hydroxyproline has been researched along with Ascorbic Acid Deficiency in 43 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Ascorbic Acid Deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of ascorbic acid deficiency on growth and calcification of bone were studied in whole 18-day fetal rat radii and ulnae cultured in a chemically defined medium." | 7.65 | The effects of ascorbic acid deficiency on calcium and collagen metabolism in cultured fetal rat bones. ( Chen, TL; Raisz, LG, 1975) |
| "Fibroblasts grown in medium containing less than 1 microg of ascorbic acid per milliliter showed evidence of ascorbic acid deficiency when compared with cells grown in medium containing 50 microg of ascorbic acid per milliliter." | 7.64 | Ascorbic acid deficiency in cultured human fibroblasts. ( Robertson, WV; Schafer, IA; Silverman, L; Sullivan, JC, 1967) |
| "The effects of ascorbic acid deficiency on growth and calcification of bone were studied in whole 18-day fetal rat radii and ulnae cultured in a chemically defined medium." | 3.65 | The effects of ascorbic acid deficiency on calcium and collagen metabolism in cultured fetal rat bones. ( Chen, TL; Raisz, LG, 1975) |
| " Incorporation of labelled proline into aortic elastin isolated from the same animals did not indicate a decrease in elastin biosynthesis in ascorbic acid deficiency, beyond that attributable to the inanition accompanying the vitamin deficiency." | 3.65 | Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs. ( Barnes, MJ; Constable, BJ; Kodicek, E, 1969) |
| "Fibroblasts grown in medium containing less than 1 microg of ascorbic acid per milliliter showed evidence of ascorbic acid deficiency when compared with cells grown in medium containing 50 microg of ascorbic acid per milliliter." | 3.64 | Ascorbic acid deficiency in cultured human fibroblasts. ( Robertson, WV; Schafer, IA; Silverman, L; Sullivan, JC, 1967) |
| " The effect of ascorbic acid deficiency on glycosaminoglycans of granulation tissue and cartilage of guinea pigs was investigated by determination of the changes in the glucosamine and galactosamine contents 12 days after tendonectomy." | 3.64 | The effect of scurvy on glycosaminoglycans of granulation tissue and costal cartilage. ( Antonowicz, I; Kodicek, E, 1968) |
| "The hydroxyproline content was higher in CCl(4)-injured rats than in the control group (4." | 1.31 | S-adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats. ( Ballesta, AM; Caballeria, J; Deulofeu, R; Gassó, M; Giménez, A; Mato, JM; Parés, A; Rodés, J; Román, J; Rubio, M; Varela-Moreiras, G, 2000) |
| "Most probably, vitamin C deficiency was responsible for the difference between diseased and morphologically healthy individuals." | 1.29 | [Etiology of the cribra orbitalia: effect of amino acid profile in bone collagen and the iron content of bone minerals]. ( Grupe, G, 1995) |
| "Parameters reflecting bone resorption in od/od rats were reduced in the distal femoral metaphysis, but were similar to those of controls in the tail vertebrae." | 1.28 | Bone histomorphometric analysis for the cause of osteopenia in vitamin C-deficient rat (ODS rat). ( Fujita, T; Fukase, M; Tsunenari, T, 1991) |
