Page last updated: 2024-09-04

hydroxyl radical and Parkinson Disease

hydroxyl radical has been researched along with Parkinson Disease in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.65)18.7374
1990's21 (48.84)18.2507
2000's13 (30.23)29.6817
2010's5 (11.63)24.3611
2020's2 (4.65)2.80

Authors

AuthorsStudies
Cao, Z; Fu, X; Wang, X; Xia, Q; Zhang, T; Zhong, L; Zhu, J1
Cao, Z; Fu, X; Wang, X; Zhang, F; Zhang, T; Zhu, J1
Deng, YL; Li, HM; Li, YJ; Meng, LY; Schläppi, M; Song, DW; Xie, BJ; Xin, N1
Kell, DB1
Gowda, B; Jaisankar, P; Mohanakumar, KP; Nagashayana, N; Sengupta, T; Vinayagam, J1
Ashihara, E; Inden, M; Kitamura, Y; Takata, K; Yasui, H; Yoshimoto, K1
Górska, A; Gołembiowska, K; Kamińska, K; Noworyta-Sokołowska, K; Wardas, J1
Kang, JH; Kim, KS1
Brus, R; Kostrzewa, JP; Kostrzewa, RA; Kostrzewa, RM; Nowak, P1
Galoyan, AA; Knaryan, VH; Mohanakumar, KP; Samantaray, S; Srinivasan, A; Varghese, M1
Allsop, D; Benson, FE; El-Agnaf, OM; King, JE; Tabner, BJ; Turnbull, S1
Deng, YL; Liu, XQ; Qing, H; Wang, R; Zheng, XL1
Cohen, G2
Lavie, L; Youdim, MB1
Dostert, P; Maruyama, W; Matsubara, K; Naoi, M1
Gutteridge, JM1
Chiueh, CC; Mohanakumar, KP; Murphy, DL; Wu, RM1
Chiueh, CC; Krishna, G; Mohanakumar, KP; Murphy, DL; Obata, T; Sternberger, LM; Wu, RM1
Dykens, JA1
Ben-Shachar, D; Eshel, G; Finberg, JP; Riederer, P; Youdim, MB1
Fukushima, T; Hojo, N; Isobe, A; Shiwaku, K; Tawara, T; Yamane, Y1
Kondo, T1
Herlinger, E; Jellinger, K; Kienzl, E; Linert, L; Youdim, MB1
Aruoma, OI; Butler, J; Dexter, DT; Halliwell, B; Jenner, A; Jenner, P; Spencer, JP1
Hayakawa, M; Ikebe, S; Katsumata, K; Mizuno, Y; Ozawa, T; Yoneda, M1
Alam, ZI; Cairns, N; Daniel, SE; Halliwell, B; Jenner, A; Jenner, P; Lees, AJ; Marsden, CD1
Jiang, DH; Lan, J1
Faucheux, BA; Hirsch, EC1
Graham, DG; Montine, TJ; Olson, SJ; Perry, G; Robertson, D; Smith, MA; Zhang, J1
Blandini, F; Desideri, S; Godi, L; Mancini, F; Martignoni, E; Nappi, G; Pacchetti, C1
Cheng, FC; Dryhurst, G; Han, J; Yang, Z1
Blandini, F; di Jeso, F; Martignoni, E; Nappi, G; Ricotti, R1
Chuda, M; Hayabara, T; Ihara, Y; Kuroda, S1
Bémeur, C; Lambert, J; Montgomery, J; Ste-Marie, L; Vachon, L1
Jameson, GN; Linert, W1
Blarzino, C; Coccia, R; De Marco, C; Foppoli, C; Rosei, MA1
Obata, T; Yamanaka, Y1
Kubota, S; Obata, T; Yamanaka, Y1
Burke, WJ; Li, SW; Lin, TS; Minteer, S1
Iravani, MM; Jenner, P; Kashefi, K; Mander, P; Rose, S1
Choi, SY; Kang, JH; Kang, TC; Kim, KS; Kwon, HY; Won, MH1
Allsop, D; El-Agnaf, OM; Tabner, BJ; Turnbull, S1

Reviews

10 review(s) available for hydroxyl radical and Parkinson Disease

ArticleYear
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.
    Archives of toxicology, 2010, Volume: 84, Issue:11

