hydroxyproline and Anasarca studies

Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
" Hydroxyproline content, edema, and mechanical properties were also evaluated at 1, 3, 7, 14, and 28 days post-trauma."	3.72	Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration. ( Côté, CH; Frenette, J; Marsolais, D, 2003)
" Pathohistological changes in pancreas, bile duct and liver as well as pathobiochemical parameters of pancreatitis (amylase and lipase activity), liver lesions (alkaline phosphatase activity and bilirubin) and fibrosis (hydroxyproline and hyaluronic acid) were measured 1 day and 1 to 24 weeks after DBTC- and DBTC/ethanol administration."	3.70	The influence of ethanol on long-term effects of dibutyltin dichloride (DBTC) in pancreas and liver of rats. ( Hennighausen, G; Jonas, L; Merkord, J; Nizze, H; Weber, H, 1998)
"Oxaceprol, an established therapeutic agent for osteoarthritis, had no effect on macrophage prostaglandin E2 release in vitro and inhibited carrageenan paw oedema at high doses (18-150 mg/kg p."	3.69	Oxaceprol, an atypical inhibitor of inflammation and joint damage. ( Brune, K; Ionac, M; Parnham, MJ; Plauchithiu, M, 1996)
"Idoxuridine treatment caused significant toxic changes in the regenerating epithelium clinically and histologically with a significant delay in epithelial wound healing in comparison to control or aciclovir treated eyes."	1.26	Aciclovir and corneal wound healing. ( Lass, JH; Park, NH; Pavan-Langston, D, 1979)

Research

Studies (19)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Body Weight

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (63.16)	18.7374
1990's	3 (15.79)	18.2507
2000's	1 (5.26)	29.6817
2010's	3 (15.79)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Ocak, S	1
Buk, OF	1
Genc, B	1
Avcı, B	1
Uzuner, HO	1
Gundogdu, SB	1
Marjanovic, G	1
Villain, C	1
Timme, S	1
zur Hausen, A	1
Hoeppner, J	1
Makowiec, F	1
Holzner, P	1
Hopt, UT	1
Obermaier, R	1
Vieira, CP	1
de Aro, AA	1
de Almeida, Mdos S	1
de Mello, GC	1
Antunes, E	1
Pimentel, ER	1
Marsolais, D	1
Côté, CH	1
Frenette, J	1
HVIDBERG, E	5
SZPORNY, L	5
LANGGAARD, H	2
HOUCK, JC	1
JACOB, RA	1
Trnavský, K	1
Lapárová, V	1
Kubo, M	1
Asano, T	1
Shiomoto, H	1
Matsuda, H	1
Ionac, M	1
Parnham, MJ	1
Plauchithiu, M	1
Brune, K	1
Merkord, J	1
Weber, H	1
Jonas, L	1
Nizze, H	1
Hennighausen, G	1
Lass, JH	1
Pavan-Langston, D	2
Park, NH	1
Marchenko, ZM	1
D'iachkova, AIa	1
Kozlova, AE	1
Kapel'ko, MA	1
Trefilova, EV	1
Langston, RH	1
Dohlman, CH	1
Témime, P	1
Stahl, A	1
Kroutil, M	1
Jezdinsky, J	1
Rotzsch, W	1
Schou, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Traditional Intravenous Versus Oral Fluid Management in Total Knee Arthroplasty[NCT03719378]		150 participants (Actual)	Interventional	2015-10-13	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Patient Weight will be monitored (NCT03719378)
Timeframe: Change is patients weight from baseline at pre op to two weeks post op.

Number of Participants With Adverse Events

Intervention	pounds (Mean)
Traditional Fluid	-1.9
Oral Fluid	-1.6

episodes such as symptomatic hypotension (light-headedness, syncope), emesis, the need the IV fluid boluses, and other hospital and post-discharge events will be recorded (NCT03719378)
Timeframe: While in hospital until the 6 week follow up appointment

Number of Participants With Off Wound Complications Post Operative

Intervention	Participants (Count of Participants)
Traditional Fluid	3
Oral Fluid	2

incidence of wound infection and wound drainage will be assessed and recorded (NCT03719378)
Timeframe: Up to 6 weeks Post OP

Number of Participants With Requiring Transfusions

Intervention	Participants (Count of Participants)
Traditional Fluid	0
Oral Fluid	0

Post Operative/Intra Operative Transfusions (NCT03719378)
Timeframe: intra operative, Post Op Day #1 or #2

Number of Participants With Thromboembolic Disease

Intervention	Participants (Count of Participants)
Traditional Fluid	0
Oral Fluid	1

