hydroxyproline has been researched along with Adhesions, Tissue in 72 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "9% intraperitoneally and those of group 3 (iloprost), and group 4 (ileus + iloprost) iloprost (2 μg/kg of body weight), immediately postoperatively and daily until the day of sacrifice." | 7.80 | The effects of iloprost on colonic anastomotic healing in rats under obstructive ileus conditions. ( Galanopoulos, G; Kanellos, I; Lazarides, C; Mantzoros, I; Pramateftakis, MG; Raptis, D, 2014) |
| "Metoclopramide is often used in the treatment of postoperative nausea and vomiting, but a literature review failed to find reports on the influence of this drug on the healing of bowel anastomoses in the setting of abdominal sepsis." | 7.79 | Effects of metoclopramide on healing of colonic anastomoses in a rat model of abdominal sepsis. ( Carneiro, FP; Ferreira, VM; Marques e Silva, S; Oliveira, PG; Sousa, JB, 2013) |
| "Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties." | 5.40 | Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats. ( Chen, F; Gong, H; Ji, A; Tao, H; Wang, K; Ye, F; Zhang, C; Zuo, Z, 2014) |
| "The main outcomes measures were serological indexes including vascular endothelial growth factor, prostaglandin E2, hydroxyproline, and C reactive protein; histological specimens from the anastomotic stoma tissue including the collagen proportion, and hydroxyproline, cycloxygenase-2, and vascular endothelial growth factor content; physical indicators, including stoma fracture pressure, fracture strength and anastomotic leakage." | 3.81 | Effect of non-steroidal anti-inflammatory drugs on the increasing the incidence of colonic anastomosis in rats. ( Guo, X; Ji, C; Li, Z; Liao, WQ; Pan, X; Qian, S; Xiong, Y; Xu, C; Yu, DH, 2015) |
| "To investigate the effect of verapamil on the prevention of epidural fibrosis in laminectomy rats." | 3.80 | Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats. ( Liu, W; Wang, Y; Wang, Z; Xie, P; Zhang, S, 2014) |
| "9% intraperitoneally and those of group 3 (iloprost), and group 4 (ileus + iloprost) iloprost (2 μg/kg of body weight), immediately postoperatively and daily until the day of sacrifice." | 3.80 | The effects of iloprost on colonic anastomotic healing in rats under obstructive ileus conditions. ( Galanopoulos, G; Kanellos, I; Lazarides, C; Mantzoros, I; Pramateftakis, MG; Raptis, D, 2014) |
| "Metoclopramide is often used in the treatment of postoperative nausea and vomiting, but a literature review failed to find reports on the influence of this drug on the healing of bowel anastomoses in the setting of abdominal sepsis." | 3.79 | Effects of metoclopramide on healing of colonic anastomoses in a rat model of abdominal sepsis. ( Carneiro, FP; Ferreira, VM; Marques e Silva, S; Oliveira, PG; Sousa, JB, 2013) |
| "Hydroxyproline levels were significantly lower in the sham (48." | 1.42 | Effect of intraperitoneal curcumin instillation on postoperative peritoneal adhesions. ( Alabalik, U; Avci, Y; Gül, M; Türkoğlu, A; Ülger, BV; Uslukaya, O; Yuksel, HK, 2015) |
| "Hydroxyproline content was measured and histologic analysis was performed." | 1.40 | Ultrapure alginate anti-adhesion gel does not impair colon anastomotic strength. ( Chaturvedi, AA; Hendriks, T; Lomme, RM; van Goor, H, 2014) |
| "Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties." | 1.40 | Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats. ( Chen, F; Gong, H; Ji, A; Tao, H; Wang, K; Ye, F; Zhang, C; Zuo, Z, 2014) |