    Topics: Alzheimer Disease; Anti-Bacterial Agents; Apoptosis; Humans; Huntington Disease; Hydrogen Peroxide; Hydroxyl Radical; Iron; Iron Chelating Agents; Ligands; Oxidative Stress; Parkinson Disease; Prion Diseases; Systems Biology

2010
Peculiarities of L: -DOPA treatment of Parkinson's disease.
    Amino acids, 2005, Volume: 28, Issue:2

    Topics: Animals; Antiparkinson Agents; Basal Ganglia; Biological Transport; Brain Chemistry; Dopamine; Dyskinesias; Humans; Hydroxyl Radical; Levodopa; Parkinson Disease; Rats; Receptors, Dopamine

2005
Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease.
    Life sciences, 1994, Volume: 55, Issue:25-26

    Topics: Amino Acid Oxidoreductases; Animals; Free Radical Scavengers; Humans; Hydroxyl Radical; Monoamine Oxidase Inhibitors; Nitric Oxide Synthase; Oxidative Stress; Parkinson Disease

1994
Hydroxyl radicals, iron, oxidative stress, and neurodegeneration.
    Annals of the New York Academy of Sciences, 1994, Nov-17, Volume: 738

    Topics: Abetalipoproteinemia; Alzheimer Disease; Animals; Antioxidants; Brain; Brain Diseases; Brain Injuries; Brain Ischemia; Cell Membrane; Ferritins; Hemosiderin; Humans; Hydroxyl Radical; Iron; Nerve Degeneration; Oxidative Stress; Parkinson Disease

1994
Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline).
    Annals of the New York Academy of Sciences, 1994, Nov-17, Volume: 738

    Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Animals; Antioxidants; Corpus Striatum; Free Radicals; Humans; Hydroxyl Radical; Lipid Peroxidation; Monoamine Oxidase; Neurons; Parkinson Disease; Rats; Selegiline; Substantia Nigra

1994
In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia.
    Annals of the New York Academy of Sciences, 1994, Nov-17, Volume: 738

    Topics: Animals; Antioxidants; Basal Ganglia; Corpus Striatum; Dopamine; Free Radical Scavengers; Free Radicals; Humans; Hydroxyl Radical; Melanins; MPTP Poisoning; Nerve Degeneration; Parkinson Disease; Rats; Salicylates; Selegiline; Substantia Nigra

1994
Parkinson's disease and free radicals. Mechanism of neurodegeneration and neuroprotection.
    Annals of the New York Academy of Sciences, 1996, Jun-15, Volume: 786

    Topics: Corpus Striatum; Deferoxamine; Free Radicals; Humans; Hydroxyl Radical; Nerve Degeneration; Neurons; Parkinson Disease

1996
Iron metabolism and Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 1998, Volume: 13 Suppl 1

    Topics: Cell Death; Dopamine; Free Radicals; Humans; Hydroxyl Radical; Iron; Lactoferrin; Neurons; Parkinson Disease; Reactive Oxygen Species; Substantia Nigra; Transferrin

1998
Redox reactions of neurotransmitters possibly involved in the progression of Parkinson's Disease.
    Journal of inorganic biochemistry, 2000, Volume: 79, Issue:1-4

    Topics: Catecholamines; Disease Progression; Dopamine; Ferritins; Humans; Hydroxyl Radical; Iron; Neurotransmitter Agents; Oxidation-Reduction; Parkinson Disease

2000
Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.
    Free radical biology & medicine, 2002, Jun-01, Volume: 32, Issue:11

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Cell Death; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen Peroxide; Hydroxyl Radical; Metals; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Synucleins

2002

Trials

3 trial(s) available for hydroxyl radical and Parkinson Disease

ArticleYear
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.
    The American journal of pathology, 1999, Volume: 154, Issue:5

    Topics: Aged; Cell Death; Cytoplasm; DNA; Female; Guanosine; Humans; Hydroxyl Radical; Immunohistochemistry; Male; Neurons; Oxidative Stress; Parkinson Disease; RNA; Substantia Nigra

1999
Peripheral markers of oxidative stress in Parkinson's disease. The role of L-DOPA.
    Free radical biology & medicine, 1999, Volume: 27, Issue:3-4