| "Scurvy and lathyrism, the only two abnormalities of collagen metabolism which can now be reasonably elucidated at a molecular level, are then discussed in some detail." | 1.24 | METABOLISM OF COLLAGEN IN MAMMALIAN TISSUES. ( ROBERTSON, WV, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (81.40) | 18.7374 |
| 1990's | 6 (13.95) | 18.2507 |
| 2000's | 2 (4.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CMUCHALOVA, B | 1 |
| CHVAPIL, M | 1 |
| ROBERTSON, WV | 2 |
| KIRCHHEINER, B | 4 |
| Goto, A | 1 |
| Tsukamoto, I | 1 |
| Schafer, IA | 1 |
| Silverman, L | 1 |
| Sullivan, JC | 1 |
| Berg, RA | 1 |
| Steinmann, B | 1 |
| Rennard, SI | 1 |
| Crystal, RG | 1 |
| Nováková, V | 1 |
| Hrubá, F | 1 |
| Mrhová, O | 1 |
| Ginter, E | 2 |
| Masek, J | 1 |
| Kodavanti, UP | 1 |
| Hatch, GE | 1 |
| Starcher, B | 1 |
| Giri, SN | 1 |
| Winsett, D | 1 |
| Costa, DL | 1 |
| Tsuchiya, H | 1 |
| Bates, CJ | 4 |
| Grupe, G | 1 |
| Deulofeu, R | 1 |
| Parés, A | 1 |
| Rubio, M | 1 |
| Gassó, M | 1 |
| Román, J | 1 |
| Giménez, A | 1 |
| Varela-Moreiras, G | 1 |
| Caballeria, J | 1 |
| Ballesta, AM | 1 |
| Mato, JM | 1 |
| Rodés, J | 1 |
| Turnbull, JD | 1 |
| Sauberlich, HE | 1 |
| Omaye, ST | 2 |
| Ostergaard, E | 2 |
| Löe, H | 2 |
| Chen, TL | 1 |
| Raisz, LG | 1 |
| Hunter, B | 1 |
| Magarelli, PC | 1 |
| Lightner, DV | 1 |
| Colvin, LB | 1 |
| Levenson, GE | 2 |
| Schiltz, JR | 2 |
| Rosenbloom, J | 1 |
| Dickerson, JW | 1 |
| Basu, TK | 1 |
| Woodruff, CW | 1 |
| Veen-Baigent, MJ | 1 |
| Ten Cate, AR | 1 |
| Bright-See, E | 1 |
| Rao, AV | 1 |
| Tsunenari, T | 1 |
| Fukase, M | 1 |
| Fujita, T | 1 |
| Miyake, T | 1 |
| Komura, H | 1 |
| Tokuhira, A | 1 |
| Yamamoto, T | 1 |
| Miyake, A | 1 |
| Tanizawa, O | 1 |
| Terada, N | 1 |
| Yamamoto, R | 1 |
| Yoshida, S | 1 |
| Tsuji, M | 1 |
| Hevia, P | 1 |
| Jacob, RA | 1 |
| Johnston, CS | 1 |
| Cartee, GD | 1 |
| Haskell, BE | 1 |
| Marckmann, A | 1 |
| Gore, I | 1 |
| Tanaka, Y | 1 |
| Fujinami, T | 1 |
| Goodman, ML | 1 |
| Antonowicz, I | 1 |
| Kodicek, E | 2 |
| Delaunay, A | 1 |
| Bazin, S | 1 |
| Barnes, MJ | 2 |
| Constable, BJ | 1 |
| Hastings, JC | 1 |
| Peacock, EE | 1 |
| Böhmer, T | 1 |
| Eddy, TP | 1 |
| Klein, LR | 1 |
| Weiss, PH | 1 |
| Rivers, JM | 1 |
| Krook, L | 1 |
| Cormier, A | 1 |
| Windsor, AC | 1 |
| Williams, CB | 1 |
| Bobek, P | 1 |
| Ovecka, M | 1 |
3 reviews available for hydroxyproline and Ascorbic Acid Deficiency
| Article | Year |
|---|---|
Ascorbic acid--scurvy.
Topics: Adult; Age Factors; Anemia; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Bone Diseases, Develop | 1975 |
Ascorbic acid and the biosynthesis of collagen and elastin.
Topics: Animals; Arteries; Ascorbic Acid; Ascorbic Acid Deficiency; Chick Embryo; Collagen; Elastin; Guinea | 1969 |
The biosynthesis of collagen.
Topics: Acromegaly; Ascorbic Acid Deficiency; Carbon Isotopes; Collagen; Ehlers-Danlos Syndrome; Hydroxylati | 1971 |
1 trial available for hydroxyproline and Ascorbic Acid Deficiency
| Article | Year |
|---|---|
Urinary hydroxyproline excretion and vitamin C status in healthy young men.
Topics: Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Diet; Dose-Response Relationship, Drug; Erythrocytes | 1990 |
39 other studies available for hydroxyproline and Ascorbic Acid Deficiency
| Article | Year |
|---|---|
[BIOCHEMICAL CHANGES DURING THE COURSE OF THE DEVELOPMENT OF CARRAGEENIN GRANULOMA WITH DEFICIENCY OF, OR INCREASED SATURATION WITH ASCORBIC ACID].