| "Hydroxyproline concentration was higher in the control group on the 3(rd) (p=0." | 1.37 | Does metoclopramide impair anastomotic healing of the left colon of rats? ( Feres, O; Ferreira, VM; Oliveira, PG; Silva, SM; Sousa, JB, 2011) |
| "The formation of adhesions and the leukocytosis on the anastomoses were significantly higher in the 2nd, 3rd and 4th group than in the 1st group (P < 0." | 1.37 | The effects of the intraperitoneal administration of oxaliplatin and 5-FU on the healing of colonic anastomoses: an experimental study. ( Despoudi, K; Kanellos, D; Koliakos, G; Lazaridis, H; Mantzoros, I; Pramateftakis, MG; Raptis, D; Zacharakis, E; Zaraboukas, T, 2011) |
| "Malondialdehyde levels were significantly higher in the 5-FU groups than in the 5-FU + AM groups." | 1.36 | Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing. ( Citgez, B; Ipcioglu, OM; Isgor, A; Kartal, A; Ozcan, O; Ozdilli, K; Polat, N; Torun, P; Uludag, M; Yetkin, G, 2010) |
| "The hydroxyproline results were found nearly similar to the bursting pressure values (subcutan (p < 0." | 1.35 | Does low molecular weight heparin impair anastomotic wound healing? ( Barit Ozgun, G; Ergul, E; Kiyak, G; Korukluoglu, B; Kusdemir, A; Ozgun, YM, 2009) |
| "The hydroxyproline levels were higher in the IGF-I and the IGF-I +5-FU groups as a result of the stimulating act of IGF-I." | 1.35 | Effect of IGF-I on healing of colonic anastomoses in rats under 5-FU treatment. ( Betsis, D; Demetriades, H; Kanellos, I; Koliakos, G; Lambrou, I; Pramateftakis, MG; Zacharakis, E; Zaraboukas, T, 2008) |
| "Hydroxyproline (HP) levels were significantly higher in control group than all other groups (P < 0." | 1.34 | Antiadhesive effects of mitomycin C and streptopeptidase A in rats with intraperitoneal adhesions. ( Ariturk, E; Bernay, F; Bicakci, U; Kilicoglu-Aydin, B; Rizalar, R; Tander, B, 2007) |
| " Forty New Zealand rabbits and 48 Sprague-Dawley (SD) rats were assigned randomly to one of the five groups: sham adhesion, adhesion with saline, adhesion with low dosage of the CT, adhesion with middle dosage of the CT and adhesion with high dosage of the CT." | 1.33 | Chinese medicine compound Changtong oral liquid on postoperative intestinal adhesions. ( Hou, LB; Shi, HP; Yang, XX, 2005) |
| "Sepsis was produced by cecal ligation and puncture." | 1.33 | [Does sepsis impair the healing of colonic anastomosis in splenectomized rats?]. ( Aksöyek, S; Avlan, D; Çıngı, E; Çömelekoğlu, Ü; Naycı, A; Renda, N; Taşkınlar, H, 2005) |
| "Lexipafant plays a role in the prevention of adhesion formation without affecting wound healing." | 1.31 | Lexipafant inhibits postsurgical adhesion formation. ( Cevikel, MH; Kozaci, LD; Ozgün, H; Sakarya, S, 2002) |
| " The inefficiency of BAPN in these experiments might have been due to either inadequate dosage or wrong timing, or both." | 1.26 | Improvement of gliding function of flexor tendons by topically applied enriched collagen solution. ( Porat, S; Rousso, M; Shoshan, S, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (12.50) | 18.7374 |
| 1990's | 6 (8.33) | 18.2507 |
| 2000's | 22 (30.56) | 29.6817 |
| 2010's | 35 (48.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Ren, G | 1 |
| Zhang, W | 2 |
| Liu, X | 1 |
| Jia, H | 1 |
| Xia, H | 1 |
| Marques e Silva, S | 1 |
| Carneiro, FP | 1 |
| Ferreira, VM | 2 |
| Oliveira, PG | 2 |
| Sousa, JB | 2 |