    Topics: Antiparkinson Agents; Biomarkers; Blood Platelets; Dopamine; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Levodopa; Linear Models; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Sodium Salicylate; Superoxide Dismutase; Tyrosine

1999
Determination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Sep-10, Volume: 732, Issue:1

    Topics: Adult; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Hydroxybenzoates; Hydroxyl Radical; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine

1999

Other Studies

30 other study(ies) available for hydroxyl radical and Parkinson Disease

ArticleYear
Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease.
    European journal of medicinal chemistry, 2023, Mar-05, Volume: 249

    Topics: Animals; Antioxidants; Chelating Agents; Hydroxyl Radical; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease

2023
Discovery of novel 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives as multifunctional MAO-B inhibitors for the treatment of Parkinson's disease.
    Journal of enzyme inhibition and medicinal chemistry, 2023, Volume: 38, Issue:1

    Topics: Benzothiazoles; Humans; Hydroxyl Radical; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Structure-Activity Relationship

2023
Formation of a salsolinol-like compound, the neurotoxin, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, in a cellular model of hyperglycemia and a rat model of diabetes.
    International journal of molecular medicine, 2014, Volume: 33, Issue:3

    Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Dopaminergic Neurons; Glucose; Hydroxyl Radical; Hyperglycemia; Isoquinolines; Neurotoxins; Parkinson Disease; Rats; Tetrahydroisoquinolines

2014
Antiparkinsonian effects of aqueous methanolic extract of Hyoscyamus niger seeds result from its monoamine oxidase inhibitory and hydroxyl radical scavenging potency.
    Neurochemical research, 2011, Volume: 36, Issue:1

    Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Free Radical Scavengers; Humans; Hydroxyl Radical; Hyoscyamus; Male; Medicine, Ayurvedic; Methanol; Mice; Mice, Inbred BALB C; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Parkinson Disease; Plant Extracts

2011
Detoxification of 6-hydroxydopamine-induced dopaminergic neurodegeneration by 5,5-dimethyl-1-pyrroline N-oxide, a radical trapper, in hemiparkinsonian rats.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:9

    Topics: Animals; Antioxidants; Behavior, Animal; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyl Radical; Iron; Male; Mental Disorders; Oxidative Stress; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase

2012
Effects of adenosine receptor antagonists on the in vivo LPS-induced inflammation model of Parkinson's disease.
    Neurotoxicity research, 2013, Volume: 24, Issue:1

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Corpus Striatum; Dopamine; Dopaminergic Neurons; Glutamic Acid; Hydroxyl Radical; Inflammation; Lipopolysaccharides; Male; Microinjections; Parkinson Disease; Purines; Rats; Receptor, Adenosine A2A

2013
Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.
    Molecules and cells, 2003, Feb-28, Volume: 15, Issue:1

    Topics: alpha-Synuclein; Amino Acid Substitution; Anserine; Antioxidants; Antiparkinson Agents; Biopolymers; Carnosine; Chelating Agents; Codon; Copper; Edetic Acid; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydroxyl Radical; Isopropyl Thiogalactoside; Lewy Bodies; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Phenylmethylsulfonyl Fluoride; Point Mutation; Resins, Synthetic; Spin Labels; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tyrosine

2003
Synthetic bovine proline-rich-polypeptides generate hydroxyl radicals and fail to protect dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity in mice.
    Neuropeptides, 2006, Volume: 40, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biogenic Amines; Cattle; Cell-Free System; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Hydroxyl Radical; Mice; Mice, Inbred BALB C; Mitochondria; MPTP Poisoning; Neurons; Neurotoxins; Parkinson Disease; Peptides; Proline-Rich Protein Domains

2006
A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein.
    Free radical research, 2006, Volume: 40, Issue:7

    Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzenesulfonates; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Humans; Hydroxyl Radical; Nitroso Compounds; Parkinson Disease; Peptide Fragments; Peptides; Reactive Oxygen Species; Recombinant Fusion Proteins

2006
Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells.
    Neuroscience bulletin, 2008, Volume: 24, Issue:3

    Topics: Apoptosis; Catechols; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Humans; Hydroxyl Radical; Iron; Iron Metabolism Disorders; Isoquinolines; Malondialdehyde; Models, Biological; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinson Disease; Salsoline Alkaloids; Up-Regulation