The incidence of thromboembolic events will be recorded. (NCT03719378)
Timeframe: Post Opeartive until the 6 week follow up appointment

Number of Patients Re-admitted Post TKA

Intervention	Participants (Count of Participants)
Traditional Fluid	1
Oral Fluid	0

Number of patients re-admitted post TKA (NCT03719378)
Timeframe: up to 6 weeks post op

Total IV Fluids Received

Intervention	Participants (Count of Participants)
Traditional Fluid	1
Oral Fluid	0

Total amount of IV fluids that the patients received while in the hospital (NCT03719378)
Timeframe: Duration of IV intervention, up to 2 days

30 Second STS Test

Intervention	ML (Median)
Traditional Fluid	3895
Oral Fluid	350

30 second sit-to-stand tests (NCT03719378)
Timeframe: preoperative appointment and once again at their 2 and 6 weeks postoperatively

Bioimpedence

Intervention	sit-to-stand events (Mean)
	Change from Preop to 2 weeks Post op	Change from Preop to 6 weeks Post op
Oral Fluid	-4.4	0.3
Traditional Fluid	-5.3	-0.4

body composition before and after surgery to measure swelling. Lower numbers represent more swelling. (NCT03719378)
Timeframe: pre-op visit, Post Op Day #1 as well as their 2 week and 6 week visit

Blood Pressure

Intervention	ohms (Mean)
	Change from Preop to Post Op Day1	Change from Preop to 2 weeks post op	Change from Preop to 6 weeks post op
Oral Fluid	4.2	-38.5	-31.0
Traditional Fluid	-17.8	-41.4	-30.9

Blood Pressure (Diastolic/ Systolic) (NCT03719378)
Timeframe: Daily up to 2 days while hospitalized

Knee Range of Motion

Intervention	Change in mmHg (Mean)
	Change in mmHg Pre Op to Recovery Room (Systolic)	Change in mmHg Pre Op to Recovery Room (Diastolic)	Change in mmHg Pre Op to Arrival on 4th floor (Systolic)	Change in mmHg Pre Op to Arrival on 4th floor (Diastolic)	Change in mmHg Pre Op to 08:00 on floor (Systolic)	Change in mmHg Pre Op to 08:00 on floor (Diastolic)	Change in mmHg Pre Op to 16:00 on floor (Systolic)	Change in mmHg Pre Op to 16:00 on floor (Diastolic)	Change in mmHg Pre Op to 24:00 on floor (Systolic)	Change in mmHg Pre Op to 24:00 on floor (Diastolic)
Oral Fluid	26.0	17.2	19.4	9.3	23.4	16.0	25.8	18.7	12.5	11.1
Traditional Fluid	21.5	18.4	10.6	10.5	17.0	16.5	20.9	16.3	12.5	14.6

Measurements will be done with a standard goniometer (Measurements below are shown as the difference from their pre operative base line measurement to the time points below) (NCT03719378)
Timeframe: Post Op Day 1, 2 Weeks and 6 Weeks Post Op

Leg Anthropometric (Girth) Measurements

Intervention	degrees (Mean)
	Post Op Day 1	2 Weeks Post Op	6 Weeks Post OP
Oral Fluid	-26.7	-25.5	-4.8
Traditional Fluid	-30.5	-27.9	-7.7

measurements will be performed at 5 & 10 cm suprapatellar, midpatella, and 10 cm infrapatellar with the use of a standard tape measure. measurements below show the difference from their pre operative base line measurement to the timepoints below. (NCT03719378)
Timeframe: Post op Day 1, 2 weeks and 6 weeks Post Op

Patient Reported Outcomes - Knee Injury and Osteoarthritis Outcome Score (KOOS)

Intervention	inches (Mean)
	(10 cm suprapatellar) Post Op day 1	(10 cm suprapatellar) 2 weeks post op	(10 cm suprapatellar) 6 weeks post op	(5 cm suprapatellar) Post Op day 1	(5 cm suprapatellar) 2 weeks post op	(5 cm suprapatellar) 6 weeks post op	(Midpatellar) Post Op day 1	(Midpatellar) 2 weeks post op	(Midpatellar) 6 weeks post op	(10 cm inferior patella) Post Op day 1	(10 cm inferior patella) 2 weeks post op	(10 cm inferior patella) 6 weeks post op
Oral Fluid	2.1	1.6	0.00	4.0	2.8	1.0	4.1	3.0	1.3	1.5	0.9	0.1
Traditional Fluid	2.5	0.9	0.00	4.1	2.0	0.9	4.6	2.2	1.3	2.7	0.8	-0.2