| Zheng, Z | 1 |
| Sun, W | 1 |
| Li, X | 3 |
| Duan, J | 1 |
| Cui, J | 1 |
| Feng, Z | 1 |
| Mansour, HM | 1 |
| Wang, Z | 2 |
| Wang, Y | 3 |
| Xie, P | 1 |
| Liu, W | 1 |
| Zhang, S | 1 |
| Glatz, T | 2 |
| Boldt, J | 1 |
| Timme, S | 3 |
| Kulemann, B | 3 |
| Seifert, G | 2 |
| Holzner, PA | 2 |
| Chikhladze, S | 2 |
| Grüneberger, JM | 1 |
| Küsters, S | 1 |
| Sick, O | 2 |
| Höppner, J | 2 |
| Hopt, UT | 2 |
| Marjanovic, G | 3 |
| Galanopoulos, G | 2 |
| Raptis, D | 4 |
| Pramateftakis, MG | 6 |
| Mantzoros, I | 5 |
| Kanellos, I | 3 |
| Lazarides, C | 1 |
| Liang, Y | 2 |
| Sun, Y | 4 |
| Yan, L | 4 |
| Wang, J | 4 |
| Hu, J | 2 |
| Yu, H | 2 |
| Xiao, H | 1 |
| Chen, H | 1 |
| Sun, Z | 1 |
| Cai, J | 1 |
| Feng, X | 3 |
| Xiong, C | 1 |
| He, J | 1 |
| Li, M | 1 |
| Wang, G | 1 |
| Zhou, B | 1 |
| Xia, X | 1 |
| Li, N | 1 |
| Holzner, P | 1 |
| Hopt, U | 1 |
| Bronsert, P | 1 |
| Zhou, C | 1 |
| Chaturvedi, AA | 1 |
| Lomme, RM | 1 |
| Hendriks, T | 1 |
| van Goor, H | 1 |
| Lv, P | 2 |
| Zhao, J | 2 |
| Su, W | 2 |
| Liang, X | 1 |
| Zhang, K | 2 |
| Lu, R | 1 |
| Wang, D | 2 |
| Chen, F | 1 |
| Zuo, Z | 1 |
| Wang, K | 1 |
| Zhang, C | 2 |
| Gong, H | 1 |
| Ye, F | 1 |
| Ji, A | 1 |
| Tao, H | 1 |
| Li, Y | 1 |
| Ma, X | 1 |
| Yu, P | 1 |
| Wang, S | 1 |
| Türkoğlu, A | 1 |
| Gül, M | 1 |
| Yuksel, HK | 1 |
| Alabalik, U | 1 |
| Ülger, BV | 1 |
| Uslukaya, O | 1 |
| Avci, Y | 1 |
| Evtushenko, DA | 1 |
| Cheng, H | 1 |
| Douglas, P | 1 |
| Lu, Y | 1 |
| Ji, C | 1 |
| Xiong, Y | 1 |
| Pan, X | 1 |
| Guo, X | 1 |
| Li, Z | 1 |
| Qian, S | 1 |
| Xu, C | 1 |
| Yu, DH | 1 |
| Liao, WQ | 1 |
| Zhu, L | 1 |
| Zhang, YQ | 1 |
| Danielski, LG | 1 |
| Walczewski, E | 1 |
| de Jesus, CR | 1 |
| Florentino, D | 1 |
| Giustina, AD | 1 |
| Goldim, MP | 1 |
| Kanis, LA | 1 |
| Pereira, GW | 1 |
| Pereira, VD | 1 |
| Felisberto, F | 1 |
| Petronilho, F | 1 |
| Ayten, R | 1 |
| Cetinkaya, Z | 1 |
| Girgin, M | 1 |
| Ozercan, I | 1 |
| Ustundag, B | 1 |
| Aygen, E | 1 |
| Ergul, E | 1 |
| Ozgun, YM | 1 |
| Kiyak, G | 1 |
| Barit Ozgun, G | 1 |
| Korukluoglu, B | 1 |
| Kusdemir, A | 1 |
| Ersoz, N | 3 |
| Ozler, M | 2 |
| Altinel, O | 1 |
| Sadir, S | 2 |
| Ozerhan, IH | 2 |
| Uysal, B | 1 |
| Topal, T | 2 |
| Guven, A | 1 |
| Korkmaz, A | 4 |
| Uludag, M | 1 |
| Ozdilli, K | 1 |
| Citgez, B | 1 |
| Yetkin, G | 1 |
| Ipcioglu, OM | 1 |
| Ozcan, O | 1 |
| Polat, N | 1 |
| Kartal, A | 1 |
| Torun, P | 1 |
| Isgor, A | 1 |
| Kece, C | 1 |
| Yildiz, F | 1 |
| Simsek, A | 1 |
| Ozer, MT | 1 |
| Deveci, S | 1 |
| Ozgurtas, T | 1 |
| Korkmaz, O | 1 |
| Tufan, T | 1 |
| Dai, S | 2 |
| Jiang, B | 2 |
| Wang, Q | 2 |
| Yu, T | 2 |
| Shi, X | 1 |
| Yang, J | 1 |
| Kuesters, S | 1 |
| Hoeppner, J | 1 |
| Ward, BC | 1 |
| Kavalukas, S | 1 |
| Brugnano, J | 1 |
| Barbul, A | 1 |
| Panitch, A | 1 |
| Öter, Ş | 1 |
| Silva, SM | 1 |
| Feres, O | 1 |
| Kanellos, D | 3 |
| Despoudi, K | 2 |
| Angelopoulos, S | 2 |
| Koliakos, G | 5 |
| Zaraboukas, T | 5 |
| Lazaridis, C | 2 |
| Zacharakis, E | 3 |
| Lazaridis, H | 1 |
| Gu, J | 1 |
| Hu, H | 1 |
| Yin, B | 1 |
| Lv, G | 1 |
| Liu, K | 1 |
| Zhang, M | 1 |
| Yu, Y | 1 |
| Cai, X | 1 |
| Liu, J | 1 |
| Zhou, XL | 2 |
| Zhang, P | 1 |
| Zhao, ZC | 1 |
| Altuntas, I | 1 |
| Tarhan, O | 1 |
| Delibas, N | 1 |
| Avsar, AF | 1 |
| Avsar, FM | 1 |
| Sahin, M | 1 |
| Topaloglu, S | 1 |
| Vatansev, H | 1 |
| Belviranli, M | 1 |
| Sha, DF | 1 |
| Xin, CT | 1 |
| Yang, XX | 2 |