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Carrageenan; Collagen; DNA; Eukaryota; Granulation | 1963 |
METABOLISM OF COLLAGEN IN MAMMALIAN TISSUES.
Topics: Amino Acids; Animals; Ascorbic Acid Deficiency; Collagen; Histocytochemistry; Hydroxyproline; Lathyr | 1964 |
VITAMIN C DEFICIENCY AND CONNECTIVE TISSUE: HEXOSAMINE, HEXURONIC ACID AND HYDROXYPROLINE IN COSTAL CARTILAGE AND INTACT SKIN OF THE GUINEA PIG.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Cartilage; Collagen; Connective Tissue; Costal Car | 1965 |
Increase in tartrate-resistant acid phosphatase of bone at the early stage of ascorbic acid deficiency in the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Ascorbic Acid Deficiency; Body Weight; Bone Resorpt | 2003 |
Ascorbic acid deficiency in cultured human fibroblasts.
Topics: Amino Sugars; Ascorbic Acid; Ascorbic Acid Deficiency; Collagen; Connective Tissue; Connective Tissu | 1967 |
Ascorbate deficiency results in decreased collagen production: under-hydroxylation of proline leads to increased intracellular degradation.
Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Cells, Cultured; Collagen; Fibroblasts; Humans; Hydroxyprol | 1983 |
The effect of vitamin C deficiency on the aorta of the guinea pig.
Topics: Animals; Aorta, Thoracic; Arteries; Ascorbic Acid Deficiency; Guinea Pigs; Hydroxyproline; Muscle Pr | 1982 |
Ozone-induced pulmonary functional, pathological, and biochemical changes in normal and vitamin C-deficient guinea pigs.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Collagen; Desmosine; Elastin; Female; | 1995 |
Ascorbic acid deficiency in guinea pigs: contrasting effects of tissue ascorbic acid depletion and of associated inanition on status indices related to collagen and vitamin D.
Topics: Alkaline Phosphatase; Animals; Ascorbic Acid Deficiency; Bone and Bones; Calcium; Collagen; Connecti | 1994 |
[Etiology of the cribra orbitalia: effect of amino acid profile in bone collagen and the iron content of bone minerals].
Topics: Amino Acids; Anemia, Iron-Deficiency; Ascorbic Acid Deficiency; Collagen; Ethmoid Bone; Fossils; Hum | 1995 |
S-adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats.
Topics: Animals; Antioxidants; Ascorbic Acid Deficiency; Carbon Tetrachloride Poisoning; Glutathione; Hydrox | 2000 |
Effects of ascorbic acid deficiency and of erythorbic acid on blood components in the Cynomolgus monkey.
Topics: Administration, Oral; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Cell Count; Blood Cell | 1979 |
The collagen content of skin and gingival tissues in ascorbic acid-deficient monkeys.
Topics: Animals; Ascorbic Acid Deficiency; Cercopithecus; Collagen; Gingiva; Hydroxyproline; Periodontal Lig | 1975 |
The effects of ascorbic acid deficiency on calcium and collagen metabolism in cultured fetal rat bones.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Bone and Bones; Calcification, Physiologic; Calciu | 1975 |
Ascorbic acid-dependent collagen formation in penaeid shrimp.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Collagen; Decapoda; Diet; Hydroxyprol | 1979 |
The role of ascorbic acid on the structural integrity of developing tooth germs.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Collagen; Hydroxyproline; Mice; Odontoblasts; Odon | 1979 |
Vitamin C deficiency in guinea pigs: variable sensitivity of collagen at different sites.
Topics: Adrenal Glands; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Proteins; Body Weight; Colla | 1979 |
Vitamin C deficiency in guinea pigs: changes in urinary excretion of proline, hydroxyproline and total amino nitrogen.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Creatinine; Guinea Pigs; Hydroxyproline; Male; Nit | 1979 |
The effects of ascorbic acid deficiency on collagen synthesis by mouse molar tooth germs in organ culture.
Topics: Animals; Ascorbic Acid Deficiency; Collagen; Hydroxyproline; Mice; Molar; Organ Culture Techniques; | 1977 |
Specific vitamin deficiencies and their significance in patients with cancer and receiving chemotherapy.
Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Breast Neoplasms; Female; Humans; Hydroxyproline; Lipid Met | 1977 |
Proline and hydroxyproline excretion and vitamin C status in elderly human subjects.
