hydroxyproline has been researched along with Alloxan Diabetes in 102 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epigallocatechin-3-gallate (EGCG) possesses anti-fibrotic potential in diverse tissues; however, the molecular mechanisms underlying the impacts of EGCG on diabetes-induced myocardial fibrosis remain unclear." | 8.12 | Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy. ( Jia, Q; Li, Y; Mehmood, S; Yang, R, 2022) |
| "In order to explore the effects of hydrogen sulfide (H2S) on myocardial fibrosis in diabetic rats and its underlying mechanisms, intraperitoneal injections of streptozotocin were used to establish the diabetes models and sodium hydrosulfide (NaHS) was used as an exogenous donor of H2S." | 7.81 | Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2015) |
| "To investigate the effect of ursolic acid (UA) on the alloxan-induced myocardial fibrosis in mice and discuss the possible mechanism." | 7.79 | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. ( Gong, Y; Qi, MY; Shi, J; Yang, JJ, 2013) |
| "Myocardial fibrosis is the predominant pathological characteristic of diabetic myocardial damage." | 5.43 | Effects of hydrogen sulfide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2016) |
| "Epigallocatechin-3-gallate (EGCG) possesses anti-fibrotic potential in diverse tissues; however, the molecular mechanisms underlying the impacts of EGCG on diabetes-induced myocardial fibrosis remain unclear." | 4.12 | Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy. ( Jia, Q; Li, Y; Mehmood, S; Yang, R, 2022) |
| "In order to explore the effects of hydrogen sulfide (H2S) on myocardial fibrosis in diabetic rats and its underlying mechanisms, intraperitoneal injections of streptozotocin were used to establish the diabetes models and sodium hydrosulfide (NaHS) was used as an exogenous donor of H2S." | 3.81 | Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2015) |
| "To investigate the effect of ursolic acid (UA) on the alloxan-induced myocardial fibrosis in mice and discuss the possible mechanism." | 3.79 | [Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]. ( Gong, Y; Qi, MY; Shi, J; Yang, JJ, 2013) |
| " Glucose infusion rates (index of insulin resistance, insulin resistance), heart weight, the heart weight to body weight ratio, myocardial apoptotic index, cardiac hydroxyproline content, and cardiac tissue collagen type I and collagen type 3 content were measured." | 3.76 | Insulin resistance and heart injury in rats with insulin resistance or type 2 diabetes mellitus. ( Peng, XD; Yang, ZH, 2010) |
| "Aldose reductase inhibitors, and particularly sorbinil, have been reported to prevent glomerular basement membrane thickening (GBMT) and albuminuria development in diabetic rats, but contradictory observations have been published." | 3.69 | Renal and microvascular effects of an aldose reductase inhibitor in experimental diabetes. Biochemical, functional and ultrastructural studies. ( Andre, J; Bellon, G; Claperon, N; Feldmann, G; Guillot, R; Kassab, JP; Peyroux, J; Sternberg, M, 1994) |
| "Myocardial fibrosis is the predominant pathological characteristic of diabetic myocardial damage." | 1.43 | Effects of hydrogen sulfide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats. ( Li, F; Luo, J; Wu, Z; Xiao, T; Yang, J; Zeng, O, 2016) |
| "Mangiferin treatment, post to hyperglycemia, successfully inhibited all of these changes and protected the cells from apoptotic death." | 1.40 | Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats. ( Pal, PB; Sil, PC; Sinha, K, 2014) |