| Joels, CS | 1 |
| Matthews, BD | 1 |
| Kercher, KW | 1 |
| Austin, C | 1 |
| Norton, HJ | 1 |
| Williams, TC | 1 |
| Heniford, BT | 1 |
| Shi, HP | 1 |
| Hou, LB | 1 |
| Naycı, A | 1 |
| Çömelekoğlu, Ü | 1 |
| Çıngı, E | 1 |
| Taşkınlar, H | 1 |
| Avlan, D | 1 |
| Renda, N | 3 |
| Aksöyek, S | 1 |
| Aydin, C | 2 |
| Aytekin, FO | 2 |
| Tekin, K | 2 |
| Kabay, B | 2 |
| Yenisey, C | 2 |
| Kocbil, G | 2 |
| Ozden, A | 1 |
| Tarhan, OR | 3 |
| Barut, I | 3 |
| Sutcu, R | 1 |
| Akdeniz, Y | 2 |
| Akturk, O | 1 |
| Vasiliadis, K | 1 |
| Blouhos, K | 1 |
| Demetriades, H | 2 |
| Alamdari, DH | 1 |
| Betsis, D | 2 |
| Chen, SW | 1 |
| Liao, GD | 1 |
| Shen, ZJ | 1 |
| Zhang, ZL | 1 |
| Sun, L | 1 |
| Yu, YJ | 1 |
| Hu, QL | 1 |
| Jin, XD | 1 |
| Erdem, E | 1 |
| Wasserberg, N | 1 |
| Nunoo-Mensah, JW | 1 |
| Ruiz, P | 1 |
| Tzakis, AG | 1 |
| Tander, B | 1 |
| Bicakci, U | 1 |
| Kilicoglu-Aydin, B | 1 |
| Ariturk, E | 1 |
| Rizalar, R | 1 |
| Bernay, F | 1 |
| Lambrou, I | 1 |
| Sezik, M | 1 |
| Uguralp, S | 1 |
| Akin, M | 1 |
| Karabulut, AB | 1 |
| Harma, B | 1 |
| Kiziltay, A | 1 |
| Kiran, TR | 1 |
| Hasirci, N | 1 |
| Porat, S | 3 |
| Rousso, M | 1 |
| Shoshan, S | 3 |
| Nöthiger, F | 1 |
| Ziegler, WJ | 1 |
| Finger, J | 1 |
| Kaufmann, R | 1 |
| Kolachevskaia, EN | 1 |
| Smirnova, NA | 1 |
| Andrzheiuk, NI | 1 |
| van der Ham, AC | 2 |
| Kort, WJ | 2 |
| Weijma, IM | 2 |
| Jeekel, H | 1 |
| Evans, DM | 1 |
| McAree, K | 1 |
| Guyton, DP | 1 |
| Hawkins, N | 1 |
| Stakleff, K | 1 |
| Nyska, M | 2 |
| Nyska, A | 1 |
| Rivlin, E | 1 |
| Pines, M | 1 |
| Nagler, A | 1 |
| Ozoğul, Y | 1 |
| Baykal, A | 2 |
| Onat, D | 1 |
| Sayek, I | 2 |
| Vural, B | 1 |
| Cantürk, NZ | 1 |
| Esen, N | 1 |
| Solakoglu, S | 1 |
| Cantürk, Z | 1 |
| Kirkali, G | 1 |
| Sökmensüer, C | 1 |
| Ozdemir, A | 1 |
| Ozgün, H | 1 |
| Cevikel, MH | 1 |
| Kozaci, LD | 1 |
| Sakarya, S | 1 |
| Peacock, EE | 2 |
| Lane, JM | 2 |
| Bora, FW | 2 |
| Black, J | 1 |
| van den Ingh, HF | 1 |
| Jeekel, J | 1 |
| Sofer, B | 1 |
| Lukoianova, GM | 1 |
| Paramonov, AA | 1 |
| Kosykh, AA | 1 |
| Vasilechko, GA | 1 |
| Prockop, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Multi-center Randomized Double-blind Placebo-controlled Efficacy and Dose Ranging Trial of the Drug Product Seroguard, Solution (JSC Pharmasyntez, Russia) Used for the Prevention of Pelvic Adhesions[NCT03660787] | Phase 2 | 114 participants (Actual) | Interventional | 2017-05-04 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Absolute change of count of participants was measured with detecting pelvic organs limited mobility from the baseline (NCT03660787)
Timeframe: 30±4 days after surgery
| Intervention | participants (Number) |
|---|---|
| Placebo, 1.5 mL/kg | -17 |
| Placebo, 2.4 mL/kg | -17 |
| Seroguard, 1.5 mL/kg | -21 |
| Seroguard, 2.4 mL/kg | -21 |
The change from baseline was defined. It was evaluated by comparing baseline MRI data and repeated MRI data. Results were estimated according to scale from 0 to 3 where 0 - no adhesions, 1 - thin (filmy or filiform), 2 - marked, 3 - marked with an impaired passage through organs involved. (NCT03660787)
Timeframe: 30±4 days after surgery
| Intervention | score on a scale (Median) |
|---|---|
| Placebo, 1.5 mL/kg | 0 |
| Placebo, 2.4 mL/kg | 0 |
| Seroguard, 1.5 mL/kg | 0 |
| Seroguard, 2.4 mL/kg | 0 |
Frequency of detecting after repeated transvaginal ultrasound results was compared to baseline indications (4 or more) (NCT03660787)