2008
The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence.
    Journal of neural transmission. Supplementum, 1983, Volume: 19

    Topics: Animals; Brain; Catalase; Catecholamines; Dopamine; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Levodopa; Monoamine Oxidase; Nerve Degeneration; Neurons; Parkinson Disease; Rats; Selegiline; Superoxide Dismutase; Superoxides

1983
N-methyl(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity.
    Free radical biology & medicine, 1995, Volume: 19, Issue:1

    Topics: Animals; Ascorbic Acid; Catalase; Chromatography, High Pressure Liquid; Dopamine; Ferric Compounds; Ferrous Compounds; Free Radicals; Glutathione; Humans; Hydroxyl Radical; Isoquinolines; Methylation; Neurons; Oxidation-Reduction; Parkinson Disease; Salsoline Alkaloids; Superoxide Dismutase; Tetrahydroisoquinolines

1995
Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: implications for neurodegeneration.
    Journal of neurochemistry, 1994, Volume: 63, Issue:2

    Topics: Adenosine Diphosphate; Animals; Calcium; Cell Hypoxia; Cerebellum; Cerebral Cortex; Electron Spin Resonance Spectroscopy; Electron Transport; Free Radicals; Humans; Hydroxyl Radical; Male; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Neurons; Nitrogen Oxides; Parkinson Disease; Pyridines; Rats; Rats, Wistar; Sodium; Spin Labels

1994
The neurotoxicity of iron and nitric oxide. Relevance to the etiology of Parkinson's disease.
    Advances in neurology, 1993, Volume: 60

    Topics: Animals; Deferoxamine; Dominance, Cerebral; Ferritins; Free Radicals; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Injections, Intraventricular; Iron; Lipid Peroxidation; Nitric Oxide; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Stereotyped Behavior; Substantia Nigra

1993
Radical formation site of cerebral complex I and Parkinson's disease.
    Journal of neuroscience research, 1995, Oct-15, Volume: 42, Issue:3

    Topics: Animals; Brain; Cattle; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Hydroxyl Radical; Lipid Peroxidation; Mitochondria; NAD; NAD(P)H Dehydrogenase (Quinone); Niacinamide; Paraquat; Parkinson Disease; Reactive Oxygen Species; Superoxide Dismutase; Superoxides

1995
Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease.
    Journal of neural transmission. Supplementum, 1995, Volume: 46

    Topics: Dopamine; Electron Transport; Ferric Compounds; Ferritins; Hydroxydopamines; Hydroxyl Radical; In Vitro Techniques; Kinetics; Molecular Structure; Neurotoxins; Oxidation-Reduction; Oxidopamine; Oxygen; Parkinson Disease; Spectrophotometry; Spectrophotometry, Ultraviolet

1995
Evaluation of the pro-oxidant and antioxidant actions of L-DOPA and dopamine in vitro: implications for Parkinson's disease.
    Free radical research, 1996, Volume: 24, Issue:2

    Topics: Animals; Antioxidants; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Free Radical Scavengers; Hydroxyl Radical; Hypochlorous Acid; Lipid Peroxidation; Liposomes; Male; Oxidants; Oxygen; Parkinson Disease; Superoxides

1996
Fragile mitochondrial DNA: the missing link in the apoptotic neuronal cell death in Parkinson's disease.
    Biochemical and biophysical research communications, 1997, Jun-09, Volume: 235, Issue:1

    Topics: Adolescent; Adult; Aged; Apoptosis; Child; Child, Preschool; Corpus Striatum; DNA Fragmentation; DNA, Mitochondrial; Female; Humans; Hydroxyl Radical; Male; Neurons; Oxidative Stress; Parkinson Disease; Particle Size; Sequence Deletion

1997
Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Base Composition; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Hydroxyl Radical; Middle Aged; Nitrates; Oxidants; Oxidation-Reduction; Parkinson Disease; Pyrimidines; Reference Values; Regression Analysis; Substantia Nigra

1997
Excessive iron accumulation in the brain: a possible potential risk of neurodegeneration in Parkinson's disease.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:6-7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Stem; Corpus Striatum; Glutathione; Glutathione Disulfide; Hydroxyl Radical; Iron; Iron, Dietary; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Parkinson Disease; Risk Factors