| "Coronary fibrosis was also increased in diabetic WT and AI(+/+)AII(-/-) mice (1." | 1.38 | Diabetes-induced vascular dysfunction involves arginase I. ( Ali, MI; Caldwell, RB; Caldwell, RW; Cederbaum, SD; Iddings, JA; Platt, DH; Romero, MJ; Stepp, DW, 2012) |
| "Icariin is a major constituent of flavonoid isolated from the plant Herba epimedii, which is used as a traditional Chinese medicine to nourish the kidney and reinforce yang." | 1.37 | Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats. ( Liu, HR; Qi, MY; Su, YH; Yu, SQ, 2011) |
| "Full-thickness excisional skin wounds were made in 38 rats, of which 30 had diabetes." | 1.36 | Topical erythropoietin promotes wound repair in diabetic rats. ( Hamed, S; Hellou, E; Khamaysi, Z; Masoud, M; Teot, L; Ullmann, Y, 2010) |
| "Pravastatin sodium was gavaged at 0." | 1.36 | Effect of pravastatin on experimental diabetic wound healing. ( Bouchier-Hayes, D; Chan, F; Hanson, R; Laing, T, 2010) |
| "Curcumin is a potent inhibitor of the transcription factor activator protein-1 which plays an essential role in osteoclastogenesis." | 1.35 | Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. ( Hie, M; Tsukamoto, I; Yamazaki, M, 2009) |
| "Also hydroxyproline (Hyp) was measured using a method based on alkaline hydrolysis." | 1.35 | Expression of transforming growth factor beta1 gene, basic fibroblast growth factor gene and hydroxyproline in diabetes-induced bladder dysfunction in a rat model. ( Benkang, S; Jianping, Z; Keqin, Z; Laudon, V; Lingxia, R; Wei, B; Yaofeng, Z; Yongzhi, L, 2008) |
| "Hydroxyproline levels also were assessed in the wound skin." | 1.34 | Effects of plasma fibronectin on the healing of full-thickness skin wounds in streptozotocin-induced diabetic rats. ( Kamiyama, Y; Kwon, AH; Qiu, Z, 2007) |
| " Ten db/db mice were given, for 3 months, a solution containing a daily dosage of creatine of 50 mg/kg body weight." | 1.29 | Creatine reduces collagen accumulation in the kidneys of diabetic db/db mice. ( Adamiker, D; Aufricht, C; Fang-Kircher, S; Gialamas, H; Herkner, K; Hoeger, H; Lubec, B; Lubec, G, 1994) |
| " The repeated application of bFGF for 7 d showed a bell-shaped dose-response in the rate of wound closure, and the optimal dose was as small as 0." | 1.29 | Acceleration of wound healing in diabetic mice by basic fibroblast growth factor. ( Nakamura, T; Okuda, T; Okumura, M; Yajima, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (31.37) | 18.7374 |
| 1990's | 17 (16.67) | 18.2507 |
| 2000's | 18 (17.65) | 29.6817 |
| 2010's | 31 (30.39) | 24.3611 |
| 2020's | 4 (3.92) | 2.80 |
| Authors | Studies |
|---|---|
| Alsarayreh, AZ | 1 |
| Attalah Oran, S | 1 |
| Shakhanbeh, JM | 1 |
| Jia, Q | 1 |
| Yang, R | 1 |
| Mehmood, S | 1 |
| Li, Y | 1 |
| Albaayit, SFA | 1 |
| Abdullah, R | 1 |
| Noor, MHM | 1 |
| Rezvanian, M | 1 |
| Ng, SF | 2 |
| Alavi, T | 1 |
| Ahmad, W | 1 |
| Singla, R | 1 |
| Soni, S | 1 |
| Patial, V | 1 |
| Kulurkar, PM | 1 |
| Kumari, A | 1 |
| S, M | 1 |
| Padwad, YS | 1 |
| Yadav, SK | 1 |
| Zhao, M | 1 |
| Zhou, J | 1 |
| Chen, YH | 1 |
| Yuan, L | 1 |
| Yuan, MM | 1 |
| Zhang, XQ | 1 |
| Hu, Y | 1 |
| Yu, H | 1 |
| Qayoom, A | 1 |
| Aneesha, VA | 1 |
| Anagha, S | 1 |
| Dar, JA | 1 |
| Kumar, P | 2 |
| Kumar, D | 1 |
| Badr, G | 2 |
| Lodhi, S | 1 |
| Singhai, AK | 1 |
| Yan, H | 1 |
| Peng, KJ | 1 |
| Wang, QL | 1 |
| Gu, ZY | 1 |
| Lu, YQ | 1 |
| Zhao, J | 2 |
| Xu, F | 1 |
| Liu, YL | 1 |
| Tang, Y | 1 |
| Deng, FM | 1 |
| Zhou, P | 1 |
| Jin, JG | 1 |
| Wang, XC | 1 |
| Rosa, CM | 1 |
| Xavier, NP | 1 |
| Henrique Campos, D | 1 |
| Fernandes, AA | 1 |
| Cezar, MD | 1 |
