hydroxyproline has been researched along with Benign Neoplasms in 47 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Excerpt | Relevance | Reference |
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"to observe the influence of aging on urinary secretion of 3-hydroxyproline (3-Hyp) in normal subjects and in cancer patients and study the effects of aging on the accuracy of urinary 3-Hyp as a general-purpose cancer screening test." | 7.69 | [Effects of aging on urinary secretion of 3-hydroxyproline and its importance for cancer screening in the elderly with ROC analysis]. ( Arai, M; Bos, AJ; Maruta, A; Matsuyama, S; Okazaki, I; Yuan, P, 1994) |
"Osteocalcin (serum bone-Gla protein, sBGP), serum alkaline phosphatase (sAP) and urinary hydroxyproline/creatinine ratio (uOH-Prol/creatinine) have been measured in 21 patients with primary hyperparathyroidism (PHPT) and in nine patients with hypercalcaemia of malignancy (HM)." | 7.67 | Osteocalcin and urinary hydroxyproline/creatinine ratio in the differential diagnosis of primary hyperparathyroidism and hypercalcaemia of malignancy. ( de la Piedra, C; Rapado, A; Toural, V, 1987) |
"to observe the influence of aging on urinary secretion of 3-hydroxyproline (3-Hyp) in normal subjects and in cancer patients and study the effects of aging on the accuracy of urinary 3-Hyp as a general-purpose cancer screening test." | 3.69 | [Effects of aging on urinary secretion of 3-hydroxyproline and its importance for cancer screening in the elderly with ROC analysis]. ( Arai, M; Bos, AJ; Maruta, A; Matsuyama, S; Okazaki, I; Yuan, P, 1994) |
"We have measured classic markers of bone turnover, serum alkaline phosphatase (sAP), urinary hydroxyproline/creatinine ratio (uOH-Prol/creatinine) and osteocalcin (sBGP), in two bone disorders characterized by an increase in bone remodelling, namely Paget's disease of bone and primary hyperparathyroidism (PHPT) and in two other bone diseases characterized by an increase in bone resorption without the concomitant increase in bone formation, hypercalcaemia of malignancy (HM) and involutional osteoporosis (IO)." | 3.67 | Osteocalcin and bone remodelling in Paget's disease of bone, primary hyperparathyroidism, hypercalcaemia of malignancy and involutional osteoporosis. ( de la Piedra, C; Rapado, A; Torres, R, 1989) |
"Osteocalcin (serum bone-Gla protein, sBGP), serum alkaline phosphatase (sAP) and urinary hydroxyproline/creatinine ratio (uOH-Prol/creatinine) have been measured in 21 patients with primary hyperparathyroidism (PHPT) and in nine patients with hypercalcaemia of malignancy (HM)." | 3.67 | Osteocalcin and urinary hydroxyproline/creatinine ratio in the differential diagnosis of primary hyperparathyroidism and hypercalcaemia of malignancy. ( de la Piedra, C; Rapado, A; Toural, V, 1987) |