Topics: Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Creatinine; Female; Humans; Hydroxyproline; Male; Pro | 1977 |
Effects of ascorbic acid on health parameters in guinea pigs.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Cholesterol; Dose-Response Relationsh | 1975 |
Bone histomorphometric analysis for the cause of osteopenia in vitamin C-deficient rat (ODS rat).
Topics: Alkaline Phosphatase; Animals; Ascorbic Acid Deficiency; Body Weight; Bone and Bones; Bone Diseases, | 1991 |
Impaired development of mammary glands in scorbutic rats unable to synthesize ascorbic acid.
Topics: Animals; Ascorbic Acid Deficiency; Body Weight; Cells, Cultured; Estradiol; Female; Fibroblast Growt | 1990 |
Effect of ascorbic acid nutriture on protein-bound hydroxyproline in guinea pig plasma.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Proteins; Complement Activating Enzymes; Com | 1985 |
Vitamin C deficiency and connective tissue. 3. Determinations of hexosamine, uronic acid, hydroxyproline and uptake of radiosulfate (35S) in granulation tissue.
Topics: Animals; Ascorbic Acid Deficiency; Collagen; Glycosaminoglycans; Granulation Tissue; Guinea Pigs; He | 1965 |
Vitamin C deficiency and connective tissue. II. Determinations of hexosamine, uronic acid and hydroxyproline in guinea pig carcasses.
Topics: Animals; Ascorbic Acid Deficiency; Collagen; Glycosaminoglycans; Guinea Pigs; Hexosamines; Hydroxypr | 1965 |
Aortic acid mucopolysaccharides and collagen in scorbutic guinea pigs.
Topics: Animals; Aorta; Ascorbic Acid Deficiency; Collagen; Glycosaminoglycans; Guinea Pigs; Hydroxyproline; | 1965 |
Vitamin C deficiency and connective tissue. IV. Determinations of mucopolysaccharides and collagen in carrageenan-granulomas.
Topics: Animals; Ascorbic Acid Deficiency; Azoles; Carrageenan; Chemistry Techniques, Analytical; Collagen; | 1966 |
The effect of scurvy on glycosaminoglycans of granulation tissue and costal cartilage.
Topics: Ascorbic Acid Deficiency; Carbon Isotopes; Cartilage; Galactose; Glucosamine; Glycosaminoglycans; Gr | 1968 |
Chemical analyses of the collagen content in the gingiva and periodontal ligament of normal and vitamin C deficient monkeys.
Topics: Ascorbic Acid Deficiency; Collagen; Gingiva; Hydroxyproline; Periodontium; Proline | 1969 |
[Collagen. I. Natural condition, chemistry, physics, metabolism].
Topics: Ascorbic Acid Deficiency; Carbohydrates; Cathepsins; Collagen; Endoplasmic Reticulum; Fibroblasts; G | 1969 |
Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs.
Topics: Animals; Aorta; Ascorbic Acid Deficiency; Chick Embryo; Collagen; Elastin; Guinea Pigs; Hydroxyproli | 1969 |
Effect of injury, repair, and ascorbic acid deficiency on collagen accumulation in peripheral nerves.
Topics: Animals; Ascorbic Acid Deficiency; Collagen; Guinea Pigs; Hydroxyproline; Peripheral Nerve Injuries; | 1973 |
A study of the relationship between Hess tests and leucocyte ascorbic acid in a clinical trial.
Topics: Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Capillary Fragility; Collagen; Humans; Hydroxyproline | 1972 |
Induced connective tissue metabolism in vivo: reutilization of pre-existing collagen.
Topics: Animals; Ascorbic Acid Deficiency; Chromatography; Collagen; Connective Tissue; Granuloma; Guinea Pi | 1966 |
Biochemical and histological study of guinea pig fetal and uterine tissue in ascorbic acid deficiency.
Topics: Adrenal Glands; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Bone and Bones; Collagen; Connecti | 1970 |
Urinary hydroxyproline in the elderly with low leucocyte ascorbic acid levels.
Topics: Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Collagen; Creatinine; Female; Humans; Hydroxyproline; | 1970 |
Model of chronic hypovitaminosis C in guinea-pigs.
Topics: Adipose Tissue; Adrenal Glands; Animals; Aorta; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Prote | 1968 |