| Martinez, PF | 1 |
| Cicogna, AC | 1 |
| Gimenes, C | 1 |
| Gimenes, R | 1 |
| Okoshi, MP | 1 |
| Okoshi, K | 1 |
| Yang, JJ | 1 |
| Gong, Y | 1 |
| Shi, J | 1 |
| Qi, MY | 2 |
| Pal, PB | 1 |
| Sinha, K | 1 |
| Sil, PC | 1 |
| Bagdas, D | 1 |
| Etoz, BC | 1 |
| Gul, Z | 1 |
| Ziyanok, S | 1 |
| Inan, S | 1 |
| Turacozen, O | 1 |
| Gul, NY | 1 |
| Topal, A | 1 |
| Cinkilic, N | 1 |
| Tas, S | 1 |
| Ozyigit, MO | 1 |
| Gurun, MS | 1 |
| Wang, T | 1 |
| Gu, Q | 1 |
| Mei, J | 1 |
| Shao, M | 1 |
| Pan, Y | 1 |
| Zhang, J | 1 |
| Wu, H | 1 |
| Zhang, Z | 2 |
| Liu, F | 1 |
| Elsherbiny, NM | 1 |
| El-Sherbiny, M | 1 |
| Said, E | 1 |
| Xiao, T | 2 |
| Zeng, O | 2 |
| Luo, J | 2 |
| Wu, Z | 2 |
| Li, F | 2 |
| Yang, J | 2 |
| Lai, JC | 1 |
| Lai, HY | 1 |
| Nalamolu, KR | 1 |
| Abo El Gheit, R | 1 |
| Emam, MN | 1 |
| Ye, X | 1 |
| Tong, Z | 1 |
| Dang, Y | 1 |
| Tu, Q | 1 |
| Weng, Y | 1 |
| Liu, J | 1 |
| Hamed, S | 2 |
| Ullmann, Y | 2 |
| Masoud, M | 1 |
| Hellou, E | 2 |
| Khamaysi, Z | 1 |
| Teot, L | 2 |
| Hie, M | 2 |
| Yamazaki, M | 1 |
| Tsukamoto, I | 2 |
| Laing, T | 1 |
| Hanson, R | 2 |
| Chan, F | 2 |
| Bouchier-Hayes, D | 2 |
| Luo, ZF | 1 |
| Feng, B | 1 |
| Mu, J | 1 |
| Qi, W | 1 |
| Zeng, W | 1 |
| Guo, YH | 1 |
| Pang, Q | 1 |
| Ye, ZL | 1 |
| Liu, L | 1 |
| Yuan, FH | 1 |
| Aktunc, E | 1 |
| Ozacmak, VH | 1 |
| Ozacmak, HS | 1 |
| Barut, F | 1 |
| Buyukates, M | 1 |
| Kandemir, O | 1 |
| Demircan, N | 1 |
| Yang, ZH | 1 |
| Peng, XD | 1 |
| O'Sullivan, JB | 1 |
| Bouchier-Hayes, DJ | 1 |
| Egozi, D | 1 |
| Daod, E | 1 |
| Ashkar, M | 1 |
| Gilhar, A | 1 |
| Arul, V | 1 |
| Masilamoni, JG | 1 |
| Jesudason, EP | 1 |
| Jaji, PJ | 1 |
| Inayathullah, M | 1 |
| Dicky John, DG | 1 |
| Vignesh, S | 1 |
| Jayakumar, R | 1 |
| Liu, HR | 1 |
| Su, YH | 1 |
| Yu, SQ | 1 |
| Romero, MJ | 1 |
| Iddings, JA | 1 |
| Platt, DH | 1 |
| Ali, MI | 1 |
| Cederbaum, SD | 1 |
| Stepp, DW | 1 |
| Caldwell, RB | 1 |
| Caldwell, RW | 1 |
| Yang, G | 1 |
| Luo, C | 1 |
| Yan, X | 1 |
| Cheng, L | 1 |
| Chai, Y | 1 |
| Yu, L | 1 |
| Nie, X | 1 |
| Pan, H | 1 |
| Ling, S | 1 |
| Zhang, D | 1 |
| Bian, K | 1 |
| Lee, YH | 1 |
| Chang, JJ | 1 |
| Chien, CT | 1 |
| Yang, MC | 1 |
| Chien, HF | 1 |
| Witte, MB | 1 |
| Kiyama, T | 1 |
| Barbul, A | 1 |
| Martinez, DA | 1 |
| Guhl, DJ | 1 |
| Stanley, WC | 1 |
| Vailas, AC | 1 |
| Deiters, U | 1 |
| Barsig, J | 1 |
| Tawil, B | 1 |
| Mühlradt, PF | 1 |
| Maiya, GA | 1 |
| Rao, L | 1 |
| Babu, PV | 1 |
| Sabitha, KE | 1 |
| Shyamaladevi, CS | 1 |
| Kamalakkannan, N | 1 |
| Stanely Mainzen Prince, P | 1 |
| Qiu, Z | 1 |
| Kwon, AH | 1 |
| Kamiyama, Y | 1 |
| Nayak, BS | 1 |
| Isitor, GN | 1 |
| Maxwell, A | 1 |
| Bhogadi, V | 1 |
| Ramdath, DD | 1 |
| Yongzhi, L | 1 |
| Benkang, S | 1 |
| Jianping, Z | 1 |
| Lingxia, R | 1 |
| Wei, B | 1 |
| Yaofeng, Z | 1 |
| Keqin, Z | 1 |
| Laudon, V | 1 |
| Shimono, M | 1 |
| Fujii, K | 1 |
| Chan, FC | 1 |
| Kennedy, C | 1 |
| Hanson, RP | 1 |
| O'Sullivan, B | 1 |
| Kelly, J | 1 |
| Pari, L | 1 |
| Murugan, P | 1 |
| Ceylan-Isik, A | 1 |
| Hünkar, T | 1 |
| Aşan, E | 1 |
| Kaymaz, F | 1 |
| Ari, N | 1 |
| Söylemezoğlu, T | 1 |
| Renda, N | 1 |
| Soncul, H | 1 |
| Bali, M | 1 |
| Karasu, C | 1 |
| Schneir, M | 4 |
| Ramamurthy, N | 4 |
| Golub, L | 4 |
| Schneir, ML | 1 |
| Ramamurthy, NS | 7 |
| Golub, LM | 7 |
| Hasslacher, C | 2 |
| Reichenbacher, R | 2 |
| Gechter, F | 2 |
| Timpl, R | 1 |
| Kopischke, HG | 1 |
| Bürklin, E | 1 |
| Cohen, MP | 2 |
| Dasmahapatra, A | 1 |
| Wu, VY | 2 |
| Haider, B | 1 |
| Yeh, CK | 1 |
| Thomas, G | 1 |
| Oldewurtel, HA | 1 |
| Lyons, MM | 1 |