"Amongst the bone resorption markers studied are: 1) Calcium/creatinine urinary quotient; 2) Tartrate resistant acid phosphatase; 3) Urinary hydroxyproline; 4) Other substance derived from collagen disruption such as hydroxylysine glycoside, piridinolinic intermolecular bridges and the enzymatic activity of proline iminopeptidase." | 2.38 | [Usefulness of bone remodelling biochemical markers in the diagnosis and follow-up of Paget's bone disease, primary hyperparathyroidism, tumor hypercalcemia, and postmenopausal osteoporosis. II. Bone resorption markers]. ( de la Piedra Gordo, C; Torres Jiménez, R, 1990) |
"In this malignancy, the HCG level suggests the diagnosis and stage, confirms response to therapy, and predicts relapse." | 2.37 | Tumor markers: value and limitations in the management of cancer patients. ( Bates, SE; Longo, DL, 1985) |
"Lung fibrosis was evaluated by histological examinations and hydroxyproline colorimetric assay." | 1.91 | Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis. ( Assarehzadegan, MA; Bayati, P; Mojtabavi, N; Poormoghim, H; Soleimani, M; Taherian, M, 2023) |
"Two of the patients had primary prostate cancer and one had a squamous cell lung tumour." | 1.43 | Inhibition of cancer cell mitosis by reducing the availability of phosphate. ( Condon, JR, 2016) |
"3-Hyp-containing peptides in cancer patients might be destroyed by the elevated peptidase levels found in these patients." | 1.36 | ELISA measurement for urinary 3-hydroxyproline-containing peptides and its preliminary application to healthy persons and cancer patients. ( Hayashi, T; Imamura, Y; Inagaki, Y; Itoh, J; Kashiwazaki, K; Kitagawa, Y; Maruta, A; Matsuyama, S; Okazaki, I; Saito, J; Sato, A; Wada, N; Watanabe, T, 2010) |
"Increases without any evidence of metastases are either due to other diseases with connective tissue changes or to occult micrometastases." | 1.27 | [The value of the free hydroxyproline and the N-acetyl-beta- glucosaminidase for the observation of the course of malignant tumors]. ( Lange, H; Müller, A; Ruffert, K, 1986) |
"This was associated with a decrease in bone resorption as judged by decreases in urinary excretion of hydroxyproline and calcium." | 1.27 | Treatment of the hypercalcaemia of malignancy with intravenous clodronate. ( Gray, RE; Greaves, M; Hamdy, NA; Kanis, JA; McCloskey, EV; Neil, FE; Preston, FE; Urwin, GH; Yates, AJ, 1987) |
"Those who had marrow metastasis produced elevated levels of hydroxyproline; the highest excretions were observed when marrow fibrosis was associated with metastasis." | 1.26 | Urinary hydroxyproline excretion in myelofibrosis. ( Aung, MK; Tobin, MS; Wang, JC, 1980) |
"The development of human tumors is accompanied very often by tumor-associated phenomena such as production of tumor-derived substances, production of certian substances in response to the tumor or immunological reactions." | 1.26 | Biological markers of human tumors and monitoring of cancer treatment. ( Nissen, E; Tanneberger, S; Ziegenbein, R, 1979) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 32 (68.09) | 18.7374 |
1990's | 6 (12.77) | 18.2507 |
2000's | 3 (6.38) | 29.6817 |
2010's | 3 (6.38) | 24.3611 |
2020's | 3 (6.38) | 2.80 |
Authors | Studies |
---|---|
Phang, JM | 1 |
Taherian, M | 1 |
Bayati, P | 1 |
Assarehzadegan, MA | 1 |