Knee injury and Osteoarthritis Outcome Score (KOOS), the scale is 0 to 100, 100 being the best score possible. (NCT03719378)
Timeframe: pre-operatively as well as at their 2 week and 6 week follow up appointments

Patient Reported Outcomes - Knee Society Score(KSS)

Intervention	score on a scale (Mean)
	Change is score from pre op to 2 weeks	Change is score from pre op to 6 weeks
Oral Fluid	3.1	12.3
Traditional Fluid	-1.6	9.4

Knee Society Score(KSS), the total scores range from 0 - 200, 200 being the best. (NCT03719378)
Timeframe: pre-operatively as well as at their 2 week and 6 week follow up appointments

PONV (Post-operative Nausea and Vomiting)

Intervention	score on a scale (Mean)
	Change from Preop to 2 weeks Post op	Change from pre op to 6 weeks
Oral Fluid	-0.2	40.5
Traditional Fluid	-14.6	31.9

patients will be asked about Nausea: None, Mild, Moderate or Severe (NCT03719378)
Timeframe: Daily up to 2 days while hospitalized

Postoperative Pain Assessment Using Visual Analog Scale

Intervention	Participants (Count of Participants)
	None	Mild	Moderat	Severe
Oral Fluid	46	12	3	4
Traditional Fluid	51	9	3	2

Pain will be assessed using a pain Visual Analog scale(VAS), the scale is from 1 to 10, the higher the score the worse the pain. (NCT03719378)
Timeframe: Every 4 hours, averaged daily, reported at Post op day 1 and 2 (while in the hospital), weeks 1, 2, 3, and 4 (3 times a day)

Quadriceps Strength Measure With a Handheld Dynamometer

Intervention	units on a scale (Mean)
	Average Post Op Day 1	Average Post Op Day 2	Average Week 1	Average Week 2	Average Week 3	Average Week 4
Oral Fluid	2.3	4.5	4.1	3.4	3.2	2.6
Traditional Fluid	2.6	4.4	4.3	3.6	3.0	2.7

The strength testing will be calculated using a handheld dynamometer (NCT03719378)
Timeframe: Post Op day 1, 2 Week and 6 Week Post OP

Time up and GO

Intervention	KG (Mean)
	Change from Preop to Post Op Day1	Change from Preop to 2 weeks post op	Change from Preop to 6 weeks post op
Oral Fluid	-11.2	-9.6	-3.8
Traditional Fluid	-10.4	-9.0	-3.2

timed up and go (TUG) (NCT03719378)
Timeframe: preoperative appointment and once again at their 2 and 6 weeks postoperatively

Veterans Rand -12

Intervention	Seconds (Mean)
	Change from Preop to 2 weeks Post op	Change from Preop to 6 weeks Post op
Oral Fluid	3.3	-4.0
Traditional Fluid	4.4	-4.7

"Patient Reported Outcomes- Veterans Rand(VR-12), there is an algorithm to calculate this score, not a specific range. The higher the number the more positive the output. The score has two components a mental score (MCS) and Physical Score (PCS). Higher values represent a better outcome.~MCS Scale 35.089613 to 46.341715 PCS Scale 14.957554 to 63.235672" (NCT03719378)
Timeframe: 2 week and 6 week follow up appointments

Intervention	score on a scale (Mean)
	Change from Preop - 2 Weeks Post Op Mental Score	Change from Preop - 2 Weeks PostOp Physical Score	Change from Pre op - 6 Weeks Post Op Mental Score	Change from Preop - 6 Weeks PostOp Physical Score
Oral Fluid	-1.2	-4.5	-3.2	2.2
Traditional Fluid	-4.7	-8.3	-2.5	-0.5