| Regan, TJ | 1 |
| Romen, W | 1 |
| Heck, T | 1 |
| Rauscher, G | 1 |
| Lange, HU | 1 |
| Hempel, K | 1 |
| Modrak, J | 1 |
| Covington, DS | 1 |
| Xue, H | 1 |
| Pizzini, R | 1 |
| Lally, KP | 1 |
| Andrassy, RJ | 2 |
| Lubec, B | 1 |
| Aufricht, C | 1 |
| Herkner, K | 1 |
| Hoeger, H | 1 |
| Adamiker, D | 1 |
| Gialamas, H | 1 |
| Fang-Kircher, S | 1 |
| Lubec, G | 1 |
| Kassab, JP | 1 |
| Guillot, R | 1 |
| Andre, J | 1 |
| Claperon, N | 1 |
| Bellon, G | 1 |
| Feldmann, G | 1 |
| Peyroux, J | 1 |
| Sternberg, M | 1 |
| Pałka, J | 1 |
| Bańkowski, E | 1 |
| Wolańska, M | 1 |
| Mavrikakis, ME | 1 |
| Karli, J | 1 |
| Antoniades, LG | 1 |
| Sfikakis, PP | 1 |
| Kontoyannis, SA | 1 |
| Moulopoulou, DS | 1 |
| Koutras, DA | 1 |
| Raptis, SA | 1 |
| Yu, Z | 1 |
| Leung, M | 1 |
| Chang, KM | 1 |
| McNamara, TF | 2 |
| Takeshita, N | 2 |
| Ishida, H | 2 |
| Yamamoto, T | 1 |
| Koh, G | 1 |
| Kurose, T | 1 |
| Tsuji, K | 1 |
| Okamoto, Y | 1 |
| Ikeda, H | 1 |
| Seino, Y | 3 |
| Han, X | 1 |
| Karpakka, J | 1 |
| Kainulainen, H | 1 |
| Takala, TE | 1 |
| Okumura, M | 1 |
| Okuda, T | 1 |
| Nakamura, T | 1 |
| Yajima, M | 1 |
| Bitar, MS | 1 |
| Kucine, AJ | 1 |
| McClain, SA | 1 |
| Cantürk, NZ | 1 |
| Vural, B | 1 |
| Esen, N | 1 |
| Cantürk, Z | 1 |
| Oktay, G | 1 |
| Kirkali, G | 1 |
| Solakoglu, S | 1 |
| Seyer-Hansen, M | 1 |
| Andreassen, TT | 1 |
| Christensen, H | 1 |
| Oxlund, H | 1 |
| Noma, T | 1 |
| Mizushige, K | 1 |
| Yao, L | 1 |
| Yu, Y | 1 |
| Kiyomoto, H | 1 |
| Hosomi, N | 1 |
| Kimura, S | 1 |
| Abe, Y | 1 |
| Ohmori, K | 1 |
| Matsuo, H | 1 |
| Knuuttila, ML | 1 |
| Kuoksa, TH | 1 |
| Svanberg, MJ | 1 |
| Mattila, PT | 1 |
| Karjalainen, KM | 1 |
| Kolehmainen, E | 1 |
| Unlüçerçi, YM | 1 |
| Bekpinar, S | 1 |
| Seferoglu, G | 1 |
| Galeano, M | 1 |
| Torre, V | 1 |
| Deodato, B | 1 |
| Campo, GM | 1 |
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| Cavallari, V | 1 |
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| Skill, NJ | 1 |
| Griffin, M | 1 |
| El Nahas, AM | 1 |
| Sanai, T | 1 |
| Haylor, JL | 1 |
| Fisher, M | 1 |
| Jamie, MF | 1 |
| Mould, NN | 1 |
| Johnson, TS | 1 |
| Hanzlik, J | 1 |
| Tomaszewski, J | 1 |
| Garant, PR | 1 |
| Bowersox, J | 1 |
| Yavelow, J | 1 |
| Murray, J | 1 |
| Edlin-Folz, E | 1 |
| Brownlee, M | 1 |
| Spiro, RG | 1 |
| Klepser, H | 1 |
| Hennessey, PJ | 1 |
| Black, CT | 1 |
| Odetti, PR | 1 |
| Borgoglio, A | 1 |
| De Pascale, A | 1 |
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| Adezati, L | 1 |
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| Kimura, M | 2 |
| Reddi, AS | 4 |
| Sahebjami, H | 1 |
| Denholm, D | 1 |
| Tengrup, I | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of High Voltage Pulsed Current and Low Level Laser Therapy on Wound Healing in Diabetic Ulcers.[NCT00719251] | 28 participants (Actual) | Interventional | 2004-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
102 other studies available for hydroxyproline and Alloxan Diabetes
| Article | Year |
|---|---|
In vitro and in vivo wound healing activities of Globularia arabica leaf methanolic extract in diabetic rats.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Hydroxyproline; Methanol; Plant Extracts; Planta | 2022 |
Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Autophagy; Beclin-1; Blood Glucose; Catechin; Col | 2022 |
Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Cytokines; Diabetes Mellitus, Experimenta | 2022 |
In-vivo evaluation of Alginate-Pectin hydrogel film loaded with Simvastatin for diabetic wound healing in Streptozotocin-induced diabetic rats.