Soleimani, M | 1 |
Poormoghim, H | 1 |
Mojtabavi, N | 1 |
Mao, J | 1 |
Zhang, H | 1 |
Wang, X | 1 |
Gao, J | 1 |
Tang, J | 1 |
Zhang, J | 1 |
Kach, J | 1 |
Sandbo, N | 1 |
La, J | 1 |
Denner, D | 1 |
Reed, EB | 1 |
Akimova, O | 1 |
Koltsova, S | 1 |
Orlov, SN | 1 |
Dulin, NO | 1 |
Condon, JR | 1 |
Saito, J | 1 |
Imamura, Y | 1 |
Itoh, J | 1 |
Matsuyama, S | 3 |
Maruta, A | 3 |
Hayashi, T | 1 |
Sato, A | 1 |
Wada, N | 1 |
Kashiwazaki, K | 1 |
Inagaki, Y | 1 |
Watanabe, T | 1 |
Kitagawa, Y | 1 |
Okazaki, I | 3 |
VAN ROBERTSON, WB | 1 |
HIWETT, J | 1 |
HERMAN, C | 1 |
KLEIN, L | 1 |
LAFFERTY, FW | 1 |
PEARSON, OH | 1 |
CURTISS, PH | 1 |
SHELTON, E | 1 |
Platt, WD | 1 |
Doolittle, LH | 1 |
Hartshorn, JW | 1 |
LEE, CA | 1 |
LLOYD, HM | 1 |
KORTING, GW | 1 |
HOLZMANN, H | 1 |
Lewis, I | 1 |
Albert, R | 1 |
Kneuer, R | 1 |
Pless, J | 1 |
Simeon, C | 1 |
Kerrad, S | 1 |
Hoyer, D | 1 |
Bruns, C | 1 |
Grosfeld, A | 1 |
Stolze, IP | 1 |
Cockman, ME | 1 |
Pugh, CW | 1 |
Edelmann, M | 1 |
Kessler, B | 1 |
Bullock, AN | 1 |
Ratcliffe, PJ | 1 |
Masson, N | 1 |
Freimark, B | 1 |
Clark, D | 1 |
Pernasetti, F | 1 |
Nickel, J | 1 |
Myszka, D | 1 |
Baeuerle, PA | 1 |
Van Epps, D | 1 |
Parsons, V | 1 |
Baum, M | 1 |
Self, M | 1 |
Douglas, DL | 1 |
Duckworth, T | 1 |
Russell, RG | 1 |
Kanis, JA | 4 |
Preston, CJ | 1 |
Preston, FE | 2 |
Prenton, MA | 1 |
Woodhead, JS | 1 |
Portmann, L | 2 |
Häfliger, JM | 1 |
Bill, G | 1 |
Burckhardt, P | 2 |
Kelleher, PC | 1 |
Smith, CJ | 1 |
Bower, L | 2 |
Manley, G | 2 |
Wang, JC | 1 |
Aung, MK | 1 |
Tobin, MS | 1 |
Plosker, GL | 1 |
Goa, KL | 1 |
Bos, AJ | 1 |
Yuan, P | 1 |
Arai, M | 1 |
Tanneberger, S | 1 |
Nissen, E | 1 |
Ziegenbein, R | 1 |
Dickerson, JW | 1 |
Basu, TK | 1 |
Anson, A | 1 |
Zysset, E | 1 |
Ammann, P | 1 |
Jenzer, A | 1 |
Gertz, BJ | 1 |
Rizzoli, R | 1 |
Jaquet-Müller, F | 1 |
Pryor-Tillotson, S | 1 |
Bonjour, JP | 1 |
Suzuki, F | 1 |
Maruyama, K | 1 |
Kubochi, K | 1 |
Yoshino, K | 1 |
Kobayashi, Y | 1 |
Abe, O | 1 |
Tsuchiya, M | 1 |
Bickerstaff, DR | 1 |
O'Doherty, DP | 1 |
McCloskey, EV | 3 |
Hamdy, NA | 3 |
Mian, M | 1 |
de la Piedra Gordo, C | 1 |
Torres Jiménez, R | 1 |
Bates, SE | 2 |
Longo, DL | 2 |
Ruffert, K | 1 |
Müller, A | 1 |
Lange, H | 1 |
Torres, R | 1 |
de la Piedra, C | 2 |
Rapado, A | 2 |
Urwin, GH | 2 |
Yates, AJ | 1 |
Gray, RE | 2 |
Greaves, M | 1 |
Neil, FE | 1 |
Canfield, RE | 1 |
Siris, ES | 1 |
Jacobs, TP | 1 |
Beneton, MN | 1 |
Murray, SA | 1 |
Conte, N | 1 |
Di Virgilio, R | 1 |
Roiter, I | 1 |
Caberlotto, L | 1 |
Toural, V | 1 |
Gambella, GR | 1 |
Zunino, M | 1 |
Kreysel, HW | 1 |
Kimmig, J | 1 |
Bańkowski, E | 1 |
Galasiński, W | 1 |
Guzzo, CE | 1 |
Pachas, WN | 1 |
Pinals, RS | 1 |
Krant, MJ | 1 |
Gennari, C | 1 |
Rubegni, M | 1 |
Forconi, S | 1 |
Romano, S | 1 |
Hosley, HF | 1 |
Taft, EG | 1 |
Olson, KB | 1 |
Gates, S | 1 |
Beebe, RT | 1 |
Bonadonna, G | 1 |
Merlino, MJ | 1 |
Myers, WP | 1 |
Sonenberg, M | 1 |
5 reviews available for hydroxyproline and Benign Neoplasms
Article | Year |
---|---|
Collagen metabolites in the urine and serum of patients with cancer.