Timeframe: 30±4 days after surgery
| Intervention | participants (Number) |
|---|---|
| Placebo, 1.5 mL/kg | -17 |
| Placebo, 2.4 mL/kg | -16 |
| Seroguard, 1.5 mL/kg | -19 |
| Seroguard, 2.4 mL/kg | -18 |
The frequency was estimated based on transvaginal ultrasound results (NCT03660787)
Timeframe: 30±4 days after surgery
| Intervention | participants (Number) |
|---|---|
| Placebo, 1.5 mL/kg | 3 |
| Placebo, 2.4 mL/kg | 2 |
| Seroguard, 1.5 mL/kg | 1 |
| Seroguard, 2.4 mL/kg | 3 |
No limited mobility of pelvic organs and no hyperechoic linear lesions should be shown (NCT03660787)
Timeframe: 30±4 days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo, 1.5 mL/kg | 19 |
| Placebo, 2.4 mL/kg | 19 |
| Seroguard, 1.5 mL/kg | 23 |
| Seroguard, 2.4 mL/kg | 20 |
The frequency was estimated based on transvaginal ultrasound results (NCT03660787)
Timeframe: 30±4 days after surgery
| Intervention | participants (Number) |
|---|---|
| Placebo, 1.5 mL/kg | 4 |
| Placebo, 2.4 mL/kg | 4 |
| Seroguard, 1.5 mL/kg | 0 |
| Seroguard, 2.4 mL/kg | 2 |
The number of adhesions according to the first MRI data was compared to the number according to the data of second MRI (NCT03660787)
Timeframe: 30±4 days after surgical intervention
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo, 1.5 mL/kg | 1 |
| Placebo, 2.4 mL/kg | 1 |
| Seroguard, 1.5 mL/kg | 10 |
| Seroguard, 2.4 mL/kg | 10 |
1 review available for hydroxyproline and Adhesions, Tissue
| Article | Year |
|---|---|
[Suture material in intestinal anastomosis].
Topics: Alkaline Phosphatase; Animals; Biocompatible Materials; Catgut; History, Ancient; History, Medieval; | 1980 |
1 trial available for hydroxyproline and Adhesions, Tissue
| Article | Year |
|---|---|
[Preventive effects of modified chitosan medical anti-adhesion membrane on postoperative intra-abdominal adhesion].
Topics: Abdominal Cavity; Aged; Aged, 80 and over; Biocompatible Materials; Chitosan; Female; Humans; Hydrox | 2012 |
70 other studies available for hydroxyproline and Adhesions, Tissue
| Article | Year |
|---|---|
Reduction of Abdominal Adhesions with Elecrospun Fiber Membranes in Rat Models.
Topics: Animals; Cecum; Chitosan; Disease Models, Animal; Fibrosis; Humans; Hydroxybutyrates; Hydroxyproline | 2018 |
REDUCTION OF INTRA-ARTICULAR ADHESION BY TOPICAL APPLICATION OF DAIDZEIN FOLLOWING KNEE SURGERY IN RABBITS.
Topics: Animals; Collagen; Humans; Hydroxyproline; Isoflavones; Knee Joint; Postoperative Complications; Rab | 2017 |
Effects of metoclopramide on healing of colonic anastomoses in a rat model of abdominal sepsis.
Topics: Abdominal Wall; Anastomosis, Surgical; Animals; Cecum; Colon; Disease Models, Animal; Hydroxyproline | 2013 |
Influence of the carboxymethyl chitosan anti-adhesion solution on the TGF-β1 in a postoperative peritoneal adhesion rat.
Topics: Animals; Chitosan; Hydroxyproline; Male; Peritoneal Diseases; Postoperative Complications; Rats; Rat | 2013 |
Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats.
Topics: Animals; Calcium Channel Blockers; Cicatrix; Dura Mater; Epidural Space; Fibrosis; Hydroxyproline; I | 2014 |
Impact of intraoperative temperature and humidity on healing of intestinal anastomoses.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; C-Reactive Protein; Humidity; Hydroxyproline; Inte | 2014 |
The effects of iloprost on colonic anastomotic healing in rats under obstructive ileus conditions.