Topics: Alginates; Animals; Biological Dressings; Collagen; Diabetes Mellitus, Experimental; Drug Evaluation | 2021 |
In vivo diabetic wound healing potential of nanobiocomposites containing bamboo cellulose nanocrystals impregnated with silver nanoparticles.
Topics: Animals; Biocompatible Materials; Cellulose; Collagen; Diabetes Mellitus, Experimental; Hydroxyproli | 2017 |
Folic Acid Promotes Wound Healing in Diabetic Mice by Suppression of Oxidative Stress.
Topics: Animals; Diabetes Mellitus, Experimental; Folic Acid; Glutathione; Hydroxyproline; Lipid Peroxidatio | 2018 |
Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats.
Topics: Animals; Chemokine CXCL12; Collagen; Deferoxamine; Diabetes Mellitus, Experimental; Drug Carriers; G | 2019 |
Camel whey protein enhances diabetic wound healing in a streptozotocin-induced diabetic mouse model: the critical role of β-Defensin-1, -2 and -3.
Topics: Animals; Anti-Infective Agents; beta-Defensins; Biomarkers; Camelus; Collagen; Diabetes Mellitus, Ex | 2013 |
Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn. on streptozotocin induced diabetic rats.
Topics: Administration, Cutaneous; Animals; Antioxidants; Diabetes Mellitus, Experimental; Dose-Response Rel | 2013 |
Effect of pomegranate peel polyphenol gel on cutaneous wound healing in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Female; Gels; Hydroxyproline; Lythraceae; Male; N | 2013 |
Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Cardiac Myosins; Diabetes Mellitus, Experimental; Diabetic Cardi | 2013 |
[Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice].
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Fibrosis; Hydroxyproline; Male; M | 2013 |
Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Blood Glucose; Diabetes Mellitus, E | 2014 |
In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile.
Topics: Animals; Antioxidants; Blood Glucose; Catalase; Chlorogenic Acid; Diabetes Mellitus, Experimental; D | 2015 |
Calcium alginate enhances wound healing by up-regulating the ratio of collagen types I/III in diabetic rats.
Topics: Alginates; Animals; Collagen Type I; Collagen Type III; Diabetes Mellitus, Experimental; Dose-Respon | 2015 |
Amelioration of experimentally induced diabetic nephropathy and renal damage by nilotinib.
Topics: Animals; Blood Urea Nitrogen; Collagen; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephro | 2015 |
Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Heart; Hydrogen Sulfi | 2015 |
Effects of hydrogen sulfide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats.
Topics: Animals; Autophagy; Biomarkers; Collagen Type I; Collagen Type II; Cystathionine gamma-Lyase; Diabet | 2016 |
Treatment for diabetic ulcer wounds using a fern tannin optimized hydrogel formulation with antibacterial and antioxidative properties.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Bacteria; Biphenyl Compounds; Cell Proliferation; Coll | 2016 |
Targeting heme oxygenase-1 in early diabetic nephropathy in streptozotocin-induced diabetic rats.
Topics: Animals; Biomarkers; Blood Glucose; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetic Nephro | 2016 |
Effects of blood glucose fluctuation on skin biophysical properties, structure and antioxidant status in an animal model.
Topics: Animals; Blood Glucose; Body Water; Diabetes Mellitus, Experimental; Elasticity; Glucose; Glycation | 2010 |
Topical erythropoietin promotes wound repair in diabetic rats.
Topics: Administration, Topical; Animals; Apoptosis; Diabetes Mellitus, Experimental; Erythropoietin; Hydrox | 2010 |
Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes.
Topics: Acid Phosphatase; Amino Acids; Animals; Blood Glucose; Body Weight; Bone Marrow Cells; Bone Resorpti | 2009 |
Effect of pravastatin on experimental diabetic wound healing.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl-CoA Reductase Inhibit | 2010 |
Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Experimental; Diabetic Ne | 2010 |
N-acetyl cysteine promotes angiogenesis and clearance of free oxygen radicals, thus improving wound healing in an alloxan-induced diabetic mouse model of incisional wound.