1997
Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease.
    Journal of neurochemistry, 1999, Volume: 73, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Cysteine; Glutamic Acid; Glutathione; Glycine; Hydrolysis; Hydroxyl Radical; Iron; Kinetics; Male; Microdialysis; Mitochondria; Models, Chemical; Nitro Compounds; Oxygen Consumption; Parkinson Disease; Perfusion; Propionates; Rats; Rats, Sprague-Dawley; Substantia Nigra

1999
Hydroxyl radical and superoxide dismutase in blood of patients with Parkinson's disease: relationship to clinical data.
    Journal of the neurological sciences, 1999, Nov-30, Volume: 170, Issue:2

    Topics: Age Factors; Age of Onset; Aged; Antiparkinson Agents; Bromocriptine; Disease Progression; Erythrocytes; Humans; Hydroxyl Radical; Levodopa; Middle Aged; Multiple System Atrophy; Parkinson Disease; Pergolide; Severity of Illness Index; Statistics as Topic; Superoxide Dismutase; Time Factors

1999
Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate.
    Free radical biology & medicine, 1999, Volume: 27, Issue:9-10

    Topics: 1-Methyl-4-phenylpyridinium; Allyl Compounds; Animals; Antioxidants; Butylamines; Corpus Striatum; Dopamine; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Hydroxylation; Injections, Intraperitoneal; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neurotoxins; Parabens; Parkinson Disease; Rats; Rats, Sprague-Dawley; Selegiline

1999
Interaction of enkephalin derivatives with reactive oxygen species.
    Biochimica et biophysica acta, 2001, Feb-16, Volume: 1525, Issue:1-2

    Topics: Animals; Enkephalins; Free Radical Scavengers; Humans; Hydroxyl Radical; In Vitro Techniques; Lipid Peroxidation; Melanins; Oxidation-Reduction; Parkinson Disease; Peroxides; Reactive Oxygen Species; Superoxides

2001
Nitric oxide enhances MPP(+)-induced hydroxyl radical generation via depolarization activated nitric oxide synthase in rat striatum.
    Brain research, 2001, Jun-01, Volume: 902, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Allopurinol; Animals; Dopamine; Enzyme Inhibitors; Extracellular Space; Herbicides; Hydroxybenzoates; Hydroxyl Radical; Iron; Iron Chelating Agents; Male; Membrane Potentials; Microdialysis; Neostriatum; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Parkinson Disease; Potassium; Rats; Rats, Wistar

2001
Allopurinol suppresses para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical generation in rat striatum.
    Neuroscience letters, 2001, Jun-22, Volume: 306, Issue:1-2

    Topics: 1-Methyl-4-phenylpyridinium; Allopurinol; Animals; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Hazardous Substances; Hydroxyl Radical; Male; Microdialysis; Neostriatum; Nerve Degeneration; Parkinson Disease; Parkinson Disease, Secondary; Phenols; Rats; Rats, Wistar

2001
3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson's disease pathogenesis.
    Brain research. Molecular brain research, 2001, Sep-10, Volume: 93, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aldehydes; Brain; Catechols; Humans; Hydrogen Peroxide; Hydroxyl Radical; Male; Nerve Degeneration; Parkinson Disease; Spectrophotometry, Atomic

2001
Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration.
    Neuroscience, 2002, Volume: 110, Issue:1

    Topics: Animals; Cell Count; Cell Death; Dopamine; Encephalitis; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Hydroxyl Radical; Lipopolysaccharides; Macrophages; Male; NADPH Dehydrogenase; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Parkinson Disease; Peroxynitrous Acid; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase

2002
Aggregation of alpha-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.
    Free radical biology & medicine, 2002, Mar-15, Volume: 32, Issue:6

    Topics: alpha-Synuclein; Humans; Hydrogen Peroxide; Hydroxyl Radical; Macromolecular Substances; Nerve Tissue Proteins; Parkinson Disease; Protein Binding; Superoxide Dismutase; Synucleins

2002
Monoamine oxidase, hydrogen peroxide, and Parkinson's disease.
    Advances in neurology, 1987, Volume: 45

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Culture Techniques; Dopamine; Humans; Hydrogen Peroxide; Hydroxides; Hydroxydopamines; Hydroxyl Radical; Macaca fascicularis; Monoamine Oxidase; Neurons; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Superoxides

1987