Topics: Bone Neoplasms; Breast Neoplasms; Collagen; Colorimetry; Female; Humans; Hydroxylysine; Hydroxyproli | 1982 |
Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease.
Topics: Animals; Bone Neoplasms; Bone Resorption; Calcinosis; Clinical Trials as Topic; Clodronic Acid; Dose | 1994 |
[Usefulness of bone remodelling biochemical markers in the diagnosis and follow-up of Paget's bone disease, primary hyperparathyroidism, tumor hypercalcemia, and postmenopausal osteoporosis. II. Bone resorption markers].
Topics: Acid Phosphatase; Adult; Biomarkers; Bone Resorption; Child; Female; Follow-Up Studies; Humans; Hydr | 1990 |
Tumor markers: value and limitations in the management of cancer patients.
Topics: Acid Phosphatase; Adrenocorticotropic Hormone; Alkaline Phosphatase; alpha-Fetoproteins; Breast Neop | 1985 |
Use of serum tumor markers in cancer diagnosis and management.
Topics: Acid Phosphatase; Alkaline Phosphatase; alpha-Fetoproteins; Antigens, Neoplasm; Blood Proteins; Carc | 1987 |
2 trials available for hydroxyproline and Benign Neoplasms
Article | Year |
---|---|
Comparison of a rapid (2-h) versus a slow (24-h) infusion of alendronate in the treatment of hypercalcemia of malignancy.
Topics: Aged; Aged, 80 and over; Alendronate; Bone Neoplasms; Bone Resorption; Calcium; Diphosphonates; Doub | 1992 |
Dichloromethylene diphosphonate action in hematologic and other malignancies.
Topics: Administration, Oral; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Clinical Tr | 1987 |
40 other studies available for hydroxyproline and Benign Neoplasms
Article | Year |
---|---|
Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis.
Topics: Collagen; Extracellular Matrix; Humans; Hydroxyproline; Neoplasms; Proline; Small Molecule Libraries | 2021 |
Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis.
Topics: Animals; Carrier Proteins; Fibrosis; Hydroxyproline; Idiopathic Pulmonary Fibrosis; Mammals; Mechani | 2023 |
Design, synthesis, and biological evaluation of 4-phenoxybenzenesulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.
Topics: Animals; Antineoplastic Agents; Caffeic Acids; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2020 |
Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.
Topics: Animals; Antineoplastic Agents; Antitussive Agents; Bleomycin; Cell Line, Tumor; Cyclic AMP-Dependen | 2014 |
Inhibition of cancer cell mitosis by reducing the availability of phosphate.
Topics: Acid Phosphatase; Alkaline Phosphatase; Bone and Bones; Carcinoma, Squamous Cell; Glucagon; Humans; | 2016 |
ELISA measurement for urinary 3-hydroxyproline-containing peptides and its preliminary application to healthy persons and cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antibodies; Biomarkers, Tumor; Case-Control Studies; Colonic Neoplas | 2010 |
The relation of ascorbic acid to the conversion of proline to hydroxyproline in the synthesis of collagen in the carrageenan granuloma.
Topics: Ascorbic Acid; Carrageenan; Collagen; Encephalomyelitis; Granuloma; Hydroxyproline; Neoplasms; Proli | 1959 |
CORRELATION OF URINARY HYDROXYPROLINE, SERUM ALKALINE PHOSPHATASE AND SKELETAL CALCIUM TURNOVER.