Topics: Acetylcysteine; Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Free Radi | 2010 |
Insulin resistance and heart injury in rats with insulin resistance or type 2 diabetes mellitus.
Topics: Analysis of Variance; Animals; Apoptosis; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, E | 2010 |
Tight glycaemic control is a key factor in wound healing enhancement strategies in an experimental diabetes mellitus model.
Topics: Animals; Blood Glucose; Body Fluids; Diabetes Mellitus, Experimental; Fibroblasts; Hydroxyproline; I | 2011 |
Fibronectin potentiates topical erythropoietin-induced wound repair in diabetic mice.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Drug Synergism; Endothelial Cells; Erythropoiet | 2011 |
Glucose oxidase incorporated collagen matrices for dermal wound repair in diabetic rat models: a biochemical study.
Topics: Animals; Antioxidants; Catalase; Collagen; Diabetes Mellitus, Experimental; Fluorescent Dyes; Glucos | 2012 |
Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Collagen Type IV; Creatinine; Diabetes Mellitus, Experi | 2011 |
Diabetes-induced vascular dysfunction involves arginase I.
Topics: Animals; Aorta; Arginase; Arteries; Carotid Arteries; Compliance; Coronary Vessels; Diabetes Mellitu | 2012 |
Extracorporeal shock wave treatment improves incisional wound healing in diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Hydroxyprol | 2011 |
Supplementation with undenatured whey protein during diabetes mellitus improves the healing and closure of diabetic wounds through the rescue of functional long-lived wound macrophages.
Topics: Animals; Apoptosis; Blood Glucose; Camelus; Collagen; Cytokines; Diabetes Mellitus, Experimental; Di | 2012 |
[Diabetes mellitus ulcers treatment with Bletilla striata polysaccharide].
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Fibroblasts | 2011 |
Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Ascorbic Acid; Diabetes Mellitus, Experimental; Drug Delivery Syst | 2012 |
Nitric oxide enhances experimental wound healing in diabetes.
Topics: Animals; Blotting, Northern; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimen | 2002 |
Extracellular matrix maturation in the left ventricle of normal and diabetic swine.
Topics: Amino Acids; Animals; Chromatography, High Pressure Liquid; Collagen; Diabetes Mellitus, Experimenta | 2003 |
The macrophage-activating lipopeptide-2 accelerates wound healing in diabetic mice.
Topics: Animals; Dendritic Cells; Diabetes Mellitus, Experimental; Gene Expression Regulation; Humans; Hyalu | 2004 |
Effect of low intensity helium-neon (He-Ne) laser irradiation on diabetic wound healing dynamics.
Topics: Animals; Capillaries; Cell Proliferation; Collagen; Diabetes Mellitus, Experimental; Epithelium; Fib | 2005 |
Therapeutic effect of green tea extract on advanced glycation and cross-linking of collagen in the aorta of streptozotocin diabetic rats.
Topics: Animals; Antioxidants; Aorta; Blood Glucose; Blood Pressure; Body Weight; Collagen; Cross-Linking Re | 2006 |
The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracell | 2006 |
Effects of plasma fibronectin on the healing of full-thickness skin wounds in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Proteins; Collagen; Diabetes Mellitus, Experimental; Fibroblasts; Fibronectins; Hydro | 2007 |
Wound-healing activity of Morinda citrifolia fruit juice on diabetes-induced rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Exp | 2007 |
Expression of transforming growth factor beta1 gene, basic fibroblast growth factor gene and hydroxyproline in diabetes-induced bladder dysfunction in a rat model.
Topics: Animals; Diabetes Mellitus, Experimental; Fatty Alcohols; Fibroblast Growth Factor 2; Hydroxyproline | 2008 |
Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Biomarkers; Body Weight; Calcium; Cathepsin K; Cath | 2007 |
Topical diphenylhydantoin sodium can improve healing in a diabetic incisional animal wound model.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Evaluation, Preclin | 2007 |
Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes.
Topics: Animals; Collagen; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hydroxyprol | 2007 |
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Blood Glucose; Cardiovascular Diseases; Cod Liver Oil; Diabetes Melli | 2007 |
Skin collagen metabolism in the streptozotocin-induced diabetic rat. Enhanced catabolism of collagen formed both before and during the diabetic state.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Hydroxyproline; Male; Rats; Rats, Inbred Strains | 1982 |
Extensive degradation of recently synthesized collagen in gingiva of normal and streptozotocin-induced diabetic rats.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Gingiva; Hydroxyproline; Male; Procollagen; Rats | 1984 |
Skin collagen metabolism in the streptozotocin-induced diabetic rat: free hydroxyproline, the principal in vivo degradation product of newly synthesized collagen--probably procollagen.
Topics: Animals; Autoradiography; Chromatography, Gel; Collagen; Diabetes Mellitus, Experimental; Hydroxypro | 1984 |
Glomerular basement membrane synthesis and serum concentration of type IV collagen in streptozotocin-diabetic rats.