Topics: Anastomosis, Surgical; Animals; Body Weight; Collagenases; Colon; Disease Models, Animal; Hydroxypro | 2014 |
The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Disease Models, Animal; Femur; Hydroxyprol | 2014 |
Does long intestinal tube splinting aggravate intestinal adhesions?
Topics: Animals; Digestive System Surgical Procedures; Female; Hydroxyproline; Intestinal Mucosa; Intestinal | 2014 |
Double 90 Degrees Counterrotated End-to-End-Anastomosis: An Experimental Study of an Intestinal Anastomosis Technique.
Topics: Anastomosis, Surgical; Animals; Feasibility Studies; Hydroxyproline; Intestinal Mucosa; Intestines; | 2015 |
Ultrapure alginate anti-adhesion gel does not impair colon anastomotic strength.
Topics: Abdominal Abscess; Alginates; Anastomosis, Surgical; Animals; Biocompatible Materials; Collagen; Col | 2014 |
An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1.
Topics: Animals; Cicatrix; Collagen; Down-Regulation; Epidural Space; Fibroblasts; Fibrosis; Gene Expression | 2015 |
Immunomodulatory effectiveness of licofelone in preventing epidural fibrosis in post-laminectomy rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Disease Models, Animal; Double-Blind Met | 2015 |
Reduction of intraarticular adhesion by topical application of colchicine following knee surgery in rabbits.
Topics: Administration, Topical; Animals; Cartilage, Articular; Colchicine; Collagen; Fibroblasts; Hydroxypr | 2014 |
Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Cell Proliferation; Cicatrix; Double-Blind Method; D | 2014 |
Intra-articular adhesion reduction after knee surgery in rabbits by calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Fibroblasts; Hydroxyproline; Knee Joint; Orthopedic Procedures; R | 2014 |
Effect of intraperitoneal curcumin instillation on postoperative peritoneal adhesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Curcumin; Disease Models, Animal; Hydroxypr | 2015 |
[Prognostication and prophylaxis of the adhesions recurrence postoperatively in patients suffering acute adhesive peritoneal disease complicated by ileus].
Topics: Acute Disease; Anastomosis, Surgical; Aprotinin; Drug Combinations; Female; Fibrinogen; Glycosaminog | 2015 |
All-trans retinoic Acid reduces joint adhesion formation: an experimental study in rats.
Topics: Animals; Bone Wires; Dose-Response Relationship, Drug; Femur; Hindlimb; Histological Techniques; Hyd | 2015 |
Effect of non-steroidal anti-inflammatory drugs on the increasing the incidence of colonic anastomosis in rats.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarker | 2015 |
Postoperative anti-adhesion ability of a novel carboxymethyl chitosan from silkworm pupa in a rat cecal abrasion model.
Topics: Animals; Bombyx; Cecum; Chitosan; Cytokines; Disease Models, Animal; Hydroxyproline; Leukocytes; Mal | 2016 |
Preoperative vitamin C supplementation improves colorectal anastomotic healing and biochemical parameters in malnourished rats.
Topics: Anastomosis, Surgical; Animals; Ascorbic Acid; Body Weight; Collagen; Colon; Dietary Supplements; Hy | 2016 |
The effects of intraperitoneal sildenafil administration on healing of left colonic anastomoses and intra-abdominal adhesion formation in the presence of intra-abdominal infection.
Topics: Anastomosis, Surgical; Animals; Colon; Disease Models, Animal; Hydroxyproline; Injections, Intraperi | 2008 |
Does low molecular weight heparin impair anastomotic wound healing?
Topics: Anastomosis, Surgical; Animals; Enoxaparin; Fibrinolytic Agents; Hydroxyproline; Intestines; Rats; R | 2009 |
Melatonin prevents peritoneal adhesions in rats.
Topics: Administration, Oral; Animals; Antioxidants; Cecum; Disease Models, Animal; Hydroxyproline; Male; Ma | 2009 |
Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Biological Dressings; Body Weight; | 2010 |
Synergistic effects of hyperbaric oxygen and granulocytecolony stimulating factor on postoperative adhesion formation in a rat cecal abrasion model.
Topics: Animals; Cecum; Filgrastim; Granulocyte Colony-Stimulating Factor; Hydroxyproline; Hyperbaric Oxygen | 2010 |
The effect of mitomycin C in reducing intraarticular adhesion after knee surgery in rabbits.
Topics: Administration, Topical; Animals; Cell Count; Cicatrix; Collagen; Disease Models, Animal; Femur; Fib | 2010 |
Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses.
Topics: Anastomosis, Surgical; Animals; Arginine; Hydroxyproline; Intestine, Small; Ischemic Preconditioning | 2011 |
Peptide inhibitors of MK2 show promise for inhibition of abdominal adhesions.