Topics: Alkaline Phosphatase; Bone and Bones; Bone Diseases; Bone Neoplasms; Breast Neoplasms; Calcium; Geri | 1964 |
EFFECT OF TUMOR CELLS ON PRE-EXISTING COLLAGEN AND ON COLLAGEN PRODUCTION BY NORMAL CELLS GROWN IN DIFFUSION CHAMBERS.
Topics: Animals; Collagen; Connective Tissue; DNA; DNA, Neoplasm; Hydroxyproline; Mice; Neoplasms; Neoplasms | 1964 |
URINARY HYDROXYPROLINE EXCRETION IN METASTATIC CANCER OF BONE.
Topics: Acid Phosphatase; Biomedical Research; Bone Neoplasms; Breast Neoplasms; Collagen; Humans; Hydroxypr | 1964 |
URINARY HYDROXYPROLINE IN DISEASES INVOLVING BONE AND CALCIUM METABOLISM.
Topics: Acute Kidney Injury; Alkaline Phosphatase; Bone Diseases; Bone Neoplasms; Breast Neoplasms; Calcium; | 1964 |
[ON THE HYDROXYPROLINE EXCRETION IN THE URINE OF DERMATOLOGIC PATIENTS].
Topics: Collagen Diseases; Humans; Hydroxyproline; Joint Diseases; Melanoma; Neoplasms; Osteomalacia; Psoria | 1965 |
Medicinal chemistry of somatostatin analogs leading to the DTPA and DOTA conjugates of the multi-receptor-ligand SOM230.
Topics: Chelating Agents; Heterocyclic Compounds, 1-Ring; Humans; Hydroxyproline; Isotope Labeling; Neoplasm | 2005 |
Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Cell Line; Collagen Type IV; E | 2007 |
Targeting of humanized antibody D93 to sites of angiogenesis and tumor growth by binding to multiple epitopes on denatured collagens.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Collagen Type IV; Epitopes; Humans; | 2007 |
Effect of mithramycin on calcium and hydroxyproline metabolism in patients with malignant disease.
Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Female; Humans; Hydroxyproline; Hypocalce | 1967 |
Effect of dichloromethylene diphosphonate in Paget's disease of bone and in hypercalcaemia due to primary hyperparathyroidism or malignant disease.
Topics: Alkaline Phosphatase; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Humans; Hydroxyproli | 1980 |
[Simple treatment of tumor-induced hypercalcemia: i.v. aminohydroxypropylidene biphosphonate].
Topics: Adenosine Diphosphate; Adult; Aged; Calcium; Cyclic AMP; Female; Humans; Hydroxyproline; Hypercalcem | 1983 |
Urinary excretion of glycosaminoglycans and hydroxyproline in Paget's disease of bone, compared with neoplastic invasion of bone.
Topics: Aged; Bone Neoplasms; Creatinine; Female; Glycosaminoglycans; Humans; Hydroxyproline; Male; Middle A | 1981 |
Urinary hydroxyproline excretion in myelofibrosis.
Topics: Bone Neoplasms; Collagen; Fibroblasts; Humans; Hydroxyproline; Neoplasm Metastasis; Neoplasms; Prima | 1980 |
[Effects of aging on urinary secretion of 3-hydroxyproline and its importance for cancer screening in the elderly with ROC analysis].
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers, Tumor; Female; Humans; Hydroxyproline; Male; Mass | 1994 |
Biological markers of human tumors and monitoring of cancer treatment.
Topics: Alkaline Phosphatase; alpha-Fetoproteins; Bone Neoplasms; Carcinoembryonic Antigen; Choriocarcinoma; | 1979 |
Specific vitamin deficiencies and their significance in patients with cancer and receiving chemotherapy.
Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Breast Neoplasms; Female; Humans; Hydroxyproline; Lipid Met | 1977 |
Urinary excretion of glycosaminoglycans in disseminated neoplasm.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Neoplasms; Creatinine; Female; Glycosaminoglycans; Hexosamin | 1978 |
Endogenous urinary 3-hydroxyproline has 96% specificity and 44% sensitivity for cancer screening.
Topics: Adult; Aged; Biomarkers, Tumor; Creatinine; Female; Humans; Hydroxyproline; Male; Middle Aged; Neopl | 1992 |
Effects of amino-butylidene diphosphonate in hypercalcemia due to malignancy.
Topics: Adult; Aged; Bone Resorption; Calcium; Diphosphonates; Female; Humans; Hydroxyproline; Hypercalcemia | 1991 |
[The value of the free hydroxyproline and the N-acetyl-beta- glucosaminidase for the observation of the course of malignant tumors].
Topics: Acetylglucosaminidase; Bone Neoplasms; Breast Neoplasms; Female; Hexosaminidases; Hodgkin Disease; H | 1986 |
Osteocalcin and bone remodelling in Paget's disease of bone, primary hyperparathyroidism, hypercalcaemia of malignancy and involutional osteoporosis.
Topics: Aged; Alkaline Phosphatase; Calcium-Binding Proteins; Creatinine; Female; Humans; Hydroxyproline; Hy | 1989 |
Treatment of the hypercalcaemia of malignancy with intravenous clodronate.
Topics: Adult; Aged; Bone Resorption; Calcium; Clodronic Acid; Diphosphonates; Female; Humans; Hydroxyprolin | 1987 |
Effects of intravenous etidronate disodium on skeletal and calcium metabolism.
Topics: Aged; Bone and Bones; Bone Diseases, Metabolic; Calcium; Etidronic Acid; Female; Humans; Hydroxyprol | 1987 |
Hypercalcemia in malignancies: treatment with dichloromethylene diphosphonate (Cl2MDP).
Topics: Adult; Aged; Bone Neoplasms; Calcium; Clodronic Acid; Diphosphonates; Drug Evaluation; Female; Human | 1985 |
Osteocalcin and urinary hydroxyproline/creatinine ratio in the differential diagnosis of primary hyperparathyroidism and hypercalcaemia of malignancy.
Topics: Adult; Aged; Alkaline Phosphatase; Calcium-Binding Proteins; Creatinine; Diagnosis, Differential; Fe | 1987 |
[The role of the urinary hydroxyproline level in the screening for collagen diseases].
Topics: Adult; Aged; Arthritis, Rheumatoid; Collagen Diseases; Diabetes Mellitus; Female; Humans; Hydroxypro | 1986 |
[Metabolism of glycosaminoglycane, collagen, and kidney function in dermatomyositis].
Topics: Autoradiography; Blood Proteins; Collagen; Dermatomyositis; Female; Glomerular Filtration Rate; Gluc | 1974 |
[Collagen biosynthesis (author's transl)].
Topics: Amino Acid Sequence; Amino Acids; Biological Transport, Active; Cell Membrane Permeability; Collagen | 1974 |
Urinary hydroxyproline excretion in patients with cancer.
Topics: Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; Calcium; Collagen; Creatine; Female; Humans; | 1969 |
[Correlation between hydroxyprolinuria, alkaline phosphatasemia and Ca45 dynamics].
Topics: Adult; Aged; Alkaline Phosphatase; Bone Resorption; Calcium; Female; Humans; Hydroxyproline; Hyperpa | 1965 |
Hydroxyproline excretion in malignant neoplastic disease.
Topics: Adult; Aged; Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; Carcinoma, Bronchogenic; Female | 1966 |
Urinary hydroxyproline and calcium metabolism in patients with cancer.
Topics: Bone Neoplasms; Calcium; Humans; Hydroxyproline; Hypercalcemia; Neoplasm Metastasis; Neoplasms; Urin | 1966 |
Hydroxyproline excretion in cancer.
Topics: Humans; Hydroxyproline; Neoplasms | 1966 |