Topics: Age Factors; Animals; Basement Membrane; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; H | 1984 |
In vivo studies on basement membrane synthesis in diabetic and nondiabetic rats.
Topics: Animals; Basement Membrane; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Glycine; Hydro | 1982 |
Deposition of basement membrane in vitro by normal and diabetic rat renal glomeruli.
Topics: Animals; Basement Membrane; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hydroxyproline; | 1981 |
Influence of diabetes on the myocardium and coronary arteries of rhesus monkey fed an atherogenic diet.
Topics: Animals; Collagen; Coronary Disease; Coronary Vessels; Diabetes Mellitus, Experimental; Diet, Athero | 1981 |
Glomerular basement membrane turnover in young, old, and streptozotocin-diabetic rats.
Topics: Age Factors; Amino Acids; Animals; Basement Membrane; Diabetes Mellitus, Experimental; Diabetic Neph | 1980 |
Collagen metabolism in the myocardium from streptozotocin-diabetic rats.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Glycosuria; Hydroxyproline; Male; Myocardium; Pr | 1980 |
Streptozotocin and alloxan are comparable agents in the diabetic model of impaired wound healing.
Topics: Alloxan; Analysis of Variance; Animals; Collagenases; Diabetes Mellitus, Experimental; Disease Model | 1993 |
Creatine reduces collagen accumulation in the kidneys of diabetic db/db mice.
Topics: Animals; Binding Sites; Blood Glucose; Body Weight; Collagen; Creatine; Diabetes Mellitus, Experimen | 1994 |
Renal and microvascular effects of an aldose reductase inhibitor in experimental diabetes. Biochemical, functional and ultrastructural studies.
Topics: Albuminuria; Aldehyde Reductase; Animals; Capillaries; Collagen; Diabetes Mellitus, Experimental; Hy | 1994 |
Changes in IGF-binding proteins in rats with experimental diabetes.
Topics: Animals; Blood Proteins; Carrier Proteins; Collagen; Diabetes Mellitus, Experimental; Hydroxyproline | 1993 |
Twenty-four hours urinary hydroxyproline excretion in long-term experimental diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hydroxyproline; Rats; Rats, Wistar | 1993 |
Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: a dose-response study.
Topics: Administration, Oral; Analysis of Variance; Animals; Collagen; Diabetes Mellitus, Experimental; Dose | 1993 |
Circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein in rat models of non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Bone and Bones; Bone Diseases, Metabolic; Calcium; Diabetes Mellitus, Experi | 1993 |
Effects of streptozotocin-induced diabetes, physical training and their combination on collagen biosynthesis in rat skeletal muscle.
Topics: Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimental; Glucosyltransferases | 1995 |
Acceleration of wound healing in diabetic mice by basic fibroblast growth factor.
Topics: Animals; Diabetes Mellitus, Experimental; DNA; Epidermis; Female; Fibroblast Growth Factor 2; Granul | 1996 |
Insulin-like growth factor-1 reverses diabetes-induced wound healing impairment in rats.
Topics: Animals; Diabetes Mellitus, Experimental; DNA Replication; Hydroxyproline; Insulin-Like Growth Facto | 1997 |
Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin.
Topics: Administration, Topical; Animals; Collagenases; Diabetes Mellitus, Experimental; Gelatinases; Granul | 1998 |
Effects of granulocyte-macrophage colony-stimulating factor on incisional wound healing in an experimental diabetic rat model.
Topics: Animals; Blood Cell Count; Collagen; Diabetes Mellitus, Experimental; Granulocyte-Macrophage Colony- | 1999 |
Effect of experimental diabetes and growth hormone administration on the strength of colonic anastomoses in rats.
Topics: Anastomosis, Surgical; Animals; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Experimental; | 1999 |
Alteration in aortic wall stiffness and accumulation of collagen during the prediabetic stage of type II diabetes mellitus in rats.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimental; Diabetes Mell | 1999 |
Effects of dietary xylitol on collagen content and glycosylation in healthy and diabetic rats.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Dietary Supplements; Glycosylatio | 2000 |
The effect of aminoguanidine on urinary heparan sulphate levels in experimental diabetes.
Topics: Animals; Basement Membrane; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Guani | 2000 |
Raxofelast, a hydrophilic vitamin E-like antioxidant, stimulates wound healing in genetically diabetic mice.
Topics: Animals; Antioxidants; Benzofurans; Diabetes Mellitus, Experimental; Female; Hydroxyproline; Malondi | 2001 |
Increases in renal epsilon-(gamma-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy: pathologic implications.
Topics: Animals; Carbocyanines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dipeptides; Extrace | 2001 |
Glycosoaminoglycans and hydroxyproline of rabbit lens in the course of artificial atherosclerosis and alloxan diabetes.
Topics: Animals; Arteriosclerosis; Diabetes Mellitus, Experimental; Glycosaminoglycans; Hydroxyproline; Lens | 1975 |
Inflammatory changes in gingival collagen in the alloxan-diabetic rat.