Topics: Abdomen; Animals; Cell-Penetrating Peptides; Cells, Cultured; Dose-Response Relationship, Drug; Epit | 2011 |
The effect of alpha-lipoic acid in the prevention of peritoneal adhesions.
Topics: Animals; Antioxidants; Disease Models, Animal; Hydroxyproline; Male; Malondialdehyde; Oxidative Stre | 2011 |
Does metoclopramide impair anastomotic healing of the left colon of rats?
Topics: Anastomosis, Surgical; Animals; Colon; Dopamine Antagonists; Gastrointestinal Motility; Hydroxyproli | 2011 |
Intraperitoneally administered irinotecan with 5-fluorouracil impair wound healing of colonic anastomoses in a rat model: an experimental study.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Antimetabolites, Antineoplastic; Antineoplastic Ag | 2011 |
The effects of the intraperitoneal administration of oxaliplatin and 5-FU on the healing of colonic anastomoses: an experimental study.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colon; Fluor | 2011 |
The effects of iloprost on colonic anastomotic healing in rats.
Topics: Anastomosis, Surgical; Animals; Collagenases; Colon; Hydroxyproline; Iloprost; Male; Neovascularizat | 2011 |
A comparative study of the preventive effects of mitomycin C and chitosan on intraarticular adhesion after knee surgery in rabbits.
Topics: Alkylating Agents; Animals; Chitosan; Cicatrix; Disease Models, Animal; Fibroblasts; Hydroxyproline; | 2012 |
Sutureless primary repair of colonic perforation with a degradable stent in a porcine model of fecal peritonitis.
Topics: Albumins; Animals; Biocompatible Materials; Collagen; Colon; Disease Models, Animal; Feces; Female; | 2012 |
Seprafilm reduces adhesions to polypropylene mesh and increases peritoneal hydroxyproline.
Topics: Abdominal Muscles; Animals; Biocompatible Materials; Female; Hernia, Ventral; Hyaluronic Acid; Hydro | 2002 |
Diphenhydramine and hyaluronic acid derivatives reduce adnexal adhesions and prevent tubal obstructions in rats.
Topics: Adnexal Diseases; Animals; Aspartate Aminotransferases; Biocompatible Materials; Diphenhydramine; Fa | 2003 |
[Experimental study on basic fibroblast growth factor combined slow-releasing degradable membrane to prevent tendon adhesion].
Topics: Achilles Tendon; Animals; Delayed-Action Preparations; Female; Fibroblast Growth Factor 2; Fibroblas | 2004 |
Evaluation of adhesion formation, mesh fixation strength, and hydroxyproline content after intraabdominal placement of polytetrafluoroethylene mesh secured using titanium spiral tacks, nitinol anchors, and polypropylene suture or polyglactin 910 suture.
Topics: Alloys; Animals; Equipment Design; Hernia, Ventral; Hydroxyproline; Laparoscopy; Polyglactin 910; Po | 2005 |
Chinese medicine compound Changtong oral liquid on postoperative intestinal adhesions.
Topics: Administration, Oral; Animals; Drugs, Chinese Herbal; Female; Hydroxyproline; Male; Peritoneum; Post | 2005 |
[Does sepsis impair the healing of colonic anastomosis in splenectomized rats?].
Topics: Anastomosis, Surgical; Animals; Colon; Disease Models, Animal; Hydroxyproline; Pressure; Rats; Rats, | 2005 |
Effect of temporary abdominal closure on colonic anastomosis and postoperative adhesions in experimental secondary peritonitis.
Topics: Abdomen; Anastomosis, Surgical; Animals; Colon; Hydroxyproline; Peritoneum; Peritonitis; Postoperati | 2006 |
Pentoxifylline, a methyl xanthine derivative, reduces peritoneal adhesions and increases peritoneal fibrinolysis in rats.
Topics: Animals; Drug Evaluation, Preclinical; Female; Fibrinolysis; Hydroxyproline; Pentoxifylline; Periton | 2006 |
Effect of iloprost on impaired anastomotic healing caused by 5-fluorouracil plus leucovorin.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Collagen; Colon; Female; Fibroblast | 2007 |
Preventive effect of gelatinizedly-modified chitosan film on peritoneal adhesion of different types.
Topics: Abdominal Cavity; Abdominal Injuries; Animals; Biocompatible Materials; Chitosan; Female; Hydroxypro | 2007 |
The effect of different temporary abdominal closure techniques on fascial wound healing and postoperative adhesions in experimental secondary peritonitis.
Topics: Animals; Bacterial Infections; Bandages; Cecal Diseases; Dermatologic Surgical Procedures; Fascia; F | 2008 |
The effect of immunosuppression on peritoneal adhesions formation after small bowel transplantation in rats.