Article	Year
The effects of platelet-rich-plasma gel application to the colonic anastomosis in hyperthermic intraperitoneal chemotherapy: An experimental rat model. International wound journal, 2019, Volume: 16, Issue:6 Topics: Anastomosis, Surgical; Animals; Antineoplastic Agents; Cisplatin; Colon; Edema; Gels; Hydroxyproline	2019
Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses. International journal of colorectal disease, 2010, Volume: 25, Issue:4 Topics: Anastomosis, Surgical; Animals; Colloids; Crystalloid Solutions; Digestive System Surgical Procedure	2010
Effects of acute inflammation induced in the rat paw on the deep digital flexor tendon. Connective tissue research, 2012, Volume: 53, Issue:2 Topics: Acute Disease; Animals; Carrageenan; Disease Models, Animal; Edema; Electrophoresis, Agar Gel; Extra	2012
Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration. Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:7 Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Edema; Female; Hindli	2003
THE COMPOSITION OF OEDEMA FLUID PROVOKED IN MICE BY OESTRADIOL. Acta pharmacologica et toxicologica, 1963, Volume: 20 Topics: Animals; Body Fluids; Chemistry Techniques, Analytical; Chlorides; Edema; Estradiol; Hexosamines; Hy	1963
THE EFFECT OF AGE ON THE CHEMISTRY OF INFLAMMATION. The Journal of investigative dermatology, 1964, Volume: 42 Topics: Aging; Collagen; Croton Oil; Edema; Fucose; Glycoproteins; Hexosamines; Hexoses; Hydroxyproline; Inf	1964
THE CHEMICAL COMPOSITION OF THE OEDEMA FLUID DURING THE COURSE OF ACUTE INFLAMMATION. Acta pharmacologica et toxicologica, 1964, Volume: 21 Topics: Animals; Blood; Body Fluids; Chemistry Techniques, Analytical; Chlorides; Edema; Hexosamines; Hydrox	1964
QUANTITATIVE INVESTIGATIONS ON THE COMPOSITION OF ACUTE INFLAMMATORY EDEMA. Acta rheumatologica Scandinavica, 1964, Volume: 10 Topics: Animals; Chlorides; Edema; Hexosamines; Hot Temperature; Hydroxyproline; Inflammation; Metabolism; M	1964
EFFECTS OF ANTI-INFLAMMATORY AGENTS ON THE CHEMICAL COMPOSITON OF NORMAL AND INFLAMED CONNECTIVE TISSUE. Acta rheumatologica Scandinavica, 1964, Volume: 10 Topics: Animals; Anti-Inflammatory Agents; Chlorides; Connective Tissue; Edema; Exudates and Transudates; He	1964
Anti-inflammatory activity of 6-azauridine. Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1967, Volume: 16, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Body Weight; Carrageenan; DNA; Edema; Extremitie	1967
Studies on rehmanniae radix. I. Effect of 50% ethanolic extract from steamed and dried rehmanniae radix on hemorheology in arthritic and thrombosic rats. Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:9 Topics: Acetates; Animals; Arthritis, Experimental; Blood Cell Count; Blood Viscosity; Capillary Permeabilit	1994
Oxaceprol, an atypical inhibitor of inflammation and joint damage. Pharmacological research, 1996, Volume: 33, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dinoprostone	1996
The influence of ethanol on long-term effects of dibutyltin dichloride (DBTC) in pancreas and liver of rats. Human & experimental toxicology, 1998, Volume: 17, Issue:3 Topics: Administration, Oral; Amylases; Animals; Drug Synergism; Edema; Ethanol; Fibrosis; Hyaluronic Acid;	1998
Aciclovir and corneal wound healing. American journal of ophthalmology, 1979, Volume: 88, Issue:1 Topics: Animals; Collagen; Cornea; Corneal Injuries; Drug Evaluation, Preclinical; Edema; Epithelium; Guanin	1979
[Study of the pathogenesis of the edema syndrome in newborn premature infants]. Voprosy okhrany materinstva i detstva, 1975, Volume: 20, Issue:8 Topics: 11-Hydroxycorticosteroids; Adrenal Cortex Diseases; Adrenal Gland Diseases; Cell Membrane Permeabili	1975
Antiviral medication and corneal wound healing. Archives of ophthalmology (Chicago, Ill. : 1960), 1974, Volume: 92, Issue:6 Topics: Adenine; Animals; Antiviral Agents; Arabinose; Collagen; Cornea; Corneal Injuries; Edema; Epithelium	1974
[Disabling ulcerated and extended scleroatrophic lichen]. Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1971, Volume: 78, Issue:5 Topics: Edema; Humans; Hydroxyproline; Leg Injuries; Lumbosacral Region; Male; Middle Aged; Purpura; Skin Di	1971
[Effects of thyroxine and carnitines on the experimental inflammations]. Acta biologica et medica Germanica, 1967, Volume: 19, Issue:5 Topics: Animals; Carnitine; Collagen; Edema; Exudates and Transudates; Foreign Bodies; Granulation Tissue; H	1967
A quantitative method for studying formation, composition and dynamics of inflammatory oedema fluid. Bibliotheca anatomica, 1965, Volume: 7 Topics: Animals; Blood; Chemical Phenomena; Chemistry; Chlorides; Edema; Exudates and Transudates; Hexosamin	1965

hydroxyproline and Anasarca