Topics: Animals; Antigen-Antibody Complex; Blood Glucose; Chronic Disease; Collagen; Diabetes Mellitus, Expe | 1977 |
Response of rat connective tissues to streptozotocin-diabetes. Tissue-specific effects on collagen metabolism.
Topics: Animals; Aorta; Collagen; Diabetes Mellitus, Experimental; Hydroxyproline; Intestinal Mucosa; Male; | 1979 |
Glomerular basement membrane metabolism in the diabetic rat. In vivo studies.
Topics: Animals; Basement Membrane; Diabetes Mellitus, Experimental; Hydroxyproline; Kidney Glomerulus; Male | 1979 |
Effect of alpha-glucosidase inhibition on the nonenzymatic glycation of glomerular basement membrane.
Topics: Animals; Basement Membrane; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glycated Hemogl | 1991 |
EGF increases short-term type I collagen accumulation during wound healing in diabetic rats.
Topics: Administration, Topical; Analysis of Variance; Animals; Collagen; Diabetes Mellitus, Experimental; D | 1990 |
Prevention of diabetes-increased aging effect on rat collagen-linked fluorescence by aminoguanidine and rutin.
Topics: Aging; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Guani | 1990 |
[Mechanism of action of pronase on chronic proliferative inflammation including granuloma angiogenesis in mice].
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Granuloma; Hydrocortisone; Hydroxyproline; Indom | 1986 |
Metabolism of glomerular basement membrane in short- and long-term streptozotocin diabetic rats.
Topics: Animals; Basement Membrane; Collagen; Diabetes Mellitus, Experimental; Hydroxyproline; Kidney Glomer | 1986 |
Insulin-induced granuloma tissue formation and angiogenesis in alloxan-treated diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Freund's Adjuvant; Granuloma; Hydroxyproline; Insulin; Mal | 1987 |
Effects of streptozotocin-induced diabetes on lung mechanics and biochemistry in rats.
Topics: Animals; Biomechanical Phenomena; Diabetes Mellitus, Experimental; DNA; Elasticity; Hydroxyproline; | 1988 |
Granulation tissue formation and metabolism of zinc and copper in alloxan-diabetic rats.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Blood Glucose; Child; Collagen; Copper; Diabetes Me | 1988 |
Metabolism of glomerular basement membrane in normal, hypophysectomized, and growth-hormone-treated diabetic rats.
Topics: Acetylglucosaminidase; Animals; Basement Membrane; Collagen; Diabetes Mellitus, Experimental; Glucos | 1985 |
Collagen metabolism in the retina of normal and diabetic rats.
Topics: Animals; Basement Membrane; Body Weight; Collagen; Diabetes Mellitus, Experimental; Glucosyltransfer | 1985 |
The in vivo fractional rate of gingival collagen production in non-diabetic and diabetic rats. Application of a novel approach for quantification-pool expansion.
Topics: Animals; Body Weight; Collagen; Diabetes Mellitus, Experimental; Gingiva; Hydroxyproline; Male; Prol | 1986 |
Abnormalities of granulation tissue and collagen formation in experimental diabetes, uraemia and malnutrition.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimental; | 1986 |
Collagen metabolism in the myocardium of normal and diabetic rats.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Hydroxyproline; Insulin; Male; My | 1988 |
Experimental diabetes and the lung. II. In vivo connective tissue metabolism.
Topics: Animals; Collagen; Connective Tissue; Diabetes Mellitus, Experimental; DNA; Elastin; Hydroxyproline; | 1988 |
Promotion of wound collagen formation in normal and diabetic mice by quadrol.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Ethylenediamines; Female; Hydroxyproline; Mice; | 1988 |
Circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein are decreased in streptozocin-induced diabetes. Possible marker for diabetic osteopenia.
Topics: Animals; Bone and Bones; Bone Diseases, Metabolic; Calcium; Calcium-Binding Proteins; Diabetes Melli | 1988 |
C14-proline metabolism in alloxan treated rats.
Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Hydroxyproline; Peptides; Proline; Rats | 1970 |
Wound healing in experimental diabetes: histological, histochemical and biochemical studies.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Female; Glycosaminoglycans; Histocytochemistry; | 1973 |
Collagenolytic activity of gingivae from alloxan-diabetic rats.
Topics: Animals; Collagen; Culture Techniques; Diabetes Mellitus, Experimental; Gingiva; Hydroxyproline; Mal | 1973 |
Insulin reversal of alloxan-diabetes induced changes in gingival collagen metabolism of the rat.
Topics: Animals; Blood Glucose; Collagen; Culture Techniques; Depression, Chemical; Diabetes Mellitus, Exper | 1974 |
The effect of alloxan diabetes on gingival collagen metabolism in rats.
Topics: Acetates; Age Factors; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimenta | 1972 |
Studies in wound healing in experimental diabetes.
Topics: Animals; Biomechanical Phenomena; Collagen; Diabetes Mellitus; Diabetes Mellitus, Experimental; Fema | 1974 |