Topics: Animals; Hydroxyproline; Immunosuppression Therapy; Intestine, Small; Male; Postoperative Complicati | 2007 |
Antiadhesive effects of mitomycin C and streptopeptidase A in rats with intraperitoneal adhesions.
Topics: Animals; Anti-Inflammatory Agents; Clostridium histolyticum; Disease Models, Animal; Hydroxyproline; | 2007 |
Effect of IGF-I on healing of colonic anastomoses in rats under 5-FU treatment.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Collagen; Colon; Colonic Neoplasms; | 2008 |
[Can dexpanthenol prevent peritoneal adhesion formation? An experimental study].
Topics: Animals; Fibrinolysis; Hydroxyproline; Infusions, Intravenous; Injections, Intraperitoneal; Male; Pa | 2007 |
An evaluation of normal saline and taurolidine on intra-abdominal adhesion formation and peritoneal fibrinolysis.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Female; Fibrinolysis; Hydroxyproline; Perito | 2008 |
Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor.
Topics: Animals; Epidermal Growth Factor; Hydroxyproline; Male; Peritoneum; Rats; Rats, Wistar; Statistics, | 2008 |
Improvement of gliding function of flexor tendons by topically applied enriched collagen solution.
Topics: Aminopropionitrile; Animals; Biomechanical Phenomena; Chickens; Collagen; DNA; Foot; Hydroxyproline; | 1980 |
[Importance of determining the somatotropic hormone, serotonin and oxyproline levels in assessing the degree of fibrosis in modern phthisiogynecology].
Topics: Adult; Female; Growth Hormone; Humans; Hydroxyproline; Middle Aged; Serotonin; Time Factors; Tissue | 1980 |
Transient protection of incomplete colonic anastomoses with fibrin sealant: an experimental study in the rat.
Topics: Anastomosis, Surgical; Animals; Collagen; Colon; Fibrin Tissue Adhesive; Hydroxyproline; Male; Posto | 1993 |
Dose dependency and wound healing aspects of the use of tissue plasminogen activator in the prevention of intra-abdominal adhesions.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyproline; Ischemia; Ligatio | 1993 |
Topically applied halofuginone, an inhibitor of collagen type I transcription, reduces peritendinous fibrous adhesions following surgery.
Topics: Animals; Chickens; Collagen; Gene Expression Regulation; Hydroxyproline; Inflammation; Piperidines; | 1996 |
An experimental study of the effect of aprotinin on intestinal adhesion formation.
Topics: Animals; Aprotinin; Fibrinolysis; Hemostatics; Hydroxyproline; Intestinal Diseases; Intestine, Small | 1998 |
The role of neutrophils in the formation of peritoneal adhesions.
Topics: Animals; Blood Cell Count; Collagen; Cyclophosphamide; Granulocyte-Macrophage Colony-Stimulating Fac | 1999 |
The effect of octreotide on postoperative adhesion formation.
Topics: Animals; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrinolysis; Growth Substa | 2000 |
Lexipafant inhibits postsurgical adhesion formation.
Topics: Animals; Female; Hydroxyproline; Imidazoles; Interleukin-6; Leucine; Peritoneal Diseases; Platelet A | 2002 |
Some biologic and technical considerations in the repair of long tendons.
Topics: Aminopropionitrile; Animals; Cadaver; Cicatrix; Collagen; Connective Tissue; Dogs; Fingers; Foreign- | 1977 |
cis-hydroxyproline limits work necessary to flex a digit after tendon injury.
Topics: Animals; Biomechanical Phenomena; Cicatrix; Collagen; Disease Models, Animal; Dose-Response Relation | 1975 |
Effect of fibrin sealant on the healing colonic anastomosis in the rat.
Topics: Anastomosis, Surgical; Animals; Collagen; Colon; Fibrin Tissue Adhesive; Hydroxyproline; Male; Neutr | 1991 |
Increased collagenolytic activity in severed and sutured tendons following topical application of exogenous collagen in chickens.
Topics: Animals; Chickens; Collagen; Dialysis; Hydroxyproline; Microbial Collagenase; Proteins; Stimulation, | 1985 |
[Prognosis of the course of abdominal adhesions in children].
Topics: Abdomen; Adolescent; Child; Child, Preschool; Hexosamines; Humans; Hydroxyproline; Prognosis; Tissue | 1988 |
Inhibitors of collagen biosynthesis as a means of controlling scar formation in tendon injury.
Topics: Aminopropionitrile; Animals; Chelating Agents; Cicatrix; Collagen; Hindlimb; Hydroxyproline; Penicil | 1972 |
Symposium on biological control of scar tissue.
Topics: Aminopropionitrile; Animals; Cicatrix; Collagen; Humans; Hydroxyproline; Nitriles; Penicillamine; Ri | 1968 |