long-term treatment with calcitonin.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Clavicle; Hydroxyproline; Magnesium; | 1971 |
Non-protein-bound hydroxyproline in plasma in renal bone disease.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Diseases; Bone Resorption; Creatinine; Fibrous Dysplasia | 1971 |
The effect of supplemental oral phosphate on the bone mineral changes during prolonged bed rest.
Topics: Administration, Oral; Adult; Alkaline Phosphatase; Body Weight; Bone and Bones; Bone Resorption; Cal | 1971 |
Glucagon in the treatment of Paget's disease of bone.
Topics: Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcitonin; | 1971 |
Metabolic studies and 47 Ca kinetics during high calcium intake in senile osteoporosis.
Topics: Aged; Aging; Bone Resorption; Calcium; Calcium Isotopes; Female; Humans; Hydroxyproline; Kinetics; M | 1971 |
Quantitative histology of bone in hyperparathyroidism. Its relation to clinical features, x-ray, and biochemistry.
Topics: Adult; Aged; Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Resorption; Calcium; Child; Female; | 1971 |
Microradiographic evaluation of bone and ultrastructure of C-cells and parathyroid glands of cows receiving parathyroid extract.
Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Cattle; Collage | 1971 |
Distortions of bone cell metabolism in uremia and their cause.
Topics: Acidosis; Adult; Aged; Animals; Bone Diseases; Bone Resorption; Calcium; Calcium Isotopes; Female; G | 1969 |
The acute effects of porcine calcitonin in man.
Topics: Adult; Aged; Animals; Bone Resorption; Calcitonin; Calcium; Creatinine; Female; Humans; Hydroxyproli | 1969 |
Circadian rhythm of urinary total and free hydroxyproline excretion and its relation to creatinine excretion.
Topics: Adult; Aged; Bone Resorption; Calcium; Circadian Rhythm; Collagen; Creatinine; Female; Humans; Hydro | 1970 |
Fibrous dysplasia of the bone and high cardiac output.
Topics: Adult; Aged; Alkaline Phosphatase; Biopsy; Blood Circulation; Bone and Bones; Bone Regeneration; Bon | 1970 |
Treatment of osteoporosis by calcium infusions.
Topics: Bone and Bones; Bone Resorption; Calcitonin; Calcium; Humans; Hydroxyproline; Microradiography; Oste | 1970 |
Effect of phosphate infusion on bone metabolism and parathyroid hormone action.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Hydroxyproline; Infusions, Parenteral | 1970 |
Parathyroidectomy in the treatment of renal osteodystrophy. Calcium dynamic studies.
Topics: Adolescent; Adult; Aged; Bone Diseases; Bone Resorption; Calcium; Calcium Isotopes; Female; Humans; | 1970 |
Remissions in Paget's disease produced by human synthetic calcitonin (calcitonin M).
Topics: Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Humans; Hydroxyproline; | 1970 |
Renal effects of calcitonin.
Topics: Aged; Animals; Bone Resorption; Breast Neoplasms; Calcitonin; Calcium; Female; Humans; Hydroxyprolin | 1970 |
Comparative effects of phosphate and thyrocalcitonin on skeletal turnover.
Topics: Analysis of Variance; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Calcium Isotope | 1970 |
[Hydroxiprolinuria in bone diseases].
Topics: Bone Diseases; Bone Resorption; Female; Humans; Hydroxyproline; Male | 1970 |
Normophosphatemic vitamin D-resistant osteomalacia in a patient with normal calcium and fat absorption.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Calcium Chloride; Dietary Fat | 1971 |
Thyrocalcitonin suppression of hydroxyproline rlease from bone.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Depression, Chemical; Hydroxyproline; Kidney; Male; P | 1968 |
Effect of thyrocalcitonin on urinary hydroxyproline and calcium in rats.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Calcium Isotopes; Collagen; Depression, Chemical; Hyd | 1968 |
Some effects of ethinyl oestradiol on calcium and phosphorus metabolism in osteoporosis.
Topics: Adult; Aged; Bone Resorption; Calcium; Ethinyl Estradiol; Feces; Female; Humans; Hydroxyproline; Men | 1968 |
[Influence of thyrocalcitonin on the urinary excretion of hydroxyproline in humans].
Topics: Bone Resorption; Calcitonin; Humans; Hydroxyproline | 1968 |
Effect of disuse osteoporosis on bone composition: the fate of bone matrix.
Topics: Animals; Atrophy; Bone and Bones; Bone Resorption; Collagen; Dogs; Femur; Humerus; Hydroxyproline; M | 1968 |
The inhibition of the maturation of newly synthesized bone collagen by beta-aminopropionitrile in tissue culture.
Topics: Aminopropionitrile; Animals; Bone and Bones; Bone Development; Bone Resorption; Collagen; Culture Te | 1968 |
On the mechanisms of bone resorption. The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by bone cells.
Topics: Acids; Animals; Bone Resorption; Calcium; Calcium Isotopes; Citrates; Culture Techniques; Hydrolases | 1968 |
The quantitative measurement of bone resorption and balance in vitro by analysis of hydroxyproline metabolism.
Topics: Aging; Animals; Biological Transport; Bone and Bones; Bone Resorption; Carbon Isotopes; Collagen; Cu | 1968 |
The effect of sodium fluoride on the rates of synthesis and degradation of bone collagen in tissue culture.
Topics: Animals; Bone Development; Bone Resorption; Collagen; Culture Techniques; Fluorides; Hydroxyproline; | 1968 |
Some hormonal effects on bone in tissue culture.
Topics: Animals; Bone Resorption; Calcitonin; Culture Techniques; Diethylstilbestrol; Hydrocortisone; Hydrox | 1969 |
Correlations between biochemical, kinetic(45Ca) and histological measurements in hyperparathyroidism.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Calcium Isotopes; Humans; Hydroxypro | 1969 |
Effect of sex hormones on bone in primary osteoporosis.
Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Bone Resorption; Calcium; Estrogens; Female; Huma | 1969 |
Bone matrix turnover and balance in vitro. I. The effects of parathyroid hormone and thyrocalcitonin.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitonin; Carbon Isotopes; Collagen; DNA; Hydroxyproline | 1969 |
Bone matrix turnover and balance in vitro. II. The effects of aging.
Topics: Aging; Animals; Bone and Bones; Bone Resorption; Collagen; DNA; Hydroxyproline; In Vitro Techniques; | 1969 |
Endocytosis of sugars in embryonic skeletal tissues in organ culture. IV. Lysosomal and other biochemical effects. General discussion.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Resorption; Carbohydrate Metabolism; Carbon Isotopes | 1969 |
Collagenolytic activity during active bone resorption in tissue culture.
Topics: Animals; Bone Resorption; Collagen; Culture Media; Culture Techniques; Guinea Pigs; Heparin; Hydroxy | 1965 |
[Correlation between hydroxyprolinuria, alkaline phosphatasemia and Ca45 dynamics].
Topics: Adult; Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Female; Humans; Hydroxyproline; Hyperpa | 1965 |